Small Molecule Might Play Big Part in Lung Cancer

High levels of miR-21 were found in nonsmoking patients; could be target for treatment SATURDAY, July 18 (HealthDay News) -- Researchers have isolated a small molecule that might play a big part in a form of lung cancer that typically strikes people who have never smoked, opening up th...

New role discovered for molecule important in development of the pancreas

PHILADELPHIA For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, to no avail. Now, they may be one step closer. A protein, whose role in pancreatic development has long been recognized, has been discovered to play an additiona...

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

LA JOLLA, Calif., and BARCELONA, July 8 /PRNewswire/ -- Fate Therapeutics, Inc. announced today the presentation of data from its research on small molecule modulators of the Wnt pathway for osteo-regeneration at the 7th Annual Meeting of the International Society for Stem Cell Research (ISSCR...

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone ma...

LSUHSC research identifies enzyme that makes survival molecule for key vision cells

New Orleans, LA Research lead by Dr. Nicolas Bazan, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center New Orleans, identifying an enzyme that makes neuroprotectin D1 which specifically and selectively protects retinal cells key for vision, will be ...

Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer

ORLANDO (June 1, 2009)Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic breast cancer who have progressed on previous trastuzumab b...

More>>

Molecule in Medical Technology

USC Keck School of Medicine's Dr. Alan Epstein Receives Prestigious National Cancer Institute RAID Award for Breakthrough IL-2 Molecule Therapeutic

LOS ANGELES, July 7 /PRNewswire-USNewswire/ -- The University of Southern California today announced that Dr. Alan Epstein of the USC Keck School of Medicine has received approval for a $3.5 million drug development project through the Rapid Access to Intervention Development (RAID) program of...

TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009

SAN DIEGO, May 26 /PRNewswire/ -- TRACON Pharmaceuticals, a biotechnology company that develops targeted therapies for oncology and related diseases, announced today that Phase 1 clinical results from studies of TRC105 and TRC102 in patients with advanced cancer will be presented at the American S...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

SEATTLE, April 21 /PRNewswire-FirstCall/ -- Dendreon Corporation (Nasdaq: DNDN ) today announced that the Company has enrolled the first patient in a Phase 1 clinical trial of D3263 in patients with advanced cancer. D3263 is Dendreon's lead small molecule drug candidate designed to target TRPM8...

Avineuro Pharmaceuticals, Inc. Announces Beginning of Phase I Clinical Studies of AVN-211, Potent Small Molecule for Treatment of Schizophrenia.

SAN DIEGO, March 10 /PRNewswire/ -- Avineuro Pharmaceuticals, Inc. announced today an initiation of Phase I clinical studies of AVN-211, a potent and selective small molecule antagonist of 5-HT6 receptor for treatment of Schizophrenia. The results of Phase I studies are expected to be available in...

Nektar to Webcast Presentation of Phase 1 Clinical Results for Lead Small Molecule PEG-Oncolytic Program, NKTR-102 (PEG-irinotecan)

SAN CARLOS, Calif., May 30 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR ) will host a meeting and Webcast on Monday, June 2, 2008 at 6:30 PM Central Time to discuss the company's lead oncology program, NKTR-102 (PEG-irinotecan). The Webcast will include a presentation by featur...

Longevinex(R) Found to be Superior to Green Tea Molecule in Independent Human Study

Growing body of evidence shows matrix of polyphenols, as provided in Longevinex(R), exert greater benefit than resveratrol alone. 150-year lifespan not far off? SAN DIMAS, Calif., March 31 /PRNewswire/ -- While molecular biologists and news reporters present jaw-dr...

More>>

Molecule in Medical Products

PTH Intact Molecule with Calcium

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

PTH Intact Molecule

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Drugs of Abuse Array Evidence Benzodiazpine Class Assay

Description:... Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

Drugs of Abuse Array Evidence Phencyclidine Assay

Description:... Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

Drugs of Abuse Array Evidence Cannabiniods Assay

Description:... Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

Drugs of Abuse Array Evidence Ampphetimine

Description:... Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

Molecule in Medical Definition

Cryostasis (clathrate hydrates)

...ecules. These "cages" are unstable when empty, collapsing into conventional ice crystal structure, but they are stabilised by the inclusion of the gas molecule within them. Most low molecular weight gases (including O 2 , N 2 , CO 2 , CH 4 , H 2 S, Ar, Kr, and Xe) will form a hydrate under some pressure-tempe...

Molecule in Medical Dictionary

Vitamin A

... Vitamin A , a bi-polar molecule formed with bi-polar covalent bonds between carbon and hydrogen, is linked to a family of similarly shaped molecules, the retinoids, which complete ...

