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Increased hepcidin expression: A novel oncogenic signalling mechanism
Historically anaemia, which is associated with colorectal cancer, has been attributed to blood loss. Previous studies have elegantly shown that the anti-microbial peptide hepcidin can also induce anaemia as a consequence of infection and or inflammation. This type of anaemia has been termed anaemi...DMP1 deletion cooperates with oncogenic K-ras in lung cancer
Scientists have identified the transcription factor DMP1 as a pivotal tumor suppressor for both human and mouse lung cancers, especially in carcinomas that exhibit intact Arf-p53 pathways. The research, published by Cell Press in the October 2007 issue of Cancer Cell , may lead to development of ......t of non-small cell lung cancers. "Efforts to develop drugs that inhibit oncogenic RAS proteins have been largely unsuccessful, despite the fact that RAS gene...er investigation. "The new mantra, quite simply, is that cancers bearing oncogenic mutations in a kinase are dependent on that kinase for growth and survival,...
... Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced ...hibition profile targeting angiogenic, stromal and oncogenic receptor tyrosine kinases (TK). BAY 73-4506 has b...optosis (cell death) by directly targeting several oncogenic TK receptors. The mechanism may offer promise to t...
American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide
... some cancers. Hans-Guido Wendel, M.D., Memorial Sloan-Kettering Cancer Center, will test whether proteins that translate the mRNAs expressed from oncogenic genes respond to small molecules as potential cancer treatments. Cancer Cell Biology and Metastasis John Wilkinson, Ph.D., Wake Forest......howed an inverse correlation with the rate of programmed cell death in prostate cancer biopsy samples. "The experimental evidence we provide on the oncogenic role of FASN in the prostate suggests that pharmacological targeting of FASN might represent an effective treatment for prostate cancer," the authors ...
JCI table of contents: March 23, 2009
... . View the PDF of this article at: https://www.the-jci.org/article.php?id=37630 ACCOMPANYING COMMENTARY TITLE: Preventing and exploiting the oncogenic potential of integrating gene vectors AUTHOR CONTACT: Christopher Baum Hannover Medical School, Hannover, Germany. Phone: 49-511-532-6069; Fax: ...FDA Approves Two Hologic HPV Tests
...16/18 marks the first FDA approved HPV genotyping test available in the United States. The HPV strains identified by this test represent the two most oncogenic and persistent types of HPV, together believed to cause approximately 70% of cervical cancer. Previous studies have shown HPV 16 and 18 are respecti...Brain tumor treatment may increase number of cancer stem-like cells
...s is mainly mediated by ABCG2, as shown by the almost complete abolition of this phenotype when ABCG2 activity is blocked, we subsequently studied the oncogenic potential of ABCG2," explains Dr. Holland. The researchers confirmed that SP cells are highly tumorigenic, have the ability to self-renew, and are ...Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
...ll growth, proliferation, differentiation and survival. Mutations in the RAF kinase B-RAF have been found in many types of human cancer but, while oncogenic B-RAF V600E has been linked with tumor induction, growth, maintenance and progression, the specific molecular mechanisms have not been identified. Dr....oncogenic in Medical Technology
Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506
...or (TKI) with a kinase inhibition profile targeting angiogenic, stromal and oncogenic receptor tyrosine kinases (TK). In preclinical studies, BAY 73-4506 has be... lines while promoting apoptosis (cell death) by directly targeting several oncogenic TK receptors. The clinical significance of these studies is not known and ...EntreMed Presents Initial Clinical Results for ENMD-2076
...al malignancies. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 targets a defined set...Susan G. Komen for the Cure(R) Makes Unprecedented Research and Local Program Grants
...icians and scientists that improvements need to be made in the treatment of patients with advanced disease. Dr. Wu's grant, titled "Investigation of oncogenic properties and therapeutic application of PIK3CA mutations in breast cancer," focuses on the crucial need for information about a target gene which co...CERVARIX(R) Shown to Provide Longest Duration of Sustained Neutralizing Antibodies to Date
...t: SGO's Annual Meeting on Women's Cancer. March 10, 2008 Tampa Convention Center. (13) Gravitt PE, Jamshidi R. Diagnosis and management of oncogenic cervical human papillomavirus infection. Infect Dis Clin North Am, 2005; 19:439-458 (14) Munoz N, Bosch FX, de Sanjose S,et al. Epidemiolog...Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC)
...growth and cell fate. The process itself is called the "oncogenic pathway." In the past, most scientists in the field believed that there was only one oncogenic "pathway" in HCC. HCC is one of the most common tumors worldwide. Most cases of HCC result from a viral infection (Hepatitis B or C) or from cirrhos...Basic Science Discoveries Yield Progress in Hepatology
