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mRNAs in Medical News

The future of personalized cancer treatment: An entirely new direction for RNAi delivery

...'s negative charge. This allows the resultant fusion protein to enter the cell and deliver the siRNA into the cytoplasm where it specifically targets mrnas from cancer-promoting genes and silences them. To determine the ability of this PTD-DRBD fusion protein to deliver siRNA, the researchers generat...

American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide

...rolled cell growth of some cancers. Hans-Guido Wendel, M.D., Memorial Sloan-Kettering Cancer Center, will test whether proteins that translate the mrnas expressed from oncogenic genes respond to small molecules as potential cancer treatments. Cancer Cell Biology and Metastasis John Wilk...

Master molecular switch may prevent the spread of cancer cells to distant sites in the body

...rmation for protein synthesis -- together in different ways so that there can be more than one messenger RNA (mRNA) produced from the same gene. These mrnas then go on to make different proteins. The mRNA for Fibroblast Growth Factor Receptor 2 (FGFR2) is the focus of the Molecular Cell study. FGFR2 m...

Wyeth Pharmaceuticals and Santaris Pharma Announce Strategic Alliance to Develop RNA-based Medicines

...in regulation of gene expression in both normal and diseased cells, whereas mrnas are translated into the proteins that determine all aspects of cell identit...he LNA Drug Platform used to develop new classes of RNA medicines targeting mrnas and miRNAs associated with disease. Santaris Pharma's drug discovery engin...

Breakthrough in cell-type analysis offers new ways to study development and disease

...otransmitter involved in muscle movement and emotion regulation, among other things. They used the handle they had made to pluck out the ribosomes and mrnas from these brain cells and freeze them within minutes of dissection, preserving the "messages" largely as they were inside the living animal and minim...

A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found

...erexpression at protein level was found and significantly associated with depth of invasion, recurrence, poor prognosis, and FGFR1 overexpression. The mrnas for ephrin ligands were coexpressed in various combinations in gastric cancer cell lines and cancer tissues. Downregulation of EphA4 expression by siR...

Penn researchers gain new insights on spinal muscular atrophy

...r RNA (mRNA) before it leaves the nucleus to travel to the cytoplasm. Here, mrnas get translated into working proteins. "SMN plays a key role in determini...lls and mice and found that changes in levels of the snRNPs, as well as the mrnas their spliced products were affected, producing numerous abnormal mRNAs. ...

RNA-associated introns guide nerve-cell channel production

...n is not in the final channel protein doesnt mean that it doesnt have an important purpose. The group surmises that the intron may control how many mrnas are brought to the dendrite and translated into functional channel proteins. The correct number of channels is just as important for electrical impuls...

Biotech Company Builder Papadopoulos Says Investment in Innovation Needed to Advance Drug Pipeline at Massachusetts Biotechnology Council's Ninth Annual MASS Opportunities Investment Conference

...ssues, and that there are between 5,000 and 50,000 mrnas per cell. Understanding the balance of mrnas in healthy cells could lead to diagnostic tests fo...by characterizing the role of the various types of mrnas in humans, new therapies could be pursued. Indust...

Researchers identify unusual molecular switch for common form of advanced breast cancer

...-BP1 trigger hypoxia inhibition of conventional protein synthesis in tumor cells, and with eIF4G, then increases the selective translation of specific mrnas that promote tumor survival and angiogenesis, thereby functioning as a hypoxia controlled switch for tumor growth and survival. These results prese...
mRNAs in Medical Technology

Another LNA-based RNA Inhibitor Enters Clinical Trials

...rma is a privately held biopharmaceutical company with exclusive rights to use the LNA Drug Platform to develop new classes of RNA medicines targeting mrnas and miRNAs associated with disease. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic disord...

Study Shows Intradigm's RNAi Nanoplex Technology To Be Effective Systemic siRNA Delivery Platform for the Treatment of Various Cancer Models

...echnology is its ability to incorporate multiple siRNAs in a single drug product. These multi-targeted therapeutics can simultaneously silence several mrnas that represent parallel or synergistic elements of the same disease pathway resulting in a more comprehensive and/or novel therapeutic potential. Re...

Gen-Probe Begins U.S. Clinical Study of Molecular Test for Human Papillomavirus, Which Causes Cervical Cancer

... RNAs (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes that targeting these mrnas may more accurately identify women at higher risk of having, or developing, cervical cancer than competing assays that target HPV DNA. Detecting HPV D...

