Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.
Scientists at E...
U-M scientists find new causes for neurodegeneration
October 23, 2007 - Diseases that cause neurons to break-down, such as Alzheimer's, Multiple Sclerosis and Creutzfeldt-Jakob disease (Mad Cow Disease), continue to be elusive to scientists and resistant to treatments.
A new finding from University of Michigan researchers demonstrates an unpredicte...
Looking at language
... them may involve shifting attention to this "background" information from main-clause "foreground" information.
These joint effects of subcortical neurodegeneration
on syntax and "set-switching" are consistent with widely publicized research indicating that mutations in the human FOXP2 gene cause deficits in langu...
Hard to Treat Diseases, Inc. (HTDS) Experiments with Hyperbaric Oxygenation (HBO) Traumatic Brain Injury
...was able to attenuate the effects of brain damage by reducing the progression of neuronal injury.
These data indicate that HBO-induced prevention of neurodegeneration
might be beneficial in improvement of neurological outcome after traumatic brain injury.
Dr. Sanja Pekovic, Chief Project Scientist, Chief Strategy ...
New Therapies, Including Novel Biologic Agents from Elan/Wyeth and Eli Lilly, Will Drive Robust 11 Percent Annual Growth In the Alzheimer's Disease Market
...d commercial promise are the anti-beta amyloid monoclonal therapies such as bapineuzumab and solanezumab, which have the potential to slow the rate of neurodegeneration
and cognitive decline," said Decision Resources Analyst Matthew Winton, Ph.D. "However, the efficacy and safety of these monoclonal antibodies has yet...
Science Zeroes In on New Alzheimer's Drug Target
...rs have developed a number of experimental HDAC inhibitor compounds, especially for cancer, which target these enzymes.
Using a mouse model of the neurodegeneration
that accompanies Alzheimer's disease, Tsai's group in 2007 found that a nonspecific HDAC inhibitor could restore learning ability and memory in the s...
FDA Gives Clinical Trial Green Light on Drug to Treat Alzheimer's Disease
...to move forward with clinical trials," said Dr. Daniel Alkon, Scientific Director of BRNI. "Bryostatin shows the promise to repair and protect against neurodegeneration
caused by Alzheimer's disease, stroke and other brain trauma, as well as enhance the brain's normal memory functions."
Bryostatin was originally...
Brain Cells Give New Clues to Alzheimer's
...s with the protein Drp1, causing the fragmentation of mitochondria -- the cell's energy storehouses -- in the brain, a violent process that causes the neurodegeneration
linked to Alzheimer's disease.
When mitochondria break apart, the reaction damages synapses leading to nerve cell death. As brain synapses are vita...
Protein-Folding Problem May Help Spur Alzheimer's
...e of neurofibrillary degeneration and ... that the prolonged activation of the [unfolded protein response] is involved in both tau phosphorylation and neurodegeneration
in [Alzheimer's disease] pathogenesis ... Future studies will address the therapeutic opportunities of this pathway for the treatment of [Alzheimer's ...
Experts examine causes, treatment and prevention of glaucoma
...The report from the Fourth Annual ARVO/Pfizer Ophthalmics Research Institute Conference examined four areas of research into the cause of glaucomatous neurodegeneration
and is published in the March 2009 issue of Association for Research in Vision and Ophthalmology's peer-reviewed journal Investigative Ophthalmology ...
neurodegeneration in Medical Technology
CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders
--Orally Active Enhancer of Human Nerve Growth Factor Has Demonstrated Promising Activity Preclinically--
--Broad Potential Applications Include Neuropathies, Alzheimer's and Huntington's Disease and Others--
RESEARCH TRIANGLE PARK, N.C., June 16 /PRNewswire/ -- CeNeRx BioPharma, Inc., a...
Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
...apoptosis, meaning that the DNA-damaged cells were more likely to survive, even when crippled. Such cells would ultimately die, however, producing the neurodegeneration
characteristic of ATLD in humans. In contrast, the NBS mice showed normal apoptosis, but because fewer brain cells survived, developed significantly s...
Dutch Top Institute Allocates 150 Million Euro to R&D Projects Targeting Early Diagnosis and Treatment of Disease
...tal of 150 million Euro will be injected into Netherlands-based
research related to the most prevalent diseases in the cardiovascular area,
cancer and neurodegeneration
(Alzheimer disease). These three areas of
disease have the biggest impact on people throughout the western world. The
funding is provided by the Dutch...
Data to be presented at AAN Meeting -Study results of drug
candidate for MS
...t; Preclinical studies suggest FTY720 stimulates cells
that may help reduce neurodegeneration
and enhance repair of the
CNS affected by multiple sclerosis
· Sep...in the brain. The data suggest
that FTY720 may have the potential to reduce neurodegeneration
enhance repair of the central nervous system (CNS) by modulating
neurodegeneration in Medical Dictionary
...ducting Meeting: Hallervorden -Spatz Syndrome Association and ... "Julius Hallervorden's War-time Activities: Implications for Science in a ... neurodegeneration
with Brain Iron Accumulation( Hallervorden -Spatz disease) information sheet compiled by the National Institute of Neurological Disorders and Stroke ...
neurodegeneration in Biological News
Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimer's disease
WOODS HOLE, MATiny, toxic protein particles severely disrupt neurotransmission and inhibit delivery of key proteins in Alzheimer's disease, two separate studies by Marine Biological Laboratory (MBL) researchers have found.
