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modifies in Medical News

Scientists find gene that modifies severity of cystic fibrosis lung disease

WINSTON-SALEM, N.C. Researchers at Wake Forest University Baptist Medical Center, and colleagues, have identified a gene that modifies the severity of lung disease in people with cystic fibrosis, a lethal genetic condition. The findings open the door to possible new targets for treatment, researc...

Isolagen Modifies Ongoing Clinical Program for Acne Scars

- FDA Recommends Further Analysis of Evaluator Assessment Scale and Photo Guide; Company Proposes Amending Previously Announced Phase III Study as a Phase II/III Study - - No Impact on Ongoing Pivotal Phase III Clinical Program in Wrinkles - EXTON, Pa., Nov. 27 /PRNe...

CNS Response, Inc. Modifies rEEG(SM) Trial Protocol for 'Treatment-Resistant Depression' Study

COSTA MESA, Calif., Oct. 25 /PRNewswire-FirstCall/ -- CNS Response, Inc. (OTC Bulletin Board: CNSO) announced today that it has conducted a quality assurance analysis of its current multi-center trial of rEEGSM -guided pharmacotherapy for individuals with treatment-resistant depression. Based ...

Grab a Tool and Change Your Brain

... New research suggests that the brain considers tools to be extensions of the body. The mere act of holding a mechanical grasping tool "temporarily modifies the cerebral representation of a subject's arm," said Lucilla Cardinali, a graduate student in France and lead author of the study. In other words,...

Cocaine Spurs Long-Term Change in Brain Chemistry

...nsight into how addictive drugs such as cocaine "cook" the brain. "The study's findings enable us to glimpse for the first time exactly how cocaine modifies the activity of genes in regions of the brain that that mediate reward," explained Nora Volkow, the director of the U.S. National Institute on Drug Ab...

Sunrise Signs Twelfth Amendment to Bank Credit Facility through December 2, 2009

...rise to provide the lenders with additional financial, operational and liquidity reports through the maturity date. The amendment further extends and modifies the application of certain existing negative covenants through the maturity date. As of April 27, 2009, Sunrise had outstanding borrowings of $72...

WA discovery a key to blood cell development

...n and blood where activity of the enzyme Lyn is heightened." The focus of the team's investigations, Lyn has now been identified as an enzyme which modifies proteins that triggers the cell to develop further. Associate Professor Ingley said in their investigations into blood cell development, Lyn became...

A potential new target for treatment of hormone refractory prostate cancer

... A new study identifies a protein that modifies the androgen receptor (AR) and influences its ability to regulate target genes linked with the progression of prostate cancer. The research, published...

Scripps research scientists develop general-purpose method for detecting trace chemicals

... supply of the subunits. In this latest research, Joyce and his colleagues extended this basic system by adding "aptamers" to the RNA enzymes. This modifies the enzymes such that they will only replicate if they first bind a completely separate chemical. The chemical must be present for cross replication t...

Living with females extends the reproductive life of the male mouse, says Penn veterinary researcher

...s, and thereby fertility, of the male. Whether this female influence occurs in other species is not known, but it is known that the female profoundly modifies a variety of responses in males in many areas of male physiology and psychology. The study was performed by Brinster of the Department of Animal B...
modifies in Medical Technology

Human Genome Sciences Modifies Dosing in Achieve Trials of Albuferon(R)

ROCKVILLE, Md., Jan. 23 /PRNewswire-FirstCall/ -- Human Genome Sciences Inc. (Nasdaq: HGSI ) announced today that it will modify the dosing in one arm of each of its ACHIEVE clinical trials of Albuferon(R) (albinterferon alfa-2b) for chronic hepatitis C. Patients in the Phase 3 trials who hav...

Stallergenes S.A.: Positive Results From a Phase IIb/III Clinical Trial on the House Dust Mite Desensitization Tablet

...thout addressing its cause. To date, desensitization therapy is the only treatment option that treats the immunological causes of allergies and modifies the natural course of the disease, preventing it from worsening. Since 2003, Stallergenes has been running the Stalair(R) program, which aims t...

