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mediates in Medical News

Protein level may serve as predictor of severe osteoarthritis

...stem ells). The authors suggest that increased VCAM-1 levels may therefore mirror active cartilage damage or an inflammatory component in OA. Since it mediates the interaction of chondrocytes with immune cells, VCAM-1 may also contribute to immune-mediated cartilage damage. Establishing laboratory biomarke...

Dynamic molecular mechanism to keep brain activity stable

...h as PSD-95, and move out them into dendrites of neurons. In contrast, DHHC2 are located mainly in dendrites of neurons. Dendritically localized DHHC2 mediates dynamic palmitoylation of PSD-95 at synapses upon extracellular signals. When synaptic activity decreases, DHHC2 translocates to the synaptic site to ...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

...00 was metabolized via the expected major pathway, from phenylbutyrate (PBA) to phenylacetic acid (PAA) and then to phenylacetylglutamine (PAGN). PAGN mediates waste nitrogen excretion and ammonia removal. The extent of plasma exposure to PAA significantly correlated with MELD score (r2= 0.15; p= 0.03), but d...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...y at NYU School of Medicine and a member of the NYU Cancer Institute, showed that the V(D)J recombinase, which consists of the RAG1 and RAG2 proteins, mediates this pairing and helps ensure that only one allele undergoes recombination at a time (a process known as allelic exclusion). In "RAG-1 and ATM Coor...

Cynosure Enhances Industry-Leading Smartlipo Laser Lipolysis Workstation with Increased Energy and Intelligent Temperature Sensing

...haracteristics. The 30-watt 1064-nm wavelength disrupts a broad region of tissue while heating the treated areas evenly. The 1064-nm wavelength also mediates blood vessel coagulation enhancing hemostasis. The 16-watt 1320-nm wavelength is highly concentrated with minimal scatter, and is rapidly absorbed by...

Now we know what blocks the effects of a newly developed anticancer therapy

... expressing the protein CEACAM6 were not sensitive to being killed by adenoviruses. Further analysis revealed the molecular mechanism by which CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human ...
mediates in Medical Technology

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

...is the first highly selective, small molecule inhibitor of the immunoproteasome. The proteasome is an intracellular complex present in most cells that mediates the degradation of intracellular proteins, including key components of pathways that contribute to cancer cell growth and immune signaling. It is a p...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

...ritic cell recruiter and activator (DCRA) being studied for the treatment of several life-threatening diseases including RCC and NSCLC. Talactoferrin mediates its anti-cancer activity by targeting dendritic cells which play an important role in activating innate and adaptive immunity. After being transporte...

RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial

...ic breast cancer who develop resistance to Herceptin." Preclinical data have shown that RAD001, an inhibitor of mTOR, acts on the pathway that mediates Herceptin resistance and has the potential to help restore response in these patients. RAD001 works through direct antitumor activity and through its ...

InCode BioPharmaceutics, Inc. Announces Key Data Supporting New Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH)

... the enzymatic partial depletion of C3, the hub of the complement cascade. Complement protein C3 is the master regulator of complement protein C5 that mediates cell damage in PNH patients. The reduction of C3 has been shown to reduce PNH cell destruction. PNH is a rare debilitating and life-threading diseas...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

...ical to native human lactoferrin in all material respects, differing only in its glycosylation. Talactoferrin is an orally administered protein that mediates its activity through the gut and the GALT -- the largest lymphoid organ in the body. It acts through a novel mechanism of dendritic cell recruitment a...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

...esistance is important for restoring activity to treatment. Preclinical studies have shown that RAD001, an inhibitor of mTOR, acts on the pathway that mediates trastuzumab resistance and has the potential to help restore response in patients who are refractory to therapy. RAD001 works through direct antitumor...
mediates in Medical Products

ACE - REA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-ACD Angiotensin Converting Enzyme

Description:... circulation as soluble enzyme. Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II. The enzyme also mediates the cleavage of a synthetic substrate, 3H hippuryl-glycylglycine, into 3H-hippuric acid and a dipeptide1. After acidification, the tritiated hippuric ...
Company:ALPCO Diagnostics

IGF-1 EIA Endocrine Function 026-AC-27F1 Insulin Growth Factor

Description:... GH-independent secretion. IGF-1 has numerous growth-promoting effects, including mitogenic effects and the promotion of cartilage sulphation. It also mediates growth promoting actions of growth hormone on skeletal and other body fluids. Almost all (>95%) of serum IGF-1 circulates bound to specific IGF bin...
Company:ALPCO Diagnostics
mediates in Medical Definition

Depolarization-induced suppression of inhibition

...excitatory and inhibitory fibers. Neuropharmacology. Sep;43(4):503-10. Hajos N, Ledent C, Freund TF. (2001) Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience. 106(1):1-4. Herkenham M, Lynn AB, Little MD, Johnson MR, Mel...
mediates in Medical Dictionary

Serotonin

...eeded ... Serotonin information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Serotonin mediates several important ... ...

