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nicotinic in Medical News

Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition

Scientists to Present Data and Discuss Emerging Advances in Basic Research and Clinical Science at Neuroscience 2007 Satellite Symposium ABBOTT PARK, Ill., Nov. 1 /PRNewswire-FirstCall/ -- The human brain relies on chemicals called "neurotransmitters" that nerve cells use to communicate to ...

EnVivo to Share Results of its EVP-6124 Phase Ib/IIa Trial at The International Conference on Alzheimer's Disease

... trial in Alzheimer's disease patients with its nicotinic alpha-7 agonist EVP-6124. WHEN: Wednesday, July 15, 2009. ...itive Disorders and Schizophrenia. The company's lead product is an alpha-7 nicotinic acetylcholine receptor agonist and has been tested in Phase 2a clinical tri...

Another Blood Fat Fuels Heart Attack Risk

...eeded to tell whether drugs aimed at reducing lipoprotein(a) (LPA) levels would lower the risk, Nordestgaard said. One compound, niacin, also known as nicotinic acid or vitamin B3, is known to reduce LPA levels, he said. "I am not aware of other drugs being developed to lower lipoprotein(a), but I certainly...

JCI online early table of contents: April 6, 2009

...ffects of a drug from the adverse side effects nicotinic acid is one of the most effective drugs for raisin...ation. A way to separate the beneficial effects of nicotinic acid from the flushing response has now been eluci...cell lines determined a signaling pathway by which nicotinic acid could initiate the flushing response. This pa...

EnVivo and Mitsubishi Tanabe Enter License Agreement on EVP-6124 in Japan, Korea, Taiwan and Other Asian Countries

...ountries. EVP-6124 is EnVivo's novel alpha-7 nicotinic acetylcholine receptor agonist currently in develo...ghts to develop and commercialize EnVivo's alpha-7 nicotinic acetylcholine receptor agonists such as EVP-6124 i...ophrenia. The company's lead product is an alpha-7 nicotinic acetylcholine receptor agonist and is being tested...

Genetic Markers Identified for Alcohol Response in UCSF Gallo Study

...her genes surrounding this marker could be responsible for the variation in level of response. However, the authors did say that they suspect that the nicotinic receptor gene CHRNA5 may be responsible. Co-authors on the paper were Geoff Joslyn, Gerry Brush and Margaret Robertson, from the Gallo Center; and...

Roche Signs Definitive Agreement to Acquire Memory Pharmaceuticals

...ders such as Alzheimer's disease and schizophrenia. Memory Pharmaceuticals' nicotinic alpha-7 agonist drug candidates in these disease areas are already in partn...uticals will enable Roche to secure the future development of its promising nicotinic alpha-7 agonists," said William Burns, CEO Division Roche Pharmaceuticals. ...

Memory Pharmaceuticals Announces Issuance of Key U.S. Patent for R3487/MEM 3454 and R4996/MEM 63908

...664, which provides composition of matter patent protection for a series of nicotinic alpha-7 receptor agonists. These include R3487/MEM 3454 and R4996/MEM 63908...f 2008. About R3487/MEM 3454 R3487/MEM 3454 is a partial agonist of the nicotinic alpha-7 receptor, a highly specialized receptor found in the central nervou...

The APCs of nerve cell function

...unctions in directing the surface membrane delivery and stable retention of nicotinic acetylcholine receptors at the synapse." "A single nerve cell synthesiz... at the complex. This study identifies several novel components of neuronal nicotinic cholinergic synapses. Jacob and colleagues showed that blocking APC fun...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...d alpha- linked acidic dipeptidase (NAALADase); N-cadherin (NCAD); neural precursor cell expressed, developmentally downregulated 8 (NEDD8); NFkappaB; nicotinic acid phosphoribosyltransferase (NAPRT); nucleolin; 17 alpha-hydroxylase/C17,20 lyase; ornithine decarboxylase 1 (ODC1); p38 mitogen-activated protein ...
nicotinic in Medical Technology

Roche Exercises its Option to Further Develop and Commercialize Memory Pharmaceuticals' Nicotinic Alpha-7 Agonist, MEM 3454

-Memory Receives $6 Million Milestone Payment- -Memory to Host Conference Call at 9:00 a.m. EDT Today- MONTVALE, N.J. and BASEL, Switzerland, May 2 /PRNewswire-FirstCall/ -- Memory Pharmaceuticals Corp. (Nasdaq: MEMY ) and Roche (SWX: ROG) today announced that Roche has ex...

EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia

BOSTON, April 2, 2008 /PRNewswire/ -- EnVivo Pharmaceuticals announced today that it has initiated a clinical safety and biomarker study of its alpha-7 nicotinic agonist (EVP-6124) in Schizophrenia patients chronically treated with atypical antipsychotic medications. The objectives of this stu...

AstraZeneca and Targacept Announce Top-Line Results from Phase IIb Study of AZD3480 in Cognitive Dysfunction in Schizophrenia

...t meet our objectives, we continue to pursue medicines that target neuronal nicotinic receptors (NNRs) with Targacept to treat cognitive disorders," said Bob Hol...and disorders. Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote the...

Memory Pharmaceuticals Achieves Enrollment Goal for Phase 2 Study of MEM 3454 in Cognitive Impairment Associated With Schizophrenia

... Phase 2 trial of R3487/MEM 3454, its lead alpha-7 nicotinic receptor agonist, in cognitive impairment associat...is the one of the first major studies evaluating a nicotinic alpha-7 receptor agonist in schizophrenia and we a...54 R3487/MEM 3454 is a partial agonist of the nicotinic alpha-7 receptor, a highly specialized receptor fo...

Memory Pharmaceuticals and Roche Expand R3487/MEM 3454 Development Program

...q: MEMY ) today announced that it has amended its nicotinic alpha-7 receptor agonist agreement with Roche to e...r CIAS trial is the first major trial evaluating a nicotinic alpha-7 receptor agonist in this indication, and t... 3454 R3487/MEM 3454 is a partial agonist of the nicotinic alpha-7 receptor, a highly specialized receptor fo...

AstraZeneca and Targacept Announce Top-Line Results from Phase IIb Study of AZD3480 in Alzheimer's Disease

... a new class of drugs for the treatment of central nervous system diseases and disorders. Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic effects and limit adverse side effects. Targacept has product cand...

Memory Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Financial Results

...th Quarter Highlights and Recent Developments -- nicotinic Alpha-7 Receptor Agonist Program MEM 3454. ...ine results from its Phase 2a trial of MEM 3454, a nicotinic alpha-7 receptor agonist, in Alzheimer's dise... for R4996/MEM 63908, a partial agonist of the nicotinic alpha-7 receptor. The randomized, double-bli...

Memory Pharmaceuticals & Roche Expand Development Program for MEM 3454 in Schizophrenia

...t a clinical study of MEM 3454, the Company's lead nicotinic alpha-7 partial agonist, on two biomarkers of schi...he companies' collaboration for the development of nicotinic alpha-7 receptor agonists. "This new study will ...he efficacy of MEM 3454 and other compounds in the nicotinic alpha-7 receptor program," said Stephen Murray, MD...

Xytis Names Gordon H. Busenbark as Chief Financial Officer

...CDC Innovation, and Ventech. Xytis has a rich portfolio of proprietary preclinical compounds that are novel, highly selective allosteric modulators of nicotinic acetylcholine receptors (nAChRs), GABA-A receptors and other well-validated CNS targets. The Company has two compounds in clinical development -- Nebo...

EnVivo Pharmaceuticals Announces Progress on Major Drug Programs Focusing on Alzheimer's, Schizophrenia and Huntington's Diseases

...o Pharmaceuticals is developing EVP6124, a selective, orally active Alpha 7 nicotinic Acetylcholine Receptor Agonist for the treatment of cognitive deficits asso...n's disease and Huntington's disease. The company's lead programs include a nicotinic Acetylcholine Receptor Agonist Program (alpha-7) for Alzheimer's disease an...
nicotinic in Medical Dictionary

Vitamin B

...rsies about vitamin B6? ... Vitamin B5 (pantothenic acid) forms part of your daily diet, and plays a ... Vitamin B 3 (Niacin, Niacinamide, nicotinic Acid) Vitamin B 5 (Pantothenic Acid) ... ... information on Vitamin B5 (Pantothenic Acid), natural vitamin supplement. ... Vitamin B5, a...

Vitamin

...trition products, health foods, and more, ... information on vitamin supplements, herbal supplements, minerals, amino ... Vitamin B3 (niacin) nicotinic acid. Niacinamide (nicotinamide) Vitamin B4 (adenine) ... Get Multivitamin Supplement for Woman. We provide Women's Multivitamin and supplement ...

Nicotine

...ption by the tissues of the mouth. ... Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae) ... Nicotine acts on the nicotinic acetylcholine receptors, specifically the ... The effects of nicotine on the human body create dependency through chemical reactions in the brai...

