Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity
... distinct year-long studies of velneperit, a novel neuropeptide
Y (NPY) Y5 receptor antagonist also known as S-236...erit involves blocking the Y5 binding receptor for neuropeptide
Y (NPY), a centrally acting signaling molecule tho...once-daily, oral, centrally acting, small molecule neuropeptide
Y (NPY) Y5 receptor antagonist that was discovered...
Molecular Switch in Brain May End Smokers' Cravings
... A key receptor cuts the urge for nicotine, rat study suggests
MONDAY, Nov. 24 (HealthDay News) -- Blocking a neuropeptide
receptor in the brain may be one way to quickly lessen the desire for a cigarette, a new study suggests.
Hypocretin-1, or Orexin A, a short chain o...
Brain Mechanism Can Turn Off Trauma of Bad Memories
...armacology and pharmaceutical sciences.
The UCI team, along with colleagues from the University of Muenster in Germany, found that a protein called neuropeptide
S (NPS) eliminates traumatic responses to bad memories by working on a group of neurons inside the amygdala, the brain region where negative memories ...
Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana
...R messenger RNA and protein, and also measured levels of glutamic acid decarboxylase (GAD-67), an enzyme that makes GABA, and cholecystokinin (CCK), a neuropeptide
released from GABA neurons that, among other actions, regulates the production of the brain's own cannabinoids.
"CB1R levels were significantly 15 ...
CCNY researchers demonstrate effectiveness of contrast agent Cytate in detectcing prostate cancer
...conjugate consisting of Indocyanine Green (ICG), an FDA-approved near-infrared dye, and a somatostatin receptor ligand. Somatostatin is a small cyclic neuropeptide
that is believed to regulate the production of other hormones and perform an important role in the cancer development. Previous studies had shown that...
Stress during childhood increases the risk of allergies
...ith moving house or the separation of parents. The neuropeptide
VIP could take on a mediator role between stress e...rchers found increased blood concentrations of the neuropeptide
VIP (vasoactive intestinal polypeptide) as well as...tionship between an increased concentration of the neuropeptide
VIP and allergic sensitisations among six-year old...
Your belly fat could be making you hungrier
...roduction. The researchers hope this discovery will change in the way we think about and treat abdominal obesity.
Yang identified that the hormone neuropeptide
Y (NPY) is reproduced by abdominal fat tissue. Previously, it was believed to only be produced by the brain. Yang believes this novel finding may le...
Unlocking mysteries of brain cancer, stroke
...rofessor Vink says.
This year, the Centre for Neurological Diseases has also begun two new research projects investigating the role that a specific neuropeptide
known as substance P can play in helping to prevent injury and death in victims of stroke. Substance P is a neurotransmitter and modulator that app...
Brain DNA 'remodeled' in alcoholism
... causing them to wrap with DNA more tightly, decreasing gene expression.
The UIC researchers had previously shown in an animal model that levels of neuropeptide
Y in the amygdala modulate anxiety and alcohol-drinking behavior. In the new study, they looked at the HDAC activity, acetylation of histones, and exp...
Insomniac Fish May Help Sleepless People
... scientists in their efforts to learn more about the genetics of sleep disorders.
Fish with the mutation have brain cells that lack receptors for a neuropeptide
called hypocretin. These fish got 30 percent less overall sleep than normal zebrafish. When the mutant fish did fall asleep, they slept only half as l...
neuropeptide in Medical Technology
neuropeptide in Medical Products
Leptin Soluble Receptor ELISA Test
Description:...xpenditure . Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide
Y (NPY). This feedback mechanism provided by leptin to the brain is necessary for the precise regulation of long term energy balance . Leptin expre...
Company:Diagnostic Systems Laboratories, Inc.
neuropeptide in Medical Definition
...clings of the body are hormonal release, heart rate , thermoregulation , nostril dilation and appetite . The last involves rhythmic release of neuropeptide
Y (NPY) and Corticotropin-releasing hormone (CRH), stimulating and inhibiting appetite ultradian rhythms.
Ultradian Bipolar Disorder
neuropeptide in Medical Dictionary
...ymptoms, causes, diagnosis, and treatment information for VIPoma ( Vipoma ) ... VIPoma : A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide
that ... VIPoma is a very rare type of cancer that usually grows from certain cells ... VIPoma causes cells in the pancreas to produce hig...
... Texas A&M University College of Veterinary Medicine is a major veterinary educational, medical ... Gastrin is an important gastrointestinal neuropeptide
that ... Normal The range of normal gastrin values may vary from lab to lab. ... Many conditions can change gastrin levels. ... High gastri...
neuropeptide in Biological News
Genetic variation may lead to early cardiovascular disease
...ase (CAD). More recently, the researchers focused on identifying the gene in this region that confers risk of early-onset CAD and identified it as the neuropeptide
Y (NPY) gene. NPY is one of the most plentiful and important proteins in the body and is a neurotransmitter related to the control of appetite and fee...