STALLERGENES: Oralair(R) Grasses Obtains a Pediatric MA(1) in Germany

...by allergy according to the ISAAC study. According to WHO, desensitization is the only treatment that addresses the immunological cause of allergy and modifies the natural course of the disease. Nearly 15 to 20% of these patients suffer from moderate to severe allergic rhinitis and rhinoconjunctivitis, not co...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

...d from the pattern of diffraction of the X-rays. Comparison of the two structures revealed that, when NEDD8 attaches to cullin-RING, it dramatically modifies the conformation of the enzyme, causing it to blossom from a "closed" to an "open" state. This open state eliminates the binding site for the inhibito...

Progen Resumes Phase 1 Development of Anti-Cancer Agent, PG-11047

...uticals primarily for the treatment of cancer. Progen has operations in Australia and the US. About PG-11047: PG-11047 is a polyamine analogue which modifies the production of natural polyamines. Polyamines are a class of chemical which are involved in regulation of cell growth. They are overproduced in man...

New Study Supports Efficacy of Vagus Nerve Stimulation for Treatment-Resistant Depression

...he most difficult-to-treat forms of depression and are excited to continue neurostimulation research at MUSC." The study illustrates that VNS Therapy modifies activity of the medial prefrontal cortex, the same area of the brain targeted by many antidepressant medications and electroconvulsive therapy (ECT). ...

Myriad Genetics Presents Mathematical Comparison of Disease Modification Trial Designs at Alzheimer's ConferenceCurrent Flurizan Phase 3 Study Design May Demonstrate Disease Modification

...-onset Alzheimer's disease appear to do so by increasing production of Abeta42. Myriad believes that Flurizan is the most advanced drug candidate that modifies the production of Abeta42 to be evaluated in a clinical trial for the treatment of Alzheimer's disease. About Myriad Myriad Genetics, Inc. is a bi...
modifies in Biological News

CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery

Cold Spring Harbor, N.Y. During gene transcription the process inside the nucleus of cells by which DNA, the genetic material, is copied into RNA molecules a large, ever-changing multiprotein complex is enlisted to assist the DNA-copying enzyme in its challenging job. Like an exquisitely ch...

Fraud attempt in a paternity test modifies action protocol in DNA tests

This release is available in Spanish . Researchers from all over the world have been carrying out paternity tests regularly. Samples are usually collected from mouth and saliva cells to carry out the DNA analysis. The team of Dr Jos Antonio Lorente Acosta (director of the Laboratory of G...

Electronic chip, interacting with the brain, modifies pathways for controlling movement

Researchers at the University of Washington (UW) are working on an implantable electronic chip that may help establish new nerve connections in the part of the brain that controls movement. Their most recent study, to be published in the Nov. 2, 2006, edition of Nature, showed such a device can ind...

Is this the beginning of the end of plant breeding?

...idopsis thaliana. By combining a mutation in this gene with two other previously described mutationsone that eliminates recombination and another that modifies chromosome segregationthe authors have created a strain of plant (called MiMe for 'mitosis instead of meiosis') in which meiosis is totally replaced b...

Penn researchers discover genetic risk factor for testicular cancer

...ed." Only a small proportion of men who carry the high-risk alleles will develop the disease. The key now, the researchers say, is to find out what modifies the genetic risks and pushes one individual toward cancer while another remains disease-free. By using the newly-discovered genetic risk factors as a ...

New evidence of how high glucose damages blood vessels could lead to new treatments

... found increased activity by O-GlcNAc competes with another mechanism for modifying proteins called phosphorylation. In blood vessels, phorphorylation modifies the enzyme that produces nitric oxide, called nitric oxide synthase, so that it makes more of the blood vessel dilator. But add more O-GlcNAc to the m...

SUMO protein guides chromatin remodeler to suppress genes

...degeneration. "We've only known for about 10 years that SUMO chemically modifies proteins. We have a good understanding of how SUMO modifies other proteins, but the actual mechanism of how this modification alters ce...

Getting down to cancer basics

...death but in basic gene regulation and shows the depths to which cancers will plumb in order to get themselves ready to go." The normal UTX protein modifies part of the structure holding DNA together in our cells. The composite DNAprotein structure, called chromatin, is not simply a scaffold, but plays an ...

