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murine in Medical News

Silenced genes as a warning sign of blood cancer

... appear. These were not observed before the animals were thirteen months old. Moreover, the researchers were able to show that methylation patterns in murine DNA are largely corresponding to those found in humans suffering from leukemia. This confirms that the mouse model is suitable for studying the diseas...

The 'see food' diet

... by Tuo et al, "A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration," appears in the August 2009 issue of the Am...tment of AMD." In future studies, Dr. Chan and colleagues plan to use this murine model "to evaluate [other] therapies that might delay the development of AM...

Tips from the journals of the American Society for Microbiology

...n, R. Cao, R.S. Roque, L. Zong, J. Liu, T. Li. 2009. Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vitro. Clinical and Vaccine Immunology , 16. 7: 1033-1039.) ...

Light Sciences Oncology Announces Results of Study on Immunotherapeutic Mechanism of Aptocine(TM), a Novel Light-Activated Drug Therapy for Cancer

...udy, Aptocine was used to treat primary tumors and examine prevention of metastases in the 4T1 tumor model, an aggressive, spontaneously metastasizing murine mammary tumor model that mirrors human breast cancer. When grown in the mammary fat pad of BALB/c mice, untreated 4T1 tumors rapidly metastasize to th...

MedThink Hires Associate Scientific Director to Support Its Growing Health Care Clientele

...GeneBact Biotechnologies in Athens, Ohio, and continued his career as a scientist at Ohio University , where he studied protein signaling pathways in murine tumors to elucidate their role in cancer growth and metastasis. Parker then transitioned into the medical communications field, starting as a med...

Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008

...e to 23 months. Publishing preclinical data showing that lowering of apoB-100 resulted in significant reduction of atherosclerotic plaques in murine models of atherosclerosis. In addition, Isis and its partners showed encouraging clinical results in a broad range of diseases including, ...
murine in Medical Technology

Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies

Lead drug candidate may help patients with Systemic Lupus Erythematosus (SLE) SOUTH SAN FRANCISCO, Calif., April 29 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) announced today that its lead product candidate, R788, has successfully tre...

Isis Reports Reduction of apoB-100 Levels in a Murine Model Resulting in Up to 92% Reduction of Atherosclerosis

CARLSBAD, Calif., April 18 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) presented the results of two studies designed to assess the impact of lowering apoB-100 on atherosclerosis at the 2008 Annual Atherosclerosis, Thrombosis and Vascular Biology (ATVB) Conference in A...

AlphaVax Announces Promising Results in Melanoma Studies

... AlphaVax's virus-like replicon vector particles (VRP) encoding melanoma-specific tumor antigens to reduce melanoma tumor burden in a state-of-the-art murine melanoma model. Jedd D. Wolchok, M.D., Ph.D., Lab Head and faculty member at MSKCC, is a medical oncologist who specializes in the treatment of m...

Research Finding Could Revolutionize Asthma Treatment

...n the Proceedings of the National Academy of Sciences is "Beta2-Adrenoreceptor Signaling Is Required for the Development of an Asthma Phenotype in a murine Model." Executive Director Smith invites members of the public to help fund research to find a cure and better treatments for asthma by making a ...

Inverseon's Founder and SAB Member Published in PNAS

...eedings of the National Academy of Sciences (PNAS) entitled, "Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model." The article was edited by Robert Lefkowitz, The James B. Duke Professor of Medicine at Duke University , and there is an accompanying support...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

...of cancer cells through its potentiating role in key cell survival pathways and angiogenesis. CX-4945 demonstrates potent tumor regression activity in murine xenograft models, as well as favorable PK/ADMET and safety properties in preclinical studies. "CX-4945 is a breakthrough molecule for Cylene," sa...
murine in Medical Definition

Autoimmune regulator

...sm, primary adrenocortical failure and chronic mucocutaneous candidiasis. [1] AIRE is expressed primarily in the thymus. A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients. [2] Research on the knockout mouse has d...
murine in Medical Dictionary

Typhus

...ansmitted by lice or fleas. Includes symptoms of murine and Epidemic Typhus as well as treatment optio...emic typhus is sometimes called "jail fever. ... murine typhus occurs in the southeastern and southern U...emic typhus is sometimes called "jail fever. ... murine typhus occurs in the southeastern and southern U...

