St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration
Understanding how neurons migrate to their proper place during brain development will offer insights into how malfunctions in the machinery cause epilepsy and mental retardation
MEMPHIS, Tenn., July 15 /PRNewswire-USNewswire/ -- The molecular machinery that helps brain cells migra...
Dynamic molecular mechanism to keep brain activity stable
In the brain, many types of synaptic proteins are spatio-temporally regulated to maintain synaptic activity at a constant level. Here, the Japanese research group led by Professor Masaki Fukata, Drs. Yuko Fukata and Jun Noritake in National Institute for Physiological Sciences, Japan, found that t...
Light Sciences Oncology Announces Results of Study on Immunotherapeutic Mechanism of Aptocine(TM), a Novel Light-Activated Drug Therapy for Cancer
Preclinical Study is Subject of Upcoming ASCO Presentation
BELLEVUE, Wash., May 18 /PRNewswire/ -- Light Sciences Oncology, Inc. (LSO) today announced that a new preclinical study has yielded evidence that the company's novel light-activated drug Aptocine(TM) (formerly Litx(TM)) may enhance a...
Mayo researchers discover mechanism of cell type-specific signaling in tumor development
ROCHESTER, Minn. Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current onli...
Yale researchers discover mechanism for
Two-year-olds with autism lack an important building block of social interaction that prompts newborn babies to pay attention to other people. Instead, these children pay attention to physical relationships between movement and sound and miss critical social information. Researchers at the Yale Sc...
URI scientists reveal mechanism that regulates cancer-causing gene
KINGSTON, R.I. March 26, 2009 Two University of Rhode Island scientists have revealed how a cancer causing protein is regulated by reactive oxygen species (ROS) -- a type of stress signal. Their findings provide new insight into how this protein normally behaves in human cells and may help in t...
Mechanism in Medical Technology
National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness
SEATTLE, July 21 /PRNewswire-FirstCall/ -- Cell Therapeutics (CTI) (Nasdaq and MTA: CTIC) announced today that researchers from the Laboratory of Molecular Pharmacology at the National Cancer Institute presented new preclinical research identifying unique anti-tumor mechanisms of br...
Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology
ANNAPOLIS, Md., March 31 /PRNewswire-FirstCall/ --PharmAthene, Inc. (NYSE Amex: PIP ), a biodefense company developing medical countermeasures against biological and chemical threats, announced today that new mechanism
of action data for Valortim(R) were presented at the Keystone Symposia on Mol...
Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease
SAN FRANCISCO, July 30 /PRNewswire-FirstCall/ -- Medivation, Inc.
(Nasdaq: MDVN ) today announced new data showing that its investigational
drug Dimebon continues to produce broad, clinically meaningful benefits in
Alzheimer's disease patients after long-term dosing, and appears to operate
Genaera Corporation Presents Data on Mechanism of Inhibition of PTP-1B for Trodusquemine (MSI-1436) at Federation of American Societies for Experimental Biology (FASEB) Meeting
PLYMOUTH MEETING, Pa., July 14 /PRNewswire-FirstCall/ -- Genaera
Corporation (Nasdaq: GENR ) announced today the presentation of new
preclinical data on trodusquemine (MSI-1436), a novel inhibitor of PTP-1B
and Genaera's lead drug candidate for the treatment of type 2 diabetes and
Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
Expanded HCV Development Presence Includes ANA598 and ANA773 Acting via Independent but Potentially Complementary Mechanisms Conference Call Today at 2:00 PM PDT
SAN DIEGO, July 7 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals,
Inc. (Nasdaq: ANDS ) announced today ...
DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin
REYKJAVIK, Iceland, June 30 /PRNewswire-FirstCall/ -- deCODE genetics
(Nasdaq: DCGN ) today announced positive topline results from its latest
clinical pharmacology study of DG041, the company's first-in-class
antagonist of the EP3 receptor for prostaglandin E2, developed as a
Mechanism in Medical Products
AccuDrain External CSF Drainage System
Description:...able with a dual action lever that allows the system to be easily and quickly attached to an IV pole. Similarly, it features a unique squeeze-lok(tm) mechanism
for quick and secure adjustment of the burette drip chamber. The numbers on the graduated pressure scale are very large and were designed to be easil...
Company:Integra LifeSciences Corporation
ARC-HII Reciprocating Liposuction Cannula
aspiration is achieved by eliminating
vibratory or lateral movement of the
cannula tip. Rigorous engineering
incorporated into the mechanism
the ARC-H II Reciprocating Cannula
assures that the motion of the tip is
restricted to a longitudinal axis to
maintain stability and maximu...
