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monotherapy in Medical News

FDA Grants Approval for Use of RISPERDAL(R) CONSTA(R) as Both a Monotherapy and Adjunctive Therapy in the Maintenance Treatment of Bipolar I Disorder

RISPERDAL(R) CONSTA(R) is the First and Only Long-Acting Antipsychotic Therapy Available for Bipolar I Disorder TITUSVILLE, N.J., May 18 /PRNewswire/ -- Janssen(R), Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. today announced the U.S. Food and Drug Administration (FDA) has approved ...

Amylin, Lilly Update on FDA Review of BYETTA(R) (exenatide) Injection Monotherapy Submission

SAN DIEGO and INDIANAPOLIS, Dec. 8 /PRNewswire-FirstCall/ -- Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) and Eli Lilly and Company (NYSE: LLY ) today announced that the U.S. Food and Drug Administration (FDA) is continuing with its review of the regulatory application for use of BYETTA(R) (ex...

Pharmasset Presents R7128 14-Day Monotherapy Study Results for the Treatment of Chronic Hepatitis C

-Nucleoside polymerase inhibitor demonstrates >99% mean decrease in HCV RNA with no serious adverse events- PRINCETON, N.J., Nov. 2 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) announces the results of a 14-day Phase 1 multiple ascending dose monotherapy study o...

Combination Therapy More Effective Than Monotherapy for Treating Migraine

Combining two different types of treatment for migraine results in better symptom relief than taking either one of the medications//, according to a study. "Migraine is a prevalent, often debilitating disease manifested by attacks of bilateral or unilateral headache and associated symptoms, s...

Novel Actemra monotherapy in treating patients with early aggressive rheumatoid arthritis

The first Phase III study involving the use of Actemra in the treatment of rheumatoid arthritis has revealed that it is superior to conventional treatment modality that uses disease modifying anti-rheumatic drugs (DMARDs to inhibit // joint destruction. It has also been found to provide symptomatic...

News briefs from the August issue of Chest

...rs, MD, of McMaster University in Hamilton, ON, Canada, discusses the familiar debate about the safety of using long-acting β2-agonists (LABA) in monotherapy for asthma. The commentary focuses on data provided in the metaanalysis recently undertaken by the FDA of safety outcomes of 60,954 individuals in 110...

INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder

...chizoaffective disorder. INVEGA(R) (paliperidone) extended-release tablets were approved for the acute treatment of schizoaffective disorder either as monotherapy or adjunctive therapy to mood stabilizers and/or antidepressants. INVEGA(R) was approved in 2006 for the treatment of schizophrenia. Janssen(R), Divis...

AstraZeneca Submits New Drug Applications for ZACTIMA(TM) in Second-Line Advanced Non-Small Cell Lung Cancer

...M). Evaluation of vandetanib is ongoing, as monotherapy or in combination with other anti-cancer therapies...ng thyroid cancer. Results from the ZEPHYR (300mg monotherapy study in EGFR failures in advanced NSCLC, Phase III) and ZETA (300 mg monotherapy in advanced medullary thyroid cancer, Phase III) s...

QLT Announces Second Quarter Results for 2009

...combined with Lucentis is not inferior to Lucentis monotherapy with respect to the mean change from baseline in v...ared with a 4.4 letter improvement in the Lucentis monotherapy group. In the combination therapy group, 96% of pa...t-free interval, compared with 92% in the Lucentis monotherapy group. * Announced 12-month primary analysis ...

Lilly Reports Solid Second-Quarter 2009 Results, Raises EPS Guidance

...s not progressed after four cycles of platinum-based first-line chemotherapy. The European Commission granted approval for the use of Alimta as monotherapy for maintenance treatment of patients with other than predominantly squamous cell histology in locally-advanced or metastatic NSCLC, whose disease has...
monotherapy in Medical Technology

RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors

- 82% of patients with pancreatic neuroendocrine tumors (NET) experienced clinical benefit when treated with daily RAD001 and monthly Sandostatin LAR Depot - 77% of patients with pancreatic NET experienced clinical benefit when treated with ...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

HOUSTON, July 1 /PRNewswire/ -- Agennix Incorporated today announced the publication of final results from a Phase 2 monotherapy trial with talactoferrin alfa in patients who had failed previous treatment for advanced or metastatic renal cell carcinoma (RCC). Results from the study, which were...