Phagocyte

... We are presently investigating the effects of chemicals of ... of exposure to benzene in vivo on the murine mononuclear phagocyte system. Toxicol. ... Role of Oxygen in Phagocyte Microbicidal Action, phagocyte , spin conservation, microbicidal, comb...
murine in Biological News

New asthma research opposes current drug treatment, says UH prof

... stimulating it to reduce asthma symptoms. The study, "Beta2-Adrenoreceptor Signaling is Required for the Development of an Asthma Phenotype in a murine Model," is in the current online issue of the journal Proceedings of the National Academy of Sciences ( PNAS ), one of the world's most-cited multid...

Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants

...that hairy roots from genetically modified tobacco plants can be grown in a contained novel mist bioreactor system, yielding significant quantities of murine interleukin-12. A paper detailing the results of the study has been published early, online, by the journal Biotechnology and Bioengineering and wil...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

...PS antibodies against viruses for which there are few or no effective therapeutic options." In the first study, 100% of mice infected with lethal murine CMV and treated with bavituximab recovered fully, while only 25% of control animals survived. In the second study, guinea pigs were infected with let...

Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics

...re we show two examples of how both native and transgenic plants can be used in inexpensive bioreactors for the production of the therapeutic protein, murine interleukin-12 (m-IL-12) in transgenic tobacco roots, and the sesquiterpene lactone antimalarial drug, artemisinin, in shoot cultures. "Biof...

Stress may make you itch

...e immune cells in your skin, resulting in inflammatory skin disease. The related report by Joachim et al., "Stress-induced Neurogenic Inflammation in murine Skin Skews Dendritic Cells towards Maturation and Migration: Key role of ICAM-1/LFA-1 interactions," appears in the November issue of The American Jo...

Scripps research team sheds light on immune system suppression

...ell as other invaders. The researchers showed that once in this infected condition, a secondary opportunistic agent, in this case the herpes virus murine cytomegalovirus, which the mice could have otherwise fought off, grew unchecked. Remarkably, opportunistic infections with herpes viruses are frequent...
murine in Biological Technology

Detection of Reporter Gene Activity in Cell Cultures and Murine Epidermis After Helios Gene Gun-Mediated Particle Bombardment

Andreas Henke and Eunike Grohmann, Institute of Virology, Medical Center, Friedrich Schiller University Jena, Winzerlaer Str. 10, 07745 Jena, Germany Summary The Helios gene gun-mediated DNA transfer can be used as a fast and efficient method to trans...

Purification of Murine IgG1 Using UNOsphere S and CHT Ceramic Hydroxyapatite Chromatography, Rev A

Purification of Murine IgG1 Using UNOsphere S and CHT Ceramic Hydroxyapatite Chromatography, Rev A Henry Lai, PhD, and Samuel G Franklin, PhD, Bio-Rad Laboratories, Inc., 2000 Alfred Nobel Drive, Hercules, CA 94547 USA Introduct...

Biovista Inc. Announces Positive Efficacy Results in a Pre-Clinical Trial of its BVA-601 Repositioned Drug for Epilepsy

... /PRNewswire/ -- Biovista Inc. today announced that BVA-601, its small-molecule drug targeting epilepsy, has shown positive results in the Kainic acid murine model of temporal lobe epilepsy. BVA-601, an existing drug that Biovista repositioned in epilepsy, exhibits both anti-epileptic and neuroprotective ac...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...s in humans in order to demonstrate that the L.E.A.P.S. vaccine act and stimulate human dendritic cells in man in a similar manner as seen to isolated murine and human dendritic cells ex vivo and in vivo in the mouse. Dendritic cells direct the subsequent immune response to a vaccine by presenting the vacci...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

... pm) -- Involvement of the CSF-1/CSF-1R interaction in the control of angiogenesis Overview: Two different neutralizing rat anti murine CSF-1R monoclonal antibodies (mAb), M279 and AFS98 were evaluated for their effect on mouse corneal angiogenesis and corneal macrophag...

