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pharmacogenetic in Medical News

Genetic testing may be valuable in treating colorectal cancer

...College has determined that so-called pretreatment pharmacogenetic testing is only beneficial if dose-reduced treatme...to significant potential benefits for pretreatment pharmacogenetic testing for metastatic colorectal cancer, but rema...he study, says, "Cost-effectiveness evaluations of pharmacogenetic tests can provide important insights into both the...

Daiichi Sankyo and Lilly Receive U.S. FDA Approval for Effient(TM)

...s compared with Plavix, there were 23 fewer patients with heart attacks and six more with major bleeding events. In addition, the results from a pharmacogenetic substudy of TRITON-TIMI 38 patients, as well as several early phase pharmacokinetic studies, showed that the active form of prasugrel does not appear...

Wiley-Blackwell and the American Heart Association present new book series

...01 April 2009 This book provides a comprehensive presentation of genetic factors in relation to therapeutic techniques, as well as an outline of key pharmacogenetic concepts. Adult Congenital Heart Disease edited by Carole A. Warnes (Mayo Clinic) ISBN: 9781405178204 May 2009 This new reference profiles the...

Genetics May Help Fine-Tune Warfarin Dosage

...ever, as this study is retrospective, it could not evaluate outcomes, and recent clinical trials have failed to confirm the expected benefits of other pharmacogenetic algorithms for warfarin dosing [so] prospective clinical trials are required to determine the value, if any, of the findings in this study," he said. ...

Genes influence effectiveness of weight-loss drug

...e genetic markers before prescribing the medication may even be cost-effective from a public health perspective." In this randomized, double-blind, pharmacogenetic study, Dr. Camilleri and colleagues evaluated behavioral therapy and sibutramine (10 or 15 mg daily) or placebo for 12 weeks in 181 overweight or obes...

Get the latest on premier science in medical oncology

...ors New pathways in targeted therapy IGF-1, PI 3, PARP, Met Optimal integration of newer agents in the treatment of advanced CRC Genomic and pharmacogenetic markers for treatment decision Upfront sequential vs. combination chemotherapy Renal cell cancer VEGF biology and resistance mTOR Tackling fut...

Gene Variations May Predict Antidepressant Response

...feel better as quickly as possible, so the idea of trying one drug after another until you find one that works can be discouraging. The development of pharmacogenetic testing will help increase the likelihood of selecting an effective drug the first time," study senior author Dr. V. David Mrazek, chairman of the May...

Inflammation, depression and antidepressant response: Common mechanisms

... 4 subunit) and TBX21 (T-bet). The study population was made up of 284 depressed Mexican-Americans from Los Angeles who were already enrolled in a pharmacogenetic study of antidepressant treatment response. The control group was made up of 331 individuals from the same community. Our findings suggest that a ...

SeqWright's Partnership With Third Wave Contributes to FDA Success

...shed in 2004, when the two companies began work on Third Wave's UGT1A1 Molecular Assay. SeqWright provided FDA-level sequencing to validate the UGT1A1 pharmacogenetic test, which is used to identify patients susceptible to adverse reaction from a specific colorectal cancer treatment. The assay gained FDA clearance i...

ARCA Discovery Changes Name to ARCA biopharma to Reflect Focus on Drug Commercialization

...tise in cardiovascular pathophysiology, molecular genetics and clinical development, in a unique approach that enables the efficient identification of pharmacogenetic targets. ARCA's earlier research identified pathways affecting bucindolol response that are modulated by common genetic variations. About ARCA bioph...
pharmacogenetic in Medical Technology

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

...disease, an unprecedented rate of success," Campana said. St. Jude investigators applied personalized therapy based on molecular genetics of ALL, pharmacogenetic traits of patients and pharmacodynamic principles. "We prospectively determined the activity of drug-metabolizing enzymes of each patient and adjusted...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

...pecified analysis was designed to examine whether there is a genetic variation in DNA that could affect patient response to antiplatelet therapy. The pharmacogenetic analyses with prasugrel examined DNA samples from 1,466 patients from the TRITON-TIMI 38 clinical trial. The genetic subanalysis was not powered...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... pharmacogenetic Findings May Lead to Individualized Treatment for ...Study of Genetic Markers to Predict Likelihood of Response to Iloperidone pharmacogenetic analysis in a Phase III trial studying the efficacy of iloperidone in acute...

ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia

...dition, the BEST trial investigators were able to extend the observation of pharmacogenetic targeting of bucindolol to benefits on cardiovascular hospitalizations, whi...population of beta-1 Gly389 or the alpha-2c deletion carriers, indicating a pharmacogenetic interaction. As for AF prevention and CHF endpoints, patients with the favo...

Vanda Pharmaceuticals Submits Iloperidone New Drug Application

... safety profile on adverse symptoms, such as weight gain, extrapyramidal symptoms, akathisia and prolactin elevation. The NDA submission also contains pharmacogenetic data aimed to further improve the benefit/risk profile of iloperidone in the treatment of patients with schizophrenia. "The submission of the iloperi...

Pharmion to Present Clinical Data on Commercial and Pipeline Products at 2007 American Society of Clinical Oncology (ASCO) Meeting

...py and the immunomodulatory agent thalidomide -- R. Baz; Abstract #8107; June 2, 2007; 8:00am-12:00pm; McCormick Place Convention Center, S HallA2 A pharmacogenetic study of docetaxel and thalidomide in patients with androgen-independent prostate cancer (AIPC) using targeted human DMET genotyping platform -- J. De...

Adding Thalidomide to Standard Therapy Improves Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75

... relapsed/refractory multiple myeloma (RRMM) -- P. Sonneveld; Abstract #8023; June 3, 2007; 3:00-3:15 pm; McCormick Place Convention Center, E354b A pharmacogenetic study of docetaxel and thalidomide in patients with androgen-independent prostate cancer (AIPC) using targeted human DMET genotyping platform -- J. De...

Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.

...dual genetic variations. As the field of pharmacogenetics focuses on these issues, valuable new laboratory tools have arrived to help clinicians apply pharmacogenetic knowledge to patient care. Probably the most important gene family to govern individual drug responses, CYP (also called cytochrome P450) oxida...
pharmacogenetic in Medical Dictionary

Malignant hyperthermia

...alignant hyperthermia susceptibility (MHS) is a pharmacogenetic disorder of ... Manifestations of malignant hyp...oling ... Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle ... Criteria used ...ed people Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle ... Criteria used ...
pharmacogenetic in Biological News

American College of Medical Genetics responds to new FDA labeling decision for warfarin

...o determine how best to use genetic testing to improve care, said Marc S. Williams, MD, FACMG, ACMG Board Member and a co-chair of the expert group on pharmacogenetic Testing of CYP2C9 and VKORC1 Alleles for Warfarin Use. This group is completing a report on the use of pharmacogenomic testing for warfarin and is bas...

Primitive yeast yields secrets of human cholesterol and drug metabolism

...p1 may provide clues to how and why different people react differently to certain drugs. “Understanding the molecular underpinnings of so-called pharmacogenetic variation will have a big impact on the future of medicine,?he says....

Studies look at how genes affect antipsychotic drug response

...n, as well as how genetics affect overall medication response," he said. Bishop says the project will serve as a first step toward a comprehensive pharmacogenetic analysis of metabolic pathways affecting response to the drug. He was presented with an award for new investigators from the American College of Clini...

Gene variations explain drug dose required to control seizures

...nts will need the higher dose." Before any such pharmacogenetic approaches can be put into practice, they must be ...at could be tested in the clinic to assess whether pharmacogenetic diagnostics can improve dosing decisions, he added...sponse." In Parkinson's disease, for example, a pharmacogenetic test might assist physicians in prescribing the dr...
pharmacogenetic in Biological Technology

AssureRx Closes Round of Funding to Commercialize Pharmacogenetic Test

Company commercializes technology from Cincinnati Children's and Mayo Clinic to help doctors select right drug at right dose for patients CINCINNATI, March 5 /PRNewswire/ -- AssureRx, a personalized medicine company, today announced that it has closed a round of funding. The company was fo...

Third Wave receives FDA clearance of pharmacogenetic test

Madison, Wis. -- Third Wave Technologies Inc. on Monday announced that the U.S. Food and Drug Administration (FDA) has cleared the company's Invader UGT1A1 Molecular Assay for in vitro diagnostic use. It is the first pharmacogenetic test to be approved by the FDA for use as a companion diag...

AssureRx Adds New CEO

...ommenting on the significant potential of personalized medicine, Burns noted that "AssureRx represents an exciting opportunity to bring cutting-edge pharmacogenetic science and informatics together into practical use for the benefit of behavioral health patients. The company's first product will be GeneSightRx(T...

Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association

... were: Greater Utilization of Psychiatric Services is Associated with pharmacogenetic Variation and Metabolism Deficiencies Gualberto Ruano, M.D., Ph.D., and ... Mood Disorders Unit Simon Kung, M.D. Mayo Clinic, Rochester, MN pharmacogenetic Testing in Psychiatry: Early Adopters' Attitudes and Practices Jinger G....

Diagenic Partners With DNAVision to Offer First Breast Cancer and Alzheimers Gene-Expression Blood Tests

...listed on the Oslo Stock Exchange. For more information visit http://www.diagenic.com About DNAVision DNAVision is a leading provider of applied pharmacogenetic & pharmacogenomic services. DNAVision offers the powerful combination of different technologies in expression profiling, SNP genotyping and sequenci...

As personalized, genomic medicine takes off, four developing countries show the way for others

...ic stress disorder (PTSD). An example mentioned in the Thai case study is that of patients undergoing kidney transplantation who would benefit from pharmacogenetic testing to prevent adverse reactions to azathioprine, a commonly used drug to stop organ rejection. South Africa cradle of the human species, ho...

LabCorp(R) and Vanda Pharmaceuticals Collaborate to Offer Genetic Tests

...candidate under FDA review for the treatment of schizophrenia. Financial terms of the agreement were not disclosed. Vanda has identified a series of pharmacogenetic markers during its development of Fanapta(TM), and the company continues its pioneering work in this area. Under the terms of the collaboration, LabCo...

ARCA Discovery, Inc. to Present at 26th Annual JPMorgan Healthcare Conference on January 8, 2008

...tise in cardiovascular pathophysiology, molecular genetics and clinical development, in a unique approach that enables the efficient identification of pharmacogenetic targets. Applying this approach to bucindolol, ARCA has identified pathways affecting bucindolol response that are modulated by common genetic variati...

Interleukin Genetics Announces Management and Board Appointments

...siness objectives. Also, Nazneen is an excellent addition to our research and development team. She will focus primarily on guiding the development of pharmacogenetic and nutrigenetic tests and matching preventive/therapeutic products for medical applications." Interleukin also announced that current Director James...

Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio

...ed Drug Development, Dosing Determination, and pharmacogenetic Testing Purchase Expands European Presence, A...European clinical markets. Epidauros has grown its pharmacogenetic services business in support of the pharmaceutical... to join PGxHealth as the Senior Vice President of pharmacogenetic Partnerships. Dr. Lutz commented, "We welcome the ...
pharmacogenetic in Biological Dictionary

Genetic testing

...get genetic tests and where to get them. ... .com (Launch page for pharmacogenetic Testing Consumer, pharmacogenetic Testing HCP, Hereditary Cancer Consumer, and ... understand how genetic ...
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