Stem cell microenvironment reverses malignant melanoma
Northwestern University researchers have demonstrated how the microenvironments of two human embryonic stem cell (hESC) lines (federally approved) induced metastatic melanoma cells to revert to a normal, skin cell-like type with the ability to form colonies similar to hESCs. The researchers also showed that these melanoma cells were less invasive following culture on the microenvironments of hESC...Stem cell identity in culture may strongly depend on the cellular microenvironment
Identification, isolation and large scale culture of stem cells for potential medical applications is a major challenge in cell biology. In an upcoming PLoS ONE paper, researchers, including Andras Paldi, in Genethon (Evry, France) report, on the basis of experimental observations and computer simulations, that the stem cell identity in culture may strongly depend on the cellular microenvironment...Cell’s microenvironment linked to cancer
"Medical research has for decades focused on finding the underlying genetic abnormalities that cause disease, but //this work demonstrates that genes themselves are controlled by components outside the nucleus and these, in turn, are regulated by the cell's microenvironment," said researcher Maniotis. Research finding at the University of Illinois, Chicago has found that tumor maligna...