Critical link in cell death pathway revealed
The role of a protein called XIAP in the regulation of cell death has been identified by Walter and Eliza Hall Institute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions.
A team led by Professor ...
Cell Pathway May Be Key to Lung Cancer's Spread
Researchers express hope that finding will lead to treatments,,
FRIDAY, July 3 (HealthDay News) -- U.S. researchers say they've found a major cellular flaw that may drive the rapid spread of relapsed lung cancer.
When caught early, lung cancer can often be treated. But most cases a...
Genetic pathway responsible for link between body clock disturbance and worsening arthritis
Copenhagen, Denmark, Wednesday 10 June 2009: The genes that regulate human circadian rhythm, or 'the body clock', are significantly disturbed in individuals with arthritis, according to the results of a new study presented today at EULAR 2009, the Annual Congress of the European League Against Rhe...
U-M researchers link pathway to breast cancer stem cells
ANN ARBOR, Mich. A gene well known to stop or suppress cancer plays a role in cancer stem cells, according to a new study from the University of Michigan Comprehensive Cancer Center. The researchers found that several pathways linked to the gene, called PTEN, also affected the growth of breast ca...
Research reveals molecular pathway behind invasive prostate cancers
CINCINNATIUniversity of Cincinnati (UC) cancer and cell biologists have identified a new molecular pathway
key to the development of invasive prostate cancers.
In a preclinical study led by Maria Diaz-Meco, PhD, the UC team found that simultaneous inactivation of two particular genesknown as...
Set out on the Pathway to Change with the Dermatology Nurses' Association
Dermatology Nurses to Convene in Boston, July 31-August 2
BOSTON, May 18 /PRNewswire/ -- Within health care, dermatology nursing professionals play a critical role in providing quality care to their patients. When the Dermatology Nurses' Association (DNA) hosts its Annual Summer Meeting in 2...
Pathway in Medical Technology
VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE
BEDFORD, Mass., July 30 /PRNewswire/ -- VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, announced today that scientists reporting in the July 31 issue of SCIENCE have discovered a key disease-related biologic pathway
using an integrated and ...
Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor
INDIANAPOLIS, March 17 /PRNewswire/ -- Semafore Pharmaceuticals, Inc. announced today that it has achieved proof of concept in its CRIMP (Control Resulting from Inhibiting Multiple Pathways) kinase platform by designing a small molecule that was demonstrated to inhibit members of both the PI3K (Ph...
Roche and FDA Agree on Pathway Towards U.S. Approval of ACTEMRA(R) (tocilizumab)
NUTLEY, N.J., Dec. 4 /PRNewswire/ -- Roche today announced that the U.S. Food and Drug Administration (FDA) has provided further guidance on the requirements for the Biologics License Application (BLA) for ACTEMRA(R) (tocilizumab), the first interleukin-6 (IL-6) receptor-inhibiting monoclonal anti...
Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A
BRISBANE, Australia, July 22 /PRNewswire-FirstCall/ -- Following a
thorough review that concluded late yesterday, the Board of Progen
Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) today announced that it
had discontinued the PI-88 phase 3 study in liver cancer. Progen confirmed
Anesiva Defines Regulatory Pathway for Adlea with FDA
New Phase 3 Plan Could Expedite Clinical Development Pathway
SOUTH SAN FRANCISCO, Calif., Oct. 10 /PRNewswire-FirstCall/ -- Anesiva,
Inc. (Nasdaq: ANSV ) today announced that it will conduct two Phase 3
clinical trials for the approval of Adlea(TM) -- one of which has already
Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
LAKE FOREST, Calif., Sept. 18 /PRNewswire/ -- Worldwide markets of
approved EGFr/HEr2 inhibitors grew by 34.2% during the first half of 2007,
pushing sales to more than $3.2 billion, exceeding total sales reported in
2005. Hundreds of clinical trials are ongoing, aimed at expanding
Pathway in Medical Products
Prometheus Pathway CTS 2000 Evaluation and Training System
Description: Help restore pelvic muscle function with the Prometheus Pathway
CTS 2000 evaluation and training system....
TotalCare® Bariatric Bed
Description:...egivers can easily and frequently position immobile patients per physician and nursing "up-in-chair" orders earlier, throughout the patient's clinical pathway
with the simple touch of a button.
