Cross-species transplant in rhesus macaques is step toward diabetes cure for humans
St. Louis, Oct. 18, 2007 With an eye on curing diabetes, scientists at Washington University School of Medicine in St. Louis have successfully transplanted embryonic pig pancreatic cells destined to produce insulin into diabetic macaque monkeys all without the need for risky immune suppression d...
Reduced diet thwarts aging, disease in monkeys
...14 years. Today, 33 animals remain in the study. Of those, 13 are given free rein at the dinner table, and 20 are on a calorie-restricted diet. Rhesus macaques
have an average life span of about 27 years in captivity. The oldest animal currently in the study is 29 years.
The new report details the relation...
Transplant drug stimulates immune memory
... Larsen, MD, PhD, director of the Emory Transplant Center and chair of the Department of Surgery, to show that rapamycin had similar effects in rhesus macaques
infected with vaccinia virus as in mice. That research was conducted at Emory's Yerkes National Primate Research Center.
Rapamycin, also called sir...
JHU researcher discovers brain cells have 'memory'
...s, whose visual systems closely
resemble that of humans. Located at the very back of the brain, V2 is
roughly the size of a wristwatch strap.
were rewarded for watching a screen onto which various
images were presented as the researchers recorded the animals' brain
nerve cells' response. P...
New HIV Drug May Help Those Resistant to Therapy
...is similar to HIV in humans. After six days of treatment, only three of the macaques
had detectable SIV levels, and after 13 days, only very low SIV levels coul...e found in two of the macaques.
When the researchers gave D-1mT to eight macaques
that were not treated with ART, there was no change in the levels of virus ...
Germicide Might Guard Against HIV Infection
...trick M. Schlievert, a professor of biology at the University of Minnesota.
In the new study, researchers tested the compound on five female rhesus macaques
that were vaginally exposed to the monkey equivalent of the AIDS virus. The findings were published in the March 4 online issue of Nature .
Pre-verbal number sense common to monkeys, babies, college kids
...ber of objects repeated in different-looking sets, infants recognize the novelty of a new number of objects. So do macaques. And both college kids and macaques
can do a rough sort of math by summing sets of objects without actually counting them. Their speed and accuracy are about the same, in fact.
Yerkes researchers find link between psychological stress and overeating
...rch Center, Emory University, have found socially subordinate female rhesus macaques
over consume calorie-rich foods at a significantly higher level than do dom... constant psychological stress to subordinates.
During the study, female macaques
were given access to a sweet but low-fat diet and a high-fat diet for 21 da...
AVMA Urges Outlawing Trafficking of Chimps, Monkeys and Nonhuman Primates and Pets
...icult to find veterinary care for these pets, Dr. Golab
explained, and they carry numerous zoonotic diseases. "Tuberculosis is
especially common among macaques
and their owners," she said.
"Zoos don't have the space for nonhuman primates that were formerly
pets, and sanctuaries are overburdened," Dr. Golab ...
Monkey Gene That Blocks AIDS Viruses Evolved More Than Once
... of scourge.
The TRIM5-CypA gene found in Asian macaques
is a hybrid of two existing proteins, TRIM5 and Cy...asn't found in monkey closely related to the Asian macaques
and TRIMCyp wasn't found in any other South Americ... combination genes evolved separately, once in the macaques
and once in the owl monkeys.
This development o...
macaques in Medical Technology
U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant
...2000, were promising.
Four of four (100%) rhesus macaques
Vaxfectin(R)-formulated vaccine deve...mia
(group mean 0.75 days). Only one of four (25%) macaques
unformulated vaccine developed neutr...a (group
mean 2.00 days). The unvaccinated control macaques
did not develop any
neutralizing antibodies, and w...
Successful Results for Mymetics Corporation's Mucosal HIV/AIDS Vaccine Viral Challenge Significantly Exceeds Expectations
...ytical facility, have and continue to be used by leading US scientists
and major governmental entities for ongoing scientific testing. This study
for evaluating Mymetics' latest HIV vaccine formulation and
consisted of three differing methodologies of immunizing the macaques. The
macaques were i...
Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma
... and highly expressed on melanoma cells. Consistent with the
accessibility of the respective target antigen, the CD33-specific BiTE
antibody showed in macaques
a dose-dependent depletion of CD33-expressing
blood cells, whereas the MCSP-specific BiTE antibody did not show any
activity, even at very high doses....
VIRxSYS Presents Data on HIV Vaccine at Keystone HIV Vaccine Symposia
...pressing lentiviral vector, has produced positive results in mice and in
preliminary non-human primate studies. A larger, confirmatory study in
has been initiated.
"VRX1023 shows exciting promise," says Dr. Franck Lemiale, Director of
Research and Development, Immunobiology for VIRxSYS. "The...