Phase 3 Results for Alogliptin Demonstrated Significant Blood Sugar Reductions in Monotherapy and Four Add-on Therapy Studies

Data from five pivotal phase 3 studies presented at the American Diabetes Association 68th Scientific Sessions SAN FRANCISCO, June 7 /PRNewswire/ -- Results from five pivotal phase 3 studies of alogliptin were announced today at the American Diabetes Association (ADA) 68th Scie...

TARGETED GENE DELIVERY IN VIVO: Rexin-G Monotherapy Reveals Significant Biological Activity Without Toxicity in Chemo-Resistant Metastatic Breast Cancer (ASCO 2008)

SAN MARINO, Calif., May 22 /PRNewswire/ -- Epeius Biotechnologies announced today the promising results of an on-going United States-based Phase I/II study of Rexin-G for metastatic breast cancer that is refractory to conventional chemotherapy (J Clin Oncol 26:14509, 2008). This clinical trial...

Roche and Pharmasset To Present the R7128 Monotherapy Resistance Profile

-- Study concludes there was no evidence of the development of viral resistance to R7128 after 2 weeks of monotherapy in hepatitis C patients -- PRINCETON, N.J., Feb. 6 /PRNewswire-FirstCall/ -- Pharmasset (Nasdaq: VRUS) and Roche will present the R7128 monotherapy resistance profile at the ...

King Pharmaceuticals Announces Plan to Present Results from Phase III Clinical Trial Evaluating ALTACE as Monotherapy and in Combination with Hydrochlorothiazide at the American Society of Hypertension Annual Meeting

BRISTOL, Tenn.--(BUSINESS WIRE)--May 8, 2007 - King Pharmaceuticals, Inc. (NYSE:KG) announced today that the results from a Phase III clinical trial for its ALTACE(R) (ramipril) diuretic combination product will be presented at the American Society of Hypertension's Twenty-Second Annual Scientific ...

Data Presented at ASH Demonstrate Nebivolol Lowers Blood Pressure as Long-Term Monotherapy and in Combination Therapy

Data Also Show Nebivolol Lowers Blood Pressure in Obese and Non-Obese Hypertensive Patients CHICAGO, May 21, 2007 /PRNewswire-FirstCall/ -- Forest Laboratories, Inc. today presented positive data from two clinical studies and one pooled analysis of nebivolol, a selective beta 1-blocker with vasodi...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... of mCRC. Vectibix was approved in the United States in September 2006 as a monotherapy for the treatment of patients with EGFR expressing mCRC after disease progr...007, the EMEA granted a conditional marketing authorization for Vectibix as monotherapy for the treatment of patients with EGFR-expressing mCRC with wild-type KRA...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...axel of 23.8 months compared to 16.9 months for patients treated with docetaxel alone. OncoGenex reported that OGX-427 was well tolerated as a monotherapy in a Phase 1 study and demonstrated declines in circulating tumor cells and evidence of reduction in tumor markers. Eli Lilly and Company rece...

Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program

...uman clinical studies. Access has commenced a new clinical study of ProLindac in France. The study will examine dose levels and regimens of ProLindac monotherapy in cancer patients, provide additional data to support design of combinations studies, and extend the safety database. Two ovarian cancer patients hav...
monotherapy in Medical Dictionary

Lipid

...pocytes has not been investigated. ... Discussion: This trial was designed to rigorously establish the lipid -lowering efficacy of policosanol as monotherapy and its potential additive and possibly ... The European Bioinformatics Institute ... The structure of lipid A is relatively invariant ... Lipi...
monotherapy in Biological News

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

...amide, is a small molecule that potently activates natural killer T (NKT) cells. RGI-2001 is a proprietary liposomal formulation of KRN7000. RGI-2001 monotherapy has shown to induce antigen-specific immune suppression by inducing regulatory T cells (Tregs). Tregs are believed to play a central role in inducing...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...e treatment of advanced breast cancer and a Phase II combination therapy trial for the treatment of non-small cell lung cancer. A Phase I bavituximab monotherapy trial in advanced solid cancers is also continuing. ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

...ry said. "With this promising drug profile, AR9281 has the potential to provide safe and effective therapy for patients with type 2 diabetes either as monotherapy or in combination with existing treatment regimens." Said Arte's chief medical officer Randall Whitcomb: "The Phase IIa trial will further validat...

