Navigation Links
phosphoinositide in Medical News

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

...end-stage renal disease. Keryx is also developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation. KRX-0401 has demonstrated both...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

...end-stage renal disease. Keryx is also developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation. KRX-0401 has demonstrated both...

Green Beans for Cancer Prevention and Treatment.

...which is found to have anti-cancer effects by blocking the action of enzyme phosphoinositide 3 kinase. Dr. Marco Falasca and colleagues from the University College...ated from the legumes by the scientists and was found to inhibit the enzyme phosphoinositide 3 kinase in mice model, in which they found that the inhibitors reduced the...
phosphoinositide in Medical Technology

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

...ddressing these targets. About SF1126 There is a strong and significant biological rationale for developing PI3 kinase inhibitors to treat cancer. phosphoinositide 3-kinase (PI3K) is the gate keeper of one of the major pathways of intracellular signal transduction that regulates cell growth, proliferation, angiog...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

...ddressing these targets. About SF1126 There is a strong and significant biological rationale for developing PI3 kinase inhibitors to treat cancer. phosphoinositide 3-kinase (PI3K) is the gate keeper of one of the major pathways of intracellular signal transduction that regulates cell growth, proliferation, angiog...

Semafore's SF1126 Exhibits Antitumor and Antiangiogenic Activity

...and antiangiogenic activity. The paper, entitled "A Vascular Targeted Pan phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activ...anta, Emory University School of Medicine, and M.D. Anderson Cancer Center. phosphoinositide 3-kinase (PI3K) is a powerful pathway and an emerging cancer target for inh...
phosphoinositide in Biological News

Rice University study finds possible clues to epilepsy, autism

...oral student Eric Howlett discovered an unanticipated connection between glutamate an amino acid and neurotransmitter in much of the food we eat and phosphoinositide 3-kinase (PI3K), an enzyme that, Howlett found, regulates the activity of neurons. Howlett and his colleagues, graduate student Curtis Chun-Jen Lin...

GEN reports growing focus on PI3-kinase pathway in cancer research

... New Rochelle, NY, December 4, 2008Researchers are taking a closer look at the phosphoinositide 3-kinase (PI3-kinase) pathway as studies continue to demonstrate that inhibiting this biological route suppresses tumor growth, reports Genetic Engin...

New insight into the mechanisms of voltage sensing and transduction in biological processes

...ical for understanding general mechanisms of voltage sensing and many disorders coupled with altered membrane excitabilities. The VSPs ability to tune phosphoinositide phosphatase activity by voltage will also serve as an important molecular tool to understand mechanisms of tumor suppressor phosphatase, PTEN, and oth...

Study in Science holds promise for a new approach to drug therapy

...nit can, for example, "turn on" key target enzymes like phospholipase C and phosphoinositide 3 kinase. In white blood cells, the beta-gamma subunit binds to phosphoinositide 3 kinase, sending a signal that the cell needs to move in on and attack inv...

Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy

...d prevent this loss of heart receptors, we might improve heart function in patients with heart failure." The enzyme the researchers studied, called phosphoinositide 3-kinase (PI(3)K), governs the function of beta-adrenergic receptors on the surface of heart cells. Such receptors are protein switches that nestle in...
phosphoinositide in Biological Technology

Purification of Phosphoinositide 3-Kinase With UNO Columns

Polyphosphoinositides and their metabolites are important intracellular signals involved in the responses to a number of hormones and growth factors.The discovery of a phosphatidylinositol kinase that phosphorylates PI at the 3 position of ...

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

...end-stage renal disease. Keryx is also developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation. KRX-0401 has demonstrated both...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

...end-stage renal disease. Keryx is also developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation. KRX-0401 has demonstrated both...

GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research

... NEW ROCHELLE, N.Y., Dec. 4 /PRNewswire/ -- Researchers are taking a closer look at the phosphoinositide 3-kinase (PI3-kinase) pathway as studies continue to demonstrate that inhibiting this biological route suppresses tumor growth, reports Genetic Engin...

Gq-coupled Receptor Assays Using FLEXstation

...equent experiments (1). Characterization of cP2Y 11 by phosphoinositide hydrolysis assay. The receptor was previously characterized, and its agon...>ATP (1). The EC 50 value for ADP was approximately 190 M as determined by phosphoinositide hydrolysis assay (1, Fig. 2). ...
phosphoinositide in Biological Products

Rabbit Anti-Glutamate receptor 1, phospho (Ser845) Polyclonal Antibody, Unconjugated from GeneTex

Description:...ceptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors, stimulate phospholipase C as revealed by an increase in phosphoinositide turnover, and Ca2+ release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors ...
Company:GeneTex

PIP Beads di-C6 PtdIns(4,5)P2 from Echelon Biosciences Inc.

Description:... Identify and characterize phosphoinositide (PI(4,5)P2) binding...
Company:Echelon Biosciences Inc.

PIP Beads Sample pack- 100 ul of each pip from Echelon Biosciences Inc.

Description:... Identify and characterize phosphoinositide (PI(3,4,5)P3) binding...
Company:Echelon Biosciences Inc.
Other Tags
(Date:4/25/2015)... 25, 2015 The federal multidistrict ... lawsuits filed against C.R. Bard, Inc. continues to ... District of West Virginia. According to a Pretrial ... convened that day, after certain defendants submitted amended ... The Order directed that any Preliminary Motions referenced ...
(Date:4/25/2015)... BWI (PRWEB) April 25, 2015 An ... celebrated three months of successfully welcoming visitors to the ... 2015. , As part of a major construction ... airport was completely redesigned to speed up arrivals. ... process of getting out of the airport and onto ...
(Date:4/25/2015)... OR (PRWEB) April 25, 2015 Sports controversies continue ... within team confines, as was the case with the Miami Dolphins ... team as seen in the Ray Rice domestic abuse case. In ... of Sporting News discusses the implications of locker room culture ... response and what other teams should do to improve the locker ...
(Date:4/24/2015)... New York, NY (PRWEB) April 24, 2015 ... upscale sober living residence in Westchester County. Just 35 ... to help transition individuals back into everyday life while ... for Thursday, May 7, 2015, will allow therapists, doctors ... living areas and learn more about the opportunities offered ...
(Date:4/24/2015)... 2015 Carvers' goal is to ... successful biking day in Breck. , Conveniently located ... walking distance from Breckenridge, this family-owned place since ... Breckenridge bike rentals ( http://www.breckenridgeskishop.com/en/rent-equipment ) and more. ... bike rentals in May 2015. With style and ...
Breaking Medicine News(10 mins):Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 2Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 3Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 4Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:David Steele Discusses Locker Room Culture on SCI TV 2Health News:David Steele Discusses Locker Room Culture on SCI TV 3Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Carvers Breckenridge Bike Rentals Offers Demo Mountain, Tandem, Bike Path Cruiser & JR. Bikes in May 2015 2
(Date:4/2/2015)... , April 2, 2015 ... tests DERMALOG by far outperforms the strongest competitors, ... maintaining high accuracy, the system is capable of ... the speed proves up to be ten times ... than its runner-up performance.      (Photo: ...
(Date:4/2/2015)... 2, 2015 Fingerprint Cards (FPC) ... FPC1025 from the distributor World Peace Industrial Group (WPI), ... 2015 although the major part of the shipments will ... used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK ...
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
Other Contents