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overexpression in Medical News

MEK4, genistein and invasion of human prostate cancer cells

...and protein expression of mitogen-activated protein kinase 4 (MEK4) and matrix metalloproteinase-2 (MMP-2), which is associated with cell invasion. overexpression of MEK4 increased MMP-2 expression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling sh...

New Gene May Signal Aggressive Breast Cancer

...e with an immunodeficiency. Researchers found that the altered cells had less capacity for tumor growth and metastasis. According to the study, RCP overexpression also impacts the RAS protein, which previous research has implicated in tumor growth. Researchers said RCP may promote breast cancer by activating ...

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3

...Company's second oncology pipeline candidate, MM-111 , a bispecific antibody fusion protein designed to target cancer cells that are characterized by overexpression or amplification of ErbB2 (also known as HER2). MM-111 is the first bispecific antibody binding two different receptors on the same cell to enter clin...

New piece found in colorectal cancer puzzle

.../moderate dysplasia and again at the transition between severe dysplasia and colorectal cancer. According to Vogel, "It has previously been shown that overexpression of prostasin in mammary and prostate cancer cells reduces the invasive properties of cancer cells and that high prostasin expression in gastric tumour...

Coming Soon: Lung-Cancer Spray?

...y to treat lung cancer, one stumbling block has been finding delivery mechanisms that work. "Our results demonstrated that lentivirus-mediated CTMP overexpression suppressed Akt activity and inhibited tumor progression," Cho wrote. More information The National Cancer Institute has more on lung cancer....

Vaporized viral vector shows promise in anti-cancer gene therapy

...ral proteins, such as cyclin D1, CDK4 and CDK2, which are important in cancer cell growth. "Our results demonstrated that lentivirus-mediated CTMP overexpression suppressed Akt activity and inhibited tumor progression," wrote Dr. Cho. "Repeated aerosol gene delivery may provide an effective noninvasive model of...

Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction

...oxia-inducible factor 1). It helps cells survive by "turning on" when oxygen levels are low. HIF-1 is also active in some forms of human cancer. HIF-1 overexpression is frequently detected in solid tumors; inhibition of HIF-1 has been proved to be an efficient way to prevent cancer growth. Now, scientists at the B...

NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO

...er prognostic factors, such as tumor thickness and histology, were taken into account. Abstract # 11034, Sunday, May 31, 2009, 2 p.m. to 6 p.m. overexpression of an oncogene linked to worse melanoma prognosis Iman Osman, M.D., associate professor of dermatology and urology and director of the Interdiscip...

Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009

...se receptor. Stimulation of HER2/ErbB2 is associated with cell proliferation and with multiple processes involved in tumor progression and metastases. overexpression of these receptors has been reported in a variety of human tumors and is associated with poor prognosis and reduced overall survival. Lapatinib,...

JCI online early table of contents: April 13, 2009

...ely involved in hepatic lipogenesis (and thereby hepatic steatosis), explaining why ER stress has a role in hepatic steatosis. Further, they show that overexpression of the protein GRP78 inhibits both insulin and ER stressinduced activation of SREBP-1c. TITLE: GRP78 expression inhibits insulin and ER stressinduc...
overexpression in Medical Technology

BiPar Begins Phase 2 Study of Lead PARP Inhibitor in Triple-Negative Breast Cancer Based on Overexpression Biomarker Data

BRUSSELS, Belgium and BRISBANE, Calif., Nov. 15 /PRNewswire/ -- BiPar Sciences, Inc., a privately held biopharmaceutical company developing novel cancer therapies, today announced it has initiated a Phase 2 study of its lead PARP inhibitor, BSI-201, in patients with triple-negative breast canc...

BiPar Genomic Biomarker Data Demonstrate Overexpression of PARP-1 Gene in Multiple Cancer Types

SAN FRANCISCO, Oct. 25 /PRNewswire/ -- BiPar Sciences, Inc., a privately held biopharmaceutical company developing novel cancer therapies, today announced molecular biomarker data demonstrating the overexpression of the PARP (poly-ADP-ribose polymerase) protein in multiple cancers, including o...

