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modulates in Medical News

Therapy Modulates Highly Sensitized Immune System to Let Mother Give Kidney to Daughter

As the holidays approached last year, Soraya Kohanzadeh, 30, Muir Beach, CA, was living day to day, extremely ill, with no hope and expecting to live a shortened life// dependent on kidney dialysis. She needed a kidney transplant but because her “anti-donor” antibody levels were so high, her doctor...

Avipaxin Is First Entrant in Medical Arsenal for Neuro-Endocrine-Immune Connection(C) Product and Testing Protocols

...eep. Research shows that persistent cytokine elevations lead to numerous physical and emotional symptoms that are difficult to manage. Avipaxin modulates elevated cytokine levels by supporting acetylcholine-mediated signaling. The cholinergic anti-inflammatory pathway uses the neurotransmitter acetylcho...

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

...afety and clinical efficacy in numerous adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cel...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

...afety and clinical efficacy in numerous adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cel...

Cats Purrfect at Getting Needs Met, Study Shows

...ffective in getting their owner to respond." The study suggests that Felis catus domesticus has a richer vocabulary than the standard "meow," and modulates its vocalizations to express contentment (purr), alarm (shrieking meow) or insistent persuasion (the cry-purr). "They are trying to communicate," s...

InteKrin Therapeutics Announces Appointment of Geoffrey M. Parker as Chief Business Officer

...AR-gamma is an important therapeutic tool for physicians, providing powerful glucose control and durability of effect. As a SPPARM, INT131 selectively modulates PPAR-gamma, thereby enabling the separation of PPAR gamma anti-diabetic efficacy from the well recognized TZD side effects. About InteKrin (...

Keryx Biopharmaceuticals Inc. Regains Compliance With NASDAQ Listing Requirements

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

...e anticipate that the results from our ongoing phase IIa clinical program in pre-diabetic patients will establish proof of concept that sEH inhibition modulates glucose metabolism or blood pressure in patients with impaired glucose tolerance and hypertension to further corroborate the clinical importance of th...

Keryx Biopharmaceuticals, Inc. Receives Extension for Nasdaq Listing Compliance

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals, Inc. Announces First Quarter 2009 Financial Results

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...
modulates in Medical Technology

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... KRX-0401 is a novel, oral, anticancer agent that modulates Akt and several other important signal transductio...tially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

InteKrin Therapeutics to Present at the 2009 American Diabetes Association Annual Meeting

...esistance, a key etiological feature in the onset and subsequent progression of type 2 diabetes. Purposefully designed as a SPPARM, INT131 selectively modulates PPAR-gamma, thereby allowing the retention of the clinically proven anti-diabetic efficacy of PPAR gamma activation, while mitigating or eliminating t...

Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting

...ited molecular target. CX-4945 is a potent, selective inhibitor of CK2 and modulates key survival pathways in cancer cells. CX-4945, which has broad therapeuti...pril 21, 2009: 2:00 PM CX -4945, a potent and selective inhibitor of CK2, modulates PI3K/AKT signaling and phosphorylation of p21 in vitro and in vivo: Implic...

Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

...tially first-in-class, oral anti-cancer agent that modulates Akt and a number of other key signal transduction ...tially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...r. Specifically, panobinostat causes an increased acetylation of both histone and non-histone proteins which are implicated in oncogenesis and thereby modulates their activity. In this way, panobinostat selectively induces the death of tumor cells. To date, objective clinical responses in patients with hematol...

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

...e of domains that regulate the enzymatic activity of PDE4, and in DG071 discovered a compound that binds to the PDE4 regulatory domain and effectively modulates the activity of the enzyme. DG071 has been shown in several animal models to potently and specifically improve cognitive function, and features a much...
modulates in Medical Products

DryEase® Mini-Gel Drying Frame

Description:...h outer surfaces of the gels are exposed to air. Consequently drying is even and cracking is minimized. The proprietary Gel-Dry™ Drying Solution modulates the rate of water release to ensure crack-free gels. With the DryEase System gels are dried overnight with uniform tension on all points of the gel to...
Company:Invitrogen

IGFBP-1, Total IRMA Test

Description:... Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 m...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-1, Total ELISA Test

Description:... Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 m...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-4 ELISA Test

Description:... Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein which specifically binds and modulates the actions of IGF-I and IGF-II. It is also present in a glycoslyated form with a molecular weight of 28 kDa. IGFBP-4 has been identified in all biolo...
Company:Diagnostic Systems Laboratories, Inc.

