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mechanistic in Medical News

DEET in Bug Spray Tied to Neural Damage in Mice

...n order to try to understand some of the mechanisms," said Dr. Ted Schettler, science director of the Science & Environmental Health Network. "The mechanistic information is very useful but the jury is still out on what implications this has for humans." "DEET has been used for a very long time with very ...

Studies Show Genetic Activity of Antioxidants

...ients, Force said. "They are add-ons to studies that have shown the possible value of antioxidants," he said. "Most of the literature is not at a very mechanistic level or picks out one specific protein that is regulated. These studies do provide a more global approach to how these compounds may function to do w...

Lighter Meals May Bring Longer Life

... continuing to study the monkeys, a process that could go on for 15 years. Meanwhile, they are collecting a new group of monkeys to more closely study mechanistic processes. The NIA currently supports a study looking into calorie restriction in humans although, Sierra pointed out, such a study is difficult t...

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

...ancer cells with a superior ability to survive in the bone marrow. "The link between Src-dependent signaling and metastatic cell survival provides mechanistic insights into metastasis latency, and suggests strategies to hasten the attrition of disseminated breast cancer cells," concludes Dr. Massague. "Recen...

Study pinpoints novel cancer gene and biomarker

...dies, which focus on what individual genes do to turn a cell cancerous, and mechanistic studies, which examine how they turn cells cancerous and in what setting. I...s of the GOLPH3 gene also had abnormally high levels of mTOR activity. "The mechanistic relationship we'd identified in the mouse system is also at work in human t...

2009 ISSSEEM Conference to Have Deepak Chopra Discuss Bridging Science and Spirit

...tion flows within the body and the environment. Other aspects of this year's healing conference will include a focus on transcending the classical mechanistic concepts that are typically used to define biological mechanics. The new mechanical concept of "Biotensegrity" is based on tensegrity struct...

Jackson, Rockefeller obesity researchers share Shaw Prize

...he said. "Doug Coleman's groundbreaking discovery and Jeff Friedman's subsequent work used the remarkable power of mouse genetics to provide important mechanistic insights into 'diabesity' in humans. Their work continues to influence research being conducted today at The Jackson Laboratory and institutions aroun...

Genomas Presents Drug-Specific Genetic Determinants of Statin Safety and Efficacy at the XV International Symposium on Atherosclerosis

...rphisms associate with clinical responses, we visualize the 'physiogenomic contours' of statin drugs," said Dr. Ruano. "These contours represent the mechanistic differences among statins, which we plan to use as the foundation for DNA-guided rules for treatment on a patient-individualized basis." ABOUT...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

... - Results Reported at the American Diabetes Association Meeting Validate mechanistic and Therapeutic Potential of sEH Inhibitor in Treating Type 2 Diabetes - ...cs Inc. today announced the presentation of three posters that validate the mechanistic activity and therapeutic potential of the company's lead drug candidate, AR...

Interleukin Genetics Launches Inherent Health Brand of Genetic Tests Offering Clear and Personalized Insights to Wellness

...The product was scientifically designed using validated genetic markers involved in fat and carbohydrate absorption, metabolism and storage to provide mechanistic understanding of how the individual can best lose weight and keep it off. Web-based tools will also offer individuals the ability to track thei...
mechanistic in Medical Technology

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

...disease, and heart disease, often in the same patient, and is referred to as "metabolic syndrome." Low level inflammation and oxidative stress are the mechanistic underpinnings of metabolic syndrome. The Cardax lead compound is a novel and highly bioavailable proprietary derivative of the natural dietar...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

...merican Society of Hematology. In a poster presentation entitled " Inhibiting PIM-1 is effective in vitro and in vivo against ALL: A novel mechanistic and potentially clinically relevant druggable target , " Dr. Valerie Brown and colleagues from Children's Hospital of Philadelphia and University o...

GEN Reports on the Trend Toward Predictive Toxicogenomics

...ses, which then are tested more thoroughly using other assays. Novartis is employing known toxic compounds to develop the techniques to understand the mechanistic actions of toxicity. Such screening led to the recent validation of biomarkers for kidney toxicity. Groups such as The C-Path Predictive Saf...

Napo Announces Positive Clinical Data Indicating Crofelemer, Could Effectively Treat Cholera

... treatment with crofelemer of acute infectious diarrhea of multiple etiologies in adult patients in India (see announcement dated April 10, 2008). The mechanistic cause of these diarrheas is similar to that which effects chronic diarrhea in people living with HIV/AIDS, an indication for which Napo is in final Ph...

Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus

...velopment to optimize our products, these results in end-stage liver cancer patients clearly validate our breakthrough product class. The clinical and mechanistic results were predicted based on extensive lab testing of JX-594. This peer-reviewed publication in Molecular Therapy represents a major clinical and s...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

...a modulator, was effective in the treatment of hot flashes. But unlike estrogen, it did not adversely effect the uterus. This study provides a further mechanistic explanation to the observed clinical results. We believe that the efficacy coupled with improved safety of MF101 over current estrogen treatment will ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

...o evaluate the direct therapeutic effect of SB-509 on nerve regrowth. This test is a very sensitive marker of DN severity and may provide an important mechanistic marker for efficacy. Phase 2 study of SB-509 for moderate to severe DN (SB-509-701) The clinical trial is a single-blind, placebo-controlled, repe...

