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monophosphate in Medical News

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...ctor (aFGF); activin receptor IIA (ActrIIA); adenosine deaminase; adenosine monophosphate (AMP); alpha5beta1 integrin; alphanubeta3 integrin; alphanubeta5 integrin; ...pha); interleukin 13 (IL-13); IL-13 receptor alpha2 (IL-13ralpha2); inosine monophosphate dehydrogenase (IMPDH); integrin alpha2; interleukin 6 (IL-6); interleukin 8...

Cancer gene drives pivotal decision in early brain development

... stem cells. Studies of these mice revealed that the Nf1 protein, neurofibromin, controls the activity of two signaling pathways, the cyclic adenosine monophosphate (cAMP) pathway and the Ras pathway. This allows neurofibromin to regulate the development of both neurons and astrocytes. "We found that neurofibrom...

Study suggests existing drugs may be useful in treating brain tumors

...t, glia from the mouse model divided and grew in response to CXCL12. Rubin then linked that effect to levels of a compound known as cyclic adenosine monophosphate (cAMP). Lower cAMP levels meant cells thrived after exposure to CXCL12. Higher levels meant they died in response to it. He also found the optic pathw...

Viagra may Be Useful for Treating Jet Lag

...treatment of high blood pressure and angina, works by interfering with an enzyme that reduces levels of a naturally-occurring compound, cyclic guanine monophosphate (cGMP). In the brain, cGMP has a vital function in a signalling pathway that regulates the circadian cycle, the body's daily clock. Ar...

Host of Benefits from Erectile Dysfunction Drugs

...blood vessels. For the treatment of erectile dysfunction, the drugs’ constraint of the enzyme’s action results in increased levels of cyclic guanosine monophosphate (cGMP) and nitric oxide (NO), biochemicals that promote smooth muscle relaxation and increased blood flow in erectile tissue. According to the a...
monophosphate in Medical Technology

Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930

...the signature of an exclusive license agreement for the development and commercialisation of Debio 0930, a small molecule activator of AMPK (adenosine monophosphate activated protein kinase) for the treatment of diabetes and metabolic diseases. Activation of AMPK has been shown to lower fasting blood glucose level...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

...ethyl guanosine nucleotide prodrug, which includes Idenix's proprietary liver-targeting technology. This technology enables the delivery of nucleoside monophosphate to the liver, leading to the formation of high levels of nucleoside triphosphate, potentially maximizing drug efficacy and limiting systemic side effe...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

...ents," will be presented on June 2 at the annual meeting of the American Transplant Congress in Toronto, Canada. "The production of cyclic adenosine monophosphate (cAMP) by mitogen-stimulated peripheral CD4+ T-cells using the ImmuKnow assay has previously be shown to have utility in the management of several for...

Avalon Pharmaceuticals to Present at the American Association for Cancer Research 2007 Annual Meeting

...N944 for the treatment of hematological cancers. The poster is titled, "The Modulation of Gene Expression and Guanosine Pools by Inhibition of Inosine monophosphate Dehydrogenase (IMPDH); correlating In Vitro Cell Resistance with Biomarker Response in Patient Samples from the Phase I Trial." This poster will provi...
monophosphate in Biological News

Computational biochemist uncovers a molecular clue to evolution

...m FSU, Duke University and Brandeis University, he recently produced remarkable computer models of an enzyme that carries the unwieldy name of inosine monophosphate dehrydrogenase, or IMPDH for short. IMPDH is responsible for initiating certain metabolic processes in DNA and RNA, enabling the biological system to ...

Get smart about what you eat and you might actually improve your intelligence

...oject. In the study, gerbils were given various combinations of three compounds needed for healthy brain membranes: choline, found in eggs; uridine monophosphate (UMP) found in beets; and docosahexaenoic acid (DHA), found in fish oils. Other gerbils were given none of these to serve as a baseline. Then they wer...

Viagra improves high altitude exercise performance up to 45% for some

...t strenuous physical activity than it is at sea level. Sildenafil works by inhibiting phosphodiestrase-5, an enzyme which degrades cyclic guanosine monophosphate (cGMP) a cell messenger that causes the blood vessels to relax, Friedlander explained. By inhibiting the enzyme, the drug allows greater vasodilation ...

Darkness unveils vital metabolic fuel switch between sugar and fat

... that emerged from the dark also presents a new target for obesity and type 2 diabetes research. A series of experiments pinpointed 5-prime adenosine monophosphate (5'-AMP) as the key molecular mediator of the constant darkness effect, switching mice from a glucose-burning, fat-storing state to a fat-burning, glu...
monophosphate in Biological Technology

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

Key words: cAMP • GPCR • enzyme fragment complementation • LEADseeker • assay miniaturization G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are responsible for the transduction of ...

Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure

... patients. The evaluations included safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide. Dosing concluded with the successful achievement of the primary endpoint of the study, a pre-specified reduc...

Novel compound may treat acute diarrhea

... causes travelers' diarrhea. "This newly discovered compound decreases the formation of ever-present cellular messenger molecules, cyclic guanosine monophosphate and cyclic adenosine monophosphate, caused by various bacterial toxins and might prevent or attenuate the intestinal fluid secretion, diarrhea and deh...

Palatin Technologies, Inc. Reports Positive Results of a Phase I Clinical Study With PL-3994 for the Treatment of Congestive Heart Failure

...taneously. The evaluations included safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide. Dosing concluded with the successful achievement of the primary endpoint of the study, a prespecified reduct...

cAMP DataFile: Homogenous Cyclic AMP detection using High Efficiency Fluorescence Polarization

... Requires no separation or wash steps Available in a kit and in bulk packaging Introduction Cyclic adenosine monophosphate (cAMP) is a second messenger involved in the transduction of extracellular signals. The signal is initiated by the binding of a ligand to a G-protein ...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

...t these diseases. In many cells, binding of the neurotransmitter to its receptor alters the production of the second messenger adenosine 3', 5' cyclic monophosphate (cAMP), through the enzyme adenylyl cyclase. Intracellular changes in the level of cAMP can then initiate a cascade of other cellular events. ...

Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system

...nal readouts from the sensor gene markers.

This application note describes the development of an NTR reporter assay for the cyclic adenosine monophosphate response element (CRE). CRE acts as a molecular docking site for two endogeneous transcription factors (cAMP binding protein, or CREB, and cAMP-depend...

Performance of the AMARA HitHunter Chemiluminescence Kinase Assay with the LEADseeker Multimodality Imaging System

... (Sigma A-7699) Adenosine monophosphate (AMP) (Sigma A-2002) 384-well white flat bottom polystyrene (Corning 3705) ...

Enzyme Immunoassay for Studying Intracellular Levels of cAMP

...tivity of the EIA cAMP Kit is in the nanomolar range, and sensitivity is increased to the picomolar range with acetylated cAMP. Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. Typically, the...
monophosphate in Biological Products

RNase ONE™ Ribonuclease from Promega

Description:... RNase ONE Ribonuclease is a 27kDa periplasmic enzyme from E. coli that catalyzes the degradation of RNA to cyclic nucleotide monophosphate (NMP) intermediates. Slower hydrolysis further catalyzes the degradation of these intermediates to 3-NMPs (1). RNase ONE Ribonuclease is one of the fe...
Company:Promega
monophosphate in Biological Definition

Adenosine triphosphate

...wn further to another phosphate ion and adenosine monophosphate . ATP can also be broken down to adenosine monophosphate directly, with the formation of pyrophosphate . ...o Adenosine diphosphate (ADP) Adenosine monophosphate (AMP) ATPases ATP hydrolysis Citric a...

AMP

... can refer to the following: In biology , the nucleotide adenosine monophosphate As a flavour enhancer , the nucleotide adenosine monophosphate AngryMutantPenguin, a famous fan of The Elder Scrolls In computing ...

Metabolism

...glycolysis pathway. Entner-Doudoroff Pathway , an alternative glycolysis pathway in few bacteria . Pentose phosphate pathway (hexose monophosphate shunt), generation of NADPH from glucose. Protein catabolism , the hydrolysis of proteins into amino acids . Aerobic respiration ...

Nucleotide

...l structures Nucleotides Adenosine monophosphate AMP Adenosine diphosphate ADP Adenosine triphosphate ATP Guanosine monophosphate GMP Guanosine diphosphate GDP Guanosine triphosphate GTP Thymidine monophosphate TMP Thymidine diphosphate TDP Thymidine ...

Pentose phosphate pathway

... The penthose phosphate pathway (also known as the Hexose monophosphate Shunt) is a process that serves to generate NADPH and the synthesis of pentose (5- carbon ) sugars . There are two distinct phases in the pathway. ...

Signal transduction

...through activation of its target receptor, the enzyme soluble guanylate cyclase , which when activated, produces the second messenger cyclic guanosine monophosphate (cGMP). NO can also act through covalent modification of proteins or their metal cofactors. Some of these modifications are reversible and work thr...
monophosphate in Biological Dictionary

Guanine

...Research Institute. ... that make up the letters ATGC, guanine is the "G" ... Guanine deaminase · Adenosine deaminase · AMP deaminase · Inosine monophosphate ... Hypoxanthine- guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase ... Guanine - Definition of Guanine at Dictionary.com ...

Adenosine diphosphate

...miosmosis ... ... free inorganic phosphate and adenosine diphosphate , which can be broken down ... Adenosine diphosphate (ADP) Adenosine monophosphate (AMP) ATPases. ATP hydrolysis ... ...
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