Opposing fat metabolism pathways triggered by a single gene
Regulating metabolism of fat is an important challenge for any animal, from nematodes to humans. Central players in the regulatory network are the nuclear hormone receptors (NHRs), which are transcription factors that turn on or off a set of target genes when bound by specific lipid molecules. In the premier open-access journal PLoS Biology, Keith Yamamoto and colleagues show that the nuclear hor...Attacks of King George III's madness linked to key metabolism molecule
PGC-1 mediates effects of nutrition on blood disease porphyria The me...Computational model simulates AZT metabolism in mitochondria
Researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a computational model that allows scientists to better understand the metabolism and toxicity of the HIV/AIDS drug zidovudine (azidothymidine, AZT). AZT is used successfully as part of Highly Active Anti-Retroviral Therapy (HAART) to control the level of the human immunodeficiency virus in HIV-infe...Researchers attack tumor cells by exploiting dependency on sugar metabolism
Although scientists have known for nearly 90 years that cancer cells commonly display altered sugar metabolism, the molecular significance of this phenomenon is not completely understood. Now, a new study published in the June issue of Cancer Cell reveals a functional connection between carbohydrate-driven energy production and tumor maintenance. Importantly, the results suggest that inhibition o...Huddling and a drop in metabolism allow penguins to survive the South Pole cold
March of the Penguins, the OscarĀ® winning documentary, showed how the emperor penguins endure their incubation and fast for four dark and bitterly cold months each year. The tight huddling among these South Pole penguins is a key energy-saving mechanism that allows them to endure their extremely harsh conditions. A team of scientists that had already shown that emperor penguins who are fr...In-Vitro Metabolism Studies Using Data-Dependent LC/MSn
P.R. Tiller, Thermo Finnigan W.H. Schaefer, D.M. Murphy, SmithKline Beecham Pharmaceuticals Metabolite Characterization The data presented here can be acquired using the Thermo Finnigan LCQ Series of ion trap mass spectrometers....Understanding The Link Between Movement And Metabolism
In a recent study researchers studied comparative energetics of both lean and obese adults to discover how everyday movements affect // metabolism. Results showed that NEAT -- non-exercise activity thermogenesis , creates a more effective metabolism than standard organized exercise. Researchers say calories people burn during everyday activities are more important than previously thought. They sa...Sleep cycles may be related to metabolism
US scientists have found out that mice with a mutation of a gene that controls the circadian clock tend to eat more and gain weight.// The circadian clock is a cellular mechanism that sets various rhythmic activities inside the organisms. It is this clock that sets the rhythm of sleep and wake patterns in all animals. In earlier studies, scientists had been able to find ou...Metabolism cycle of Kala-Azar parasite revealed
Researchers have found that Leishmania parasite utilizes mannose for their metabolism// and growth different from human metabolism which requires glucose. Associate Professor Malcolm McConville and his research team from Bio21 Institute at the University of Melbourne have found a break thorough to control the spread of the parasite Leishmania in the blood. Leishmania is found to utili...Adult and Children Have Varied Drug Metabolism
A new study led by Ronald Hines, professor of pediatrics at the Medical College of Wisconsin said that adult and children have very different drug metabolism. // Both have different levels of chemicals (enzymes) in their body for the processing of the drug. These enzymes vary in concentration with age. Hence this study suggests that more research is needed to understand how m...Caffeine metabolism tied to heart attacks
Your body cab decide whether you will be saved from heart disease if consume coffee.// Patients with non fatal heart attack in Costa Rica between 1994 and 2004 were studied and it was found that those with a gene variant that causes them to slowly metabolize caffeine have about a third greater risk of having a heart attack when they drank two or three cups a day, and 64 percent increa...Calcitonin EIA Bone and Mineral Metabolism 021-SDX017
Description:Calcitonin EIA Bone and Mineral Metabolism 021-SDX017...Retinol Binding Protein EIA Vitamin Assays 030-6110 RBP Bone and Minearl Metabolism
Description:Retinol binding Proetin (RBP) is small (21kD) transport protein for vitamin Awhich forms a complex with pre-albumin in blood but loses its affinity forprealbumin once the vitamin has been deliverd to the target cells. The freeRBP molecule is then rapidly filtered at the glomerulus and catabolized in therenal tubules after resorption by the proximal tubular cells (like other smallmo...Intact PTH EIA Bone and Mineral Metabolism 021-SDX016 Parathyroid Hormone
Description:Intact PTH EIA Bone and Mineral Metabolism 021-SDX016 Parathyroid Hormone...Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
Description:The OCTEIA 25-Hydroxy Vitamin D kit is an enzymeimmunoassay for the quantitation of 25-OH D and other hydroxylated metabolites in serum or plasma. Calibrators, controls and samples are diluted with biotin labelled 25-OH D. The diluted samples are incubated in microtitre wells which are coated with a highly specific sheep 25-OH D antibody for 2 hours at room temperature before aspiration and washi...Inborn Errors of Metabolism-Metabolic Disorders
Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...