ImQuest Presentation at Keystone Symposium Focuses on Advancements in Their Cancer Research and Development Program

...secondary anti-angiogenic activity as a consequence of the cytoskeletal disruption. The unique activity, novel structure, potent in vivo efficacy in murine xenograft models, as well as a favorable toxicity profile, potential for oral bioavailability and straight-forward cGMP manufacturing suggest that IQ...
murine in Biological Products

RAW 264.7 cell line slides ( mouse: Abelson murine leukemia virus - induced tumor ) from GeneTex

Description: Mouse RAW 264. 7 cells were cultured in DMEM with 4 mM L-glutamine medium and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface s...
Company:GeneTex

Rat Anti-Mouse TCR VB8.1,8.2 Monoclonal Antibody, FITC Conjugated, Clone KJ16 from GeneTex

Description:... Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
Company:GeneTex

Anti-G Protein Gi-alpha-1 Monoclonal Antibody, Unconjugated, Clone R4 from CHEMICON

Description:.... Slight reactivity with human (31%). Specificity confirmed by Western blot versus bovine Gat, rat Goa, rat Gia-1, Gia-2, rat Gia-3, bovine Gsa, and murine GoaA and GoaB....
Company:CHEMICON

Rabbit Anti-MPV17 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... MpV17 transgene, murine homolog, glomerulosclerosis...
Company:Proteintech Group, Inc.

Anti-IRF7 Polyclonal Antibody, Unconjugated from Invitrogen

Description:... Specificity: This antibody recognizes murine IRF7 protein, and does not cross-react with other related IRF proteins. Reactivity of this antibody with murine IRF7 protein was confirmed by western blot analysis of the 293T cells trans...
Company:Invitrogen

Rabbit Anti-HMGN2 / HMG-17 Polyclonal Antibody, Unconjugated from Upstate

Description:...ml BSA, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% Quality Assurance: routinely evaluated by immunoblot on acid extracts of murine 10T 1/2 and HeLa cells Recognizes HMGN2/HMG-17; slight cross-reactivity with HMGN1/HMG-14...
Company:Upstate
murine in Biological Definition

Retrovirus

...ype species: Avian leucosis virus Genus Betaretrovirus ; type species: Mouse mammary tumour virus Genus Gammaretrovirus ; type species: murine leukeamia virus ; others include Feline leukemia virus Genus Deltaretrovirus ; type species: Bovine leukaemia virus ; others include Huma...
murine in Biological Dictionary

Viral oncogene

...ESTs from 176 cDNA libraries. ... Homo sapiens FBJ murine osteosarcoma viral oncogene -like B variant 8 (...O IT AS A VIRAL ONCOGENE . ... v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelso... was raised in Rabbit and recognizes Human Abelson murine Leukemia Viral Oncogene Homolog 1 (ABL1). Sugg...

Vessel cell

...ss-jacketed cell culture vessels , 2.2 through 14 liters total volume ... NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas ... Host cell eNOS but not iNOS contributes to angiogenesis and vessel morphogenesis ... The Hox gene abdominal-A specifies hear...

Transcriptase

...s a common name for an enzyme that functions as a RNA ... All retroviruses have a reverse transcriptase , but the enzymes that are ... Moloney murine Leukemia Virus (M-MuLV) Reverse Transcriptase is an RNA-directed DNA polymerase. This enzyme can synthesize a complementary DNA strand initiatin...

Synapton

...hen G, Friedmann A. Morphogenesis of the synapton during yeast meiosis. ... Research on Basic Mechanisms Causing Aneuploidy. Cytogenet ... C: The murine SCP3 gene is required for synapton - emal complex assembly, chromosome synapsis, ... The Consultant Pharmacist is published by the. American ....

RNase

...nd remove RNases , store RNA, precipitate RNA, and determine label incorporation and yield. It is not effective against RNase 1, ... Recombinant murine RNase inhibitor does not contain the pair of cysteines ... RNase Assay: ... RNase Inhibitor is a recombinant human placental protein wh...

Reverse transcriptase

...rs, and cancer . RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that retroviruses need to reproduce. Moloney murine Leukemia Virus (M-MuLV) Reverse Transcriptase is an RNA-directed DNA polymerase. This enzyme can synthesize a complementary DNA strand initiat...
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