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melanocortin in Medical News

Inhibition of morphine tolerance by spinal melanocortin receptor blockade

Recent research suggests that the melanocortin system is an important component influencing the changes in the spinal neuronal plasticity observed after chronic morphine administration//. The chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the maj...

Palatin Technologies Announces Receipt of $4.1 Million from AstraZeneca

...ca relating to an extension of its exclusive research collaboration and license agreement to discover, develop and commercialize compounds that target melanocortin receptors and a clinical trial sponsored research agreement. Palatin also announced that it has earned a milestone payment of $2.5 million in co...

Targeted nanospheres find, penetrate, then fuel burning of melanoma

...ulature. The researchers packaged hollow, spherical gold nanospheres with a peptide - a small compound composed of amino acids - that binds to the melanocortin type 1 receptor, which is overly abundant in melanoma cells. They first treated melanoma cells in culture and later injected both targeted and untarge...

Study Finds Molecular Link Between Obesity, Hypertension

... blood pressure will go down, and if you don't have any side effects associated with it, that would be huge." MC4R, Marks explained, is one of five melanocortin receptors in the brain; these proteins regulate skin coloration and stress, among other things. But MC4R regulates body weight, "and it does that by a...

New findings about the brain lead to treatment for eating disturbances

... The discovery of the brains so-called melanocortin system and its central role in controlling appetit...ted over nearly two decades. The mapping of the melanocortin system was made possible by the cloning of genes for five different melanocortin receptors, which was performed by Jarl Wikberg in ...

Stanford researchers sniff out gene that gives dogs black fur

...rotein that's part of a large and variable family called defensins, thought to fight infections. What is clear now is that this protein engages the melanocortin pathway, a circuit of molecular interactions that controls the type of melanin and amount of cortisol produced by the body. Barsh's lab has studied th...

Scientist Move A Step Closer To Treating Genetic Obesity

..., a Wellcome Trust clinician scientist fellow at Cambridge University who was part of a team of British scientists who made the connection between the melanocortin malfunction and obesity in humans. "(This study) provides more detail and it starts to put some of the pieces of the puzzle together. It's an importan...

Serotonin the Answer for Anti-Obesity Treatment

... online and in the July 20 issue of Neuron, also reinforces the role of serotonin – a regulator of emotions, mood and sleep – in affecting the brain's melanocortin system, a key molecular pathway that controls body weight. "The more we understand about the pathways and the way serotonergic drugs regulate body wei...

Red hair connected with anaesthesia

...link between red hair and anaesthetics lies in the melanocortin system. Those with red hair have a specific variant of the melanocortin receptor in the cells that give hair and skin thei...r pigment. This variant triggers the production of melanocortin which also stimulates a related brain receptor, in...
melanocortin in Medical Technology

Palatin Technologies Presents PL-3994 Clinical Trial Results at the 12th Annual Scientific Meeting of the Heart Failure Association of America

...etary peptide, peptide mimetic and small molecule compounds with a focus on melanocortin and natriuretic peptide receptor systems. The melanocortin system is involved in a large and diverse number of physiologic functions, ...

Palatin Technologies Initiates Phase 2 Hypertension Clinical Study With PL-3994

...opharmaceutical company primarily focused on discovering and developing targeted, receptor-specific peptide and small molecule therapeutics, including melanocortin ("MC")-based therapeutics. Therapeutics affecting the activity of the MC family of receptors may have the potential to treat a variety of conditions a...

Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY

...is produced by the gut and is released into the circulation in response to food ingestion. Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide Y (NPY) systems in the arcuate nucleus. The NPY Y2 receptor (Y2R), a putative inhibitory presynaptic receptor, is highly expressed on...
melanocortin in Biological Technology

The development of a melanocortin MC5 receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: Melanocortin • receptor binding assay • LEADseeker • SPA Imaging Beads Pro-melanocortins are present in high levels in the pituitary and are processed into three major peptide hormone fragments: adrenocorticotrophin (ACTH), th...

The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: Melanocortin • receptor binding assay • LEADseeker • SPA Imaging Beads Pro-melanocortins are present in high levels in the pituitary and are processed into three major peptide hormone fragments: adrenocorticotrophin (ACTH), th...

Palatin Technologies to Report Fiscal Year 2009 First Quarter Results; Conference Call and Webcast on November 17, 2008

...echnologies, Inc. is a biopharmaceutical company dedicated to the development of peptide, peptide mimetic and small molecule compounds with a focus on melanocortin and natriuretic peptide receptor systems. The melanocortin system is involved in a large and diverse number of physiologic functions, and therapeutic ...

Palatin Technologies, Inc. Revised Call-In Number for Teleconference and Webcast to be held on September 30, 2008

...etary peptide, peptide mimetic and small molecule compounds with a focus on melanocortin and natriuretic peptide receptor systems. The melanocortin system is involved in a large and diverse number of physiologic functions, ...

Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure

...ptide, peptide mimetic and small molecule agonist compounds with a focus on melanocortin and natriuretic peptide receptor systems. The melanocortin system is involved in a large and diverse number of physiologic functions, ...

Palatin Technologies Announces New Strategic Objectives and Reports Third Quarter 2008 Financial Results

...and commercial information and data on its new melanocortin compounds under development for sexual dysfunc... female sexual dysfunction; -- Continuing its melanocortin receptor-based collaboration with AstraZeneca ... on two challenging and exciting scientific areas: melanocortin and natriuretic peptide receptors. We have generat...

Palatin Technologies, Inc. Reports Fourth Quarter and Fiscal Year End 2007 Results; Teleconference and Webcast to be held on September 18, 2007

...licensing and research collaboration agreement with AstraZeneca AB to discover, develop and commercialize small molecule compounds that target melanocortin receptors for the treatment of obesity, diabetes and related metabolic syndrome and the receipt of an up-front payment of $10 million. -- The...

Palatin Technologies Announces Reacquisition of Full Rights to Bremelanotide Program

...10 /PRNewswire-FirstCall/ -- Palatin Technologies, Inc. (Amex: PTN ) today announced it has reacquired full rights to bremelanotide, a first in class melanocortin agonist drug candidate for the treatment of male erectile dysfunction (ED) and female sexual dysfunction (FSD) from King Pharmaceuticals Inc. (NYSE: ...

Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening

... Corticotropin-releasing factor CRF 2 Histamine H1 receptor Melanin-concentrating hormone (MCH) receptor (SLC-1, HNOP801) melanocortin receptor MC4 Motilin receptor Nociceptin receptor ORL-1 Orexin receptors 1 and 2 Purinergic P2Y2 Sero...
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