Montana State team finds Yellowstone alga that detoxifies arsenic

...al Park alga that's tougher. The alga -- a simple one-celled algae called Cyanidioschyzon -- thrives in extremely toxic conditions and chemically modifies arsenic that occurs naturally around hot springs, said Tim McDermott, professor in the Department of Land Resources and Environmental Sciences at Mont...

'Scrawny' gene keeps stem cells healthy

...colleagues Michael Buszczak and Shelley Paterno, determined that the fruit fly gene scrawny (so named because of the appearance of mutant adult flies) modifies a specific chromosomal protein, histone H2B, used by cells to package DNA into chromosomes. By controlling the proteins that wrap the genes, scrawny c...
modifies in Biological Technology

Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa)

- Label change based on data previously reported, communicated in late 2007 - BRIDGEWATER, N.J., March 7 /PRNewswire/ -- Ortho Biotech Products, L.P. today modified prescribing information for PROCRIT(R) (Epoetin alfa), following guidance from the U.S. Food and ...

Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) Label Reflects Recommendations from Recent FDA Advisory Committee Meetings

BRIDGEWATER, N.J., Nov. 8 /PRNewswire-FirstCall/ -- Ortho Biotech Products, L.P. today modified prescribing information for PROCRIT(R) (Epoetin alfa), following guidance from the U.S. Food and Drug Administration (FDA) to revise labeling for all drugs within the erythropoiesis-stimulating agen...

Inimex Pharmaceuticals begins First Clinical Study of an Innate Defense Regulator

...erial infections and suppress inflammation. IMX942 is a small, proprietary, fully synthetic peptide that binds to an intracellular adaptor protein and modifies the signaling network downstream of TLR, TNF, and IL-1 receptors. IMX942 has no direct anti-bacterial activity but can control the outcome of infectio...

FDA Accepts IND for Arno Therapeutics' Pan-DAC / Akt Inhibitor, AR-42

...tigational New Drug ("IND") application for the use of AR-42. About AR-42 AR-42 is an orally available, novel, potent, small molecule that modifies the acetylation of histones and other molecules, and is a targeted inhibitor of the Pan-DAC and Akt pathways. HDAC inhibitors disrupt HDAC-PP1 comple...

Researchers decode viral process that prepares cells for HIV infection

...barrier to gain access to the center of the cell. Now we know that HIV triggers the mimicking of a cell process that activates cofilin, which cuts and modifies the cortical actin cytoskeleton and permits the virus to cross it." Wu notes that the goal of his research was to attain a fundamental understandin...

Research helps understand factors that influence efficiency of organic-based devices

...een the metallic coating and organic layer where the injection occurs is poorly understood. Placing an organic layer on top of the conductive layer modifies each layer's individual work function, or the minimum energy needed to extract the first electron from the metal. "Measuring the work functions in...

Neurobiological Technologies Announces Amendment of License and Cooperation Agreement with Merz Pharmaceuticals and Childrens' Hospital

...orporation ("CMCC") relating to memantine, which is currently marketed in the United States as Namenda(TM) and in Europe as Ebixa(TM). The amendment modifies the terms of the royalties to be paid to the company on sales of memantine, including discontinuing the payment of royalties on sales of memantine for...

MUSC Spin-Off Company to Test Regenerative Wound Healing Gel

... technology he co-invented with Ghatnekar. "This peptide has tremendous potential in all body situations that involve healing because it regulates and modifies intercellular communication at the site of the wound," he said. Since the company began a few years ago, FSR has been pleasantly surprised by the ...

Americas Third Coast nurtures biotechnology

...er, cells also contain natural ribonuclease inhibitors (RI), which bind ribonucleases to prevent cell destruction. The Evade technology genetically modifies selected ribonucleases to prevent them from binding RI and losing potency inside targeted cancer cells. The selective toxicity of ribonucleases also m...

Alzheimer's drug market to hit $5.5 billion by 2009, study says

...e medical world generally agrees that disease modification and prevention remain the major unmet needs. "What doctors want to see is something that modifies the progression of the disease," said Naissan Vahman, a senior analyst at Millennium who helped assemble the report. "Some of the drugs in the pipelin...
modifies in Biological Products

Tritirachium album Proteinase K from USB Corp.

