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mRNA in Medical News

Pluronic L-81 is a potential anti-diabetic drug?

...L-81 on apolipoprotein B (apoB) secretion and the mrna level of the MTP gene. In their study, Geneti...ed with L-81 and the effects on apoB secretion and mrna level of the MTP gene were assessed. The result...oB secretion, but also significantly decreased the mrna level of MTP gene. Similar to the action of insuli...

New piece found in colorectal cancer puzzle

...ectal tissue samples from 222 patients and 23 controls. They found that the mrna levels of the inhibitor of prostasin, PN-1, increased at both the transitio...rvival. In what may be support for this trend, our data shows that elevated mrna levels for prostasin's inhibitor, PN-1, coincides with the acquisition of m...

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

...rol subjects. The researchers found that NDRG4 promoter methylation was more prevalent in colorectal cancers than in noncancerous colon mucosa. Its mrna and protein expression were decreased in colorectal cancer tissue compared with noncancerous colon mucosa. A methylation-specific polymerase chain rea...

Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO

...ew data from a Phase 1 study of LY2181308 in patients with cancer. The new data confirmed that LY2181308 penetrates tumor tissue and reduces survivin mrna and protein levels in tumor cells. In addition, Dr. Azeem Saleem, CRUK Senior Clinical Research Fellow, University of Manchester, presented results o...

Scientists find shared genetic link between the dental disease periodontitis and heart attack

...n, but can bind specifically to the messenger RNA to form a duplex. Through this binding, the antisense strand inhibits the protein expression of the mrna . Coronary heart disease is the leading cause of death worldwide, and periodontitis, which leads to the loss of connective tissue and the bone sup...

A novel marker of colorectal carcinoma

...cted in 20 human adenocarcinoma tissues for TSPAN1 mrna assay by RT-PCR. Eighty-eight specimens of human c...ssay. By RT-PCR assay, it was shown that TSPAN1 mrna was detected in 90.0% (18/20) of cancerous tissue. The light density of TSPAN1 mrna expression levels was 0.89 0.30 in adenocarcinoma ...
mRNA in Medical Technology

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...nd Company recently completed its Phase 1 study of LY2181308 and presented data confirming that LY2181308 penetrates tumor tissue and reduces survivin mrna and protein levels in tumor cells. Isis and its collaborators highlighted new antisense therapeutic programs and targets to trea...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...onference. The additional presentations highlighted antisense inhibitors to a number of metabolic targets in a variety of animal species that reduced mrna target levels in specific tissues and provided therapeutic benefit such as improved insulin sensitivity, reduced fat mass and body weight in various m...

Getting More From Whole-Transcript Microarrays

...ative splicing activity on a genome-wide scale, without investing in new exon microarray technologies. Alternative splicing produces a variety of mrna transcripts from a single gene by splicing together different combinations of exons, which can give rise to alternative protein forms that are functio...

ExonHit Reports Proof-of-Concept in Breast Cancer Diagnostic Using its SpliceArray(TM) Platform

...rst product developed with this technology on the market." SpliceArray(TM) biochips are ExonHit's proprietary research tools [2]. They quantify mrna expression at the exon level. They also provide a comprehensive RNA splicing analysis across the entire human genome and enable the identification of ...

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

...maceuticals that are inducers of ribosomal readthrough of nonsense mutation mrna stop codons. "We are pleased to have completed enrollment of our first...enetic disorders. Nonsense mutations create a premature stop signal in the mrna causing the ribosome to terminate translation before a full-length protein ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

... those treated with placebo, results of a post-hoc analysis did show a reduction in necrotic core thickness relative to plaque thickness. Furthermore, mrna levels of IL-6, a pro-inflammatory cytokine, appeared to decrease in plaque tissue from patients treated with VIA-2291. These findings may indicate an...
mRNA in Medical Products

Streptavidin Magnetic Beads

Description:...superparamagnetic beads covalently coupled to a form of streptavidin. Captured substrates can be useful as ligands in subsequent experiments including mrna isolation and the capture of primary or secondary antibodies....
Company:New England Biolabs, Inc.
mRNA in Medical Dictionary

Viral

...ous to the spread of... Article detailing the etymology, origins, anatomy, and replication of ... Negative-sense viral RNA is complementary to mrna and thus must be converted to ... virus n. , pl. -ruses . Any of various simple submicroscopic parasites of plants, animals, and bacteria ... ...

Protein C

...eased functional activity. ... Mouse protein -coding gene Proc. Represented by 121 ESTs from 30 cDNA libraries. ... Mus musculus protein C , mrna (cDNA clone MGC:13870 IMAGE:4211329), complete ... List of 5 disease causes of Decreased protein C , patient stories, diagnostic guides. Diag...