Company:Byron Medical, Inc.
The Hugs Tag
Description:...g is a small radio transmitter combines state-of-the-art microprocessor technology with an unobtrusive ergonomic design. The tag incorporates a tamper mechanism
that is enabled as soon as the tag is attached to the infant. The tag emits an electronic Heartbeat® signal every 10 seconds to indicate it is pr...
Description:... The E-Holder™ Platform is designed with a spring-loaded mechanism
to ensure that the E-Gel® 96 and E-Gel® 48 gel cassettes stay firmly in place during robotic loading. This allows reproducible placement and l...
BD Vacutainer® Push Button Blood Collection Set
Description:... The push-button safety mechanism
instantly helps protect you against needlestick injury. Its in-vein activat...ed safety activation of the push button allows for activation of the safety mechanism
while still attending to the patient/venipuncture site, and provides easier...
Company:BD Diagnostic Systems
Ghrelin, Total ELISA Test
Description:...ogous to that of leptin resistance in obesity remains to be elucidated. In addiction, the development of a Ghrelin antagonist, or the development of a mechanism
to inhibit Ghrelin release to control appetite may be an important pharmaceutical development for the management of obesity.
Finally, recent evide...
Company:Diagnostic Systems Laboratories, Inc.
Mechanism in Medical Definition
...  AIRE is expressed primarily in the thymus.
A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism
of disease in human patients.  Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a d...
1 Disease settings
3 See also
4 External links
...ally hard, resulting in muscle atrophy .
The exact mechanism
in which these diseases cause cachexia is poorly u...
... Central tolerance is the mechanism
by which newly developing T cells and B cells are rendered non-reactive...^ Halverson R, Torres R, Pelanda R (2004). "Receptor editing is the main mechanism
of B cell tolerance toward membrane antigens". Nat Immunol 5 (6): 645-5...
Cryostasis (clathrate hydrates)
Living tissues cooled below the freezing point of water are damaged by the dehydration of the cells as ice is formed between the cells. The mechanism
of freezing damage in living biological tissues has been elucidated by Renfret (1968) (Renfret A.P. Cryobiology: some fundamentals in surgical context...
High Frequency Ventilation
...d to aid in ventilation.
High Frequency Flow Interruption (HFFI)
High Frequency Flow Interruption is similar to HFJV but the gas control mechanism
is different. Frequently a rotating bar or ball with a small opening is placed in the path of a high pressure gas. As the bar or ball rotates and the ...
Mechanism in Medical Dictionary
...between vertebrae), discs, and ... Explanation whiplash in traffic accident injuries. ... In a matter of seconds, you've experienced the classic mechanism
of injury for whiplash . ... A neck strain of the muscles around the cervical spine is often called whiplash . ... Often whiplash occurs...
...tamin K ... Other circumstances that may lead to vitamin K deficiency include: ... Vitamin K is integrally involved in the clotting mechanism
of blood. A deficiency of vitamin K results in decreased blood levels of prothrombin and ... Vitamin K deficiency is manifest as a t...
...d video clips and photo galleries - updated 24/7... Ventricular tachycardia can occur in the absence of apparent heart disease. ... A common mechanism
for ventricular tachycardia is reentry (re-stimulation of the ... Ventricular tachycardia - All Information, Ventricular tachycardia (...
...vesicle cycle. Synapses can fire at very rapid rates. ... Synaptic vesicle components are initially trafficked to the synapse using ... The mechanism
of GLUT4 vesicle exocytosis in response to insulin is not understood. ... Vesicle binding to microtubules was not mediated through direct bindin...
...y the vast numbers of ... Each category of microbes produces species that generates toxins in host cells. ... Overview of the biochemistry and mechanism
of action of bacterial toxins from the Center for Disease Control (CDC) ... These toxins , which affect eukaryotic ... Toxins that are inso...
.... Two previous ... Researchers have demonstrated that a bacterial toxin from the common bacterium Staphylococcus aureus shuts down the control mechanism
of the tunnel, called an ion ... Physician reviewed botulinum toxin type A patient information - includes botulinum toxin type A description, ...
Mechanism in Biological News
Airway cells use 'tasting' mechanism to detect and clear harmful substances
The same mechanism
that helps you detect bad-tasting and potentially poisonous foods may also play a role in protecting your airway from harmful substances, according to a study by scientists at the University of Iowa Roy J. and Lucille A. Carver College of Medicine. The findings could help explai...