... Advances in Virology Translate Into New Promising Drugs to Combat Hepatitis C Clarification of oncogenic Pathways Aids Liver Cancer Research Stem Cells of Potential Benefit in Liver Transplantation MILAN, April 26 /PRNewswire/ -- - Systems Biol...EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
... Treatment with the combination also decreased the oncogenic proteins HIF-1alpha, pAKT, and pS6 ribosomal prote...uced cell cycle arrest and decreased levels of the oncogenic transcription factor proteins HIF-1alpha, pSTAT3, ...ith tubulin may be important for the modulation of oncogenic proteins by ENMD-1198. In summary, data demonstrat...RSV Researcher Makes Gains in Finding Treatments
... said. "RNA interference can theoretically block the production of any disease-causing protein." Thus, its potential application includes blocking oncogenic proteins that cause cancer and applications to other diseases as wide-ranging as genetic diseases such as cystic fibrosis and other common diseases su......djuvanted HPV 16/18 L1 VLP Vaccine. Presented at AACR Medical Meeting. April 17, 2007 (9) Gravitt PE, Jamshidi R. Diagnosis and management of oncogenic cervical human papillomavirus infection. Infect Dis Clin North Am, 2005; 19:439-458 (10) Munoz N, Bosch FX, de Sanjose S,et al. Epidemio...
EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model
...lar Targets and Cancer Therapeutics in San Francisco, California. (Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ) Activation of the oncogenic kinase Akt and the mTOR pathway are known to be adverse prognostic factors and contributors to the pathology of metastatic RCC, therefore inhibitors o...oncogenic in Medical Definition
...CCR7. Upon entry to the peripheral bloodstream , the cells are considered mature T cells, and not thymocytes.
Cancer
Thymocytes that gain oncogenic mutations allowing uncontrolled proliferation can become thymic lymphomas .
Alternative lineages
As well as classical T cells, a number o...
oncogenic in Medical Dictionary
...y seen but osteomalacia is still a problem ... MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia . ... Carpenter TO oncogenic osteomalacia —a complex dance of factors N Engl J Med. ... Free articles and multimedia from The NY Times, including information on symptoms, dia...
oncogenic in Biological News
New binding target for oncogenic viral protein
The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb. In a study published in the Journal of Biological Chemistry, researchers at the Fred Hutchinson Cancer Research Center report the discovery of...UC San Diego engineer provides insights to decades-old DNA squabble
...up and regulates chromatin," he explained. "You could have mutations in the oncogenic or tumor suppressor genes that lead to cancer or you could have abnormaliti...one deacetylase inhibitors) that can modulate structure of chromatin around oncogenic genes so as to inhibit cancer progression, though their exact mechanisms ar...Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...treat patients with metastatic breast cancer. This was the first targeted therapeutic agent developed on the basis of a newly discovered gene with an oncogenic function in human cancer. In the early 1990s, Ullrich identified the signaling system involved in regulating tumor angiogenesis, the growth of bloo...New method for detection of phosphoproteins reveals regulator of melanoma invasion
... expression, little is known about how proteins are modified in response to oncogenic B-Raf signaling in melanoma cells. In particular, identifying cellular targ...researchers identified ninety phosphorylation events that were regulated by oncogenic B-Raf. The phosphorylated proteins included many known signaling molecules....CSHL team develops mouse models of leukemia that predict response to chemotherapy
...usion proteins. It's the proteins that are the most immediate "cause" of cancer. They profoundly disturb the developmental program of cells. Both oncogenic mutations identified by Lowe's team in AML patients have been well studied. The oncogene AML1/ETO previously has been associated with a favorable ther...Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
...as A. Lauffenburger, PhD, at Massachusetts General Hospital, Boston, Massachusetts, is working to identify new protein networks that interact with the oncogenic Ras signaling pathway, which is rewired in over half of colorectal cancer cases. Targeting these new interactions in combinatorial therapy may become...Arbor Vita presents new data on cancer diagnostic at EUrogin
...inically relevant activity. The test is engineered to specifically detect E6 oncoprotein of high-risk HPV which, in concert with E7, is necessary for oncogenic transformation of cervical epithelial cells. Previously, AVC has demonstrated E6 specificity for detecting the HPV16 strain, which is responsibl...Science expands Science Signaling, featuring research related to medical advances, and more
...ller-Hermelink, R. D. Gascoyne, J. M. Connors, L. M. Rimsza, E. Campo, E. S. Jaffe, J. Delabie, E. B. Smeland, R. I. Fisher, W. C. Chan, L. M. Staudt, oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 319, 1676-1679 (2008). Colorectal Carcinoma The Wnt signal transduction pat...Veterinary college researcher studying brain tumors in people and animals