Niacin

... Niacin , also known as vitamin B3 or nicotinic acid, is a water-soluble vitamin that prevents t...niacin in the body. ... Niacin (Vitamin B3, nicotinic acid), Niacinamide ... made up of niacin (nicoti...ted to niacin in the body. ... Also known as nicotinic acid. Describes benefits, sources, and symptoms of...
nicotinic in Biological News

Researchers 'see' structure of open nicotinic acetylcholine ion channels

The neurotransmitter acetylcholine is an essential chemical communicator, carrying impulses from neurons to skeletal muscle cells and many parts of the nervous system. Now researchers at the University of Illinois have painstakingly mapped the interior of a key component of the relay system that a...

Nicotine activates more than just the brain's pleasure pathways

...diverse peripheral information to create a unique sensory representation for nicotine." One taste pathway the Duke researchers uncovered involves nicotinic acetylcholine receptors (nAChR), which scientists previously proposed were taste receptors for nicotine. The researchers found a previously unknown li...

Researchers find link between nicotine addiction and autism

...job is to lure another protein, a specific type of nicotinic acetylcholine receptor, to the synapses, where the...n that people with autism have a shortage of these nicotinic receptors in their brains. Meanwhile, scientists a...xin would in turn not only enhance the presence of nicotinic acetylcholine receptors, but also a host of other ...

Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system

..., the University of Utah, and the pharmaceutical company Targacept. They genetically modified a type of brain receptor known as an "α6-containing nicotinic acetylcholine receptor" to make it more sensitive to both nicotine and acetylcholine. (Acetylcholine is another of the brain's neurotransmitters.) ...

Stabilizing force for good communication between neurons and muscle cells found

...l myasthenia gravis. MCG researchers are looking now to see if a mutated rapsyn still interacts with hsp90β. They used a type of acetylcholine nicotinic receptor at the neuromuscular junction as a model for their studies of brain development and communication. The junction is 1,000 times larger than co...

Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue

...otransmitter receptors. The results provide a new model of behavior for the nicotinic acetylcholine receptor, a well studied protein involved in inflammation, Al... the cholesterol required to function properly. The study focused on the nicotinic acetylcholine receptor, an ion channel found in both brain and muscle cells...

American Chemical Society's Weekly PressPac -- Sept. 10, 2008

...describes animal and human trials of several potential new drugs that focus on new disease targets, including the glutamate neurotransmitter system, a nicotinic acetylcholine receptor, and a signaling pathway mediated by cyclic nucleotides. These substances appear to help relieve a wider range of symptoms ...

New treatment mechanisms for schizophrenia

...cyclidine (PCP) decreased the density of 7 nicotinic receptors (7 nAChRs) in the mouse brain, a...that accumulating evidence suggests that 7 nicotinic receptors, a subtype of nicotinic receptors, are a most attractive target for novel ...

Nicotinic receptors may be important targets for treatment of multiple addictions

...r addictive drugs. This receptor, known as the nicotinic acetylcholine receptor (nAChR), increases excitabi...on," says McGehee. "It raises the possibility that nicotinic receptors may be important targets for the treatme...r, but this work provides insight into the role of nicotinic receptors in the vulnerability to multiple classes...

Nicotine rush hinges on sugar in neurons

...ression as targets for improved drugs that could result from the study’s findings. The study provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neu...
nicotinic in Biological Technology

EnVivo Pharmaceuticals Announces Results and Successful Completion of EVP-6124 Phase Ib/IIa Trial at the International Conference on Alzheimer's Disease

...IIa trial in Alzheimer's disease patients with its nicotinic alpha-7 agonist EVP-6124. Subjects receiving EVP-... its findings. EVP-6124 is EnVivo's novel alpha-7 nicotinic acetylcholine receptor agonist currently in develo...phrenia. The company's lead product is an alpha-7 nicotinic acetylcholine receptor agonist and has been tested...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

...ntral nervous system, with a current focus on Alzheimer's disease , Cognitive Disorders and Schizophrenia. The company's lead product is an alpha-7 nicotinic acetylcholine receptor agonist and has been tested in Phase 2a clinical trials for cognition disorders in Alzheimer's disease and Schizophrenia. The c...

Memory Pharmaceuticals Reports Third Quarter 2008 Financial Results

... our continuing performance in connection with the nicotinic alpha-7 agonist program. For the quarter ended S...ased costs associated with advancing the Company's nicotinic alpha-7 receptor agonist, 5-HT6 antagonist and PDE...sition of matter patent protection for a series of nicotinic alpha-7 receptor agonists including R3487/MEM 3454...