Vaxfectin-formulated Measles DNA Vaccine Elicits Long-term
Protection and Sterilizing Immunity in Nonhuman Primates
... on global
measles disease and death rates."
The study in juvenile rhesus macaques
tested the protective
efficacy of a bivalent DNA vaccine encoding measles h...e vaccines
were well-tolerated in all animals.
The study in infant rhesus macaques
tested only intradermal
needle-and- syringe delivery of vaccine at the same...
macaques in Biological News
A clue from macaques yields evidence for impaired retroviral defense genes in humans
Researchers Harmit Malik and Michael Emerman and colleagues at the Fred Hutchinson Cancer Research Center have found that a surprisingly large fraction of humans may be impaired in the function of a recently discovered arm of the body's defense against invading retroviruses such as HIV.
One of t...
Potential new HIV drug may help patients not responding to treatment
...of a modified amino acid called D-1mT to 11 rhesus macaques
infected with SIV. All of the macaques
had been treated with ART for at least four months. Eight of the macaques
had higher viral loads (reaching up to 100,000 cop...
Primate culture is just a stone's throw away from human evolution, study finds
...ne-handling behavior in several troops of Japanese macaques
to catch a unique glimpse of primate culture. By w... Japan assessed social learning exhibited by these macaques
during stone-handling, a behavior that has been pa...ehavior changed with each generation as individual macaques
contributed their own patterns of stone-handling, ...
Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
...ss, unlike other primate species, including rhesus macaques
and humans, that succumb to disease.
Following...cy viruses (SIV), whose transmission to humans and macaques
leads to AIDS.
Surprisingly, the natural hosts...rast to mangabeys, dendritic cells from humans and macaques
that are susceptible to developing AIDS are readil...
Simian foamy virus found in several people living and working with monkeys in Asia
...r about 86 percent of the wild population, live in urban areas because of habitat loss. Unlike the great apes, such as chimpanzees or gorillas, rhesus macaques
and other species of monkeys are very adaptable to new habitats.
"Some macaque species thrive in human-altered environments, given the tolerance of ...
Tips from the Journals of the American Society for Microbiology
...mbining genes and proteins from all four dengue virus types as well as incorporating an adenovirus agent. Following intramuscular vaccination, rhesus macaques
showed high antibody levels that neutralized all four of the dengue virus types. To further test the sustainability of the protective immune response...
Environmental enrichment can reduce cocaine use, researchers find
...rogram of the American Society for Pharmacology and Experimental Therapeutics (ASPET).
Nader and colleagues worked with a group of 24 cynomolgus macaques
who were already categorized socially. For additional enrichment, the monkeys were placed in larger-than-normal cages for three days. For increased st...
UC Davis researchers discover how HIV turns food-poisoning into lethal infection
...heir collaboration. Together, they developed a novel technique that allowed them to study early intestinal responses to Salmonella infection in rhesus macaques
infected with simian immunodeficiency virus (SIV), an established model for HIV infection.
We found that animals that had no SIV infection were abl...
Yerkes researchers identify language feature unique to human brain
...ompared the size and trajectory of the arcuate fasciculus in humans, rhesus macaques
According to Rilling, "The human arcuate fasiculus differed from that of the rhesus macaques
and chimpanzees in having a much larger and more widespread projection to a...
Monkey malaria widespread in humans and potentially fatal
...ms are usually less serious than other types of malaria.
Until recently, P. knowlesi, was thought to infect only monkeys, in particular long-tailed macaques
found in the rainforests of South East Asia. Natural infections of man were thought to be rare until human infections were described in one area in Sa...
macaques in Biological Technology
Practice makes perfect -- motor memory possible for neuroprosthetic control
...difficult to change, rapid recall upon demand, and resistance to interference when new skills are learned. All three elements were demonstrated by the macaques
in the UC Berkeley study.
To test resistance to interference, the researchers presented a new decoder marked by a different colored cursor two w...
Vaxfectin(R)-formulated Measles DNA Vaccine Could Address Unmet Need for Infants
...ulated Measles DNA Vaccine
The study in juvenile macaques
tested a bivalent DNA vaccine encoding
measles hem...doses at four- week intervals. The study in infant macaques
intradermal delivery of two 0.5 mg dos...re
similar to those previously reported for rhesus macaques
with the currently marketed liv...
JCI table of contents: April 22, 2008
... protein PPAR-gamma. Further, when PPAR-gamma agonists were administered to macaques
they impaired hematopoietic progenitor cell function. Disruption of hematop...ate early hematopoiesis through a Nef/PPAR-gamma/STAT5 signaling pathway in macaques
Institute of Emerging Disease and Innova...
macaques in Biological Definition
... known human cases and deaths during outbreaks of Ebola Sudan between 1976 and 2003 .
In 1989, Crab-eating macaques
from the Philippines brought Ebola-Reston into quarantine facilities in Reston , Virginia , Texas , and Pennsylvania . Four people developed a...