...e are several different specific types of glial cells, but two that interest Rossmeisl and colleagues most are called astrocytes and oligodendrocytes. oncogenic abnormalities associated with each of these can lead to cancers called astrocytomas and oligodendrocytomas, according to Rossmeisl. The most common...Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer
...nism involved in the carcinogenesis of different organs is not always similar. In the case of cervical cancer we know that the trigger mechanism is an oncogenic virus, HPV (human papillomavirus) and that in ovarian cancer, although not as clearly understood, inflammation and hormonal regulation are credited wi...oncogenic in Biological Technology
Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research
... treat patients with metastatic breast cancer. This was the first targeted therapeutic agent developed on the basis of a newly discovered gene with an oncogenic function in human cancer. In the early 1990s, Ullrich identified the signaling system involved in regulating tumor angiogenesis, the growth of bl...EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting
...al malignancies. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 targets a defined set...First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418
...erase I (GGTase I) that induces apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. The Phase I study is led by Dr. Peter O'D...GGTase I that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational...FDA Accepts Investigational New Drug (IND) Application for Tigris Pharmaceutical's GGTI-2418
...erase I (GGTase I) that induces apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. "We are excited to reach this important c...GGTase I that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational...Tigris Pharmaceuticals Files IND Application for GGTI-2418
...GTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. "The filing of this IND ahead of the sche...GTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational...EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma
...nisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. In addition, ENMD-2076 is relat...Daiichi Sankyo Co., Ltd. Announces Acquisition of Biotech Firm U3 Pharma AG
...any's lead product, which is being co-developed with Amgen, is U3-1287 (AMG 888), the first fully-human anti-HER3 monoclonal antibody (mAb) to inhibit oncogenic signaling and tumor proliferation. The companies intend to initiate clinical development of this compound this year. Daiichi Sankyo's current novel .......m. to 5:00 p.m. P.T. - Phosphatidylinositol 3-kinase stimulates the proliferation of bronchioalveolar stem cells in mouse models of oncogenic K-ras- induced lung cancer Abstract # 5408, Session: Stem Cells Poster Session: Wednesday, April 16, 2008, 8:00 a.m. to ...
Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform
... binding that has been implicated as an important factor in miRNA regulation [6, 7]. Many of the genes listed in Figure 4 become oncogenic when they are over-expressed, thus it is conceivable that reduced expression of a miRNA could lead to up-regulation of one or mo...Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries
...loning by screening the human Burkitts Lymphoma cDNA library for oncogenic cDNAs. cDNA Library Construction Polyadenylated mRNA was isol...d nine distinct cDNAs, none of which were obvious candidates for oncogenic transformation, and three of which were unknown. Like Onco-1 and...oncogenic in Biological Products
Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
Description:... to environmental stress, is associated with the nuclear accumulation of JNK itself, and is implicated in the immune response, cellular proliferation, oncogenic transformation, morphogenesis, and apoptosis.JIP1 (JNK-interacting protein-1, also known as Islet Brain-1 and mitogen-activated protein kinase 8-inter...Company:Invitrogen
oncogenic in Biological Definition
...of the apoptotic pathway. This severe interference in the apoptotic capability of cells plays a critical role in the fact that persistent infection by oncogenic HPVs can result in the development of cervical cancer .
Response to stress or DNA damage
Stress conditions (such as starvation) as well as d...
...ynthesis of proinflammatory prostaglandins ). Considerable research effort is now devoted to the development of vaccines (to prevent infection by oncogenic infectious agents, as well as to mount an immune response against cancer-specific epitopes) and to potential venues for gene therapy for individuals...
...ynthesis of proinflammatory prostaglandins ). Considerable research effort is now devoted to the development of vaccines (to prevent infection by oncogenic infectious agents, as well as to mount an immune response against cancer-specific epitopes) and to potential venues for gene therapy for individuals...
oncogenic in Biological Dictionary
... ... Although suppression of the transformed phenotype by Krev-1 is stable when cells ... 3 and PEA3 expression and the transformed and oncogenic phenotype in CREF cells. ... ... (IPTG) to IR-1 cells caused the expression of the transformed phenotype ... cells that had lost their ...
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