Macrophage

...hage differentiation is partially restored by transduction with a PU.1 ... mrna for macrophage -specific genes including M-CSF receptor (Fig 2 A), manno...es at a ratio of 1:10 ( macrophage /amastigotes) ... Extracted macrophage mrna was reverse transcribed by M-MuLV Reverse ... Home page of Macrophage ...

Leucine aminopeptidase

...d by 1114 ESTs from 403 cDNA ... Homo sapiens leucine aminopeptidase 3, mrna (cDNA clone IMAGE:2821948), partial cds ... Mouse protein-coding gen...STs from 158 cDNA libraries. ... Mus musculus leucine aminopeptidase 3, mrna (cDNA clone MGC:27841 IMAGE: ... Leucine aminopeptidase urine tes...

Histamine

...ficult ... 92, 281-287), we investigated whether histamine regulates IL-6 synthesis. ... Histamine alone did not induce protein synthesis or mrna accumulation for IL-6. ... Response Modulation by Histamine . Mechanical/Chemical. Pharmacodynamics-Mechanism of Action ... Histamine : Storage ...

Epididymis

...es sperm to vas deferens ... of the epididymis are? Read answer... What is in the epididymis secretion? ... Multiple promoter and splicing mrna variants of the epididymis -specific gene EP2. ... a family of androgen-dependent, epididymis -specific secretory proteins. ... The developmen...
mRNA in Biological News

Yale scientists visualize the machinery of mRNA splicing

New Haven, Conn. Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our genomes; it illuminated a relationship between gene processing in humans and the most primitive organisms by creating the first crystal structure of a crucial self-splicing region of RNA...

Oliguridylation-mediated histone mRNA decay

In the January 1st issue of G&D, Drs. Thomas Mullen and William Marzluff (UNC Chapel Hill) lend new insight into the degradation of mammalian histone mRNA. Histone mRNA is rapidly degraded at the end of S phase, but the mechanism by which this occurs has remained elusive, as metazoan histone mRNA...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems. However, do nucleic acids possess other attributes that contribute to their biological functions? Recent work of a team led by Stoyno Stoynov, working at the Bulgarian Academy of Scien...

ISU researchers find possible treatment for spinal muscular atrophy

...e mutated or malfunctioning SMN1 gene. All proteins in human bodies are made by copying genes. This copy is called pre-mRNA. Pre-mRNA then becomes mrna by splicing out certain parts of the sequence that are non-coding, meaning they don't help the function of the gene. These non-coding portions of th...

MicroRNAs help control HIV life cycle

...e Program for RNA Biology at Burnham, and colleagues, found that the microRNA miR29 suppresses translation of the HIV-1 genome by transporting the HIV mrna to processing-bodies (P-bodies), where they are stored or destroyed. This results in a reduction of viral replication and infectivity. The study also ...

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

... its double-stranded DNA is first transcribed into a corresponding single-stranded piece of messenger RNA. Then an enzyme called the ribosome uses the mrna as a template to make a protein by reading out its genetic sequence and then translating it into a string of amino acids. That's where the tRNA synthe...
mRNA in Biological Technology

Comparison of Different Methods of mRNA Quantitation

Feature Nuclease Protection Assays Northern Blotting RT-PCR ...

Bacterial mRNA Isolation, Fast and Easy

NEW Cyanobacterial Module MICROB Express (patent pending) is currently the only commercially available bacterial mRNA purification kit. It uses a novel strategy that rapidly removes >95% of the 16S and 23S rRNA from ...

Gene-Expression Analysis of TP, DPD, and TS Using the LightCycler mRNA Quantification KitsPLUS

In human cells, the enzymes thymidin phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and thymidylate synthase (TS) play a pivotal role in the metabolism of pyrimidines. In cancer disease medical care, the cyt...

Measuring siRNA-mediated knockdown of IL-8 mRNA

By Genospectra, Inc., 6519 Dumbarton Circle, Fremont, CA 94555. A critical step in siRNA-mediated gene expression knockdown studies is the validation of expression inhibition. The QuantiGene Reagent System and the Molecular Devices LMax II 384 microplate luminomete...

pSilencer 4.1-CMV: Versatile Vectors for Expression of siRNA, miRNA, and mRNA

Ambion's p Silencer 4.1-CMV plasmid vectors are designed for long-term gene silencing experiments in a broad range of cell lines. The vectors carry an RNA polymerase II-type CMV promoter (human ...

First Catalog Cancer Biochip for Sequence Capture Now Available from febit

...for release in 2010. Multiplex NGS studies based on sequence capture can be supplemented by other molecular fingerprinting methods, including mrna and miRNA expression profiling. Both of these high-throughput methods can be performed using the same febit technology as HybSelect, thereby reducing ...

