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Myosin in Medical News

Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29

...rcised its option to the worldwide rights (excluding Japan) of Cytokinetics' cardiac contractility program, which includes CK-1827452, a novel cardiac myosin activator being developed for the treatment of heart failure. Emerging Pipeline: The Company provided an update on several of its clinical ...

St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration

...ad produced evidence that a molecular motor called myosin II might power the migration. Myosins are proteins...f microscopic time-lapse imaging to establish that myosin II and actin made up the machinery of neuronal mig..., the investigators used fluorescent dyes to label myosin II and actin proteins, as well as key cell structu...

Results from 8 late-breaking clinical trials presented at Heart Failure 2009

...n in stable heart failure patients and was well tolerated in a proof of concept study. CK-1827452 is a new drug in a class known as Selective Cardiac myosin Activators. Bigger trials are now needed to assess safety and effect on clinically meaningful endpoints. Pre-RELAX-AHF is another proof of concep...

Heart regenerates after infarction -- first trials with mice

...s exist. So far, these cells had not been characterized clearly. They could demonstrate that two markers for heart cells the structural protein alpha myosin heavy chain and the transcriptionfactor Tbx5 - are also expressed on heart precursor cells. "The evidence of cells with these markers in the adult hea...

From mother to daughters: A central mystery in cell division solved

...le. As happens during muscle contraction, the myosin filaments move along the actin filaments and const...ht actin filaments, which serve as tracks on which myosin filaments move along to drive constriction," said ...s, preventing them from being efficient tracks for myosin filament movement." "This discovery will open...

Researchers gain new insight on wonder of cell division

...here a cell divides into two identical daughter cells. The researchers have opened a new window on the assembly and activity of a ring of actin and myosin filaments that contract to pinch a cell at just the right time. They focused on key proteins whose roles drive signaling mechanisms that promote the p...

MYH9 gene variations help explain high rate of kidney disease in African-Americans

...onal Institutes of Health (NIH) in Bethesda, MD, and Johns Hopkins University published independent studies showing that variations of the "non-muscle myosin heavy chain 9" gene (MYH9) are linked to certain types of kidney disease that are more common in African Americans, including focal segmental glomerul...

Molecular motor works by detecting minute changes in force

...gos in nearly all cells. In two specific cases, myosin I puts tension on the specialized spring-like stru...e piconewton and nanometer level) to discover that myosin I motors are regulated by force. The motors pull o...m ATP to generate force and motion. Humans have 40 myosin genes that sort into 12...

Researchers find new way to block destructive rush of immune cells

...LFA-1), control whether or not the tail end of the T cell can let go (de- adhesion). Data revealed for the first time that a protein called non-muscle myosin heavy chain-IIA (MyH9) is recruited to LFA-1 at the trailing end of migrating T lymphocytes. Experiments that interfered with the association between ...

The structural basis of familial hypertrophic cardiomyopathy is revealed

... FHC is thought to be caused by a mutation in the myosin heavy chain, one of the components of muscle cells...ecular level caused by the R403Q point mutation in myosin is linked to the characteristic misalignment of mu...rit Hanein (Burnham Institute), used smooth muscle myosin to investigate the structural effects of the R403Q...
Myosin in Medical Technology

Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting

...on. Cytokinetics' lead compound, CK-1827452, a novel small molecule cardiac myosin activator, is anticipated to enter Phase II clinical trials for the treatme...06, Cytokinetics and Amgen will conduct research with activators of cardiac myosin in order to identify potential treatments for patients with heart failure. ...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...farct zone of rats, the GRNCM1 cells survived for at least four weeks and formed grafts expressing key markers of human cardiomyocytes, including Beta myosin heavy chain. Echocardiographic and magnetic resonance imaging analysis showed that the animals transplanted with GRNCM1 cells had improved (smaller) e...

Cytokinetics Reports Additional Clinical Trials Data for Ispinesib

...lead compound from this program, CK-1827452, a novel small molecule cardiac myosin activator, recently entered Phase II clinical trials for the treatment of h...kinetics and Amgen Inc. plan to conduct research with activators of cardiac myosin in order to identify potential treatments for patients with heart failure. ...
Myosin in Medical Definition

Proteopathy

...sis Lactoferrin Pulmonary alveolar proteinosis Surfactant protein C (SP-C) Critical illness myopathy (CIM) Hyperproteolytic state of myosin ubiquitination References ^ Walker LC and LeVine H (2000). "The cerebral proteopathies". Neurobiol Aging 21 : 559-561. PM...
Myosin in Medical Dictionary

Smooth muscle

...ession in Vascular Smooth Muscle Cells ... The 2.3 kb smooth muscle myosin heavy chain promoter directs gene expression ... Smooth muscle contraction is initiated by Ca2+-calmodulin activation of myosin ... Thus, Ca2+ plays a key role in controlling smooth muscle contractil...