Growth Hormone Binding Protein ELISA Test

Description:... and possibly related enzymes (1). GHBP circulates in plasma in nanomolar concentrations, sufficient to complex approximately 50% of plasma GH. GHBP modulates GH action via a variety of mechanisms. It inhibits GH action by competing with the GH receptor for ligand and by generating unproductive heterodimers...
Company:Diagnostic Systems Laboratories, Inc.
modulates in Medical Dictionary

Serum calcium

... Failure (CRF) Crohn's Disease ... Serum Calcium , Corrected Serum Calcium , Ionized Calcium , Free Calcium ... Parathyroid Hormone (PTH) modulates serum calcium . PTH rises in response to low calcium ... ... a calcium test is ordered, how a calcium test is used, and what the results ...
modulates in Biological News

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems. However, do nucleic acids possess other attributes that contribute to their biological functions? Recent work of a team led by Stoyno Stoynov, working at the Bulgarian Academy of Scien...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

...t consists of an array of microscopic split metal rings. The rings can be controlled by nearby electrodes; modulating the ring's capacitance, in turn, modulates the radiation; that is, the THz light (sometimes called T rays) can be switched so as to pass through or not. The modulator consists of 16 pixels in a...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

...cs. "This is the first clinical study of a s-EH inhibitor in patients, and the first study designed to establish proof of concept that s-EH inhibition modulates glucose metabolism or blood pressure in patients with impaired glucose tolerance and hypertension." ."AR9281 has demonstrated an excellent safety p...

Rice psychologist explores perception of fear in human sweat

...e. Chen's conclusion is consistent with what's been found with processing emotions in both the face and the voice. There, an emotion from one sense modulates how the same emotion is perceived in another sense, especially when the signal to the latter sense is ambiguous. "Our findings provide direct behav...

Researchers identify gene linked to aggressive progression of liver cancer

...ncreases as the tumor becomes more and more aggressive. Using microarray technology, they analyzed cDNA from the tumor cells and determined that AEG-1 modulates expression of genes relevant to the progression of HCC, including invasion, metastasis, resistance to chemotherapy, the formation of new blood vessels...

Neural mechanisms of value bias in the human visual cortex

...ng interactions with the environment. There is no doubt that prior rewards have a strong influence on decision making and that the value of a stimulus modulates the activity of neurons involved in initiating movements towards the more favorable of alternatives. However, although recent studies have suggest...

Honey bees on cocaine dance more, changing ideas about the insect brain

...opamine system. Dopamine plays a role in the human ability to predict and respond to pleasure or reward. It is also important to motor function and modulates many other functions, including cognition, sleep, mood, attention and learning. One aspect of reward in the human brain involves altruistic behavio...

Adiponectin is a metabolic link between obesity and bone mineral density

...fi Ealey, Postdoctoral Fellow and predoctoral student Jovana Kaludjerovic, in the Department of Nutritional Sciences, investigated whether adiponectin modulates bone development using transgenic mice that overexpress this protein. These mice were initially developed by Dr. P. Scherer's research group at Albert...

Acoustical Meeting, Nov. 10-14, 2008 in Miami, Florida

...ide the vessel, vibrates at 1 MHz, causing an ultrasonic wave to travel through the wall. On the other side, the second crystal vibrates in a way that modulates how much of the initial wave reflects back to the first crystal. It is through these modulations that the second crystal encodes whatever measurements...

Green tea may delay onset of type 1 diabetes

... the mouse, EGCG reduced the severity and delayed onset of salivary gland damage associated with Sjogren's syndrome, which has no known cure. "EGCG modulates several important genes, so it suppresses the abnormality at the molecular level in the salivary gland. It also significantly lowered the serum autoan...
modulates in Biological Technology

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

...afety and clinical efficacy in numerous adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cel...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

...afety and clinical efficacy in numerous adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cel...

AEterna Zentaris Partner, Keryx, Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial with Perifosine (KRX-0401) for the Treatment of Multiple Myeloma

...eeded to treat these patients and extend their survival. About Perifosine Perifosine is a novel, first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and JNK that have been shown to be critical for the survival of cancer cells. Perifosin...

Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia

...ire/ -- Palkion, Inc. announced today that it has initiated preclinical development studies for its orally available anemia therapeutic candidate that modulates the Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PH) enzyme system. In February 2008, Palkion was founded when a novel drug discovery and developm...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

...r were presented at ASH and ASCO meeting, respectively." About Perifosine Perifosine is a novel, first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and JNK that have been shown to be critical for the survival of cancer cells. Perifosin...

Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals Announces Appointment of Ron Bentsur as Chief Executive Officer

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals Announces Poster Presentations Highlighting Clinical Activity of KRX-0401 (Perifosine) at the Upcoming Annual Meeting of the American Society of Clinical Oncology

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on First Quarter 2009 Financial Results on Thursday, May 14, 2009 at 8:30am EDT

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...

Keryx Biopharmaceuticals, Inc. Announces Michael P. Tarnok as Interim Chairman and Chief Executive Officer

...rifosine), a novel, potentially first-in-class, oral anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and M...
modulates in Biological Products

Human, Porcine Endothelin-1 from Biotrend Chemikalien GmbH

Description:... Endothelin-1 (human, porcine) Endogenous potent vasoconstrictor peptide. Displays selectivity for the endothelin ETA receptor and modulates vascular tonus. ET-1, ET-2, and ET-3 are the products of three distinct endothelin genes. ET-2 and ET-3 are similar to ET-1, but differ in two and six...
Company:Biotrend Chemikalien GmbH

Rat Anti-Vitamin D Receptor Monoclonal Antibody, Unconjugated, Clone 9A7 from ABR-Affinity BioReagents

Description:...he superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidn...
Company:ABR-Affinity BioReagents
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Breaking Biology News(10 mins):New book about life as seen from physics 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
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