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pigmentosum in Medical News

Enhanced skin cancer risk linked to defects in cellular aging controls

...gmentation. Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin ...

Skin Cancer Risk Increases With Ultraviolet-B Radiation Exposure

...s the commonest cause of skin cancer and is responsible for breaking DNA strands in exposed skin cells. Patients who have a condition called xeroderma pigmentosum are unable to repair these broken strands and hence are at increased risk of developing skin cancer. Li-E Wang, M.D., and Qingyi Wei, M.D., Ph.D., of ...
pigmentosum in Medical Technology

Dimericine(R) Receives FDA Fast Track Designation for Treatment Of Photosensitivity in XP Patients

...tion (FDA) has granted Fast Track designation for Dimericine (T4N5) for treatment of solar and ultraviolet photosensitivity in patients with Xeroderma pigmentosum (XP). Dimericine, also known as T4N5 Liposome Lotion, is a topical drug developed by AGI currently in clinical trials for treating XP patients with sk...
pigmentosum in Medical Dictionary

Xeroderma Pigmentosum

Xeroderma pigmentosa, or XP, is an autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient. :574 This disorder leads to multiple basal cell... Xeroderma pigmentosa, or XP, is an autosomal recessive genetic...
pigmentosum in Biological News

Enzyme crystal structure reveals 'unexpected' genome repair functions

...leotide excision repair (NER), as well as other cell processes. "XPB was initially identified as the gene responsible for NER defects in xeroderma pigmentosum patients, who are hypersensitive to light and have a dramatically increased risk of skin cancer," says John A. Tainer, a professor at Scripps Research...

Discovering the first steps in transcription-coupled repair

...cells from patients with Cockayne Syndrome (CS) versus those with xeroderma pigmentosum (XP), two different hereditary diseases with a common feature: both entail ...icant because XPB and XPD, the other two proteins associated with xeroderma pigmentosum that can cause Cockayne Syndrome when defective (in addition to XPG), are e...
pigmentosum in Biological Technology

AGI Dermatics President to be Keynote Speaker at the 11th Annual Sunscreen Symposium

...ministration recently granted Fast Track designation for Dimericine for treatment of solar and ultraviolet photosensitivity in patients with Xeroderma pigmentosum (XP), a rare genetic disorder that blocks the body's natural ability to repair DNA damage caused by ultraviolet light. AGI Dermatics is also the deve...
pigmentosum in Biological Dictionary

Xeroderma pigmentosum

Xeroderma pigmentosa, or XP, is an autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient. :574 This disorder leads to multiple basal cell... Xeroderma pigmentosa, or XP, is an autosomal recessive genetic dis...
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