Nontoxic nanoparticle can deliver and track drugs

A nontoxic nanoparticle developed by Penn State researchers is proving to be an all-around effective delivery system for both therapeutic drugs and the fluorescent dyes that can track their delivery. In a recent online issue of Nano Letters , an interdisciplinary group of materials scientists, ...

'Smart bomb' nanoparticle strategy impacts metastasis

A new treatment strategy using molecular "smart bombs" to target metastasis with anti-cancer drugs leads to good results using significantly lower doses of toxic chemotherapy, with less collateral damage to surrounding tissue, according to a collaborative team of researchers at the University of C...

Gold nanoparticle probes may allow earlier cancer detection

Using tiny gold particles embedded with dyes, researchers have shown that they can identify tumors under the skin of a living animal. These tools may allow doctors to detect and diagnose cancer earlier and less invasively Studded with antibody fragments called ScFv peptides that bind cancer cel...

ULURU Inc. Announces Issuance of Notice of Allowance for Nanoparticle Aggregate Patent

ADDISON, Texas, Dec. 17 /PRNewswire-FirstCall/ -- ULURU Inc. (Amex: ULU) today announced that it has received a Notice of Allowance from the United States Patent and Trademark Office for its nanoparticle aggregate patent. This patent covers the underlying science behind the Company's nanopar...

Developing a modular, nanoparticle drug delivery system

There are two aspects to creating an effective drug: finding a chemical compound that has the desired biological effect and minimal side-effects and then delivering it to the right place in the body for it to do its job. With the support from a $478,000, five-year CAREER award from the National S...

'Suicide' Genes Help Slow Ovarian Tumor Growth in Mice

...y, according to a news release from the American Association for Cancer Research. In the laboratory experiments on mice, the researchers found that nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells significantly slowed the growth of ovarian tumors. The finding...

Nanoparticle-delivered 'Suicide' Genes Slowed Ovarian Tumor Growth

... Philadelphia (Vocus) July 29, 2009 -- nanoparticle delivery of diphtheria toxin-encoding DNA selectiv...dable beta-amino ester polymer as a vector for the nanoparticle delivery of a DNA encoding diphtheria toxin suicid...apy like this is not just the functionality of the nanoparticle construct molecule, but the ability to deliver the...

AlphaRx Presents Positive Preclinical Data on Zysolin(TM) Inhalable Nanoparticles at Controlled Release Society Annual Meeting

... ON, July 23 /PRNewswire-FirstCall/ - AlphaRx, Inc. (OTCBB: ALRX) announced positive preclinical results which demonstrated that an inhaled tobramycin nanoparticle (Zysolin(TM)) formulation was a more effective treatment in animal models of acute Pseudomonas aeruginosa pneumonia when compared to inhaled and injec...

Abbott and Oasmia Pharmaceutical Announce Exclusive Distribution Agreement for Paccal(R) Vet, a New Chemotherapeutic Agent for Dogs

...iring the medication to be dissolved in solvents, which led to low tolerability and severe adverse effects in dogs. Paccal Vet uses a novel, non-toxic nanoparticle formulation that overcomes those challenges and provides a high level of water solubility. If approved, Paccal Vet would be one of the first cancer t...

Zysolin(TM) Pre-clinical Data Supports Once-a-day Dosing in Humans

... AlphaRx's inhaled Tobramycin nanoparticle formulation provides 300% more availability than standard free drug in ...icant breakthrough in the development of Zysolin(TM), an inhaled Tobramycin nanoparticle formulation utilizing the company's proprietary drug delivery platform, and...

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Nanoparticle in Medical Technology

CytRx Announces RNAi Delivery Nanoparticle Technology Exclusively Licensed to Subsidiary, RXi Pharmaceuticals, Described in Peer-Reviewed Journal

LOS ANGELES--(BUSINESS WIRE)--Apr 23, 2007 - CytRx Corporation (NASDAQ:CYTR) today announced that the RNA interference (RNAi) delivery technology exclusively licensed to its majority-owned subsidiary, RXi Pharmaceuticals Corporation (RXi), has been published in the April 2007 issue of peer-reviewed...

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

...ology platform for the development of (anti-cancer) therapeutics based on angiostatic miRNAs. miRNA is utilized as a therapeutic modality and advanced nanoparticle delivery systems accomplish intracellular delivery of nucleic acid agents. These will be combined with the identification of surface receptor targets ...