Muscle

...uscle sections, and more. From French muscle , from Latin mūsculus (" little mouse'"), because of the ... Muscle consists largely of actin and myosin filaments. ... Muscle cells are specialized to generate force and movement. ... Skeletal muscle cells have longitudinal bundles called myofibr...
Myosin in Biological News

Muscle atrophy through thick but not thin

...onents in a specific order. The researchers hypothesize that removal of certain thick filament components first permits subsequent MuRF1 access to the myosin heavy chain. However, MuRF1 doesn't exert the same power over the thin filament, which began to come apart even when MuRF1 was absent. "Up to now, ...

Why 'lazy Susan' has a weak heart

...lood flow. Dr. Benjamin Meder and Christina Laufer from Dr. Wolfgang Rottbauer's research group (Department of Cardiology) examined its muscle protein myosin light chain-1, which is involved in contraction of the heart muscle. They discovered the crucial change in the amino acid Serine 195, which was lost t...

Study offers clues to beating hearing loss

...deafness. The Leeds team has discovered that the myosin 7 motor protein - found in the tiny hairs of the i...egenerative deaf-blindness." There are around 40 myosin motor proteins in the human body, the most familiar of which is the type of myosin found in skeletal and heart muscle. But all cells...

Rong Li Lab offers insight into adaptive ability of cells

...therapy treatment. The work was published in the November 26 issue of Cell . Working with yeast cells, the team disabled a motor protein, type II myosin which normally powers cell division and observed the cellular response. As predicted, blocking division initially resulted in severe growth and cyto...

Dense tissue promotes aggressive cancers

...ed mechanotransduction. Proteins that generate contractile forces, such as myosin "motors," are important players in mechanotransduction. Weaver and colleagues confirmed that myosin motors are involved in sparking more degradation by invadopodia in response...

UIC researchers make promising finding in severe lung disease

...ing to death in 30 percent to 40 percent of cases. There is no effective treatment. It has previously been shown that the enzyme, called nonmuscle myosin light-chain kinase, or MYLK, plays a pivotal role in the disruption of the endothelial barrier -- a single thin layer of cells that line blood vessels...

Ancient protein offers clues to killer condition

...Leeds researchers have found that a motor protein, myosin 2, remains structurally identical in both creature...ogical Sciences: This is an astonishing discovery. myosin 2s function is to make the smooth muscle in intern...ve completely different regulatory mechanisms: the myosin in a turkeys gizzards allows it to chew food in th...

Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers

...lls to coexist and move on. The team found that both actin and non-muscle myosin were involved in the attack of foreign sheep cells due to recognition of th...rotein CD47 affects its receptor, SIRP-alpha, which in turn inactivates the myosin by preventing the addition of a phosphate group to the brawny molecule. By ...

How molecular muscles help cells divide

...as been known that the contractile ring is made up of muscle-like actin and myosin contractile proteins that are involved a process in some ways similar to t...ilaments grow in random directions until they encounter another node, where myosin motors in the contacted node pull on the actin filament, bringing the two n...

Media highlights in the Dec. 15 issue of Biophysical Journal

...words: cardiac contraction; interfilament spacing; myosin cross-bridges; x-ray diffraction The intrinsi...olves sensing the spacing between the filaments of myosin and actin as the heart fills with blood. The stren... complex nature involving binding of both Ca2+ and myosin (a linear force-generating motor) to actin filamen...
Myosin in Biological Technology

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... The license includes CK-1827452, a novel cardiac myosin activator being developed for the treatment of hea...atus of CK-1827452 CK-1827452, a novel cardiac myosin activator, has been the subject of a clinical tria...n reported previously. Background on Cardiac myosin Activators and Cardiac Contractility Cardiac...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

...istochemical staining with a mouse-monoclonal slow myosin heavy chain (MyHC) antibody (NOQ7-5-4D) 6 . SIFs s...(Arcturus, Cat. # KIT0201) ◊ Slow myosin MyHC Antibody NOQ7-5-4D ◊ PCR Pri... 3. Rubinstein NA, Hoh JF. The distribution of myosin heavy chain isoforms among rat extraocular muscle ...

Easily Amplify Genomic DNA with Long-Distance PCR

...d from ear clips is suitable for amplifying large DNA fragments with TaqPlus Long DNA polymerase, we genotyped the smooth muscle myosin heavy chain (SMHC) gene ( Figure 1 ). Two microliters of DNA were added to 16 l of PCR mixture [2 l of 10X TaqPlus Long low-salt PCR ...
Myosin in Biological Products

Rabbit Anti-Nonmuscle Myosin II Heavy Chain B (MHC-B) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc

Description: Polyclonal Antibody against Nonmuscle Myosin II Heavy Chain Isoform B Affinity Purified Antibody (Stored in TBS + 0.03% Thimerosal) This antibody was raised against the peptide SDVNETQPPQSE corresponding to the C-terminus of nonmuscle myosin heavy chain isoform B (MHC-B) This antibody is effective ...
Company:Covance Research Products, Inc