ViroDefense Inc Announces Selection of Poliovirus Antiviral Preclinical Candidate

...c determined in laboratory tests that compounds of the series had promising anti-poliovirus activity. The licensed compounds belong to the antiviral mechanistic class termed "capsid inhibitors." Compounds of this class inhibit the function of the poliovirus capsid, the outer protein coat of the virus, by integ...

EntreMed Presents MKC-1 Phase 2 Data at American Society of Clinical Oncology Annual Meeting

...onded to MKC-1 treatment. Combining information from these studies with new mechanistic insights that have revealed mTOR and HIF-1alpha as molecular targets of MKC...and through collaborations. We feel that the information derived from these mechanistic and clinical studies will assist in defining how best to utilize MKC-1, whi...

Pharmacyclics' Novel Factor VIIa Inhibitor Demonstrates Potential Inhibition of Tumor Growth in Multiple Types of Cancer

...t either 60 mg/kg or 90 mg/kg, resulting in 42 percent and 85 percent inhibition of tumor growth, respectively, after 15 days of treatment. Additional mechanistic studies showed that PCI-27483 blocked key tumor growth signals. Previous work has shown significant growth inhibition in lung and colorectal cancer mo...
mechanistic in Biological News

Conserved amino acids play both structural and mechanistic roles in sandwich-like protein

The question of whether amino acids in sandwich-like proteins are there to stabilize the structure or to speed up the protein-folding process is best answered by "all of the above," according to researchers at Rice University in Houston. This discovery, reported in today's issue of the Proceedin...

August 2009 Geology and GSA Today media highlights

... of time. For five different experimental deltas, they were able to predict the avulsion location with 93% accuracy. These results represent the first mechanistic understanding of avulsions that allows for accurate prediction of their location. Mapping potentially asbestos-bearing rocks using imaging sp...

'Shortcuts' of the mind lead to miscalculations of weight and caloric intake, says Penn study

... is that missing information was literally thrust in the face of participants, and yet they didn't use it. "We have heuristics in our brain simple mechanistic shortcuts that have evolved over hundreds of thousands of years, which free up precious space in our consciousness," said Andrew Geier, lead author in...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

...cally engineered mouse model that lacks selected proteins of the notch signaling pathway in the intervertebral disc. This model will provide important mechanistic insights into the role of the notch signaling pathway in controlling disc cell activities. "Eventually, we hope to be able to regulate the activiti...

Simple drug treatment may prevent nicotine-induced SIDS: Study

...at nicotine mimics the effects of one of these chemicals, thereby allowing us to test the idea. The present study was significant in that it led to a mechanistic understanding of how nicotine works in this context." ...

Synthetic catalyst mimics nature's 'hydrogen economy'

...fers plenty of potential glamour such as the hydrogen economy, green energy and bio-fuel cells but the lasting breakthroughs result from manipulable mechanistic models like ours," said graduate student and co-author Matthew Whaley. "By building a model that contains a hydride ligand, we have proven that the be...

SRI International to screen drugs that fight 2009 H1N1 influenza A

...tly only one class of antiviral drugs, the neuraminidase inhibitors, available to treat this H1N1 infection. Identifying drugs from other chemical and mechanistic classes could provide more effective alternatives to current therapies and make it easier to provide sufficient quantities of drugs to a broad populat...

New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity

... the history of the "insuperable" DNA entanglement problem and describes research that led to the discovery of the DNA topoisomerases. He details the mechanistic features of the different subfamilies of DNA topoisomerases, and explains how cutting-edge laboratory techniques are used to visualize individual enzy...

Genes from tiny marine algae suggest unsuspected avenues for new research

...er to understand more about community interaction, synergies, and how together they shape ecosystem responses. With this in mind we can develop a more mechanistic understanding of how carbon is moving within the marine environment and develop more sensitive tools for investigating carbon flow." Sequencing the...

New high-throughput screening technique makes probing puzzling proteins possible

...ets, or substrates, are not known, for instance by exploiting structural or mechanistic elements used by a wide range of proteins in a given class. This allows sci.... The group had similar success working with an enzyme from a different mechanistic class, called glutathione S-transferase omega 1 (GSTO1), an oxidoreductase ...
mechanistic in Biological Technology

YM BIOSCIENCES REPORTS DAIICHI-SANKYO ENROLLS FIRST PATIENTS IN PHASE II, FIRST-LINE LUNG CANCER TRIAL WITH NIMOTUZUMAB

...treatments typically involve radiation-containing regimens that have been demonstrated to enhance the expression of EGFR. Nimotuzumab's differentiated mechanistic attributes result in it selectively targeting tissues over-expressing EGFR while avoiding normal tissue. The debilitating and dangerous side effects o...