Renin

... Renin , also known as Angiotensinogenase, is a circulating enzyme that participates in the body's renin -angiotensin system (RAS) that mediates extracellular volume, and arterial vasoconstriction. Thus it regulates the body's mean arterial blood pressure. The renin -angiotensin syst...

Macrophage

... zinc ... Cells overexpressing p19 acquire macrophage characteristics. ... Macrophage -derived chemokine (MDC/CC chemokine ligand 22 (CCL22)) mediates its ... Macrophage -derived chemokine is localized to thymic medullary epithelial cells ... Macrophage recognition of cells undergoing programm...

Erythrocyte

..., the lipid bilayer and the cytoskeleton.3 ... The cytoskeleton is the other domain of the erythrocyte membrane. ... The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Stamenkovic I, Seed B. ... Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen ... ...
mediates in Biological News

Activation of thermoreceptors mediates raw garlic's burning pungency

The worldwide popularity of garlic as a food ingredient and its therapeutic stature in folklore both stem in part from the distinctive pungency associated with its raw, uncooked state. Researchers this week report that this pungency, manifested as a characteristic mixture of burning and prickling s...

Protein that promotes cancer cell growth identified

...tituting the Caspase-8 deficient cells with Caspase-8 with mutations in the RXDLL domain did not result in EGF signaling. This suggests that Caspase-8 mediates signaling through the RXDLL domain. The scientists had previously shown in another study that Caspase-8 associates with Src, a protein known to be inv...

Scientists capture the first image of memories being made

...aptic plasticity require changes in gene expression and yet can occur in a synapse-specific manner. This study provides evidence that a mechanism that mediates this gene expression during neuronal plasticity involves regulated translation of localized mRNA at stimulated synapses. These findings are instrument...

New mediator of smoking recruits

...tissue fibrosis, how cigarette smoke causes these changes is largely unknown. To determine if osteopontin, a molecule that attracts immune cells, mediates cell recruitment in smokers, Prasse et al compared osteopontin levels from smokers with different types of lung diseases, healthy smokers, and healthy...

Burnham researchers present at 100th AACR Meeting

...ctivation Induced by Protein Kinase C and Antigen Receptors. Changming Fang, Ph.D., who will also present two papers: Ileal Bile Acid Binding Protein mediates the Chemopreventative Effect of Ursodeoxycholic Acid by Activating Nuclear Receptor FXRα in Colorectal Cancer and Genetic Deletion of FXRα P...

Evolutionary origin of bacterial chromosomes revealed

...ies to allow the inference of a general model for bacterial genome evolution. It appears that the transfer of genes from chromosomes to large plasmids mediates second chromosome formation." "Examination of different genome sequences within the Rhizobiales family has revealed that gene migration is rife amo...
mediates in Biological Technology

Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack

...he human genome (SNPs) that increase levels of eosinophils in the bloodstream. These are a type of white blood cell that fights parasite infection and mediates inflammation. One of these SNPs, located on chromsome 12q24, was then shown to confer increased risk of heart attack through analysis of the genomes o...

Affitech and Omeros Enter Into Antibody Discovery and Development Agreement

...for the discovery and development of fully human antibodies for Omeros' MASP-2 program. MASP-2, or mannan-binding lectin-associated serine protease-2, mediates activation of the complement system via the lectin pathway and is linked to multiple potential indications across a wide range of inflammatory disease...

Cynosure Introduces Smartlipo MPX(TM) Dual Wavelength Workstation for LaserBodySculpting(SM)

... characteristics. The 20 watt 1064-nm wavelength disrupts a broad region of tissue while heating the treated areas evenly. The 1064-nm wavelength also mediates blood vessel coagulation enhancing hemostasis. The 12 watt 1320-nm wavelength is highly concentrated with minimal scatter, and is rapidly absorbed by ...

JCI table of contents: April 22, 2008

...the observation that endothelial cellderived microparticles are found in the blood of patients with several of these diseases. TITLE: Platelet CD36 mediates interactions with endothelial cellderived microparticles and contributes to thrombosis in mice AUTHOR CONTACT: Roy L. Silverstein Cleveland Clini...

Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO

...and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates complement dependent cell killing; and finally, the antibody alters cellula...

