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miRNAs in Medical News

Study Shows a Link Between Schizophrenia & Genetic Mutations

...n, neurological diseases and cancer, suggesting wide ranging involvement of mirnas in disease. In this study, the sequences of 59 miRNA genes on th...A function or expression levels. The overwhelming majority of the mirnas are NOT on the X-chromosome, so it is possible that mutations in the miRNA ...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

...tune protein levels in all cells of the body. The GICD team discovered that mirnas control VSMC differentiation and growth. Gene expression is the process... as templates for protein production. The current study found that two mirnas in particular, miR-143 and miR-145, are part of a molecular switch that det...

Study shows promise for new cancer-stopping therapy

...cell development and cell balance. Dysfunction of mirnas has been linked to multiple human diseases includi...utism and cancer. "The pattern of expression of mirnas has emerged as critically useful information for u...gnificant work to be done both in identifying such mirnas and optimizing their delivery, our findings highli...

NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO

...ic melanoma patients. Higher levels of 18 specific mirnas were associated with surviving more than 18 months...luating whether 10 of these co-called "protective" mirnas identified in the study can help predict the likel...8 months after cancer recurrence and whether these mirnas may help predict the aggressiveness of the disease...

InteRNA Technologies and Radboud University Nijmegen Medical Centre to Develop microRNA-based Therapeutics for Prostate Cancer

...y explores and exploits opportunities to translate its unique collection of mirnas and miRNA discovery and validation technologies into successful diagnostic,...ions. The company's primary focus is to unravel the role of its proprietary mirnas in cancer. InteRNA Technologies was incorporated in 2006 by Aglaia O...

MicroRNA undermines tumor suppression

...archers have previously identified other genes and mirnas that indirectly affect p53's activity. CAMBRI...archers have previously identified other genes and mirnas that regulate p53's activity indirectly. "For c...or protein creation. To investigate whether any mirnas directly affect p53, Le, who is a joint graduate s...

Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Research Awards

...nvestigate "MicroRNA Regulation in Idiopathic Pulmonary Fibrosis." Preliminary data from the OSU laboratory indicate that the expression of several mirnas -- small regulatory RNAs that regulate gene expression -- encoded by the "miR-17~92 cluster" are decreased in the lungs of IPF/ILD patients, as well a...

Michael J. Fox Foundation Awards $2.5 Million for Parkinson's Drug Development Projects Led By Academic Investigators

... projects are listed below. Detailed information, including grant abstracts and researcher bios, is available at www.michaeljfox.org . Modified mirnas Targeted at Alpha-synuclein as PD Therapy Asa Abeliovich, MD, PhD, Columbia University Pre-clinical Characterization of 5-HT1A/1B Receptor ...

Wyeth Pharmaceuticals and Santaris Pharma Announce Strategic Alliance to Develop RNA-based Medicines

...asses of RNA targets for this collaboration. messengerRNAs and microRNAs. mirnas are recognized as important elements in regulation of gene expression in bo...g Platform used to develop new classes of RNA medicines targeting mRNAs and mirnas associated with disease. Santaris Pharma's drug discovery engine provides ...

Harnessing miRNA natural gene repressors for anticancer therapy

...xpression of genes for therapeutic purposes, and used this to mediate effective anticancer therapy in mice. Small, noncoding RNA molecules known as mirnas are powerful natural repressors of gene expression. In the study, the miRNA miR-181a was harnessed to segregate expression of genes in immune cells kn...
miRNAs in Medical Technology

Another LNA-based RNA Inhibitor Enters Clinical Trials

...rivately held biopharmaceutical company with exclusive rights to use the LNA Drug Platform to develop new classes of RNA medicines targeting mRNAs and mirnas associated with disease. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic disorders. In add...

InteRNA Technologies and VU University Medical Center to Develop microRNA-Based Diagnostics and Therapeutics for Cancer

...says to identify the biological role of individual mirnas and novel therapeutic targets in leukemia, colon, ...pportunities to translate its unique collection of mirnas and miRNA discovery and validation technologies in...ry focus is to unravel the role of its proprietary mirnas in cancer. InteRNA Technologies was incorporated...

Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center

..., thus comprising an up till now hidden level of regulation. Interestingly, mirnas have already been found to play important roles in several types of cancers and in processes involved in cellular differentiation. In the cell, mirnas are found in form of single-stranded RNA molecules, which are typically 20-...

Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity

...oimmune disorders, these findings further validate mirnas as disease targets and point to new potential ther...t represents the first clear example of a role for mirnas in the immune response to antigens." "In our ...uthor of the publication. "Alnylam's research on mirnas derives from our discovery of antagomirs, a novel ...

Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression

...ements in this release concerning Rosetta's future expectations, plans and prospects, including without limitation, statements relating to the role of mirnas in human physiology and disease and the potential of microRNAs in the development of therapeutics and diagnostic products constitute forward-looking s...
miRNAs in Biological News

MicroRNAs help control HIV life cycle

...fectivity was reduced or eliminated. In addition, the team suppressed P-bodies in the cells and noted a similar effect. This suggests that HIV may use mirnas to become dormant and escape immune response. ...

Research uncovers clues to virus-cancer link

...s accurately identify stages of tumor progression. They found that certain mirnas were lost as the tumors progressed, effectively accelerating the cancer's g...ry different types of cells," Dittmer noted. His team found that several mirnas known to suppress tumor activity were significantly less active in both typ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

...istant sites in the body. Though other researchers have found that altered mirnas contribute to breast cancer metastasis, this is the first study to examine ...ein expression, acting like the volume control on a radio. In recent years, mirnas have been linked to the over- or under-expression of a variety of genes lin...

Scientists identify novel inhibitor of human microRNA

... Ph.D., co-senior author of the study. Although mirnas were discovered less than two decades ago, their i... only a few hundred have been described. Thus, mirnas represent a largely unexplored class of targets fo... infancy, but its potential is tremendous. Because mirnas have the ability to shut down genes and prevent th...

Blood 'fingerprints' for cancer

...r a revolutionary non-invasive diagnostic tool. mirnas are a class of naturally occurring small non-codin...r development. Recent studies reporting individual mirnas as diagnostic biomarkers of specific cancers were unable to rule out the possibility that these mirnas appeared as a result of contamination. Chen-Yu ...

Two suppressor molecules affect 70 genes in leukemia

...bri says. They show that microRNAs can affect different biochemical pathways in different ways, and they explain at the molecular level what these two mirnas do in this disease. ...

Yale scientists show that a microRNA can reduce lung cancer growth

...le for a miRNA in cancer progression and introduces a new paradigm of using mirnas as effective therapeutic agents to treat human cancer. We believe this ... CEO of Asuragen. This work provides further evidence of the importance of mirnas in the development of cancer and provides additional support for miRNA repl...

Less can be more, for plant breeders too

...specific gene silencing using so-called artificial mirnas in rice (Oryza sativa). MicroRNAs are 20-22 bp ...he corresponding gene is silenced. With artificial mirnas (amiRNAs), this natural silencing pathway can be h...e function between different varieties, artificial mirnas also accelerate the initial identification of impo...

Genetic Engineering & Biotechnology News reports on advances in miRNA

...he effects of over- or underexpression of specific mirnas on the development and inhibition of pathogenesis ...ological disorders as well as on aging. As more mirnas are identified, researchers are correlating change... metastasis. Also covered in the GEN article on mirnas is research taking place at Asuragen, the Universi...

Making sense of antisense microRNAs

... the antisense miRNA causes subtle derepression of a hox gene and results in sterility of the mutant flies. The identification of additional antisense mirnas in Drosophila and mammals suggests this as a mechanism that may contribute to the diversification of miRNA function. ...
miRNAs in Biological Technology

Precursor miRNAs for Successful miRNA Functional Studies

Pre-miR miRNA Precursor Molecules miRNA target site identification and validation Screening for miRNAs that regulate target gene expression Screening for miRNAs that affect a cellular process ...

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

Ambion has developed a complete line of research tools for the analysis of microRNAs (miRNAs). Recently, we introduced the mir Vana miRNA microarray platform (consisting of the mir Vana miRNA Labeling Kit and the mir Vana miRNA Probe Set...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...genesis. BMC Med Genomics In June 2009 Santaris Pharma and academic partners published an article titled: Identification and analysis of mirnas in human breast cancer and teratoma samples using deep sequencing. During H1 2009 the Company made presentations at several scientific conferen...

LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit

...ris Pharma (founded in 2003) is a privately held biopharmaceutical company developing new classes of RNA medicines targeting disease-related mRNAs and mirnas based on its proprietary LNA Drug Platform. The Company's own research and development activities focus on microRNAs, infectious diseases and metaboli...

Santaris Pharma Director Appointed Adjunct Professor in RNA Biology at the University of Aalborg, Denmark

...ris Pharma (founded in 2003) is a privately held biopharmaceutical company developing new classes of RNA medicines targeting disease-related mRNAs and mirnas based on its proprietary LNA chemistry. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic di...

Santaris Pharma Delivers Six LNA-Based RNA Inhibitors to Enzon Pharmaceuticals Ahead of Schedule

...ris Pharma (founded in 2003) is a privately held biopharmaceutical company developing new classes of RNA medicines targeting disease-related mRNAs and mirnas based on its proprietary LNA chemistry. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic di...

LNA-Based RNA oligonucleotides Potently Inhibit Cancer microRNAs

...nded in 2003) is a privately held clinical stage biopharmaceutical company developing new classes of RNA medicines targeting disease-related mRNAs and mirnas based on its proprietary LNA chemistry. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic di...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

...iRNA expression clone collections cover all known mirnas for human (750), mouse (450), and rat (270). These...ression constructs allow efficient transduction of mirnas into dividing and non-dividing cells transiently o...ch allows specific and sensitive quantification of mirnas individually or in an array format. GeneCopoe...

Interim Report for the Period 1 January - 30 September 2008 (Unaudited)

...the third quarter of 2008 Exiqon expanded its product line for detection of mirnas by a new miRNA array that allows for simultaneous screening of more than 1300 different mirnas and the expansion of our real-time PCR offering for quantitative analysis o...

Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D.

...interfering RNAs to confer in vivo protection from viral disease. In related work, Dr. Lieberman's laboratory is also working in the emerging field of mirnas by developing their potential as diagnostic and therapeutic tools. Professor Patrice Courvalin, M.D., is head of the Antibacterial Agents Unit at th...
miRNAs in Biological Products

mirVana™ qRT-PCR Primer Set for Normalization (5S) from Ambion

Description:... Quantitative results in less than 3 hours Detection from as little as 25 pg of total RNA Specific primers available for hundreds of mammalian mirnas Suitable for either real-time or end-point RT-PCR Ideal for validating expression profiling data and high-throughput applications ...
Company:Ambion

miRCURY LNA Northern Blotting Detection probes from Exiqon

Description:...ional probes. Furthermore, the exposure time is reduced to just a few hours. Pre-designed miRCURY LNA Detection probes are available for all known mirnas in invertebrates, vertebrates and plants, as annotated in the miRNA Registry at The Wellcome Trust Sanger Institute. Custom miRCURY detection probes a...
Company:Exiqon

miRCURY LNA in situ Detection probes from Exiqon

Description:... situ detection probes are available for all known mirnas in invertebrates, vertebrates and plants, as regis...IG*, biotin, fluorescence. Detect low abundance mirnas Probes available for all mirnas Single- or dual-base discrimination Probes a...
Company:Exiqon

microRNA Expression Profiling - Comprehensive Service from LC Sciences

Description:...NA) expression profiling service using Paraflo technology and proprietary probe design, which enable highly sensitive and specific direct detection of mirnas (1-3). We have standard arrays for mature miRNA of all species available in the latest version of the Sanger miRBase database (Release 8.2). Our servi...
Company:LC Sciences

miRCURY LNA Array microarray slides from Exiqon

Description:...chment) labeled using the miRCURY Array labeling kit. The miRCURY LNA microarray slides consist of LNA capture probes for all human, mouse and rat mirnas as well as a number of control probes and can be used in combination with standard microarray slides and microarray analysis instruments and software....
Company:Exiqon
miRNAs in Biological Dictionary

Unicellular

...RNAs in a unicellular organism. This is the first finding of microRNAs in a unicellular organism. ... The researchers showed that unicellular mirnas share functional characteristics ... ...

MicroRNA

...molecules of 21-23 nucleotides in length, which regulate gene expression. mirnas are encoded by genes from whose DNA they are transcribed but mirnas are not translated... A gateway to all types of information about microR...
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