Researchers gain insight into mechanism underlying Huntington's
LEXINGTON, Ky. (July 13, 2009) Researchers at the University of Kentucky Markey Cancer Center and Graduate Center for Toxicology (GCT) have gained new insight into the genetic mechanisms underlying Huntington's disease and other neurodegenerative or neuromuscular disorders caused by trinucleotide...
Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action
CAMBRIDGE (UK). 8th July 2009 / b3c newswire / - Funxional Therapeutics Ltd (Funxional) has announced today the successful completion of the first Phase I study with FX125L , an orally available small molecule which belongs to a new therapeutic class named Broad Spectrum Chemokine Inhibitors ( BS...
Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimer's disease
WOODS HOLE, MATiny, toxic protein particles severely disrupt neurotransmission and inhibit delivery of key proteins in Alzheimer's disease, two separate studies by Marine Biological Laboratory (MBL) researchers have found.
The particles are minute clumps of amyloid beta, which has long been kno...
New and unexpected mechanism identified how the brain responds to stress
Calgary, AB -- Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain. Being able to quickly and successfully respond to stress is essential for surv...
Molecular mechanism of anaphylactic shock decoded
Researchers at Heidelberg University have found a molecular mechanism
for anaphylactic shock. The activation of specific proteins in the cell walls of small blood vessels plays an important role. Suppressing the respective genes protects mice from the potentially fatal reactions of the immune and ...
Mechanism in Biological Technology
Funxional Successfully Completes Initial Clinical Trial of FX125L, an Anti-Inflammatory Drug With a Novel Mechanism of Action
CAMBRIDGE, England, July 8 /PRNewswire/ -- Funxional Therapeutics Ltd
(Funxional) has announced today the successful completion of the first Phase
I study with FX125L, an orally available small molecule which belongs to a
new therapeutic class named Broad Spectrum Chemokine Inhibitors (BSCIs)....
Bionovo Announces Publication of Data on Active Compound and Mechanism of Action for Its Preclinical Cancer Treatment, BN108
EMERYVILLE, Calif., April 20 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) today announced the poster presentation of significant, new data on the nature of the active compound and mechanism
of action for its preclinical cancer drug candidate, BN108. The presentation is being made at t...
DNA duplication: A mechanism for 'survival of the fittest'
The end of an era
Some 65 million years ago, the earth's most recent 'mass extinction' took place. One or more catastrophic events - such as a comet strike or increased volcanic activity - produced widespread fires and clouds of dust and smoke that obstructed sunlight for a long period of tim...
New Insights into the Mechanism of Action of Antipsychotic Drugs
ROCKVILLE, Md., March 10 /PRNewswire-FirstCall/ -- Vanda Pharmaceuticals Inc. (Nasdaq: VNDA ) reports the publication in Schizophrenia Research , the official journal of the Schizophrenia International Research Society, of a manuscript entitled "Common effect of antipsychotics on the biosynthes...
Medivation Presents New Data on Dimebon's Novel Mechanism of Action
SAN FRANCISCO, Dec. 9 /PRNewswire-FirstCall/ -- Medivation, Inc.
(Nasdaq: MDVN ) presented new data that provide additional evidence that
Dimebon, its lead product candidate in development to treat Alzheimer's and
Huntington's diseases, potentially operates via a novel mitochondrial
Revealing the regulating mechanism behind signal transduction in the brain
Leuven, Belgium Our brain consists of billions of cells that continually transmit signals to each other. This dynamic process − which enables us to learn, remember, and so much more − works only when the brain cells make contact correctly, or, in other words, when there is a good 'syn...
Mechanism in Biological Products
COPAS 500 from Union Biometrica
Description:...ed with traditional flow cytometry. Second, our patented pneumatic sorting mechanism
works with a gentle puff of air. This is much less harmful than the electr...fined ranges of these parameters, and achieved using our patented pneumatic mechanism
which sorts live organisms without affecting their viability. Objects are ...
MMP-2/MMP-9 Inhibitor IV [SB-3CT] from CHEMICON
Description:... MMP-2 / MMP-9 Inhibitor IV is a potent, selective, slow binding and mechanism
based inhibitor of human gelatinases. • Molecular weight: 306.4 • Molecular Formula: C(15)H(14)O(3)S(2). • The inhibitor is soluble i...
Biomek NX P Span-8 Laboratory Automation Workstation (w/ Gripper) from Beckman Coulter
Description:...ytokines Automated PCR* and sequencing reaction setup/cleanup Flexibility to Accommodate Your Needs Multiple configurations Optional gripper mechanism
on Span 8 Multiple syringe and probe options 360 rotating gripper
*The PCR process is covered by patents owned by Roche Molecular Systems an...
