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metastasized in Medical News

Chicago team uses artificial intelligence to diagnose metastatic cancer

...ctly affects how her doctors will approach treatment -- which may in turn influence the outcome of that treatment. Determining whether a tumor has metastasized is not always straightforward, however. Radiologists often start by using diagnostic ultrasound to non-invasively probe the nearby lymph nodes -- tiss...

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

... "We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis m...marrow and promoted cell survival. Further, Src increased the resistance of metastasized breast cancer cells to a key cell death-inducing signal that was abundantly...

Research Reveals Clues to Breast Cancer's Spread

... treatments to prevent breast cancer's return, according to the researchers. "We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a breast tumor," senior study ...

RNA snippet suppresses spread of aggressive breast cancer

...ells into mice, the cells formed highly aggressive tumors. Mice injected with the cancer cells lacking miR-31 had 6 to 10 times more cancer cells that metastasized to their lungs than did their counterparts implanted with unmodified cancer cells. To see how increasing miR-31 levels could affect metastasis, Val...

Stem Cell Study Offers Hope for Targeting Tumors

... the specialized cells shrunk subcutaneous breast tumors by about 80 percent, and when injected intravenously, they helped destroy about 38 percent of metastasized lung tumors in rodents. The study results combined findings from two previous areas of research: one that found that mesenchymal stem cells (MSCs)...

Mayo Clinic Researchers Say Triple Drug Combination is Promising Option to Treat Metastatic HER2+ Breast Cancer

...ion in the size of the metastatic tumor of more than 30 percent by computed tomography. Four patients had a complete response with no more evidence of metastasized tumors on diagnostic scans, the researchers say. Average survival was improved when compared historically to traditional treatment, Dr. Tan says. "N...

Triple drug combination is promising option to treat metastatic HER2+ breast cancer

...ion in the size of the metastatic tumor of more than 30 percent by computed tomography. Four patients had a complete response with no more evidence of metastasized tumors on diagnostic scans, the researchers say. Average survival was improved when compared historically to traditional treatment, Dr. Tan says. "N...

MIT's implantable device offers continuous cancer monitoring

...ide up-to-the-minute information about what a tumor is doing whether it is growing or shrinking, how it's responding to treatment, and whether it has metastasized or is about to do so. "What this does is basically take the lab and put it in the patient," said Cima, who is also an investigator at the David H. ...

American Urological Association/Engineering & Urological Society 2009 -- news tips

...s have speculated that this vulnerability may be responsible for the high cure rates observed in men with testicular cancer, even when this cancer has metastasized throughout the body. Wondering whether heat has a similar effect on prostate cancer cells, Zeng and his colleagues warmed cells sampled from patien...

Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation

...age of five, are diagnosed with neuroblastoma in the United States each year. Close to two-thirds of these children are diagnosed after the cancer has metastasized to other parts of the body. For these patients with high-risk neuroblastoma, long-term survival is less than 40 percent because the tumors are often r...
metastasized in Medical Technology

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

...monstrate that inhibiting RANK Ligand with denosumab provides a clinically meaningful benefit for advanced cancer patients with solid tumors that have metastasized to the bone, and to patients with multiple myeloma, both groups who routinely suffer SREs," said Roger M. Perlmutter, M.D., Ph.D., executive vice pres...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...he cancer is confined to the kidney, the five-year survival rate is 60 to 70 percent; but the survival rate is considerably lower after the cancer has metastasized to other parts of the body. Even with the recent approval of several biological therapies for the treatment of advanced metastatic RCC (VEGF inhibitor...

PSA Screening Cuts Deaths by 20%, Says World's Largest Prostate Cancer Study

...y initially screening men 55 to 69 years with the PSA marker and offering regular follow up, this led to an increase in early detection. Deaths due to metastasized disease were then reduced. Exact data showed that on average for every 1,408 men screened, 48 had cancer diagnosed and received treatment, resulting i...

Phase 1 Trial of Quadramet in Combination with Velcade Shows Positive Results

...amarium-lexidronam) is a radioactive medication that targets the bone, specifically bone cancer, and is used to treat pain caused by cancer that has metastasized or spread to the bone. Velcade (bortezomib) is approved for the treatment of multiple myeloma alone and in addition to chemotherapy. Preclinical...

Helix Biopharma to Present L-DOS47 Lung Cancer Research Findings at the Fourth International Conference on Tumor Microenvironment in Florence, Italy

...h show that L-DOS47 binds not only to primary lung adenocarcinoma tissues preferentially over a host of other cancerous or normal tissues, but also to metastasized cells in lymph nodes. The poster also highlights the ability of L-DOS47 to localize and concentrate in tumor tissues specifically following injection ...

Idera Pharmaceuticals Announces Presentations of Preclinical Data on New Potential Oncology Applications of its TLR9 Agonists at AACR

...tudy, the antitumor activity of a murine analog of IMO-2055 was examined following intranasal delivery in mouse models of colon carcinoma and melanoma metastasized to the lungs. Results show that the TLR9 agonist delivered by the intranasal route in the study lead to potent inhibition of lung metastases. About ...

Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and Effective in Colorectal Cancer with Liver Metastases

...uzumab, labeled with the radioisotope, iodine-131, was found to be safe and active when given in two doses to patients with colorectal cancer that has metastasized to the liver. Dr. Johannes Meller of the University of Gottingen, Germany, reported results from this study in an oral presentation at the 54th Annual...
metastasized in Medical Dictionary

Primary brain tumor

... cells to other sites in the ... Brain Tumors : Primary . Article Page Navigation. Introduction. Symptoms ... it may work more effectively for metastasized brain tumors than primary tumors . ... Glioblastomas are the most aggressive type of primary brain tumor . These may or may not arise ...
metastasized in Biological News

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

Few things about growing older are as inevitable and obvious as “going gray,?yet scientists have been unable to explain the precise cause of this usually unwelcome transformation. In a report posted today on the Web site of the journal Science, researchers from Dana-Farber Cancer Institute and Chil...