Description:...tion of native, high molecular weight DNA and RNA. *Used as a general protease to inactivate DNases, RNases and to degrade proteins. *Specifically modifies cell surface proteins and glycoproteins for analysis of membrane structures for protein localization (5,6) . *Produces characteristic protein fragme...
Company:USB Corp.
modifies in Biological Definition

Activation energy

... result in the release of energy (shown on the enthalpy profile diagram, Fig. 1 , as both positions lie below the transition state). A substance that modifies the transition state to lower the activation energy is termed a catalyst ; a biological catalyst is termed an enzyme . Fig 1. The ent...

Disulfide bond

...ical polymer, with over 90% of its dry weight made of proteins called keratins . Under normal conditions, human hair contains around 10% water, which modifies its mechanical properties considerably. Hair proteins are held together by disulfide bonds, from the amino acid cysteine. These links are very robust:...

Endoplasmic reticulum

...eticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in all eukaryotic cells . The ER modifies proteins , makes macromolecules , and transfers substances throughout the cell. Prokaryotic organisms do not have organelles and thus do not have ...

Homeostasis

...pothesis , James Lovelock stated that the entire mass of living matter on Earth (or any planet with life) functions as a vast organism that actively modifies its planet to produce the environment that suits its needs. In this view, the entire planet maintains homeostasis. Whether this sort of system is pres...

Blood type

...i , A , and B . The gene encodes a glycosyltransferase , an enzyme that modifies the carbohydrate content of the red blood cell antigens. The gene is lo...s. For instance, the B allele must be present to produce the B enzyme that modifies the H antigen to become the B antigen. It is the same for the A allele. H...

Endoplasmic reticulum

...eticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in all eukaryotic cells . The ER modifies proteins , makes macromolecules , and transfers substances throughout the cell. Prokaryotic organisms do not have organelles and thus do not have ...

Endoplasmic reticulum

...eticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in all eukaryotic cells . The ER modifies proteins , makes macromolecules , and transfers substances throughout the cell. Prokaryotic organisms do not have organelles and thus do not have ...

Endoplasmic reticulum

...eticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in all eukaryotic cells . The ER modifies proteins , makes macromolecules , and transfers substances throughout the cell. Prokaryotic organisms do not have organelles and thus do not have ...
modifies in Biological Dictionary

Sympatric

... same or ... Pronunciation of sympatric . sympatric synonyms. sympatric usage examples and sympatric quotes. ... sympatric Usage Examples. modifies a noun ... We provide free short urls for web forwarding and web redirection. ... 79 degrees west by 72 degrees south. six song cd. ep now availabl...

Run-on

... the Right Fuel for ... Definition of run - on from Webster's New World College Dictionary. Meaning of run - on . ... run - on Usage Examples. modifies a noun ... ...

Kinase

...h as ATP, to specific substrates. The process is referred to as phosphorylation. An enzyme that... A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein (subst...

Initiator tRNA

...ransfer ribonucleic acid (RNA) that Involvement of 16S rRNA Nucleotides G1338 and A1339 in Discrimination of Initiator tRNA ... This enzyme modifies exclusively the initiator tRNA in position 64 using 5 ... laboratory for expression of the human initiator tRNA gene in yeasts. ... ...

Heterotrophic

...Water Quality and Human... heterotrophic synonyms. heterotrophic usage examples and heterotrophic quotes. ... heterotrophic Usage Examples. modifies a noun ... Heterotrophic organisms on the other hand, cannot produce their own photo ... material in net primary producers or other heterotrop...

Ecdysone

...n larval housefly mitochondria. ... Pronunciation of ecdysone . ecdysone synonyms. ecdysone usage examples and ecdysone quotes. ... enzyme modifies the host hormone ecdysone to render it inactive. ... Find out about the science and chemistry of Ecdysone (20-hydroxyecdysone), see colourf...
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Breaking Biology News(10 mins):A semi-artificial leaf faster than 'natural' photosynthesis 2
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