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mRNA in Biological Products

Quantikine mRNA Base Kit from R&D Systems

Description: ...
Company:R&D Systems

mScript mRNA Production System from EPICENTRE Biotechnologies

Description: Create 100% capped transcripts with the translation boosting Cap 1 structure. mScript™ offers higher yields of 100% capped (versus 40% to 80% capped using co-transcriptional systems) eukaryotic mRNA messages in about 2 hours. mScript™ also features the Cap 1 structure, which has been shown ...
Company:EPICENTRE Biotechnologies

Rabbit Anti-Human RAB32 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... RAB32, member RAS oncogene family, mrna (cDNA clone MGC:13500 IMAGE:4280407), complete cds...
Company:Proteintech Group, Inc.

BL21 Star (DE3) One Shot Chemically Competent E. coli from Invitrogen

Description:...rformance BL21 hosts designed for improved protein yield in T7 promoter-based expression systems (Figure 1). Because the T7 RNA polymerase synthesizes mrna more rapidly than E. coli RNA polymerases transcription from the T7 p...
Company:Invitrogen

Rabbit Anti-Human UCP2 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... uncoupling protein 2 (mitochondrial, proton carrier), mrna (cDNA clone MGC:19567 IMAGE:4335185), complete cds...
Company:Proteintech Group, Inc.

Rabbit Anti-Human DCTN4,DYNACTIN 5 (P25) Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... dynactin 4, mrna (cDNA clone MGC:3248 IMAGE:3505855), complete cds...
Company:Proteintech Group, Inc.
mRNA in Biological Definition

Alternative splicing

...in which the splicing process of a pre-mRNA can lead to different ripe mrna molecules and therefore to different proteins. Also viruses have adapte...this case, instead of splicing out an intron, the intron is retained in the mrna transcript. However, the intron must be properly encoding for amino acids...

Anticodon

...uding RNA translation . It is, specifically, the group of nucleotides on a strand of tRNA that is complementary to specific codons on a strand of mrna . See also protein synthesis . The first base on the anticodon can be modified to another nucleotide such as inosine which allows that base to pa...

Bioinformatics

..." DNA sequencing , and the prediction of gene regulation with data from mrna microarrays or mass spectrometry . Making sense of the hu...n analysis The expression of many genes can be determined by measuring mrna levels with multiple techniques including microarrays , expressed cDNA se...

Genetic code

...codes for methionine and serves as an initiation site: the first AUG in an mrna 's coding region is where translation into protein begins. 2 This is a s...nearby initiation sequences are also required to induce transcription into mrna and binding by ribosomes . The most notable start codon is AUG, which al...

Bioinformatics

..." DNA sequencing , and the prediction of gene regulation with data from mrna microarrays or mass spectrometry . Making sense of the hu...n analysis The expression of many genes can be determined by measuring mrna levels with multiple techniques including microarrays , expressed cDNA se...

Morphogenesis

...described here. Maternal effect genes mrna distributions A Drosophila oocyte is a polar...erior-posterior axis of the fly is established by mrna molecules that are differentially localized withi...ocyte and can be used to allow the localization of mrna molecules to specific parts of the cell. Maternall...
mRNA in Biological Dictionary

Vitelline membrane

...an protein-coding gene VMO1. Represented by 37 ESTs from 22 cDNA libraries. ... Homo sapiens vitelline membrane outer layer 1 homolog (chicken), mrna (cDNA ... The dictionary term vitelline membrane was found in Taber's Medical Dictionary Online, along with 60,000 other medical and nursing de...

Untranslated RNA

...of RNA encoding a chemical "blueprint" for a protein product. mrna is transcribed from a DNA template, and carries coding information to the s...t of all living cells and many viruses, consisting ... of specific target mrna by hybridizing to its 3' untranslated region. ... BioInfoBank Library ...

Untranslated region

... ... in the 3' untranslated region of caudal mrna ... The coding region plus 3' untranslated region (UTR) of PC mrna is 3926 bases and ... 5' Untranslated Regions....oly(A) tail and 3' untranslated region control mrna translation? ... Register today for a free tria...

Tubulin

... SIMILARITIES ... Norway rat protein-coding gene Tuba3a. Represented by 47 ESTs from 2 cDNA libraries. ... Rattus norvegicus tubulin , alpha 3A, mrna (cDNA clone MGC:94913 IMAGE: ... ...

Transport protein

...ding gene Vat1. Represented by 685 ESTs from 170 cDNA libraries. ... Mus musculus vesicle amine transport protein 1 homolog (T californica), mrna ... ... Auxin Transport Proteins ... fluorescent protein fusion to an IAA transport protein (PIN1) ... protein , which is the site of ...

Translation

...... translation n. The act or process of translating , especially from one language into another. ... the second step, called translation , the mrna directs the ... ... translation software, French, German, Italian, Russian, Spanish languages. ... Translation . Dictionary. Text To Speech. ImT...
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