The particles are minute clumps of amyloid beta, which has long been kno...
Molecular basis for neurodegeneration in Ataxia telangiectasia
An upcoming paper from Dr. David Wassarman (University of Wisconsin School of Medicine and Public Health) in the May 1 issue of G&D lends new insight into the pathogenesis of neurodegeneration
in Ataxia telangiectasia.
Ataxia telangiectasia (A-T) is a rare, genetic immunodeficiency disease that...
Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
PROVIDENCE New research from Rhode Island Hospital found that obesity and Type 2 Diabetes Mellitus (T2DM) can contribute to mild neurodegeneration
with features common with Alzheimer's disease (AD) the first study to show that obesity can cause neurodegeneration. The study appeared in the Journ...
The birth and death of dopamine neurons: A new model for neurodegeneration
The gradual loss of dopamine neurons is a hallmark of many neurodegenerative diseases - Parkinsons Disease chief among them. Stem cell biology and regenerative medicine offer novel therapies for the restoration of dopamine neurons. This week in the online open-access journal PLoS Biology Dr. Raja...
Huntington's disease deciphered
...urther. Eventually, the neuron falls below the threshold needed to maintain cell health."
Brady's group has also linked this pattern of progressive neurodegeneration
-- marked by a loss of signaling between neurons, a slow dying back of neurons, and eventual neuron death -- to damage to the transport system in seve...
Tips from the American Journal of Pathology
... response, such as in Alzheimer's disease, may lead to cell death.
Hoozemans et al hypothesized that the unfolded protein response contributed to neurodegeneration
in Alzheimer's disease partially though its effects on the accumulation of hyperphosphorylated tau, a major component of tangles in Alzheimer's diseas...
Epstein-Barr virus may be associated with progression of MS
... BUFFALO, N.Y. -- Epstein-Barr virus (EBV), the pathogen that causes mononucleosis, appears to play a role in the neurodegeneration
that occurs in persons with multiple sclerosis, researchers at the University at Buffalo and the University of Trieste, Italy, have shown.
New study provides further evidence that apple juice can delay onset of Alzheimer's disease
... Disease .
Thomas B. Shea, PhD, of the Center for Cellular Neurobiology; neurodegeneration
Research University of Massachusetts, Lowell and his research team have car...rther evidence linking nutritional and genetic risk factors for age-related neurodegeneration
and suggest that regular consumption of apple juice can not only help to ke...
Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
...rior transportation grid may be a common mechanism underlying neurodegeneration.
"Understanding why distinct neurons are selectively vulnerable to neurodegeneration
in different brain disorders is one of the greatest puzzles in neuroscience," says the study's lead investigator, Matthew J. Farrer, Ph.D., a professo...
Protecting neurons could halt Alzheimer's, Parkinson's diseases
...fied by Biehl and D'Mello, called "3-substituted indolin-2-one compounds" are derivatives of another compound called GW5074 which was shown to prevent neurodegeneration
in a past report published by the D'Mello lab. While effective at protecting neurons from decay or death, GW5074 is toxic to cells at slightly elevat...
neurodegeneration in Biological Technology
TauTaTis Discovers Potent Inhibitor of Parkinson's Disease Gene Activity
...to progressive loss of movement control and rigidity. In some instances the disease may progress further to dementia, sometimes involving the type of neurodegeneration
seen in Alzheimer's Disease. Most cases are not obviously linked to genetic mutations, but about 10% of the cases are inherited. Several genes have ...
Alseres Pharmaceuticals Presents Inosine and Dopamine Transporter (DAT) Blocker Preclinical Data at the American Society for Experimental NeuroTherapeutics (ASENT) Conference
...aq: ALSE ) announced that data from preclinical
studies of the Company's nerve repair candidate, Inosine, and DAT Blocker
product candidates from its neurodegeneration
program were presented at the
ASENT conference, March 6-8, 2008 in Arlington, VA.
(Logo: http://www.newscom.com/cgi-bin/prnh/20070608/NEF043LOGO )...
Amarin Provides Business Update and Announces Implementation of Reverse Stock Split
...arin with access to a platform messenger RNA
(mRNA) silencing technology which targets the cholinergic pathway, and a
promising preclinical program in neurodegeneration
Amarin also successfully progressed its oral apomorphine candidate
through a series of Phase I pharmacokinetic studies and is curr...
Amarin Signs Agreement to Acquire Ester Neurosciences
... clinical study
and other non-clinical studies in preparation for commencing a Phase IIb or
Phase II/III study.
EN101 in Preclinical Development for neurodegeneration
Preclinical studies have shown that EN101 may have potential
application in other peripheral nervous system diso...
GE Healthcare, Harvard medical school to collaborate on nervous system research
... Waukesha, Wis . -- GE Healthcare will collaborate with the Harvard Center for neurodegeneration
& Repair, using GE Healthcare's cellular imaging system, the IN Cell Analyzer, to enhance research of the human central nervous system and neurodegene...