Synthetic biology can help extend anti-malaria drug effectiveness

...larial drug "cocktail" rather than selling it as a monotherapy should delay or even prevent malaria parasites fro...that some manufacturers have sold artemisinin as a monotherapy rather than as a co-therapy as is recommended by t...producing artemisinin. "Any drug that is used as a monotherapy raises the possibility of microbes developing resi...

Researchers identify new anti-tumor gene

... number of solid tumors and hematological malignancies, such as melanoma, renal cell carcinoma, malignant glioma, lymphomas and leukemias, either as a monotherapy or as an adjuvant to chemotherapy of radiotherapy. "We have uncovered a new way by which interferon can induce anti-tumor activity. The identificat...

New cardiology research presented at CHEST 2008

...with PAH, of whom 53 percent were taking concomitant bosentan, to two study arms. The groups received either tadalafil or placebo orally once daily as monotherapy or as add-on therapy to bosentan. Compared with placebo, tadalafil, 40 mg, increased 6-minute walk distance, delayed the time to clinical worsening, a...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...r activity in vitro and in vivo. Halichondrin B was originally isolated from a type of marine sponge. This study was designed to evaluate E7389 as a monotherapy in patients with refractory breast cancer. The primary endpoint of this trial was response rate, measured using the RECIST (Response Evaluation Criter...

Two studies document rise of superbugs in the environment

...potential resistance to antibiotics--is known. In such cases, combination antibiotic therapy (using more than one drug at a time) may be preferable to monotherapy (using one drug) because physicians want to "maximize the chance that the organism is sensitive to at least one of them," Dr. Pop-Vicas said. "Startin...
monotherapy in Biological Technology

OncoGenex Reports Second Quarter 2009 Financial Results

...-up for previously announced phase 2 clinical trials of OGX-011; - completion of its phase 1 clinical trial evaluating OGX-427 as a monotherapy in patients with solid tumors; - initiation of an investigator-sponsored phase 1 clinical trial evaluating OGX-427 treatment in patients w...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

...lymerase. Anadys has completed three Phase I clinical studies of ANA598 that have demonstrated potent antiviral activity and good tolerability. In a monotherapy study in naive genotype 1 patients, treatment with ANA598 for three days led to median declines in viral load ranging from 2.4 to 2.9 log10 in three s...

Oncolytics Biotech(R) Inc. Announces 2009 Second Quarter Results

...ree and six-month periods ended June 30, 2009. "Clinical results from our monotherapy and combination clinical trials with REOLYSIN(R) continued to emerge in the...ated anti-tumour activity in a U.S. Phase I systemic administration monotherapy trial. Of 18 patients treated in the trial, eight demonstrated SD o...

Sanofi-aventis Announces Second Quarter 2009 Results

...ue to competition from clopidogrel besylate in the monotherapy segment in Germany, where Plavix((R))/Iscover((R))...9, irbesartan generics began to be marketed in the monotherapy segment in Spain and Portugal. In these two countr...hrough August 2012. Net sales of Aprovel((R)) as a monotherapy in European countries with no active ingredient pa...

New Report Just Published: World Prostate Cancer Therapeutics Market Report

...ogen Hormonal Therapy Drugs for Prostate Cancer II-34 Anti-Androgen monotherapy II-34 Orchiectomy II-35 Side Effects of Orchiectomy II-35 Time ... Androgen Deprivation Therapy (ADT) II-44 High Dose Radiation (HDR) monotherapy II-45 Drawbacks of HRD II-45 Choosing the Optimal Treatment Method ...

Glenmark's Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials

...d with Melogliptin and are due to start at the end of 2009 following regulatory approvals. These studies are designed to evaluate the compound both as monotherapy and in combination with other anti-diabetic therapies in patients with type 2 diabetes mellitus". said Mr. Glenn Saldanha, MD & CEO, Glenmark Phar...