FullChair® Chair Egress Position Mechanism This simple mechanism facilitates foot-of-bed or side egress red...
Company:Hill-Rom Services, Inc.
AL2500 AirLife™ Prefilled Humidifier Systems
Description:...stems feature a dual-purpose reservoir with a snap-open trigger, which makes a round opening for secure attachment of a humidifier adapter. The oxygen pathway
is designed to help prevent particulate from reaching oxygen delivery tubing. An audible relief valve warns if the patient`s tubing becomes occluded.
Company:Cardinal Health, Inc.
Endotrol® Tracheal Tube with Controllable Tip
Description:...g; tracheal tube with directional distal tip control for fast, easy intubation.
Indications For Usage:
Emergency situations When the intubating pathway
Blind nasal intubations. ...
Epidural Spinal Electrodes
Description:... Ad-Techs Spinal Electrodes are intended for intraoperative monitoring of Evoked Potentials (EPs) of the descending pathway
during spinal surgery. They are offered with 2 or 3 platinum contacts....
Wiseguide Guide Catheter
Description:... Boston Scientific Guide Catheters are intended for use in general intravascular and coronary applications. They provide a pathway
through which medical instruments such as balloon dilatation catheters, guide wires or other therapeutic devices may be introduced. These devices are ...
Company:Boston Scientific Corporation
Pathway in Medical Dictionary
...tion on Urea Cycle Disorder (UCD) ... A urea cycle disorder (UCD) is an inherited disease caused by ... Deficiency of an enzyme in the pathway
causes a urea cycle disorder (UCD) ... Urea cycle ... B, Touati, G, et al. Urea cycle defects: management and outcome. ... The urea ...
... Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway
. They are broadly classified as acute (hepatic) porphyrias and cutaneous porphyrias , based on the site of the... " Porphyria's ...
...ic nerves, or the optic chiasma. An optic pathway
glioma is a tumor arising from a specific type...enter can be affected by a glioma of the optic pathway
system. ... Rarely, a malignant optic gliom...d neurofibromatosis Type 1 (NF1) ... Optic pathway
Gliomas : A review of this tumor and its operat...
...raumatic glaucoma refers to a heterogeneous group of posttraumatic ocular disorders with different underlying mechanisms that lead to the common pathway
... A diagnosis of ocular albinism (OA) is probable in the presence of congenital ... Ocular albinism with sensorineural deafness (O...
... A nerve is an enclosed, cable-like bundle of peripheral axons . A nerve provides a common pathway
for the electrochemical nerve impulses that are transmitted along each of the axons. Nerves are found only in the peripheral... ... interosseou...
...e of dietary wheat gluten and ... Immune-Mediated Intestinal Disease . Edward J. Hall, MA, VetMB, PhD, DECVIM-CA, MRCVS ... is the final common pathway
by which many intestinal diseases are manifested. ... Stomach or Intestines a pain? Don't know what to eat or avoid with ulcers? ... Intestin...
Pathway in Biological News
UCLA researchers discover new molecular pathway for targeting cancer, disease
A UCLA study has identified a way to turn off a key signaling pathway
involved in physiological processes that can also stimulate the development of cancer and other diseases. The findings may lead to new treatments and targeted drugs using this approach.
In the study, which is currently ava...
Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
In recent years, obesity has taken on epidemic proportions in developed nations, contributing significantly to major medical problems, early death and rising health care costs. According to Centers for Disease Control and Prevention estimates, at least a quarter of all American adults and more tha...
ISU researcher identifies genetic pathway responsible for much of plant growth
AMES, Iowa -- Researchers at Iowa State University have discovered a previously unknown pathway
in plant cells that regulates plant growth.
Yanhai Yin, an assistant professor in genetics, development and cell biology, examined signaling mechanisms of a plant hormone called brassinosteroids. The ...
Identification of a key molecular pathway required for brain neural circuit formation
Montral, May 15, 2009 The research group of Dr. Frdric Charron, a researcher at the Institut de recherches cliniques de Montral (IRCM), has made a discovery which could help treat spinal cord injuries and neurodegenerative diseases. This new finding has been published in the current issue of the ...