Gemin X Presents Positive Preclinical Data of GX15-070 in Infant ALL at AACR Meeting

...ivity and IC(50) values were within clinically achievable concentrations. High BCL-2 expression and low expression of particular BH3-only BCL-2 family mrnas in this disease correlate with GX15-070 sensitivity in vitro. "GX15-070 is an appropriate candidate for ALL treatment because the imbalanced expr...
mRNAs in Medical Products

MagPrep® Streptavidin Beads

Features:...gPrep Streptavidin Beads are for molecular applications such as hybrid capture techniques, e.g., isolation and enrichment of specific DNA sequences or mrnas using appropriate biotinylated probes or primers. The beads are compatible with downstream applications such as sequencing and cDNA synthesis, and ca...
Company:EMD Biosciences, Inc.
mRNAs in Biological News

Researchers see evidence of memory in the songbird brain

...nger RNAs in the auditory forebrain of finches exposed to a new song. These mrnas are templates that allow the cell to translate individual genes into the proteins that do the work of the cells. Any surge or drop in the number of mrnas in brain cells after a stimulus offers clues to how the brain is responding...

Research uncovers clues to virus-cancer link

...expressed higher levels of KSHV miRNA. In second study, published June 4 in the journal Blood, the team looked for the presence of tumor suppressor mrnas in primary effusion lymphoma and Kaposi's Sarcoma. "We chose these two cancers because, while they are both associated with the same virus, they o...

Genetic switch potential key to new class of antibiotics

...acid (DNA) chains are copied into messenger ribonucleic acids (mRNAs). The mrnas are then transported to ribosomes that pair them with transfer RNAs that co... (e.g. preQ0), and lock the mRNA into a stable conformation to counter that mrnas role in a bacterium's disease-causing ability. Previous experiments showed ...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

...d to increase the number of patients who could be helped, he said. The next problem became developing siRNAs that could discriminate between target mrnas and non-target. "That turned out to be frustratingly difficult," Zamore said. In tests of human cells, the siRNA sometimes sliced up the disease RNA, ...

New technique used to profile anthrax genome

... marks the first time any bacterial transcriptomethe complete collection of mrnas produced by a bacterium as it expresses different geneshas been comprehensi...applying it to bacteria has been difficult, said Bergman, because bacterial mrnas have a different structure and cannot be easily separated from the other RN...

Researchers identify gene linked to aggressive progression of liver cancer

...sion, metastasis, resistance to chemotherapy, the formation of new blood vessels, and senescence. cDNAs are complementary DNAs that are generated from mrnas to analyze gene expression profiles. "AEG-1 also activates multiple intracellular signaling pathways that are known to be involved in HCC progressi...

Mutant host cell protein sequesters critical HIV-1 element

...scription. The mRNA molecules must be properly "spliced", or rearranged, and then transported out of the cell nucleus and into the cytoplasm where the mrnas can be "translated" into viral proteins. "Although there has been a great deal of effort directed at understanding HIV-1 transcription, mRNA splici...

8 National Medals of Science awardees to be honored at gala, then the White House

...d hormones act in target cells. They showed that steroid hormones regulate de novo synthesis of specific proteins by regulating the levels of specific mrnas in target cells. Using cell-free transcription methods, they substantiated "initiation of transcription" as the rate-limited step at which nuclear rec...

Plant biologists discover unexpected proteins affecting small RNAs

...08 online issue of Developmental Cell, shows that the RNA world is more complex than imagined. Ecker and colleagues tinkered with factors that process mrnas in the mustard weed Arabidopsis thaliana and observed affects on short, or small RNAs. Their findings could impact fields as diverse as plant patholog...

Single-celled bacterium works 24-7

... over 48 hours. At a given time, the mRNA levels indicated what the cells were doing. For example, when the researchers identified high levels of many mrnas encoding various protein components of the nitrogenase enzyme, they knew that the cells were fixing nitrogen at that time, in this case, during the da...
mRNAs in Biological Technology

Detection of mRNAs on Cryosections of the Cardiovascular System Using DIG-Labeled RNA Probes

The following protocol was optimized from a protocol using 35S-labeled RNA probes [1, 2]. In research studies, it enables detection of the expression of rare mRNAs in the cardiovascular system (e.g., of the proinflammator...