Three Rivers Announces Positive Results from Phase 3 DIRECT Trial of Once-Daily INFERGEN(R) with Ribavirin in Hepatitis C Virus Treatment Failures

...r older with compensated liver disease who have anti-HCV serum antibodies and /or the presence of HCV RNA. INFERGEN is currently FDA approved for TIW monotherapy dosing in naive and previous treatment failure patients. Important Safety Information Physicians and patients can obtain additional prescrib...

Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity

...risk of hypertensive crisis due to the interaction between high doses of oral tyramine and therapeutic doses of rasagiline, which is indicated both as monotherapy in patients with early Parkinson's disease (PD) and as adjunctive treatment in patients receiving levodopa. The study supported the selectivity of ras...

Proteolix Presents Clinical Data from Two Clinical Studies of Carfilzomib in Multiple Myeloma at the 14th Congress of the European Hematology Association

...ion. The median time to progression for patients in this cohort was 8.9 months. Ten additional patients achieved stable disease. "Carfilzomib monotherapy achieves durable responses in relapsed multiple myeloma patients regardless of their prior exposure to bortezomib, and notably, a number of patients r...

Peregrine Pharmaceuticals Presents Promising Data From Its Phase II Bavituximab Breast Cancer Trial at 2009 ASCO Annual Meeting

...orted that researchers will present data at ASCO today from a Phase I study assessing the safety and pharmacokinetic (PK) properties of bavituximab as monotherapy in patients with advanced refractory cancers. This multi-center open label safety study is currently enrolling patients in the final cohort according...
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(Date:4/22/2014)... MD, April 22, 2014: The Association for Molecular ... The Journal of Molecular Diagnostics on recommendations ... baccalaureate and master,s levels of education. The report ... Curriculum Task Force of the AMP Training and ... critical need of educating future medical laboratory scientists ...
(Date:4/22/2014)... German . ... but their mode of action is complex: In low ... behavior, while at high concentrations they can cause "oxidative ... how redox signaling unfolds in single cells and organelles ... developed jointly by the teams of LMU Professor Martin ...
(Date:4/22/2014)... we all seem to know who we say is neurotic ... isn,t unable to act but simply doesn,t want to., ... study of nearly 4,000 college students in 19 countries has ... decisions and moving forward with life. Turns out that when ... just don,t like it as much as non-neurotics. Therefore persuasive ...
(Date:4/22/2014)... This news release is available in German . ... F. Perutz Laboratories of the University of Vienna and the ... Zurich, have now shown how double stranded RNA, such as ... a cell. During the immune response against viral infection, the ... cytoplasm. There it modifies viral RNA to inhibit reproduction of ...
(Date:4/22/2014)... like toddlers, but their total brain size suggests ... or fox squirrel, according to a new study ... from orangutans to zebra finches. , Scientists at ... than two-dozen other research institutions collaborated on this ... defined in the study as the ability to ...
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(Date:4/22/2014)... This news release is available in French . ... less than a month, sequencing of the complete genome ... in Guinea forms a clade (variant) that is distinct ... Congo and in Gabon. Epidemiological investigations also linked the ... the December 2013 outbreak. , Ebola virus is a ...
(Date:4/22/2014)... not only on weight loss but also on diabetes ... University of Cincinnati have shown that the health benefits ... size but by increased levels of bile acids in ... indicate that bile acids could be a new target ... the Sahlgrenska Academy has demonstrated that obesity surgery is ...
(Date:4/21/2014)... from dairy cows, which is commonly used as a ... identified antibiotic resistance genes from the cows, gut bacteria. ... open-access journal of the American Society for Microbiology, hints ... types of antibiotic resistance genes that transfer to bacteria ... Thousands of antibiotic resistance (AR) genes have already been ...
Breaking Biology News(10 mins):Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2Researchers identify a mechanism linking bariatric surgery to health benefits 2Cow manure harbors diverse new antibiotic resistance genes 2Cow manure harbors diverse new antibiotic resistance genes 3
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