American Chemical Society's Weekly PressPac -- Sept. 26, 2007
Several pharmaceutical companies are working on new treatments for migraine that target signaling proteins in the brain, including a receptor for a neuropeptide
and a type of ion channel. In laboratory studies, these approaches appear to reduce the risk of side effects, the article notes.
One exciting app...
Gender, coupled with diabetes, affects vascular disease development
...scular response to these substances was also observed during exposure to L-NAME (which blocks production of nitric oxide, a potent artery relaxer) and neuropeptide
Y (which augments the restriction of blood vessels).
The investigators found that:
in the early stage of the disease, both male and female di...
A new target for painkillers
...ut he believes that will take at least 10 years.
McIntosh co-authored the study with two colleagues in the University of Utah Center for neuropeptide
Pharmacology ?Baldomero "Toto" Olivera, a distinguished professor of biology, and Michael Ellison, a postdoctoral fellow in biology ?and with Michelle...
Scientists identify 36 genes, 100 neuropeptides in honey bee brains
...d a gene, it is hard to say what particular peptide it will create, because neuropeptide
precursors undergo extensive post-translational processing."
Some of th...ng honey bee research," the researchers wrote, "it demonstrates promise for neuropeptide
discovery in the large number of other new genomes currently being sequence...
Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
...eld at the David L. Lawrence Convention Center in Pittsburgh June 19 ?22.
S (NPS), so named by Rainer K. Reinscheid, Ph.D., assistant professor, Prog...ning and memory. Dr. Reinscheid and his colleagues reported finding the new neuropeptide
just last year and described animal studies showing how binding of NPS to i...
An essential regulator of body weight revealed
...ns eat excessively and become obese.
The other neurons that make up the arcuate nucleus are NPY/AgRP neurons, named for two proteins they produce, neuropeptide
Y (NPY) and agouti-related protein (AgRP). Researchers have long suspected NPY/AgRP neurons to be important regulators of feeding behavior, acting in ...
Bitter or sweet? The same taste bud can tell the difference
...weet and bitter tastes may reside in the same taste bud cells, a new study reports.
The study explains the discovery of a chemical messenger called neuropeptide
Y (NPY) in taste bud cells. Though researchers have long known that NPY is active in the brain and gut, this is the first study to show that it is als...
Discovery clarifies role of peptide in biological clock
...ce in hopes of unraveling more clues about our biological clock.
VIP is not "very important person," but vasoactive intestinal polypeptide (VIP), a neuropeptide
originally found in the gut, that is also made by a specialized group of neurons in the brain.
Erik Herzog, Ph.D., Washington University assistant ...
Alcohol's effects on gene expression in the central nervous system
...enes that appear to be responsive to alcohol include genes involved in the intracellular signaling process (which can alter how the neuron functions), neuropeptide
signaling (which modulates nerve cell activity), and myelin structure (which is needed for communication between nerve cells)," said McBride. "Gene ex...
neuropeptide in Biological Technology
Development of a CRF1 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System
Key words: CRF 1 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads
In the mammalian brain, the corticotrophin-releasing factor (CRF) system comprises four CRF-related peptides (CRF and urocortin 1, 2, and 3...
Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System
Key words: NK2 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads
Neurokinins, also known as tackykinins, are a family of small neuropeptides. Members of this family include peptides, substance P (SP), neurokin...
ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information
...the Company to describe the
synthetic peptide Sar9, Met (O2)11-Substance P. Sar9, Met (O2)11-Substance
P is an analog of the naturally occurring human neuropeptide
which can be found throughout the body, including in the airways of humans
and many other species. All of the Company's research and deve...
The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System
...vidence has suggested that melanocortins are involved in mediating appetite regulation through the effects of leptin and controlling the expression of neuropeptide
Y. Thus, the MC 4 receptor is a potential target for anti-obesity agents (2).
This application note describes a 384-well melanocortin MC...
Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*
In order to demonstrate that sex steroids increase neuronal protein synthesis
of the neuropeptide
vasopressin, Stratagenes hNT Neurons were cultured
with various physiological and supraphysiological levels of estrogen,
neuropeptide in Biological Definition
... insulin-like growth factor (IGF, also somatomedin)
luteinizing hormone (LH)
melanocyte stimulating hormone (MSH or α-MSH)
parathyroid hormone (PTH)
pancreatic polypeptide (PP)