mice

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

In experiments with mice, a team of scientists from the United States, Sweden and Japan has discovered that having a double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-causing genetic mutation will trigger a tumor there. Roughly 10 percent of people have this double protein dose as well. In...

Novel antiviral technology inhibits RSV infection in mice

A novel antiviral treatment combiningnanoparticle and gene silencing technologies thwarts attacks ofrespiratory syncytial virus (RSV) -- a virus associated with severebronchitis and asthma, an animal study by University of South Floridaresearchers found. The study was reported in the January 2005 issue ofthe journal Nature Medicine.RSV infects lung cells and can be life-threatening in very...

Signaling protein builds bigger, better bones in mice

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

A molecule designed to block cat allergies successfully prevented allergic reactions in laboratory mice, as well as in human cells in a test tube, University of California, Los Angeles (UCLA) researchers report in the April issue of Nature Medicine, available online now. In the future, the investigators say, these promising results could lead to a new therapy not only for human cat allergies, but...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

Gene therapy methods that specifically target muscle may reverse the symptoms of a rare form of muscular dystrophy, according to new research in mice conducted by medical geneticists at Duke University Medical Center. Infants born with the inherited muscular disorder called Pompe disease usually die before they reach the age of two. The researchers also said their approach of targeting corrective...

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mice at Biology Products

Rotarod Treadmill one unit for mice and rats from IITC Life Science

Description:The IITC Life Science Rotarods are used to assess the effect of drugs on the motor coordination or fatigue resistance on mice and rats using one unit in a safe and humane way. Extremely user friendly; the animals are placed on textured drums to avoid slipping. When an animal drops onto the individual sensing platforms below, its test results are recorded. • IITCs Rotarod test has the capabil...
Company:IITC Life Science

mice at Biology Technology

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice orRats Precise and cost-effective micronucleus analysis made easy with theicroFlow Micronucleus Analysis Kit Litron Laboratories, Rochester, NY Mark J. Dycaico<br...

Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice

Andrew Conn, Lindy Durrant, and Ian Spendlove, Cancer ResearchCampaign Academic Unit, Nottingham City Hospital, Hucknall Road,Nottingham NG5 1PB, UK Gene gun immunization through the skin is a reliable and reproducible method of DNA vaccine delivery, and has been shown to be capable of inducing...

Cancer treatment advances as trials show no harm to mice

said at a recent conference. Information supporting this conclusion was presented on October 7 at Bi...

mice at Medicine News

Experimental treatment for Ebola Virus Shows promising results in mice

Scientists at the Center for Disease Control and Prevention (CDC) in Atlanta, Georgia, have said that an experimental treatment for the deadly Ebola virus has shown promising results in mice. In the study, researchers led by Dr. Manish Gupta took antibodies from the immune systems of mice that had survived infection with the deadly Ebola virus and injected them into other Ebola-free mice...

Gene block keeps mice from increasing weight

Researchers at the University of Wisconsin have observed that mice lacking a specific gene can eat a high-fat diet without either putting on weight or developing diabetes. The gene called SCD-1 codes for a protein which the body needs to make the fatty acids found in fat tissue.//They have created a 'knockout' mouse that lacks SCD-1. Such animals can eat a rich, high-fat diet but do not p...

Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice

Researchers have reported in the February issue of PNAS that understanding and treating cholesterol-related illnesses in humans may now be easier with the discovery of a receptor in the cells of mice that protects them from toxins. Researchers discovered the receptor during a study of cerebrotendinous xanthomatosis (CTX), a rare and often fatal disorder caused by excessive cholesterol met...

New breed of mice to live longer

Scientists had successfully created a new breed of mice that can reduce free radicals at the cellular level to extend life for themselves.// The reactive oxygen of the free radicals are known to damage cells and tissues that may lead to poor health and even death. The new research may be the first step towards increasing mortality through the free radical theory of ageing. Th...

And now its super mice for longer memory

In a landmark breakthrough, scientists have created mice with unusually long memories raising hopes of people with severe forgetfulness and also opening a possibility of helping people forget their distressing past. “This study has given us a new insight into the molecular processes that govern memory and learning in the brain,” said Isabelle Mansuy, of the Swiss Federal Institute of Tec...

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Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice

THE WOODLANDS, Texas--(BUSINESS WIRE)--Jun 27, 2007 - OpexaTherapeutics, Inc. (NASDAQ:OPXA), a company involved in thedevelopment and commercialization of cell therapies, presentedposter presentations at the 5th International Society for Stem CellResearch Annual Meeting (ISSCR) in Cairns, Queensland, Australiafrom June 17-20 and at the 13th Annual Meeting of the InternationalSociety for Cel...

NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans

BETHESDA, Md., June 11, 2007--A team of researchers at theNational Cancer Institute (NCI), part of the National Institutes ofHealth (NIH), has uncovered a set of genes that are turned on, orexpressed, at high levels only in the blood vessels that feedtumors in mice and humans. These genes, and the proteins theyencode, are important new potential targets for novel drugs thatcould selectiv...

Vision Deficit in Retinitis Pigmentosa Mice Corrected with DNA Nanoparticles

CLEVELAND--(BUSINESS WIRE)--Jun 4, 2007 - Copernicus Therapeutics,Inc. announced today that a research team at University of OklahomaHealth Sciences Center, led by Dr. Muna Naash, Professor of CellBiology, demonstrated that Copernicus' DNA nanoparticles correctedvision defects in a mouse model of retinitis pigmentosa (RP). Thesefindings were presented at the American Society of Gene Therapy...

Peramivir Protects Mice From Lethal H5N1 Infection

St. Jude study shows intramuscular injection of peramivir for eightdays protected mice from lethal H5N1 influenza virus infection andinhibited virus replication, supporting the use of this drug tocontrol influenza during a pandemic MEMPHIS, Tenn., May 01, 2007 /PRNewswire-USNewswire/ -- Theantiviral drug peramivir might offer humans significant protectionduring a pandemic of the avian inf...

Cellerant Therapeutics Reversed Autoimmune Disease in Lupus Mice with Transplant of Purified Donor Blood Stem Cells

SAN CARLOS, Calif.--(BUSINESS WIRE)--Apr 23, 2007 - CellerantTherapeutics today announced the publication of data suggestingthat established autoimmune disease can be reversed or stabilizedby the transplantation of purified allogeneic (donated)hematopoietic (blood forming) stem cells (HSC) in a mouse study ofSystemic Lupus Erythematosus (SLE). Subjects that underwent thisprocedure exhibited...

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