Urea nitrogen

...ed by the liver, and removed from the blood by the kidneys. Urea or carbamide is an organic compound with the chemical formula (NH2)2CO. The molecule has two amine (-NH2) residues joined by a carbonyl (-CO-) functional group. ... gives methylene- urea fertilizers, which release nitrogen slowl...

Surfactant

... the lung, thereby contributing to ... Surfactant is formed relatively late in fetal life; thus premature infants born ... Each surfactant molecule has a hydrophilic (water-loving) head that is attracted ... The surfactant molecules surround the stain particles, break them up and force ... D...

Sucrose

...Council communicates science-based information on food safety and nutrition to health and ... Same sweetness as sucrose . ... The Sucrose molecule ... Sucrose (common name: table sugar, also called saccharose) is a disaccharide ... What is notable about sucrose is that unlike most ... Inf...

Slit

... Look up slit in Wiktionary, the free dictionary. ... in clothing, slit is a vertical cut from hem of the ... The midline repellant signaling molecule Slit . ... Double- slit experiment. Davisson–Germer experiment. Stern–Gerlach experiment ... In quantum mechanics, the double- slit exp...

Serotonin

...lements with unique formulations for memory enhancement, blood sugar maintenance, thyroid ... Serotonin is a neurotransmitter, a specialized molecule that allows nerve cells ... Serotonin also does double duty in the cardiovascular and gastrointestinal ... Serotonin has been at the he...

Molecule in Biological News

Pitt team finds molecule that regulates heart size by using zebrafish screening model

PITTSBURGH, July 5 Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. The findings are described in the advance...

Toxic molecule may help birds 'see' north and south

CHAMPAIGN, Ill. Researchers at the University of Illinois report that a toxic molecule known to damage cells and cause disease may also play a pivotal role in bird migration. The molecule, superoxide, is proposed as a key player in the mysterious process that allows birds to "see" Earth's magneti...

Researchers identify a molecule that increases the risk of cardiac insufficiency

This release is available in Spanish . A team of scientists from the Center for Applied Medical Research (CIMA) of the University of Navarra has identified a key enzyme in the development of cardiac insufficiency. This enzyme is involved in the accumulation of fibrous tissues in the heart...

Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers

One of the small regulatory molecules, named microRNA-125b, is a novel regulator of p53, an important protein that safeguards cells against cancers, Singapore and U.S. scientists report in the March 17, 2009 issue of the journal Genes & Development . The scientists found that during embryonic ...

UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound

DALLAS Feb. 24, 2009 Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest. Now, UT Southwestern Medical Center researchers have identified a key molecular mechanism that regulates the brain's ability to mentally compensa...

Malaria parasite zeroes in on molecule to enhance its survival, team finds

A team of researchers from Princeton University and the Drexel University College of Medicine has found that the parasite that causes malaria breaks down an important amino acid in its quest to adapt and thrive within the human body. By depleting this substance called arginine, the parasite may tr...

More>>

Molecule in Biological Technology

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

GIA announces the release of a comprehensive global report on Small Molecule Kinase Inhibitors market. World market for small molecule kinase inhibitor drugs is projected to reach $16.2 billion by the year 2015. This is primarily driven by the rising interest over the potential of kinase inhibito...

Glenmark's Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials

Release Highlights - Melogliptin continues to demonstrate potential to be the best-in-class in achieving glycemic control with low incidence of hypoglycemia and neutral effect on body weight - Global Phase III trials likely to start by end 2009 - IND approved by USFD...

Debiopharm Group and Moffitt Cancer Center Sign Development and Commercialisation Agreement for Small Molecule Debio 0928 in Early Preclinical Development for Treatment of Solid Tumours

LAUSANNE, Switzerland and TAMPA, Florida, June 18 /PRNewswire/ -- Debiopharm Group (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, and Moffitt Cancer Center (Moffitt), a non-profit Fl...

A*STAR scientists invent the world's only controllable molecule gear of minuscule size of 1.2nm

Scientists from A*STAR's Institute of Materials Research and Engineering (IMRE), led by Professor Christian Joachim 1 , have scored a breakthrough in nanotechnology by becoming the first in the world to invent a molecular gear of the size of 1.2nm whose rotation can be deliberately controlled. Thi...

PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration

Project will advance novel platform for treatment of Spinal Muscular Atrophy SOUTH PLAINFIELD, N.J. and NEW YORK, May 12 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC) and the Spinal Muscular Atrophy (SMA) Foundation today announced the expansion of their research collaboration in which the SM...

Aegera Initiates Phase 2 Clinical Trial Of AEG33773 - A Small Molecule Targeting Neuropathic Pain

MONTREAL, May 6 /PRNewswire/ - Aegera Therapeutics is pleased to announce the initiation of a Phase 2a, proof-of-concept, clinical trial for AEG33773, a novel, orally bio-available small molecule therapeutic addressing the under-served market of painful diabetic neuropathy. The Phase 2a study, e...