NIMOTUZUMAB DEMONSTRATES EFFICACY IN RANDOMIZED HEAD & NECK CANCER STUDY WITHOUT THE TOXICITIES ASSOCIATED WITH OTHER EGFR DRUGS

... stage oropharynx carcinoma. J Natl Cancer Inst 91:2081-2086, 1999). "The data from the Reddy BK et al proof-of-concept study clinically support the mechanistic attributes of nimotuzumab recently made public for the first time (Tikhomirov et al, AACR Meeting Abstract (2008) 2008: A36), that account for nimotuz...

EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting

...ce President, Research commented, "We are very excited to be working with Dr. Hedley and his staff, who have considerable experience in evaluating the mechanistic effects of kinase inhibitors like ENMD-2076 in cancer patients. The close proximity of EntreMed scientific personnel based in Toronto to our clinical...

YM BIOSCIENCES REPORTS THIRD QUARTER 2009 OPERATIONAL AND FINANCIAL RESULTS

...iscal 2009, ended March 31, 2009. "Just a few days ago we reported critically important data at the 100th AACR conference in Denver highlighting the mechanistic differences between nimotuzumab and the EGFR targeting antibody, Erbitux(R)," said David Allan, Chairman and CEO of YM BioSciences. "These data demons...

ImQuest BioSciences and Arisyn Therapeutics Announce Strategic Partnership to Develop Infectious Disease and Cancer Drugs

...agents, will provide all required support to initiate human clinical trials with lead products ATI-0312 for HIV and ATI-0810 for HCV and will initiate mechanistic studies to define the unique virus transcription inhibitory mechanism of action of the class of inhibitors. ImQuest will also lead Arisyn's efforts to...

Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting

...roLindac should provide sustained tumor exposure to platinum and provides a mechanistic rationale for the low hematoxicity observed in the clinic - DALLAS, Ap...x-vivo data on the binding of ProLindac to blood components, and suggests a mechanistic rationale for ProLindac's favorable efficacy and safety profile. "The ...

VisEn Launches Next-Generation Fast ('Fluorescence Activatible Sensor Technology') Agent Platform for Expanded Performance in Imaging Disease Biomarkers In Vivo

...gnal maximizing between 6 and 24 hours. By 96 hours, only 15% of the signal was still present in tumors. "Our study utilized MMPSense 750 FAST as a mechanistic biomarker for therapeutic activity, which was closely associated with tumor progression", said Dr. Peterson. Both of the chemotherapeutics in the stud...

Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting

...ops a deep molecular understanding of diseases and drug action, and designs mechanistic biomarkers and molecular diagnostics to facilitate drug development and per...pharmaceutical and life sciences companies, to develop new therapeutics and mechanistic biomarkers in the areas of oncology, metabolic disorders, cardiovascular di...

Maximize Data Analysis with METTLER TOLEDO FBRM

...ge - Tuesday, January 27 How does FBRM® track particle agglomeration, breakage, attrition, nucleation, growth, and shape? How can users extract a mechanistic understanding of these changes from FBRM® data? Part I will provide examples of particle changes as characterized by FBRM® and PVM®. Exam...

Covance Purchases Equity Stake in Caprion Proteomics

...f scientific leadership positions of increasing responsibility. Most recently, Dr. Turi served as the Senior Director of Translational Biomarkers and mechanistic Biology at Pfizer's laboratories in Groton, Connecticut. Dr. Turi completed his postdoctoral training at Yale University's College of Medicin...
mechanistic in Biological Definition

Classical genetics

...triction enzymes , the avenues of investigation open to geneticists were greatly broadened. Some classical genetic ideas have been supplanted with the mechanistic understanding brought by molecular discoveries, but many remain intact and in use. Classical genetics is often contrasted with reverse genetics , and...

Genetics

...triction enzymes , the avenues of investigation open to geneticists were greatly broadened. Some classical genetic ideas have been supplanted with the mechanistic understanding brought by molecular discoveries, but many remain intact and in use, such as Mendel's laws . Patterns of inheritence still remain a use...

Meiosis

...tes , sexual reproduction may play a more restricted role, while asexual reproduction gains emphasis (examples include plants and hydras ). The mechanistic differences between mitosis , which produces somatic cells, and meiosis, is best understood by considering mitosis first. (All jargon used in this ...

Nutrition

...n system contains a population of a range of bacteria which are essential to digestion, and which are also affected by the food we eat. The previous mechanistic view of food as fuel, and the simplistic notion that protein, carbohydrate etc. were each obtained from one type of food (the meat and two veg model)...
mechanistic in Biological Dictionary

Photorespiration

...out Photorespiration . Information about Photorespiration in the Columbia Encyclopedia, Computer Desktop Encyclopedia, computing dictionary. The mechanistic basis of photorespiration was found in the dual nature of ... Photorespiration results in the loss of up to 25% of the carbon that is fixed ... ...

Endotherm

...etabolic rates would remain steady, ... bility by examining endotherm energetic responses to subannual variability in air ... We first explore the mechanistic basis of endotherm metabolic ... ...

Biophysics

...ation for ... Biophysics can be generally defined as the study of biological systems from the ... Biophysics is a field of science that seeks a mechanistic approach to biology ... Biophysics , which has been traditionally taught in graduate and medical schools, ... Biophysics , interdisciplinary st...
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