Raven biotechnologies to Provide Updates on Oncology Pipeline With Four AACR Presentations

...es in vivo Session ID: Tumor Biology 5 Date and Time: Sunday, April 13, 2008, 8:00 AM Abstract Number: 385 The RAV12 monoclonal antibody mediates antitumor activity via multiple mechanisms of action and synergizes with chemotherapeutic agents in vivo Session ID: Experimental and Mole...
mediates in Biological Products

20-HETE-d6, Deuterium Conjugated/Tagged from Cayman Chemical

Description:... metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg...
Company:Cayman Chemical

20-HETE-d6, Deuterium Conjugated/Tagged from Cayman Chemical

Description:... metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg...
Company:Cayman Chemical

loxP flanked Ampicillin Selection Cassette (loxP-amp-loxP) from Gene Bridges GmbH

Description:... in prokaryotic cells. The prokaryotic promoter gb2 driving the gene for ampicillin resistance is a slightly modified version of the Em7 promoter. It mediates higher transcription efficiency than the generally used Tn5 promoter. A synthetic polyadenylation signal terminates the ampicillin expression. The cas...
Company:Gene Bridges GmbH

FRT flanked Ampicillin Selection Cassette (FRT-amp-FRT) from Gene Bridges GmbH

Description:... in prokaryotic cells. The prokaryotic promoter gb2 driving the gene for ampicillin resistance is a slightly modified version of the Em7 promoter. It mediates higher transcription efficiency than the generally used Tn5 promoter. A synthetic polyadenylation signal terminates the ampicillin expression. The cas...
Company:Gene Bridges GmbH

loxP flanked Chloramphenicol Selection Cassette (loxP-cm-loxP) from Gene Bridges GmbH

Description:...rokaryotic cells. The prokaryotic promoter gb2 driving the gene for chloramphenicol resistance is a slightly modified version of the Em7 promoter. It mediates higher transcription efficiency than the generally used Tn5 promoter. A synthetic polyadenylation signal terminates the chloramphenicol expression. Th...
Company:Gene Bridges GmbH

FRT flanked, Pro and Euk. Neomycin Selection Cassette plus loxP site(FRT-PGK-gb2-neo-FRT-loxP) from Gene Bridges GmbH

Description:...r (PGK) for expression of neomycin resistance in mammalian cells. The prokaryotic promoter gb2 is a slightly modified version of the Em7 promoter; it mediates higher transcription efficiency than the generally used Tn5 promoter. The promoter of the mouse Phosphoglucokinase gene (PGK) is used as the eukaryoti...
Company:Gene Bridges GmbH
mediates in Biological Definition

Antibody

...two to three constant domains (depending on the class of the antibody). It binds to various cell receptors and complement proteins. In this way it mediates different physiological effects of antibodies ( opsonization , cell lysis , mast cell, basophil and eosinophil degranulation and other processes). ...

Signal transduction

...ed, it may be struck by light of various wavelengths, stretched, sheared or electrified (the nerves and muscles , for example). Signal transduction mediates how cells respond to such stimuli. Most stimuli impinge from the outside and interact with the cell membrane . Several "signaling molecules", suc...
mediates in Biological Dictionary

Vessel cell

...in Cell Culture, blends air, oxygen, carbon dioxide, and ... Glass-jacketed cell culture vessels , 2.2 through 14 liters total volume ... NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas ... Host cell eNOS but not iNOS contributes to angiogenesis and vessel ...

Syncytium

...1 syncytium formation can be blocked by protein ... Syncytium assays with HIV-1-infected MT2 cells and SupT1 or HIV-1-infected U937 ... FIV mediates syncytium formation. ... as measured by syncytium formation is given ... CXCR4 is also a coreceptor for the syncytium -inducing strains of HIV (2...

Sequential Epitope

... id, ... It comprises the minimal sequential B cell epitope (BCE) (H386–400) of the ... induced antibodies to a sequential epitope that mediates neutralization of both ... Mimotopes is a global leader in research-grade custom peptide synthesis, peptide libraries for immunology and drug...

RNA polymerase

...PTION BY RNA POLYMERASE II ... RNA polymerase (thing) by The Alchemist. Tue Jul 03 2001 at 18:25:23 ... Plant Nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent ... Transcription requires that the RNA polymerase binds to the DNA at specific ... The RNA polymerase ...

Reflex arc

... A reflex arc is the neural pathway that mediates a reflex action. In higher animals, most sensory neurons do not pass di...mulus is detected by a ... A reflex arc is the neural pathway that mediates a reflex action. ... When a reflex arc consists of only two neurons (...

Proteolysis

...actor into non-tumor-bearing mice ... Ubiquitin-dependent proteolysis plays an essential role in a number of cellular ... An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. ... ...
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