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microenvironment in Medical News

Stem cells and leukemia battle for marrow microenvironment

Learning how leukemia takes over privileged "niches" within the bone marrow is helping researchers develop treatment strategies that could protect healthy blood-forming stem cells and improve the outcomes of bone marrow transplantation for leukemia and other types of cancer. In a paper in the ...

Cell’s microenvironment linked to cancer

"Medical research has for decades focused on finding the underlying genetic abnormalities that cause disease, but //this work demonstrates that genes themselves are controlled by components outside the nucleus and these, in turn, are regulated by the cell's microenvironment," said researcher Maniot...

DFG establishes nine new collaborative research centers

...transcendence and public spirit in society and more-precise research of the microenvironment of tumours. Two of the nine new centres are Transregional Collaborative Res...anisms that cause and affect the interaction between cancer cells and their microenvironment on a molecular level. At the forefront will be the research of molecular mo...

Where tumor cells boldly go: Weill Cornell cancer biologists shed light on the metastatic niche

...me time," he continues, "the challenge is to understand metastasis in its entirety by familiarizing ourselves with the shifting molecular and cellular microenvironment at each step along the way. The ramifications of this approach for cancer treatment, we believe, are inestimable." The Lyden lab at Weill Cornell w...

New test may predict spread of breast cancer

...e for Integrative Cancer Research at MIT published in Developmental Cell in December. A site with these three cells constitutes what is called a tumor microenvironment of metastasis, or TMEM. The NewYork-Presbyterian/Weill Cornell investigators, aided by the Einstein and MIT scientists, then developed a tissue test...

JCI online early table of contents: March 9, 2009

...marrow. When MuPAR was deleted or inhibited, HSPC proliferation was increased, but the ability of these cells to home and adhere to the bone marrow microenvironment was inhibited. Furthermore, the authors show that MuPAR is inactivated by plasmin, which triggers HSPC mobilization. Finally, loss of the gene encodin...

World first treatment for leukemia being developed in Australia

...r Louise Purton and Dr Maria Askmyr from St Vincent's Institute, the groups are among a handful world-wide investigating the impact of the bone marrow microenvironment on leukaemia development and progression a relatively new field of study. "Armed with our understanding we're planning to be among the first in th...

Penn vet researchers identify a critical growth factor that stimulates sperm stem cells to thrive

...ful new model in the study of stem cells and shows they interact with their microenvironment called the "niche." Future studies can now be performed in a stem cell-nich...oduction but in all adult stem cell systems." All stem cells reside in a microenvironment generated by the cells that surround them, known as the stem cell "niche." ...

Cell microenvironments hold key to future stem cell therapies

...on the road to finding out. Working with unique microenvironment microarrays (MEArrays) of their own creation, LaBa...ed combinations of components in the human mammary microenvironment that impose distinct cell fates. These results are...ult stem cells are maintained inside a specialized microenvironment called a niche, whereas progenitor cells migrate t...

Genyous Biomed Announces Private Placement Financing

...nic diseases. These multivalent therapies were designed using a systems biology strategy that takes into consideration crosstalk between cells, their microenvironment and the host organism (e.g. the immune system response). The comprehensive therapeutic activity profile of MFMT(TM) drugs represents an opportunity t...
microenvironment in Medical Technology

Helix Biopharma to Present L-DOS47 Lung Cancer Research Findings at the Fourth International Conference on Tumor Microenvironment in Florence, Italy

- Helix BioPharma Corp. (TSX: HBP /Frankfurt: WKN 918864) AURORA, ON, March 5 /CNW/Dr. Heman Chao, Vice President of Research at Helix BioPharma Corp., a developer of novel cancer therapeutics, will be presenting a scientific poster at the Fourth International Conference on Tumor Microenvi...

CEL-SCI to Present Data from Multikine Clinical Trials at National Institutes of Health (NIH), National Cancer Institute (NCI) Seminar Series

...e objectives of the collaborative study between the NIH, NCI under a current Material Transfer Agreement. This work is aimed at elucidating the tumor microenvironment changes, at the molecular level, brought about by Multikine treatment of head and neck cancer patients. The CEL-SCI / NIH collaborative study will us...

HEALTHPOINT-Sponsored Venous Leg Ulcer Clinical Trial Enrolls First Subject for Second Phase II Study

...mal keratinocytes and dermal fibroblasts. Based on in vitro studies, HP802-247 is expected to release various growth and angiogenic factors into the microenvironment of the wound through administration of these living, metabolically active, but nonproliferating cells that are trapped on the wound surface in a thin ...

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

...hers from Peregrine, Affitech and UT Southwestern Medical Center confirmed previous observations that in vitro, anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, most likely via cell-mediated mechanisms such as antibody-...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

...s to Reverse the Immune Suppressing Effects of Tumors by Changing the Tumor microenvironment and Mobilizing Key Components of the Immune System - - Studies Confir...evious observations that in vitro , anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting ant...

Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483

...urface protein known as tissue factor (TF). After binding to TF, Factor VII becomes activated and triggers a host of pathologic processes in the tumor microenvironment that facilitate the growth, invasion and spread of many cancers. Activation of Factor VII (Factor VIIa) by TF also leads to the high incidence of thro...

CEL-SCI Enters Agreement With National Institutes of Health Clinical Center To Determine the Molecular Basis of Multikine Anti-Tumor Effect

...ook for molecular genomic differences in the tumor microenvironment in patients with squamous cell carcinoma of the he...rial. "Multikine's potential to change the tumor microenvironment and, in doing so, break tumor tolerance has been a...ecular basis of Multikine's ability to cause tumor microenvironment changes," said Dr. Talor, Senior VP of Research an...

Peregrine Researchers Present New Preclinical Data at AACR Annual Meeting Confirming Unique Anti-Tumor Mechanism of Bavituximab

...ximab Causes Pro-Inflammatory Effects in the Tumor microenvironment That May Contribute to Its Anti-Tumor E...ibody in Phase II cancer trials, affects the tumor microenvironment and contributes to its anti-tumor efficacy. The re...argeting of phosphatidylserine produces a cytokine microenvironment that enhances innate anti-tumor immune responses, ...

Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference

... - New Approach to Targeting the Tumor microenvironment - SAN DIEGO, April 15 /PRNewswire-FirstCall/ -- ...ased matrices surrounding tumor cells in the tumor microenvironment of prostate tumors following systemic administrati... goal of understanding the role of HA in the tumor microenvironment and mechanism of action of PEGrHuPH20" said Gregor...

Northwest Biotherapeutics Conducting Ovarian Cancer Clinical Trial With DCVax(R)-L at University of Pennsylvania

...the low doses of two drugs intended to keep the immune system and the tumor microenvironment in a beneficial condition. The second study, which will be a follow-on to...ory cells to the tumor vasculature; the role of tumor vasculature and tumor microenvironment in controlling the outcome of antitumor immune response and immune therapy;...
microenvironment in Biological News

Gene activity reveals dynamic stroma microenvironment in prostate cancer

HOUSTON -- (June 9, 2009) As stroma the supportive framework of the prostate gland react to prostate cancer, changes in the expression of genes occur that induce the formation of new structures such as blood vessels, nerves and parts of nerves, said researchers at Baylor College of Medicine in ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

In the work defended at the University of the Basque Country (UPV/EHU), an in vitro culture model of human colon cancer was created in order to reproduce the gene regulation that is expressed in these cancer cells during their growth as metastasis in the liver of patients. This in vitro culture mo...

Stem cell microenvironment reverses malignant melanoma

Northwestern University researchers have demonstrated how the microenvironments of two human embryonic stem cell (hESC) lines (federally approved) induced metastatic melanoma cells to revert to a normal, skin cell-like type with the ability to form colonies similar to hESCs. The researchers also sh...

Xie Lab uncovers molecular machinery related to stem cell fate

... between self-renewal and differentiation by promoting proper expression of E-cadherin a molecule crucial to the stem cell's ability to attach to its microenvironment (its niche). "Our studies contribute to the understanding of stem cell fate control," said Run Shen, Ph.D., Postdoctoral Research Associate in th...

UCLA cancer researchers develop model that may help identify cancer stem cells

...t that was as close to that in which the tumor grows as possible. By using the fluid from the pleural effusions, Batra hoped to be able to create a microenvironment in which the tumor cells would remain heterogeneous and enable researchers to more easily identify candidate cancer stem cells. "Using the same en...

Tips from the American Journal of Pathology

...fore examined caveolin-1 expression in the stromal microenvironment of human breast cancer. Stromal expression of cav...fore function as a tumor suppressor in the stromal microenvironment and serve as a new prognostic marker for breast ca... of the AJP provide additional validation that the microenvironment is an important and potentially powerful source of...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...s and Affitech A/S used a fully human anti-PS antibody, PGN635, to confirm previous observations that in vitro, anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, most likely via cell-mediated mechanisms such as antibody-...

New lab evidence suggests preventive effect of herbal supplement in prostate cancer

...ll cultures were treated with red clover isoflavones, the androgenic effects of DHEA were reversed. "Something is happening in the prostate tissue microenvironment that is illustrating a potential cancer prevention effect from this supplement," said Arnold. Red clover isoflavones may modify androgenic effects...

Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche

...on the paper. A better understanding of the HSC niche may lead to more effective bone marrow transplants since a more precise understanding of the microenvironment that nurtures these therapeutically valuable cells will give physicians greater control over the entire process. "The new technique developed in t...

