Mechanism

A new mechanism of regulating RNA degradation

As any dedicated video game player knows, the first requireme...

Plants, animals share molecular growth mechanisms

A newly discovered plant protein complex that apparently switches on plants' growth machinery, has opened a scientific toolbox to learn about both plant and animal development, according Purdue University scientists. The protein complex triggers communication between molecules along a pathway that leads to the creation of long protein strings, called actin filaments, that are necessary fo...

PET/MRI scans may help unravel mechanisms of prenatal drug damage

Scientists have demonstrated a new way to assess the potentially damaging effects of prenatal drug exposure--a technique that could also be used to monitor a fetus's response to therapeutic drugs--using sophisticated, noninvasive medical imaging tools. Scientists at the U.S. Department of Energy's Brookhaven National Laboratory, whose findings are reported in the February issue of the Society of...

Researchers discover molecular mechanism that desensitizes us to cold

Mount Sinai School of Medicine researchers have discovered how the membrane protein that allows us to sense cold works and how this protein becomes desensitized so that one no longer feels the cold. The study, published this week as an advance online publication by Nature Neuroscience, focused on a specific region of the cold receptor which is found in many other receptors, including ones involve...

Chemists identify immune system mechanism for methamphetamine binges

Chemists at The Scripps Research Institute have found evidence in laboratory studies that the immune system may be able to recognize methamphetamine and boost tolerance to the drug through an unusual vaccine-like mechanism. Their finding, if confirmed in human studies, could help explain why chronic users go on long binges with the illicit drug, also known as speed. The study could lead to new tr...

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Confirming gene silencing mechanism by pGFP/GFP22 siRNA co-transfection

In addition to the specificity andefficiency of an siRNA sequencefor a target gene, which are ofhigh importance in post-transcriptionalgene silencing (PTGS), thedelivery of siRNA into cells is crucial.An efficient method to optimizetransfection and gene silenci...

Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS

465 Limestone Road Oxford, PA 19363-0277 with gas chromatography/ mass spectrometry (GC/MS) to study the structure of polymeric material must be based on an unders...

Mechanism at Medicine News

Protection mechanism of fatty acids for Cancer

A recent study by researchers at the University of Texas, have found out how omega-3 fatty acids might protect against colon cancer.Omega-3 fatty acids, which are found in fish oil, have long been known to protect against colon cancer.// They learned that the omega-3s block a molecule called protein kinase C beta II (PKCbII) - which is linked with abnormal cell division. In this study,...

Scientists Unveil Mechanism Behind Resistance to Severe Malaria

Scientists have discovered why some people are less prone to malaria//. The people with a specific type of hemoglobin — the oxygen-carrying molecule that gives red blood cells their color — are less prone to severe malaria. In a series of experiments, the researchers determined how hemoglobin type C impairs the ability of malaria parasites to cause disease symptoms. “This research give...

Scientists crack mechanism of Leptin-Obesity Hormone

A study in the May 24th issue of Nature reveals that the Obesity Hormone – Leptin, targets multiple nerve sites and affects the brain in more complex way than previously believed. This break through has opened up an avenue to develop drugs to treat Obesity and many nutrition related disorders like anorexia nervosa. Dr. Malcolm J. Low of Oregon Health Sciences University in Portland led t...

New Gene Silencing Mechanism To Prevent Cancer

The Centre for Cellular and Molecular Biology (CCMB), Hyderabad has unraveled the mystery behind gene silencing, paving the way for detecting the mechanisms that prevent cancer in human beings//. Two scientists - Manika Pal Bhadra and Utpal Bhadra have been instrumental behind this novel finding to fight a disease, which has remained a global challenge for centuries. They hope t...

Researchers discover mechanism behind protein folding

Professor Ted Laurence, Lawrence Livermore National Laboratory are studying the biopolymer structural dynamics of proteins to understand the mechanism of protein folding. The new theory on protein folding unfolds the mystery of // how a protein is incorrectly folded which leads to diseases and the study is to be published in the Journal Proceedings of the National Academy of Sciences....

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CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa

-- New Preclinical Information May Correlate with Clinical HbA1cReductions Observed in Phase 3 CARISA and MERLIN TIMI-36 ClinicalTrials -- PALO ALTO, Calif., July 9, 2007 /PRNewswire-FirstCall/ -- CVTherapeutics, Inc. announced today that researchers have completedpreliminary preclinical studies showing that ranolazine increasedglucose stimulated insulin secretion in pancreatic beta cells...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois

NEW YORK, June 22, 2007 /PRNewswire-FirstCall/ -- KeryxBiopharmaceuticals, Inc. today announced that abstracts related toSulonex(TM) (sulodexide oral gelcap) have been selected forpublication or presentation during the poster sessions scheduled totake place at the upcoming American Diabetes Association (ADA) 67thAnnual Scientific Sessions and exposition at the McCormick PlaceLakeside Cen...

Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science

- Journal Article Also Demonstrates the Promise of Anacor'sBoron-Based Chemistry in Developing Antibiotics - PALO ALTO, Calif., June 21, 2007 /PRNewswire/ -- AnacorPharmaceuticals, a privately held pharmaceutical company, announcedtoday that the journal Science will publish results of researchthat details how AN2690, the company's lead clinical candidate,kills fungal cells by interfering...

Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action

SALT LAKE CITY, June 14, 2007 /PRNewswire/ -- ProlexysPharmaceuticals and announced today a publication describing theproperties of the selective small molecule anti-tumor agent,erastin. Prolexys and Columbia applied the company'schemi-proteomics technology to understand the mechanism of actionof erastin. The results, to be published in the June 14, 2007 issueof the journal Nature reveal...

Novel Mechanism Insights and Additional Data on CombinatoRx Drug Candidates to Be Presented at Upcoming EULAR Meeting

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 6, 2007 - CombinatoRx,Incorporated (NASDAQ: CRXX), today announced that data from itsrandomized, blinded, placebo-controlled phase 2 clinical trials ofCRx-102 in patients with osteoarthritis (OA) and rheumatoidarthritis (RA) will be featured at the European League againstRheumatism (EULAR) Annual Congress of Rheumatology meeting, June13-16, 2007 in Bar...

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