Memory Pharmaceuticals Completes Phase 1 Multiple Ascending Dose Study of R4996/MEM 63908

...gram for R4996/MEM 63908, a partial agonist of the nicotinic alpha-7 receptor being developed in collaboration ...Memory Pharmaceuticals filed with Health Canada. nicotinic Alpha-7 Receptor Agonist Collaboration with Roche ...econd compound being developed under the Company's nicotinic Collaboration with Roche. Under the terms of the a...

Thought Leaders Discuss Positive Outlook for Bapineuzumab in Alzheimer's Disease in MedPredict Report

... excitement extends beyond the clinical evidence. These include ARBs, acetylcholinesterase (butyrylcholinesterase) inhibitors, NMDA, M1, 5-HT, alpha-7 nicotinic acetylcholine agonists, active and passive immunotherapy, gamma-secretase and beta-secretase inhibitors, insulin related mechanisms (IDE, RAGE), anti-...

Memory Pharmaceuticals Reports First Quarter 2008 Financial Results

...ised its option to license R3487/MEM 3454, Memory Pharmaceuticals' lead nicotinic alpha-7 receptor agonist, for further development and commercialization...esources toward development activities with two partnered programs, its nicotinic alpha-7 receptor agonist collaboration with Roche and the PDE10 collabo...

Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder

...s will present new Phase II data showing that ABT-089, a selective neuronal nicotinic receptor (NNR) agonist, is a potentially effective and safe treatment for a... on nerve cells in the central nervous system. NNRs, also known as neuronal nicotinic acetylcholine receptors (nAChRs), modulate the release of several important...

Memory Pharmaceuticals Refocuses to Advance Development and Clinical Programs

...continued development of key partnered and proprietary programs: -- nicotinic Alpha-7 Receptor Agonist Collaboration with Roche. MEM 3454, the lead compound in the Company's nicotinic alpha-7 receptor agonist collaboration with Roche, demonstrated a st...

New Report Tackles the Changing Landscape for Alzheimer's Diagnostics and Treatments

...re the excitement extends beyond the clinical evidence. These include acetylcholinesterase (butyrylcholinesterase) inhibitors, NMDA, M1, 5-HT, alpha-7 nicotinic acetylcholine agonists, active and passive immunotherapy, gamma-secretase and beta-secretase inhibitors, insulin related mechanisms (IDE, RAGE), plasm...

Memory Pharmaceuticals Initiates Phase 2a Trial of MEM 3454 in Cognitive Impairment Associated with Schizophrenia

... 2a clinical trial of MEM 3454, the Company's lead nicotinic alpha-7 receptor partial agonist, in cognitive imp... In June 2007, Memory Pharmaceuticals expanded its nicotinic alpha-7 receptor agonist agreement with Roche to s...f MEM 3454. MEM 3454 is a partial agonist of the nicotinic alpha-7 receptor, a highly specialized receptor fo...
nicotinic in Biological Products

Mouse Anti-nicotinic Acetylcholine Receptor Monoclonal Antibody, Unconjugated, Clone 88B from Abcam

Description:... Mouse monoclonal [88B] to nicotinic Acetylcholine Receptor ( Abpromise for all tested applications)....
Company:Abcam
nicotinic in Biological Definition

Nicotinamide adenine dinucleotide

...one hydrogen attaches to the carbon atom opposite to the nitrogen. The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide. See also Adenine Nucleotide References and external links NAD and NADP Nicotinamide ...

Nicotinamide adenine dinucleotide

...one hydrogen attaches to the carbon atom opposite to the nitrogen. The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide. See also Adenine Nucleotide References and external links NAD and NADP Nicotinamide ...

Nicotinamide adenine dinucleotide

...one hydrogen attaches to the carbon atom opposite to the nitrogen. The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide. See also Adenine Nucleotide References and external links NAD and NADP Nicotinamide ...

Transmembrane receptor

...ptors for which structural evidence exists, transmembrane alpha helices make up most of the transmembrane domain. In certain receptors, such as the nicotinic acetylcholine receptor , the transmembrane domain forms a protein-lined pore through the membrane, or ion channel . Upon activation of an extracell...
nicotinic in Biological Dictionary

Endodermis

...n the development of root pressure. ... Ions outside the endodermis must be actively transported across an endodermal ... Plant woody, evergreen; nicotinic acid metabolised to trigonelline; primary cell ... stem with ectophloic eustele, endodermis 0, xylem endarch, branching exogenous; ... Gibb...
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