Einstein researchers develop a new way to study how breast cancer spreads

...cating that they are disseminated throughout the body. As co-lead author, Bojana Gligorijevic Ph.D., explained, "Our work showed how important the microenvironment of a tumor is to the behavior of a cancer cell and the metastatic outcome of the tumor itself. We can now look at the early steps of metastasis in hig...
microenvironment in Biological Technology

Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies

...ers. This exciting technology is based on proprietary discoveries concerning the importance of stromal factors uniquely present within the surrounding microenvironment of malignant tumors. About Morphotek Morphotek((R)), Inc., a subsidiary of Eisai Corporation of North America, is a biopharmaceutical c...

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

... lung cancer cells in a manner that leads to their death. Among these theorized effects, L-DOS47 is believed to stimulate an increase in the pH of the microenvironment surrounding the cancerous cells, effectively reversing the acidic extra-cellular conditions that are known to be necessary for cancer cell survival. A...

Johnson & Johnson Announces Definitive Agreement to Acquire Cougar Biotechnology, Inc.

...rch & Development. "We are developing new treatments that we anticipate will change the course of cancer treatment by targeting the tumor and its microenvironment and thereby will provide a meaningful difference in the lives of millions of patients worldwide." Alan H. Auerbach, Chief Executive Officer, Pre...

Omnitura Therapeutics Announces Private Placement Financing

... Genyous Biomed International Inc., were designed using a systems biology strategy that takes into consideration crosstalk between cancer cells, their microenvironment and the host organism (e.g. the immune system response). The comprehensive therapeutic activity profile of MFMT(TM) drugs represents an opportunity t...

Frost & Sullivan Acknowledges ISTO Technologies' Role in Developing Advanced Biologic Products for Bone Healing

...o-glycolide (PLGA) and hyaluronic acid (HyA)," explains Frost & Sullivan Research Analyst Pramodh Ishwarakrishnan. "The unique InQu scaffold creates a microenvironment that is both biocompatible and conducive to new bone formation." These two major components of the scaffold have specific contributions to the overa...

Helix BioPharma to Present L-DOS47 Research Findings at the National Research Council of Canada's Eighth Annual General Meeting of the Genomics and Health Initiative in Saskatoon, Canada

... lung cancer cells in a manner that leads to their death. Among these theorized effects, L-DOS47 is believed to stimulate an increase in the pH of the microenvironment surrounding the cancerous cells, effectively reversing the acidic extra-cellular conditions that are known to be necessary for cancer cell survival. A...

Halozyme Therapeutics Reports 2008 First Quarter Financial Results

... studies explored the physiologic responses to enzymatic removal of hyaluronic acid (HA)-based matrices surrounding tumor cells in the tumor microenvironment of prostate tumors following systemic administration of its pegylated rHuPH20 (PEG PH20) pre-clinical candidate. The objectives of these st...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

...ty to survive. The organization will combine the microenvironment disruptive agents (MDAs) resulting from this appro...uence the interaction between cancer cells and the microenvironment to induce cancer cell death. The presentations inc...ay that regulates inhibition of signaling from the microenvironment to block cancer cell development and metastasis; b...

Peregrine Pharmaceuticals Announces Four Upcoming Presentations at the American Association for Cancer Research 2008 Annual Meeting

...on) - Oral presentation scheduled for Monday, April 14, 2008 at 2:10 pm. -- "Antibody targeting of phosphatidylserine produces a cytokine microenvironment that enhances innate anti-tumor immune responses" (Abstract #4079, Immunoconjugates, Peptides, and Protein Therapeutics Session) - Poster se...

Helix BioPharma Corp. contracts KBI Biopharma to develop an L-DOS47 clinical packaging format

... lung cancer cells in a manner that leads to their death. Among these theorized effects, L-DOS47 is believed to stimulate an increase in the pH of the microenvironment surrounding the cancerous cells, effectively reversing the acidic extra-cellular conditions that are known to be necessary for cancer cell survival. A...
microenvironment in Biological Products

NeuroCyte - Rat Neural Stem Cell Kit from Orion BioSolutions, Inc.

Description:...tem and progenitor cells. Using purified ECM components found in basement membranes in vivo, and our tissue-engineering expertise, we have recreated a microenvironment in vitro with the key molecules found in the germinal centers of the brain during fetal development. This process supports a unique mix of nestin expr...
Company:Orion BioSolutions, Inc.
microenvironment in Biological Dictionary

T cell

...es, research information, and more. ... Search " T cell " Get Motorola RAZR V3t Black ... T cell development occurs in the thymus; the thymic microenvironment directs ... T cell precursors enter the subcapsular cortical areas, where they encounter ... Yet, these T cells do not attack healthy parts...
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