Study helps explain fundamental process of tumor growth
...atically on the PET scan. Using a novel proteomic screen to identify new phosphotyrosine binding proteins, Cantley and his colleagues first determined that PKM2 can... investigators demonstrated that it is the ability of PKM2 to interact with phosphotyrosine that enables this form of pyruvate kinase to promote the unique glucose met...Pathogens use previously undescribed mechanism to sabotage host immune system
...e of SpvC and its complex with a phosphopeptide substrate. The enzyme-substrate complex revealed how SpvC docks with activated MAPK by recognizing the phosphotyrosine and then maneuvers the phosphothreonine into the enzyme active site. These data implicated the MAPK p38 as the likely preferred substrate for OspF and...Custom Phosphopeptide Microarray from LC Sciences
Description:... Microarrays designed for pathway studies, protein-protein interaction studies, and phosphotyrosine binding protein (PTB) Studies built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as p...