LNA-Based RNA oligonucleotides Potently Inhibit Cancer microRNAs

...harma (founded in 2003) is a privately held clinical stage biopharmaceutical company developing new classes of RNA medicines targeting disease-related mrnas and miRNAs based on its proprietary LNA chemistry. The Company's own research and development activities focus on microRNAs, infectious diseases and m...

Jivan Focuses on Solutions for Transcriptome Sequencing

...nctions, Jivan can ensure the capture of all mRNA sequences of each gene of interest, including wildtype transcripts and splice variants. For genes or mrnas with low expression, Jivan will offer mRNA Prime(TM) PCR primer designs specific to each observed mRNA. To analyze RNA sequencing data, Jivan wi...

Researchers develop new way to see single RNA molecules inside living cells

...nomena. "We are excited to use this imaging strategy to study how single viral RNAs travel from the nucleus of a cell to a virus assembly site, how mrnas are regulated by location and time, and RNA trafficking in neurons," added Santangelo. ...

Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting

...enger RNAs (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes targeting these mrnas may more accurately identify women at higher risk of having, or developing, cervical cancer than competing assays that target HPV DNA. Detecting HPV D...

Gen-Probe Launches in Europe CE-Marked APTIMA(R) HPV Assay for Detection of Human Papillomavirus

... RNAs (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes that targeting these mrnas may more accurately identify women at higher risk of having, or developing, cervical cancer than competing assays that target HPV DNA. Detecting HPV D...

Intradigm Licenses Key Next Generation RNA Interference (RNAi) Intellectual Property From University of Massachusetts Medical School

...echnology is its ability to incorporate multiple siRNAs in a single drug product. These multi-targeted therapeutics can simultaneously silence several mrnas that represent parallel or synergistic elements of the same disease pathway resulting in a more comprehensive and/or novel therapeutic potential. Re...

Protein Depletion for Plasma and Serum Proteomic Analysis

... correlate to specific diseased states. However, there are still questions about the correlation between the expression levels of mrnas and the corresponding changes in expression levels of proteins expressed, whether in human tissues [12,33,34] or in yeast cells ...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

...perimental samples. To avoid competition, GAD67 and β-actin mrnas were amplified in 2 separate PCR reactions. All samples were run...e of the real-time RT-PCR quantitation of GAD67 and β-actin mrnas expression in one individual case is shown in Figure 3. The mean...

RNA Interference and Gene Silencing: History and Overview

... silencing complex. A nuclease complex, composed of proteins and siRNA (see below), that targets and destroys endogenous mrnas complementary to the siRNA within the complex. RNA interference (RNAi) - Post-transcriptional g...
mRNAs in Biological Products

m7G(5)ppp(5)G (Cap Analog) from Ambion

Description:...ation of the cap structure into a large fraction of the transcripts. Capped mrnas are generally translated more efficiently in reticulocyte lysate and wheat germ in vitro translation systems. Uncapped mrnas are rapidly degraded after microinjection into cells. Thus, it is important...
Company:Ambion

m7G(5)ppp(5)G (Cap Analog) from Ambion

Description:...ation of the cap structure into a large fraction of the transcripts. Capped mrnas are generally translated more efficiently in reticulocyte lysate and wheat germ in vitro translation systems. Uncapped mrnas are rapidly degraded after microinjection into cells. Thus, it is important...
Company:Ambion

RNA Cap Analog, Methylated from EPICENTRE Biotechnologies

Description:... A modified nucleotide structure called a ?cap? is present on the 5?-end of most naturally-occurring eukaryotic mrnas and many viral RNAs. Substitution of Cap Analog for a portion of the GTP present in an in vitro transcription reaction results in the synthesis of tra...
Company:EPICENTRE Biotechnologies

RNA Cap Analog, Unmethylated from EPICENTRE Biotechnologies

Description:... A modified nucleotide structure called a ?cap? is present on the 5?-end of most naturally-occurring eukaryotic mrnas and many viral RNAs. Substitution of Cap Analog for a portion of the GTP present in an in vitro transcription reaction results in the synthesis of tra...
Company:EPICENTRE Biotechnologies