DSM Obtains Exclusive World-Wide License for Innovative Drug Delivery Technology

...at treating ophthalmic, (cardio)vascular, musculoskeletal diseases and at providing general pain relief. MediVas will focus its development efforts on nanoparticle based therapies in oncology, immunology and on the delivery of nucleic acids. " Through this deal we bring in the first biodegradable polymer in...

New Drug Combination is Able to Eradicate Breast Metastases in Mice

...ome of which are related to the fact that it will not dissolve in water and has to be dissolved in organic solvents for injection. Nab-paclitaxel is a nanoparticle form of paclitaxel that is coated with a nonreactive protein, albumin, allowing it to be dissolved in water. This has reduced the side effects of the ...

Advanced Magnetics Announces Presentation of Ferumoxytol Data at the National Kidney Foundation 2007 Spring Clinical Meetings

... nanoparticles used in pharmaceutical products. As a leader in our field, we are dedicated to the development and commercialization of our proprietary nanoparticle technology for use in therapeutic iron compounds to treat anemia, as well as novel imaging agents to aid in the diagnosis of cancer and cardiovascular...

Calando Pharmaceuticals Publishes the First Non-Human Primate Study on Targeted, Systemic Delivery of siRNA in National Academy of Sciences Journal

...r intravenous injection. Upon delivery to the target cell, the targeting ligand binds to membrane receptors on the cell surface and the RNA-containing nanoparticle is taken into the cell by endocytosis. There, chemistry built into the polymer functions to unpackage the siRNA from the delivery vehicle. In addition...

Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA

...r intravenous injection. Upon delivery to the target cell, the targeting ligand binds to membrane receptors on the cell surface and the RNA-containing nanoparticle is taken into the cell by endocytosis. There, chemistry built into the polymer functions to unpackage the siRNA from the delivery vehicle. In addition...

Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate

...etermined the sequence of siRNA included in Calando's lead siRNA-containing nanoparticle formulation (CALAA-01). Numerous putative candidate siRNA duplexes targetin...gand binds to membrane receptors on the cell surface and the RNA-containing nanoparticle is taken into the cell by endocytosis. There, chemistry built into the poly...

Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate

...r intravenous injection. Upon delivery to the target cell, the targeting ligand binds to membrane receptors on the cell surface and the RNA-containing nanoparticle is taken into the cell by endocytosis. There, chemistry built into the polymer functions to unpackage the siRNA from the delivery vehicle. In addition...

Advanced Magnetics Announces Positive Results from Two Additional Phase III Studies of Ferumoxytol as an Intravenous Iron Replacement Therapeutic

... nanoparticles used in pharmaceutical products. As a leader in our field, we are dedicated to the development and commercialization of our proprietary nanoparticle technology for use in therapeutic iron compounds to treat anemia, as well as novel imaging agents to aid in the diagnosis of cancer and cardiovascular...

Nanoparticle in Biological News

Researchers create freestanding nanoparticle films without fillers

Nanoparticle films are no longer a delicate matter: Vanderbilt physicists have found a way to make them strong enough so they don't disintegrate at the slightest touch. In the last 25 years, ever since scientists figured out how to create nanoparticles ultrafine particles with diameters less t...

Twin nanoparticle shown effective at targeting, killing breast cancer cells

PROVIDENCE, R.I. [Brown University] Breast cancer patients face many horrors, including those that arise when fighting the cancer itself. Medications given during chemotherapy can have wicked side effects, including vomiting, dizziness, anemia and hair loss. These side effects occur because medic...

When a good nanoparticle goes bad

Researchers at Cornell University recently made a major breakthrough when they invented a method to test and demonstrate a long-held hypothesis that some very, very small metal particles work much better than others in various chemical processes such as converting chemical energy to electricity in...

Engineer receives $1.5M grant for nanoparticle cancer research

AUSTIN, Texas A biomedical engineering assistant professor at The University of Texas at Austin has been awarded a $1.5 million National Institutes of Health/National Cancer Institute grant to conduct nanoparticle cancer research. Grant recipient James Tunnell says the five-year project will in...

MIT: Stripes key to nanoparticle drug delivery

CAMBRIDGE, Mass.--In work that could at the same time impact the delivery of drugs and explain a biological mystery, MIT engineers have created the first synthetic nanoparticles that can penetrate a cell without poking a hole in its protective membrane and killing it. The key to their approach?...

Astronomy technology brings nanoparticle probes into sharper focus

ATLANTA (February 19, 2008) While pondering the challenges of distinguishing one nano-sized probe image from another in a mass of hundreds or thousands of nanoprobes, researchers at Georgia Tech and Emory University made an interesting observation. The tiny, clustered dots of light looked a lot l...

