GeneGo Awarded NIH Grant to Develop Pharmacogenomics Software Suite
...ion resequencing projects are already generating vast amounts of data on genetic factors contributing to disease susceptibility and variability in the pharmacological and toxicological effects of drugs," said Richard Brennan, Director of Toxicology at GeneGo and PI on the grant. "What is lacking are powerful tools f...Study finds citrus-derived flavonoid prevents obesity
...e concentrations of the citrus-derived flavonoid being studied are at higher levels than you could get from dietary components. "We are examining the pharmacological properties of naringenin," explains Huff. "The next step is to find out if naringenin prevents heart disease in animal models and to explore the feas...New Cases of Alzheimer's and Dementia Continue to Rise, Even in the 'Oldest Old'
...entia Risk Continues to Rise in the "Oldest Old" Ugo Lucca, head of the Laboratory of Geriatric Neuropsychiatry at the Mario Negri Institute for pharmacological Research in Milano, Italy, and colleagues conducted a prospective, door-to-door, population-based study of all people age 80 years or older in eight m...New cases of Alzheimer's and dementia continue to rise, even in the 'oldest old'
... Dementia Risk Continues to Rise in the "Oldest Old" Ugo Lucca, head of the Laboratory of Geriatric Neuropsychiatry at the Mario Negri Institute for pharmacological Research in Milano, Italy, and colleagues conducted a prospective, door-to-door, population-based study of all people age 80 years or older in eight m...Inflammation may trigger Alzheimer's disease, Saint Louis University findings suggest
...disease, says a Saint Louis University doctor and researcher. Two research studies published by William A. Banks, M.D., professor of geriatrics and pharmacological and physiological science at Saint Louis University School of Medicine, support this conclusion and offer what he calls a "one-two punch" in giving cl...Even Steroid-Free Bodybuilders Focus on Image
...natural and non-natural bodybuilders, I found that either group is equally likely to have all of the traits of muscle dysmorphia with the exception of pharmacological use." More information The National Eating Disorders Association offers ways for males to boost body image . -- R...Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
...tastasis latency, and suggests strategies to hasten the attrition of disseminated breast cancer cells," concludes Dr. Massague. "Recently, a number of pharmacological Src inhibitors have been developed that may be worthy of consideration in this respect." ...Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
...ated to revenue from its collaboration with GSK, including the $500,000 discovery milestone payment that Regulus received from GSK for demonstrating a pharmacological effect in immune cells by specific microRNA inhibition. Excluding non-cash compensation expense related to stock options, operating expenses fo...Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease
...f Shire plc, to jointly develop Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorder...mpany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. pharmacological chaperone technology involves the use of small mol...Lilly Announces Positive Phase II Data on Investigational Medicine for Patients with Type 2 Diabetes
...f a dipeptidyl peptidase-IV (DDP-IV) protected GLP-1 analog linked to a fragment of immunoglobulin G4 that is believed to increase the duration of its pharmacological effect. Based on this study presented at this year's ADA meeting, LY2189265 is believed to reduce blood sugar in patients with type 2 diabetes by enh...Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
...etabolic Solutions Development Company ( www.msdrx.com ), based in Kalamazoo, Mich., is developing innovative therapeutics using a different pharmacological path to treat type 2 diabetes . This new approach seeks to improve the efficacy of treatment by freeing patients from the adverse side effects of cur...One Step Closer: Novel Opioid Receptor Compound in Phase I Clinical Trials
...he company, initiation of the phase 1 trial of ALKS 33 was based on the compound's potential for a superior pharmacokinetic profile and the compound's pharmacological properties relative to other commercial opioid antagonists. According to Alkermes, data from the phase 1 study of ALKS 33 showed that the compou...Amicus Therapeutics Announces Issuance of New Plicera(TM) Composition of Matter Patent
...rty portfolio for our development programs and our pharmacological chaperone technology platform." Plicera is cu...c, to develop and commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorder...mpany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human g...Tango Exercise Stress BP Monitor
Description:...our patient's systolic and diastolic BP along with heart rate. It's a Blood Pressure monitor designed specifically for use in treadmill, ergometer and pharmacological stress test environments. Tango is also ideal for use in research environments. Tango excels where other BP monitors have failed by making use ...Depolarization-induced suppression of inhibition
... vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neuroscience. Apr 5; In Press. Hajos N, Freund TF. (2002) pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers. Neuropharmacology. Sep;43(4):503-10. Hajos N, Led...Neuropathic pain: The sea provides a new hope of relief
...have specific functions with low side effects. Moreover, we need better management for chronic pain conditions," says Dr Wen. "Today there are few pharmacological agents that can help people suffering from neuropathic pain, but we believe that these marine-derived compounds could lead to the development of a new...UCLA researchers discover new molecular pathway for targeting cancer, disease
...ls within the cell, which is currently poorly understood. The next stage of the research will focus on activating the LXR pathway using various pharmacological molecules to inhibit tumor formation. Matsui will be a collaborator in this follow-up research. In addition, the team has started a medicinal c...22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey
...ap between basic research and medical practice, paving the way for improved pharmacological treatments in mental disorders. With the 22nd ECNP Congress 2009 in Istanbu...rugs, which act on specific receptors within a neurotransmitter system. The pharmacological progress achieved in recent decades is mainly due to the development of rec...Discovery may provide new treatments for alcohol dependence
...s that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacological treatment will reach the patient", says Professor Emeritus Jrgen Engel, an authority on research on alcohol dependency at the Sahlgrenska Academy. The...Fatty foods -- not empty stomach -- fire up hunger hormone
... and is found in the body in high concentrations just before meals. It is dubbed the "hunger hormone" because it has been shown that administration of pharmacological doses acts in the brain to stimulate hunger and increase food intake in animal models and humans. The ghrelin hormone is unique in that it requires...REGiMMUNE presents enhanced efficacy data in preclinical transplantation models
...f calcineurin inhibitors that are not only associated with high toxicity but suppress Treg activity. The finding suggests the possibility to develop a pharmacological approach to induce long-term transplant tolerance by promoting the body's intrinsic tolerogenic pathways using RGI-2001. RGI-2001 is in late precli...Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue
...egimen, if validated clinically, is expected to facilitate future stem cell therapy for heart failure." Lee said the next step is to use genetic and pharmacological engineering to make the stem cells more active, so good therapeutic effects can be achieved with fewer cells. "That is our goal. It would reduce t...Yale team identifies key to potential new treatment for allergy-induced asthma
...rthermore, when the Yale-Hydra team administered a pharmacological agent, HC-030031, that is known to inhibit pain re...and mucus overproduction," Jordt explained. The pharmacological agent observed in this study to diminish asthmatic...est in the potential development of HC-030031 as a pharmacological treatment. ...American Chemical Society Weekly PressPac -- April 15, 2009
...ory rats of a wireless sensor that overcomes some of those drawbacks. The scientists used a variety of techniques including physiological stimuli and pharmacological treatments to raise or lower their brain oxygen levels. The simple sensor quickly and reliably recorded real-time changes in these oxygen levels and ...Jefferson researcher awarded Landenberger Foundation grant for ALS research
... bioavailability and metabolism." said Dr. Pasinelli. "Proteins called multi-drug resistance transporters are increased during the disease, rendering pharmacological treatments for ALS mostly ineffective. This grant will support research towards finding ways to inactivate these transporter proteins to counteract t...Amicus Therapeutics Announces Second Quarter 2009 Financial Results
...f Shire plc, to jointly develop Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorder...mpany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. pharmacological chaperone technology involves the use of small mol...Amicus Therapeutics Announces Second Quarter 2009 Financial Results Release Date
...is a biopharmaceutical company developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. pharmacological chaperone technology involves the use of small molecules that selectively b...Histogen Hair Regrowth Clinical Trial Presented at ISHRS Annual Meeting
...ns suffering from hair loss. Of the 87 million people in the United States that suffer from hair loss, it is estimated that only 2-7% seek surgical or pharmacological treatment. The same is true internationally due to the general lack of effective medical options for this widespread condition. "Hair restora...Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009
...g cholesterol levels, have been selected for pharmacological studies. - The Collaboration with the Company...o high cholesterol. These candidates are ready for pharmacological studies. Collaborations Santaris Pha... and the PCSK9 lead candidates which are ready for pharmacological studies. See Santaris Pharma's pipeline thr...Human, Porcine Endothelin-1 from Biotrend Chemikalien GmbH
Description:...respectively. All three isopeptides produce strong in vitro vasoconstrictor and in vivo pressor responses. However, the quantitative profiles of their pharmacological activities vary greatly. Storage: Desiccate at -20 C...Neurobiology of Alzheimer's Disease from Promega
Description:...of beta-amyloid and tau proteins, the role of apolipoprotein E and the use of transgenic models. The neurochemistry, in particular potential areas for pharmacological intervention are also discussed....microPET Focus 120 from CTI Molecular Imaging, Inc.
Description:...rs around the world are using microPET scanners to Study animal models of human disease Study genetically engineered animals Assess new pharmacological agents in drug development Assess novel drug delivery and gene therapy approaches Develop new molecular imaging assays Develop new radi...microPET R4 from CTI Molecular Imaging, Inc.
Description:...rs around the world are using microPET scanners to Study animal models of human disease Study genetically engineered animals Assess new pharmacological agents in drug development Assess novel drug delivery and gene therapy approaches Develop new molecular imaging assays Develop new radi...microPET Focus 220 from CTI Molecular Imaging, Inc.
Description:...rs around the world are using microPET scanners to Study animal models of human disease Study genetically engineered animals Assess new pharmacological agents in drug development Assess novel drug delivery and gene therapy approaches Develop new molecular imaging assays Develop new radi...Rabbit Anti-Human PHAS-II Polyclonal Antibody, Unconjugated from Lab Vision
Description:...4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the ...