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... disease. Patients with castration-resistant (also known as hormone-refractory) prostate cancer have few treatment options and a poor prognosis. overexpression of the androgen receptor is believed to contribute to the progression of CRPC. MDV3100 is a next-generation androgen receptor antagonist that inhibits...

Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting

...ver, Colorado. Cylene scientists will unveil the first public description of CX-4945, a first-in-class oral inhibitor of protein kinase CK2. CK2 overexpression is well documented in many cancers and represents a previously unexploited molecular target. CX-4945 is a potent, selective inhibitor of CK2 and modu...

Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer

...ammed cell death). The most recognized group of such proteins are the antiapoptotic members of the Bcl-2 family, including Bcl-2, Bcl-XL, and Mcl-1. overexpression of Bcl-2 family proteins in human tumor specimens has been reported by several groups to be associated with recurrence, more advanced stage, treatment...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

...es. "CX-4945 is a breakthrough molecule for Cylene," said Dr. William Rice, President and Chief Executive Officer of Cylene Pharmaceuticals. "CK2 overexpression drives key cell survival pathways and proliferation of cancer cells, but it has been notoriously difficult to inhibit because it has an unusual active...

Medivation Completes Enrollment of Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

...isease. Patients with castration-resistant (also known as hormone-refractory) prostate cancer have few treatment options and a poor prognosis. overexpression of the androgen receptor is believed to contribute to the progression of castration-resistant prostate cancer. MDV3100 is a novel small-molecule andro...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

...edical Officer of SuperGen. "PIM-1 is known to be overexpressed in ALL, AML, CML, as well as non-Hodgkin's lymphoma. In many of these conditions PIM-1 overexpression is a poor prognostic factor. It has been postulated that inhibition of PIM kinase may potentiate the activity of m-tor inhibitors by modulation of m-t...

Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer

... About MapQuant Dx(TM) HER2 Clinical Rationale The amplification of the HER2-region of chromosome 17 results in the constitutive overexpression of the HER2 oncogene protein and fuels uncontroled tumor growth in approximately 15 to 30% of breast tumors. HER2 is considered today as a predictive ...

InteRNA Technologies and VU University Medical Center to Develop microRNA-Based Diagnostics and Therapeutics for Cancer

...ics for cancer using InteRNA's proprietary library of miRNAs. Under the research collaboration, InteRNA will apply its unique lentiviral-based miRNA overexpression library in multi-parametric, high-throughput screening assays to identify the biological role of individual miRNAs and novel therapeutic targets in le...
overexpression in Medical Products

Dual Media Kit

Description:...dium, contains two media, EXPANSION BROTH (EB) and overexpression BROTH (OB). For cell expansion, E. coli cells are ...into OB media. By using the Dual Media Set system, overexpression of diverse proteins can be reliably controlled and...n the EXPANSION BROTH (EB). Transfer the cells to overexpression BROTH (OB) and grow overnight. This media set was ...
Company:Zymo Research Corporation
overexpression in Biological News

Protein overexpression at heart of heart failure

Chronic heart failure resulting from dilated cardiomyopathy is rapidly emerging as a disease of epidemic proportions.1 Molecular mechanisms are being studied and advances have been made in a minority of cases, e.g.: the familial forms. Intracellular [Ca2+]i homeostasis is essential for normal cardi...

Abnormal overexpression of p53 is a predictive molecular biomarker

A common laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers now has been found to predict a good prognosis with treatment of p53 tumor suppressor gene therapy - making it potentially the first predictive biomarker test for a g...

Bisphenol A exposure in pregnant mice permanently changes DNA of offspring

...hese changes in the offspring's uterine DNA resulted in a permanent increase in estrogen sensitivity. The authors believe that this process causes the overexpression of the HOXA10 gene in adult mice that they found in previous studies. The permanent DNA changes in the BPA-exposed offspring were not apparent in t...