RNA Cap Analog, Trimethylated from EPICENTRE Biotechnologies

Description:... A modified nucleotide structure called a ?cap? is present on the 5?-end of most naturally-occurring eukaryotic mrnas and many viral RNAs. Substitution of Cap Analog for a portion of the GTP present in an in vitro transcription reaction results in the synthesis of tra...
Company:EPICENTRE Biotechnologies

Canine Pancreatic Microsomal Membranes from Promega

Description:... (1). Membrane preparations are assayed for both signal peptidase and core glycosylation activities using two different control mRNAs. The two control mrnas supplied with this system are the precursor for β-lactamase (or ampicillin resistance gene product) from E. coli and the precursor for α-...
Company:Promega
mRNAs in Biological Definition

Morphogenesis

...hat code for these differentially localized oocyte mrnas are called maternal effect genes . They have prof...parts of the cell. Maternally synthesized bicoid mrnas attach to microtubules and are concentrated at the...nterior ends of forming Drosophila eggs. Nanos mrnas also attach to the egg cytoskeleton but they conce...

Morphogenesis

...hat code for these differentially localized oocyte mrnas are called maternal effect genes . They have prof...parts of the cell. Maternally synthesized bicoid mrnas attach to microtubules and are concentrated at the...nterior ends of forming Drosophila eggs. Nanos mrnas also attach to the egg cytoskeleton but they conce...
mRNAs in Biological Dictionary

Untranslated RNA

...yosin Gene Suppresses Tumor Activity. ... Expression of prohibitin 3' untranslated region suppressor RNA alters ... Untranslated Regions of mrnas Play a Role in Regulating Gene Expression. ... JD: The 3' untranslated region of messenger RNA : a molecular 'hotspot' for pathology? ... RNA ...

Trans-splicing

... information in ... Cis- and trans - splicing of mrnas mediated by ... Trans - splicing Trans - sp...of an RNA after ... Cis- and trans - splicing of mrnas mediated by tRNA sequences in eukaryotic cells". P...uring the trans - splicing reaction, each of the mrnas acquires the spliced ... Spinal muscular atroph...

Start codon

...egion included the start codon , deviating from the expected location for the SD ... sequences downstream from start codons , we could explore mrnas ... The second type of overlapping stop- start codon , AUGA (AUG plus UGA), is also ... The first AUG in ORF2 is used as a start codon . ... ...

Splicing

... One important layer of regulation concerns RNA splicing , in which noncoding regions... Figure 2: Alternative splicing results in different mature mrnas and ... Splicing - Definition of Splicing at Dictionary.com a free online dictionary ... or parts of a rope by splicing . 8. ... Main Entry: ...

Signal Sequence

...aES™'s proprietary media formulations dramatically increase the expression ... ACES™ Signal Sequence Kit Application Manual (pdf) ... Certain mrnas encode what is know as a " signal sequence " or leader peptide. ... The signal sequence is then threaded through a pore called the translocon. ....

RNA Splicing

...which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing . The resulting different mrnas may be translated into different protein... A recent study claimed to offer proof of the RNA -world hypothesis or the origin of life. The evid...

Polycistronic

...ic means many genes on 1 mRNA strand. ... Polycistronic mRNA is a mRNA that encodes several proteins and is characteristic ... Polycistronic mrnas consist of a leader sequence which precedes the first gene. ... A number of genes are now known to be polycistronic , that is, they produce more...

Nonsense Mutation

... of an organism. Mutations can be caused by copying errors in the genetic material during cell division, by exposure to ultraviolet or... FBN1 mrnas carrying the Y2113X nonsense mutation are subject to NMD. ... The Y2113X nonsense mutation is indicated, the primers used in the RT–PCR assay ...

Monocistronic

...ndant, but we have shown that an E7 ... Eukaryotic mrnas are usually monocistronic and translational init... ... 5 -UTR containing monocistronic reporter mrnas continue ... monocistronic analysis of RNAs in v..... Replication occurs as above and monocistronic mrnas are produced. ... Putative IRES elements almo...

G-banding

...Health ... Page citation: G-Banding Images . In Stem Cell Information [World Wide Web site] ... Elucidation of a C-Rich Signature Motif in Target mrnas of RNA ... High resolution G-banding patterns of Syrian hamster chromosomes. Li S, Pathak S, Hsu TC ... Definition and other additional informa...
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