Researchers find pathway and enzyme unique to tularemia organism
San Antonio Researchers are closer to developing therapies to combat the deadly tularemia infection, according to a study published this week in the Proceedings of the National Academy of Sciences ' online Early Edition. Karl Klose, director of the South Texas Center for Emerging Infectious Dis...
Tracking the molecular pathway to mixed-lineage leukemia
CAMBRIDGE, Mass. (Dec. 15, 2008) Infants and adults with the blood cancer mixed-lineage leukemia (MLL) typically have a poor prognosis, and most infants die before their first birthdays. Although there are varying causes of MLL, most cases are caused by a fusion of two genes, the MLL and the AF4 ...
Pathway in Biological Technology
GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR
ST. JOSEPH, Mich.,. July 21 /PRNewswire/ -- GeneGo, Inc., the leading systems biology tools company, announced today that they have recently donated 41 canonical pathway
maps to the International Society for Interferon and Cytokine Research (www.isicr.org). These maps are constructed fro...
Biogenerics Legislation Provides Critical Pathway to Affordable Access for Patients with Chronic and Complex Conditions
WASHINGTON, March 12 /PRNewswire-FirstCall/ -- Proposed legislation that creates a regulatory framework to guide the approval of the first biogeneric medicines represents a critical step forward in providing more affordable treatment for millions of Americans suffering from chronic and complex con...
Bavarian Nordic Has Essentially Agreed a Pathway for the Licensure of IMVAMUNE(R) With the FDA After Successful End of Phase II Meeting
KVISTGAARD, Denmark, March 3 /PRNewswire-FirstCall/ -- Following the
completion of the Phase II clinical development of IMVAMUNE(R), a
third-generation smallpox vaccine, Bavarian Nordic has held an end of Phase
II meeting with the FDA to discuss the Phase III development. The meeting was
Millipore Launches an Interactive Biological Pathway Tool Using GeneGo's Manually Curated Pathway Maps
ST. JOSEPH, Mich., Feb. 17 /PRNewswire/ -- GeneGo, Inc., the leading systems biology tools company, announced today that Millipore has licensed 250 manually curated pathway
maps from GeneGo, Inc. for their new Interactive Biological Pathway
Tool. Available at www.millipore.com/pathways , the tool...
GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research
NEW ROCHELLE, N.Y., Dec. 4 /PRNewswire/ -- Researchers are taking a closer look at the phosphoinositide 3-kinase (PI3-kinase) pathway
as studies continue to demonstrate that inhibiting this biological route suppresses tumor growth, reports Genetic Engineering & Biotechnology News (GEN) . The ...
Study Suggests GAMMAGARD LIQUID May Target the Primary Pathway Involved in Alzheimer's Disease
Laboratory study shows naturally occurring antibodies contained in
GAMMAGARD LIQUID may bind to the primary culprit for Alzheimer's disease
CHICAGO, April 15 /PRNewswire-FirstCall/ -- The University of Tennessee
Health Science Center and Baxter International Inc. (NYSE: BAX ) today
Pathway in Biological Products
Rabbit Anti-Evolutionarily conserved signaling intermediate in Toll pathway Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.
Description: Evolutionarily conserved signaling intermediate in Toll pathway...
Company:GenWay Biotech, Inc.
Apoptosis Pathway SpliceArrays from ExonHit Therapeutics Inc.
Description: Alternative Splicing plays an important role in the regulation of signaling pathways involved in apoptosis and cell death. Splice variants have been reported that affect both the activation and inhibition of defined apoptotic pathways. With Apoptosis and Cell Death SpliceArrays you can perform a c...
Company:ExonHit Therapeutics Inc.
BD Pathway Bioimager from BD Biosciences - Bioimaging
Description: The BD Pathway
Bioimager is an automated, confocal, real-time, single cell kinetic and endpoint imaging system that has been integrated into a single, compact unit. The BD Pathway
was designed to provide high-resolution, automated confocal imaging with sophisticated imaging software to assist in d...