Technique controls nanoparticle size, makes large numbers

In a world that constantly strives for bigger and bigger, Washington Universitys Pratim Biswas, Ph.D., the Stifel and Quinette Jens Professor and chair of the Washington University Department of Energy, Environmental and Chemical Engineering, is working to make things smaller and smaller. Bis...

New nanoparticle vaccine is more effective but less expensive

Good news for public health: Bioengineering researchers from the EPFL in Lausanne, Switzerland, have developed and patented a nanoparticle that can deliver vaccines more effectively, with fewer side effects, and at a fraction of the cost of current vaccine technologies. Described in an article...

A new 'Pyrex' nanoparticle

Researchers in Switzerland have developed a new method to fabricate borosilicate glass nanoparticles. Used in microfluidic systems, these "Pyrex"-like nanoparticles are more stable when subjected to temperature fluctuations and harsh chemical environments than currently used nanoparticles made of ...

UCF nanoparticle offers promise for treating glaucoma

A unique nanoparticle made in a laboratory at the University of Central Florida is proving promising as a drug delivery device for treating glaucoma, an eye disease that can cause blindness and affects millions of people worldwide. “The nanoparticle can safely get past the blood-brain barrier ma...

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Nanoparticle in Biological Technology

Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells

Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing normal tissue April 21 at an American Association of Anatomists (AAA) sci...

MonoSol Rx and Midatech Group Enter Collaboration Agreement to Unite Nanoparticle and Thin Film Drug Delivery Technologies

Potential to Develop New Oral Drug Candidates with Superior Efficacy, Safety, Convenience, and Commercial Potential WARREN, N.J. and OXFORDSHIRE, England, Nov. 3 /PRNewswire/ -- MonoSol Rx, the developers of PharmFilm(R) technology and a drug delivery company specializing in dissolving thin f...

Cool! Nanoparticle research points to energy savings

Adding just the right dash of nanoparticles to standard mixes of lubricants and refrigerants could yield the equivalent of an energy-saving chill pill for factories, hospitals, ships, and others with large cooling systems, suggest the latest results from National Institute of Standards and Technol...

Sigma-Aldrich Introduces N-TER Nanoparticle siRNA Transfection System for Delivery of siRNA Into Difficult-to-Transfect Cell Types

ST. LOUIS, Oct. 18 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) announced today the global release of the N-TER(TM) Nanoparticle siRNA Transfection System. N-TER allows researchers to reproducibly interrogate gene function, via siRNA transfection, in model cell types that have previo...

New nanoparticle vaccine is more effective but less expensive

Good news for public health: Bioengineering researchers from the EPFL in Lausanne, Switzerland, have developed and patented a nanoparticle that can deliver vaccines more effectively, with fewer side effects, and at a fraction of the cost of current vaccine technologies. Described in an article...

Growth spurts

...ilored properties," says Zheng. "Also, our in situ liquid cell TEM technique can be applied to other areas of research such as soft matter imaging and nanoparticle catalysis, and offers great potential for addressing many fundamental issues in materials science, chemistry and other fields of science." Says Dah...

Microfluidics International Corporation to Report Second Quarter 2009 Financial Results on August 11, 2009

...cessing experience to produce the most uniform and smallest liquid and suspended solid particles available, and has provided manufacturing systems for nanoparticle products for more than 15 years. The Company is a leader in advanced materials processing equipment for laboratory, pilot scale and manufactur...

Nanotech particles affect brain development in mice

...o carried out the tests. He said, "Nanotechnology and the production of novel man-made nanoparticles are increasing worldwide. Titanium dioxide in its nanoparticle form has a high level of photocatalytic activity, and can be used for air and water purification and self-cleaning surfaces. Our findings, however, ad...

1 nano-step closer to weighing a single atom

...to determine the rate at which vibrations in metal nanoparticle systems are damped, because of significant variati...Professor Sader. Illuminating these bipyramidal nanoparticle systems with an ultra-fast laser pulse, set them v...long-lived and for the first time damping in these nanoparticle systems could be interrogated and characterized. ...

Sirnaomics Receives SBIR Grant from NIH/NCI for Its Multi-Targeted Lung Cancer siRNA Therapeutics

...apid delivery of novel therapeutics. The company's proprietary "Tri-Blocker" technology for multi-targeted siRNA cocktail design and "Snano" series of nanoparticle delivery systems enable its advanced RNAi therapeutic programs for treatment of various diseases including H1N1/H5N1 influenza A infection, scarless w...