MIT’s implantable device offers continuous cancer monitoring

...ide up-to-the-minute information about what a tumor is doing whether it is growing or shrinking, how it's responding to treatment, and whether it has metastasized or is about to do so. "What this does is basically take the lab and put it in the patient," said Cima, who is also an investigator at the David H. ...

Stress may hasten the growth of melanoma tumors

...nterleukin-8, are both involved in fostering tumor growth. All three of the cell lines were grown from tissues taken from secondary tumors that had metastasized from a primary site and they signify aggressive forms of cancer. But one of them C8161 represented the most aggressive and advanced form of melanoma...

Novel technique changes lymph node biopsy, reduces radiation exposure

...nd Xia's lab invented the gold nanocages. Their work can minimize invasive surgical lymph node biopsy procedures to determine if breast cancer has metastasized and reduce the patient's exposure to radioactivity. The nanocages also have the potential to serve as an alternative to chemotherapy to kill targeted...

Novel technique changes lymph node biopsy, reduces radiaiton exposure

...nd Xia's lab invented the gold nanocages. Their work can minimize invasive surgical lymph node biopsy procedures to determine if breast cancer has metastasized and reduce the patient's exposure to radioactivity. The nanocages also have the potential to serve as an alternative to chemotherapy to kill targeted...

Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds

...is of and prediction of recurrence of this disease." The study analyzed the sensitivity and specificity of plasma DNA as a preoperative marker of metastasized disease and a postoperative marker in residual or recurrent esophageal cancer. Plasma DNA was measured in 45 patients with esophageal cancer and 44 he...

T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role

... even though our models survived longer, their tumor pathology worsened. Without T-cadherin-mediated vascularization, breast cancer cells consistently metastasized to the lungs, and this did not happen in the control mice where the tumors were highly vascularized. The reasons for this trend are not clear: loos...

CSHL scientists identify cells that promote formation of lethal lung metastases

...Cs, perhaps in combination with chemotherapy, may prove to be a clinically feasible approach in the treatment of people diagnosed with cancer that has metastasized to the lungs, Dr. Mittal said. Past experiences have highlighted the challenges associated with therapies that target genetically mutant cancer ce...

Purdue research finds similarities in dog, human breast cancer pre-malignant lesions

...h that may progress to cancer. Thirty percent to 50 percent of canine mammary tumors were malignant, and 50 percent to 75 percent of these recurred or metastasized within one to two years. "Women have become more aware and conscientious of conducting their own breast self-exams, and pet owners also are more aw...

Newly created cancer stem cells could aid breast cancer research

...g a particular population of cells from human breast tissue. After being injected with just 100 of these transformed cells, mice developed tumors that metastasized (spread to distant tissues). The operational definition of a cancer stem cell is the ability to initiate a tumor, so these are cancer stem cells, d...
metastasized in Biological Technology

OncologyRx Care Advantage(TM) Specialty Pharmacy Passes $15 Million Milestone in Patient Financial Assistance

...94. In 2003, doctors at Arizona Oncology, a community-based oncology practice affiliated with US Oncology, found that his renal cell carcinoma had metastasized to his lungs; by 2006, he was in the advanced stages of his disease. Reeder's physicians began treating him with Nexavar , an oral multiple k...

Oncolytics(R) Biotech Inc. Completes Patient Enrolment in U.S. Phase 2 Sarcoma Study

...lment in its multi-centre Phase 2 clinical trial to evaluate the intravenous administration of REOLYSIN(R) in patients with various sarcomas that have metastasized to the lung. A total of 52 patients have been enrolled in the trial. "We are extremely pleased to have had the opportunity to participate in this st...

Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008

... multicentre, Phase 2 clinical trial to evaluate the intravenous administration of REOLYSIN in patients with various sarcomas that had metastasized to the lung. We reported that of 33 patients evaluable for response, five had stable disease for more than six months, and an addition...

Oncolytics Biotech Inc.'s REOLYSIN(R) Exceeds Primary Statistical Endpoint in U.S. Phase 2 Sarcoma Study

...point in its multi-centre Phase 2 clinical trial to evaluate the intravenous administration of REOLYSIN(R) in patients with various sarcomas that have metastasized to the lung. "The proportion of patients on study with significant, durable, clinically meaningful responses is highly encouraging," said Dr. Fran...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

...eed to full enrolment in our U.S. Phase II trial to evaluate the intravenous administration of REOLYSIN(R) in patients with various sarcomas that have metastasized to the lung. According to the trial protocol, to proceed to full enrolment of 52 patients, we had to demonstrate that at least one patient in the fi...

Oncolytics Biotech Inc. Reports Highlights and Financial Results for 2007

...R) and chemotherapy trials in the U.K.; - Commenced patient enrolment in a U.S. Phase II trial for patients with various sarcomas that have metastasized to the lung; - U.S. National Cancer Institute (NCI) filed a protocol with the U.S. Food and Drug Administration (FDA) to conduct a Phase II mel...

Oncolytics Biotech Inc. Proceeds to Full Enrolment in U.S. Phase II Sarcoma Clinical Trial

...eed to full enrolment in its U.S. Phase II trial to evaluate the intravenous administration of REOLYSIN(R) in patients with various sarcomas that have metastasized to the lung. According to the trial protocol, to proceed to full enrolment of 52 patients, Oncolytics had to demonstrate that at least one patient i...
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