Company:BD Biosciences - Bioimaging
BD Pathway 415 bioimager from BD Biosciences - Bioimaging
Description: For applications not requiring confocal, the BD Pathway
415 is a cost effective alternative to the Pathway
435. And, the Pathway
415 can be field-upgraded to confocal if later applications require it. High-performance, laser-based autofocus is standard. You can elect to use the laser autofocus, ...
Company:BD Biosciences - Bioimaging
BD Pathway 435 confocal bioimager from BD Biosciences - Bioimaging
Description: The BD Pathway
435 is an affordable, compact benchtop imager compatible with multiwell plates and slides, providing a broad array of automated imaging capabilities. The system rapidly acquires high-resolution images with high-performance laser autofocus, true confocal optics, flexible computer-cont...
Company:BD Biosciences - Bioimaging
Chaps Cell Extract Buffer (10X) from Cell Signaling Technology
Description:...r can be used to lyse cells under nondenaturing conditions and is recommendedfor the preparation of cell lysates to be used with our caspase signaling pathway
Company:Cell Signaling Technology
Pathway in Biological Definition
Pentose phosphate pathway
The penthose phosphate pathway
(also known as the Hexose Monophosphate Shunt) is a process that serves to generate NADPH and the synthesis of pentose (5- carbon ) sugars . There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the se...
... , then attached to coenzyme A while NAD + is subsequently reduced to NADH and H + .
Citric acid cycle
HMG-CoA reductase pathway
...roducts prime for phagocytosis by macrophages and other cells, block viral receptors and stimulate other immune responses such as the complement pathway
Antibodies that recognize viruses can block these directly by their sheer size. The virus will be unable to dock to a cell and infect it, hindered...
...ng of TNF to TNF-R1 has been shown to fire-off the pathway
that leads to activating the caspases  .
Fa...ection on biochemical execution).
The apoptotic pathway
was found to be dramatically restored in H460 cell...malignant transformation. This apoptosis-dependent pathway
for T cell activation is not present during necros...
Crassulacean acid metabolism
... Crassulacean acid metabolism ( CAM ) is a carbon fixation pathway
in some photosynthetic plants . CAM is usually found in plants living under arid conditions, including those found in the desert (for example, cac...
C4 carbon fixation
...see C4 (disambiguation)
C 4 carbon fixation is a common metabolic pathway
found in land plants ( C4 plants ). They are competitively superior to plants possessing the more common C3 pathway
under the conditions of drought, high temperatures and nitrogen limitation....
Pathway in Biological Dictionary
...ediately 3' of uvrA was an ORF encoding a putative aminopeptidase gene (pepP) ... Here we suggest that uvrA and the nucleotide excision repair pathway
are ... groups, it was necessary to inactivate the uvrA dependent nucleotide excision repair gene. ... mutant strain deficient in alkA tagA a...
...ntity with platelet ... This classical function of ubiquitin is associated with housekeeping functions, ... Home About Us Ubiquitin Proteasome pathway
New Products Products ... HOW THE UBIQUITIN –PROTEASOME SYSTEM CONTROLS TRANSCRIPTION ... Regulating UBP-Mediated Ubiquitin Deconjugation ... U...
...ion involves ... the steps involved in delivering a newly formed transport vesicle to its target. ... Functional transport vesicles in this pathway
can be generated in vitro ... Isolated COP1-derived transport vesicles should constitute an ideal basis for ... ... of SEC genes govern tran...
...: transmembrane receptor protein serine/threonine kinase signalling pathway
... as a consequence of a transmembrane receptor serine/threonine kina...:0007169 : transmembrane receptor protein tyrosine kinase signaling pathway
... 3.1.2 Signal transduction of transmembrane receptors by struct...
...e: Center ... FAX 858-822-3120. Systems Biology Short Course - Iceland. Cobra Toolbox. BiGG database. E. coli S. cerevisiae H. sapiens. Extreme pathway
Analysis. Internal Pages ... 4.2 Historical milestones in the development of systems biology ... 4.5 Systems biology as an evolutionary tre...
...ant? ... mesophyll n. The photosynthetic tissue of a leaf, located between the upper and lower epidermis. ... spongy mesophyll . Hatch-Slack pathway
(biochemistry) ... Spongy Bone. bone, illustration. Plant: mesophyll ... spongy mesophyll : Definition from Answers.com ... The spongy me...