Molecule in Biological Products

Mouse Anti-L1 Cell Adhesion Molecule Monoclonal Antibody, Unconjugated, Clone UJ127 from GeneTex

Description: Mouse Monoclonal to L1 Cell Adhesion Molecule The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia)....
Company:GeneTex

Imaging Mass Spectrometry for Small Molecule Localization from Protein Discovery, Inc.

Description: Small Molecule Localization in Early Drug Development with Imaging Mass Spectrometry Get essential drug compound localization data in early drug development using mass spectrometry. Protein Discoverys imaging mass spectrometry service maps unlabeled ions and aligns them with histological ima...
Company:Protein Discovery, Inc.

Mouse Anti-Human Procollagen Type I C-Peptide (PIP) Monoclonal Antibody, Unconjugated, Clone PC5-5 from QED Bioscience Inc.

Description:... Adhesion molecule Antibodies...
Company:QED Bioscience Inc.

Rabbit Anti-Warfarin Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small molecule conjugated to KLH...
Company:Abcam

Mouse Anti-Zeralenone Monoclonal Antibody, Unconjugated, Clone 11C9 from Abcam

Description:... Mouse monoclonal [11C9] to Zeralenone ( Abpromise for all tested applications). Antigen: Chemical / Small molecule conjugated to BSA: Zeralenone...
Company:Abcam

Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

Description:... Mouse monoclonal [RS17 ] to PRKAR2 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the si...
Company:GeneTex

Molecule in Biological Definition

Coenzyme A

...main function is to carry acyl groups such as acetyl as thioesters . A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA . Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cho...

Actin

...s towards the plus end of the actin filament. This pulls the membrane into a different shape relative to the cell cortex. For contraction, the myosin molecule is usually bound to two separate filaments and both ends simultaneously walk towards their filament's plus end, sliding the actin filaments over eac...

Activation energy

...quires energy - activation energy - and comes from the heat of the system, i.e. the translational , vibrational , and rotational energy of each molecule . If there is enough energy available, this repulsion is overcome and the molecules get close enough for attractions between the molecules to cause a ...

Active site

...y the presence of another molecule. There are three primary modes of inhibition. In competitive inhibition , the active site itself is blocked when a molecule chemically similar to the substrate binds to the active site but cannot be processed by the enzyme. In noncompetitive inhibition , the inhibitor bind...

Active transport

...e flow of one solute species from high to low concentration to move another molecule against its preferred direction of flow; but here, both solutes move in the... example is the glucose symporter, which cotransports two sodiums for every molecule of glucose it imports into the cell. See also Ion channel ...

Adenosine triphosphate

...to pyruvate in the cytosol . Two molecules of ATP are generated for each molecule of glucose. The terminal stages of ATP synthesis are carried out in the mit...the hydrolysis of 200 to 300 moles of ATP daily. This means that each ATP molecule is recycled 2000 to 3000 times during a single day. ATP cannot be stored, h...

Molecule in Biological Dictionary

Molecule

A molecule is defined as a sufficiently stable, electrically neutral group of at least two atoms in a definite arrangement held together by very strong (covalent) chemical bonds. Molecules are distinguished from polyatomic... molecule ( ) n. The smallest particle of a substance that retains ...

Recombinant DNA molecule

Recombinant DNA is a form of DNA that does not exist naturally, which is created by combining DNA sequences that would not normally occur together. In terms of genetic modification, recombinant DNA (rDNA) is introduced... ... or more sources is incorporated into a single recombinant m...

Urea

... Urea or carbamide is an organic compound with the chemical formula (NH2)2CO. The molecule has two amine (-NH2) residues joined by a carbonyl (-CO-) functional group. urea n. A water-soluble compound, CO(NH 2 ) 2 , that is the major ...

Untranslated RNA

... A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are no...n-messenger RNA (snmRNA),... Messenger ribonucleic acid (mRNA) is a molecule of RNA encoding a chemical "blueprint" for a protein product...

Trans-splicing

...molecular mechanism that ... Trans RNA reprograms tau alternative splicing defect in human neurons. ... We designed a pre- trans - splicing molecule containing human tau exons 10 to 13 ... In molecular biology, splicing is a modification of an RNA after ... Cis- and trans - splicing o...

Transmembrane receptor

...ransmembrane signaling by the aspartate receptor : a model. ... PolyMedix is a biotechnology company that is developing novel, synthetic small molecule compounds that mimic the ... Transmembrane Protein Receptor ... IMGENEX offers a large selection of antibody reagents to factors that are ...