Console Incubator Shaker, 108-125V, 50/60 Hz from Thermo Scientific
Description:...s combine high durability and performance with class-leading ergonomics, unequalled programming power. The patented triple-counterbalanced heavy-duty mechanism
prevents vibration, allowing the unit to run with heavy out-of-balance loads. A patented HEPA filtration system reduces contamination. The heavy sta...
Tabletop Orbital Shaker, 90-126V, 50/60 Hz or 180-253V, 50/60 Hz from Thermo Scientific
Description:... Forma Tabletop orbital shakers combine high durability and capacity with unequalled ease of use. The patented triple-counterbalanced heavy-duty mechanism
prevents vibration, allowing the unit to run smoothly with heavy, out-of-balance loads. Every other part, from the large rubber block vibration isolat...
80C Tabletop Incubator Shaker, 90-125V, 50/60 Hz or 180-250V, 50/60 Hz from Thermo Scientific
Description:...l Shakers combine high durability and capacity with unequalled temperature performance and ease of use. The patented triple-counterbalanced heavy-duty mechanism
prevents vibration, allowing the unit to run at high speed with heavy, out-of-balance loads. The unit's class-leading temperature range is delivered w...
Mechanism in Biological Definition
...ether with myosin filaments actin it forms Actomyosin , which provides the mechanism
for muscle contraction. Actin uses ATP for energy. The ATP allows, through ...orterning, or contraction, of the actin bundle (but not the filament). This mechanism
is responsible for muscle contraction and cytokinesis , the division of on...
Another such classification is by their mechanism
of action (that is, the mechanism
by which they selectively poison bacterial cells):
Antibiotics which ...
1 Binding change mechanism
2 Physiological role
3 Plant ATP synthas...lso
7 External links
Binding change mechanism
In the 1960s through the 1970s, Paul Boyer dev...ake place. The overall structure and the catalytic mechanism
of the chloroplast ATP synthase are almost the sam...
...enerally those which are present on the other sex chromosome (Y or W).
Mammalian X-chromosome inactivation is initiated from the X inactivation ...herited gene may be imprinted .
It is thought that this constitutes the mechanism
of choice, and allows downstream processes to establish the compact state o...
...ral selection . ( Alfred Russell Wallace is commonly recognized as the co-discoverer of this concept). Genetic drift was embraced as an additional mechanism
in the so-called modern synthesis . The evolutionary history of a species —which tells the characteristics of the various species from which i...
...iews on the function of the brain. Hippocrates believed the brain to be the seat of intelligence, but Aristotle held that the brain was a cooling mechanism
for the blood , while the heart was the seat of intelligence. Aristotle reasoned that humans are more rational than the beasts because they have a...
Mechanism in Biological Dictionary
...n-Chief to add or edit content to WikiDoc. ... The zona pellucida is seen as a thick clear girdle surrounded by ... tered in discussions on the mechanism
of loss of the mouse zona pellucida in ... stained with Mallory's trichrome, which stains the zona pellucida blue. Space within ... Compl...
...ment, ... Examples of the genes on the X chromosome include those for the enzyme steroid ... The X Chromosome . X-Linkage. X-Inactivation. mechanism
... With only a single X chromosome , males who inherit the defective gene (always ... The National Fragile X Foundation unites the fragile ...
...n. ... BioInfoBank Library :: RNA , Untranslated :: genetics :: Differential expression of H19 and vitamin D3 upregulated protein 1 as a mechanism
of the modulatory effects ... BioInfoBank Library :: RNA , Untranslated :: classification :: Small RNAs: ... classification; RNA , Untranslate...
...ans - splicing appears to reflect an archaic form of RNA processing that is used ... the two events is that trans - splicing is an intermolecular mechanism
that ... Trans RNA reprograms tau alternative splicing defect in human neurons. ... We designed a pre- trans - splicing molecule containin...
...an enzyme that binds to the ends of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism
or a replicative transposition mechanism. Aspects of the topic transposase are discussed in the following places at Britannica. Assorted Refere...
...ansmembrane receptors , GPCR, GRK, β-arrestin, 7TMR, ... Transmembrane receptors in microorganisms, such as sensory histidine kinases and ... mechanism
of transmembrane signaling by the aspartate receptor : a model. ... PolyMedix is a biotechnology company that is developing novel, synthetic s...