Mouse Anti-Myosin, heavy chain I, smooth muscle Monoclonal Antibody, Unconjugated, Clone 3F8 from Abcam

Description:... Mouse monoclonal [3F8 ] to smooth muscle myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Company:Abcam

Rabbit Anti-Myosin VIIa Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Company:Abcam

Mouse Anti-Myosin, light chain 1, cardiac Monoclonal Antibody, Unconjugated, Clone MLM544 from Abcam

Description:... Mouse monoclonal [MLM544] to cardiac myosin light chain 1 ( Abpromise for all tested applications). entrezGeneID: 4634 SwissProtID: P08590...
Company:Abcam
Myosin in Biological Definition

Myosin

Myosin is a motor protein filament found in muscle tissue . Together with actin filaments, myosin provides the mechanism for muscle contraction , utilizing energy from ATP . The specific conformational rearrangements throughout the chemo-mechanical transduction process are still not kno...

Actin

...le cells they play an essential role, along with myosin , in muscle contraction . In the cytosol , actin...ain article: Muscle contraction Together with myosin filaments actin it forms Actomyosin , which provi... energy. The ATP allows, through hydrolysis , the myosin head to extend up and bind with the actin filament...

Biomechanics

...ology , and cell biology have much to offer in the way of explaining the active and passive properties of living tissues. For example, the binding of myosin to actin is based on the biochemical reaction, where C a 2 + and ATP move the troponin and tropomyosin to allow for the crossbridges ...

Cytoskeleton

...icipate in some cell-to-cell or cell-to-matrix junctions and the transduction of signals. They are also important for cytokinesis and, along with myosin , muscular contraction . Intermediate Filaments Main article: intermediate filaments These 8 to 11 nanometers in diameter filaments are ...

List of gene families

...Genes-encoding immune system proteins Major histocompatibility complex (MHC) Related protein families Motor proteins myosin Kinesin Dynein Signal transducing proteins Receptor tyrosine kinases G-proteins Transporters ABC protein...

Actin

...le cells they play an essential role, along with myosin , in muscle contraction . In the cytosol , actin...ain article: Muscle contraction Together with myosin filaments actin it forms Actomyosin , which provi... energy. The ATP allows, through hydrolysis , the myosin head to extend up and bind with the actin filament...

Muscle

...brils ; myofibrils contain sarcomeres , which are composed of actin and myosin . Individual muscle cells are lined with endomysium . Muscle cells are bou... have significant differences, but all use the movement of actin against myosin to produce contraction and relaxation. In skeletal muscle, contraction is ...

Phylogenetic tree

...enes Fig. 2: Unrooted tree for myosin gene A phylogenetic tree is a tree sho...2 depicts an unrooted phylogenetic tree¹ for myosin , a superfamily of proteins . Links to other p... Footnote T. Hodge, M.J.T.V. Cope (2000) A myosin Family Tree . Journal of Cell Science 113, 3353-33...

Protein

... skin, hair, and cartilage . Another class are the motor proteins such as myosin , kinesin, and dynein. Muscles are composed largely of the proteins myosin and actin . Working with proteins Proteins can be picky about the ...
Myosin in Biological Dictionary

Myosin

Part of the myosin II structure. ... Thus, although myosin was originally thought to be restricted to muscle cells ... eukaryotic cells contain myosin isoforms. ... myosin n. The commonest protein in muscle cells, responsible for the elastic and contractile properties of ...

Muscle contraction

... Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term ' contraction ' implies sho...

Multi-gene family

...multi - gene sets ( IGF family ' and IGF signaling ... Pfam is a large collection of protein families, represented by multiple ... isoforms of myosin heavy chains, coded for by a multi - gene family PUBMED:2806546. ... ... is accelerated by all six members of the antiapoptotic BCL family "...

Microfilament

...ster micro-fleece lining; soft microfilament polyester sleeve lining; roomy fit two... Other microfilament proteins such as talin, gelsolin, myosin II and profilin ... All of the microfilament -related proteins determined to be most enriched by MS ... When compared to the microfilament ar...

Elongation factor

...ency EEF1A2 - eukaryotic translation elongation factor 1 alpha 2 - Bioportfolio ... Translation elongation factor eEF1A binds to a novel myosin binding protein ... TCEA1 (transcription elongation factor A (SII), 1), Authors: Dessen P, Le Minor S. Published in: Atlas Genet Cytogenet O...

Dynein

...t activated Trks to promote survival of target-dependent neurons. ... stalk coiled coil of dynein couples ATPase and microtubule binding. ... myosin and kinesin, in dynein the microtubule-binding domain ... dynein motor unit is constructed around a series of AAA ... for intra- dynein associa...

Drosophila

...hatase, receptor-linked, DPTP99A ... Molecular requirements for actin-based lamella formation in Drosophila S2 cells ... jaguar - Drosophila myosin VI, a pointed end directed molecular motor ... Drosophila melanogaster is an extraordinarily attractive model organism owing to ... We ask that ...
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