Altered gene can increase risk of schizophrenia

...investigating the consequences of increased expression of the NOS1AP gene. Firestein is looking at this gene in cells in culture and examining how the overexpression of this protein alters the way neurons branch. Identifying this specific functional genetic variant is an important step, but there are qualifiers....

UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs

...drugs that target Muc4, and this research will help change that." Carraway is now preparing to test metastasizing breast cancer tumor cells for the overexpression of Muc4. "If we find that Muc4 is all over metastasizing breast cancer cells, it will confirm that we are on the right track," he said. While Ca...

Ex vivo neural stem cell expansion

... the neurogenic niche. Their upcoming paper demonstrates that the polycomb group protein, Bmi-1, maintains forebrain neural stem cell self-renewal. overexpression of Bmi-1 in adult and embryonic forebrain neural progenitor cells increases stem cell self-renewal both in vitro and in vivo. They furthermore show th...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

...dimensions, depressed fractional shortening, a greater impairment of LV segmental function, and greater transmitral E-wave amplitude. In summary, overexpression of PAI-1 in the heart altered the response of the left ventricle to myocardial infarction. It led to increased expression of PAI-1 late after coronar...

Researchers identify gene linked to aggressive progression of liver cancer

...that findings from a separate pool of 132 HCC patients revealed significant overexpression of AEG-1 mRNA compared to normal liver. In a subset of these patients, the ...ich indicates a significant involvement of AEG-1 in HCC progression. Stable overexpression of AEG-1 converts non-tumorigenic human HCC cells into highly aggressive va...

Rice University study finds possible clues to epilepsy, autism

...s all came about as a control for a completely different experiment, and we said, 'Wow, this is some interesting stuff.'" What he saw was that the overexpression of PI3K in motor neurons had a dramatic effect. "I noticed under the scope that these nerves were really big, and electrophysiologically, they were re...

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

...ton's disease. Additionally, the human version of dKDM4A functions as an oncogene, which has the potential to cause a normal cell to become cancerous. overexpression of such a gene product can lead to esophageal squamous carcinoma and prostate cancer. The Workman Lab's efforts to learn more about the dynamic regula...
overexpression in Biological Technology

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

...gnificant unmet medical need in NF2 and other conditions resulting from the overexpression of VEGF. (Logo: http://www.newscom.com/cgi-bin/prnh/20010919/PTCLOGO...targeting the post-transcriptional processes that regulate VEGF formation. overexpression of VEGF plays a key role in the growth of many types of tumors. PTC299 sel...

PTC Therapeutics Receives $2.6 Million in Government Grants

...rietary GEMS (Gene Expression Modulation by Small-Molecules) technology by targeting the post-transcriptional processes that regulate VEGF formation. overexpression of VEGF plays a key role in the growth of many types of cancers. PTC299 inhibits VEGF production through a mechanism that is distinct from other VEGF...

Patent for Making Combination Chemotherapy Work Better

...ose, California discloses an improved method of treating lung, brain, pancreatic, breast and colon cancers that are driven by a mutation known as HER1 overexpression (also called EGFR or c-ErbB-1). The patent presents a case for why today's concurrent HER1 blocker / S-Phase cytotoxic protocols achieve only a fract...

Medivation Announces New Positive Efficacy Data From Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

...disease. Patients with castration-resistant (also known as hormone-refractory) prostate cancer have few treatment options and a poor prognosis. overexpression of the androgen receptor is believed to contribute to the progression of castration-resistant prostate cancer. MDV3100 is a novel small-molecule andr...

SuperGen Receives Clearance to Begin Clinical Trials With SGI-1776, a PIM Inhibitor

...d refractory non-Hodgkin's lymphomas. These solid tumor types have been reported to overexpress the Pim kinase family of proteins at a high frequency. overexpression of Pim-1 kinase has been shown to be a marker of poor prognosis in these tumors. A second Phase I/II study is being planned in patients with refractor...

Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients

... the disease. Patients with castration-resistant (also known as hormone-refractory) prostate cancer have few treatment options and a poor prognosis. overexpression of the androgen receptor is believed to contribute to the progression of castration-resistant prostate cancer. MDV3100 is a novel small- molecule andr...

/R E P E A T -- Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours/

... NSCLC with EGFR-based therapies have shown that patients with mutations or overexpression of EGFR, which are commonly found in NSCLC, derive clinical benefit from th...s in cancers with an activated RAS pathway resulting from EGFR mutations or overexpression may show similar benefit. However, patients with mutant K-RAS, or up to 20%...

Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours

... NSCLC with EGFR-based therapies have shown that patients with mutations or overexpression of EGFR, which are commonly found in NSCLC, derive clinical benefit from th...s in cancers with an activated RAS pathway resulting from EGFR mutations or overexpression may show similar benefit. However, patients with mutant K-RAS, or up to 20%...

JCI table of contents: April 22, 2008

...n of Pin1 in mice enhanced the stability of nonmutated tau protein, whereas overexpression of Pin1 decreased the stability of the protein and suppressed tauopathy in ...u and suppressed tauopathy in mice engineered to express P301L tau, whereas overexpression of Pin1 enhanced tauopathy in P301L tau mice. The authors therefore suggest...

GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment of HER2 Positive Breast Cancer Brain Metastases

...e kinase receptor. Stimulation of HER2 is associated with cell proliferation and with multiple processes involved in tumor progression and metastases. overexpression of this receptor has been reported in a variety of human tumors and is associated with poor prognosis and reduced overall survival. On March 13, 2007,...
overexpression in Biological Products

Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex

Description:...oteins of basement membrane, displays multiple biological activities which are mediated through its interaction with specific cell membrane receptors. overexpression of Laminin Receptor is reportedly an independent prognostic factor in breast cancer and correlates with the dissemination of the tumor cells in bone m...
Company:GeneTex

Human Cathepsin D from Calbiochem

Description:...te buffer, pH 6.5. Cathepsin D from human liver. Cathepsin D is a major lysosomal aspartyl protease in mammalian cells produced as a 52 kDa proenzyme. overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and release...
Company:Calbiochem

Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

Description:...ogy 3 (SH3) domain. Its SH3 domain is related to the SH3 domains of the tyrosine kinase c-Fyn and the p85 subunit of phosphoinositide-3 kinase (PI3K). overexpression of JIP1 causes cytoplasmic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathway. This observ...
Company:Invitrogen
overexpression in Biological Definition

Molecular genetics

...cromolecules important in biological inheritance forward and reverse genetics screens RNA interference gene knockout transgenics and overexpression mapping, cloning, and sequencing gene expression measuring spatial and temporal regulation cDNAs imprinting bacterial and phag...

Oncogene

... . Cytoplasmic Serine / Threonine kinases and their regulatory subunits , for example, the Raf kinase , and cyclin-dependent kinases (through overexpression ). Adaptor proteins in signal transduction . Transcription factors . Related articles Tumor suppressor gene Apoptosis ...
overexpression in Biological Dictionary

Heterocyst

...elopment provides an excellent model for studying cell ... PatS is proposed to control the heterocyst pattern by lateral inhibition. ... patS overexpression inhibits heterocyst formation in Anabaena strain PCC 7120, ... Heterocyst differentiation is a highly regulated process, resulting in a ......

Endoreduplication

...endoreduplication requires regulation of the cell cycle. ... Furthermore, endoreduplication was increased five- seven-fold in the mutants. ... overexpression of Rad52 prevented endoreduplication in RPA-overexpressing cells, ... DNA endoreduplication is the replication of nuclear DNA without subsequ...
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