Researchers test new therapy for advanced melanoma
Melanoma is a particularly deadly form of skin cancer very resistant to treatment. Researchers at H. Lee Moffitt Cancer Center & Research Institute and the University of South Florida are testing a promising new therapy that prompts the immune system to aid in the fight against melanoma tumors. "This is a milestone clinical trial because it is the first time that electroporation is bei...NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
A team of researchers, led by Steven A. Rosenberg, M.D., at the National Cancer Institute, part of the National Institutes of Health, have found that patients with advanced melanoma who had not responded to previous therapies experienced a significant reduction in the size of their cancers as a result of receiving a new immunotherapy. This immunotherapy consisted of a combination of chemotherapy...Engineered skin offers clues to melanoma development
When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine. Though multiple genetic alterations are associated with melanoma development, scientists have not been abl...Newfound roadblock to interferon effectiveness against malignant melanoma
Researchers have uncovered a significant contributing factor to interferon resistance of malignant melanoma cells. The finding represents a step forward in understanding the molecular events that govern the growth of this type of cancer and the changes in gene expression and cellular signaling that underlie resistance to established therapies. Malignant melanoma is the deadliest form of sk...Protein amplification in melanoma is possible drug target
A newly discovered gene mutation may account for many cases of immune deficiency, in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic test for these conditions, which make people highly susceptible to infections and often go unrecogniz...Reduction in melanoma death rate
In the last 25 years, in New York, there has been a declining trend in mortality from malignant melanoma, although its frequency has increased. Researchers at the University of Texas, have analysed data on malignant melanoma, the deadliest form of skin cancer, between 1981 and 1999.// They find there has been a 200 per cent increase in cases among men - from 2.0 cases per 150,000 population to 12...Latest device for identifying Melanomas
A research from Australian company has finalized development of a digital screening device it says will take the guesswork out of diagnosing melanomas, the third most common cancer in Australia. Victor Skladnev, managing director of Polartechnics said that in terms of its ability to diagnose melanomas, it matches top specialists.// Image analysis and computer-aided diagnostic software...Specialist surgeon not imperative in melanoma
According to a new study it is observed that the background of the surgeon does not affect the outcome in melanoma. Researchers at the University of Glasgow have surveyed 4,139 melanoma patients who had their tumour removed between 1979 and 1999.// They found the outcomes to be similar, whether the operating surgeon had a background in dermatology, cosmetic work, or general surgery. This is in co...Tumour marker for melanoma found
According to a recent study it is observed that a molecular marker is linked to prognosis in malignant melanoma. In cancer research today, there is increasing emphasis on looking for molecules// specific to that cancer which might aid in monitoring the progression of the disease. Scientists at New York University now report on a molecular marker called HDM2 which appears to be important in tracki...IDM Pharma Presents Preliminary Results from Phase II UVIDEM Melanoma Vaccine Clinical Trial
- Results show UVIDEM was well-tolerated with signs of durabledisease control in advanced melanoma patients - IRVINE, Calif., June 05, 2007 /PRNewswire-FirstCall/ -- IDMPharma, Inc. today presented preliminary results from a Phase IIUVIDEM (IDD-3) melanoma vaccine clinical trial (DC-MEL-202). Theresults showed that UVIDEM was well tolerated with evidence ofefficacy and induction of immune...Synta Presents Results for STA-4783 in Metastatic Melanoma Showing Improvement in Overall Survival
LEXINGTON, Mass.--(BUSINESS WIRE)--Jun 5, 2007 - SyntaPharmaceuticals Corp., (NASDAQ: SNTA) a biopharmaceutical companyfocused on discovering, developing, and commercializing smallmolecule drugs to treat severe medical conditions, today announcedencouraging results from the analysis of overall survival (OS) timefor patients in the Company's double-blind, randomized, controlled,multi-center...Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
Clinical Phase I and II data presented at American Society ofClinical Oncology (ASCO) 2007 Annual Meeting CHICAGO, June 05, 2007 /PRNewswire-FirstCall/ -- Medarex, Inc.and Bristol-Myers Squibb Company today presented results frommultiple clinical studies of ipilimumab (MDX-010), aninvestigational immunotherapy, for patients with advanced melanoma.The results demonstrated an anti-tumor res...