Pharmion and Methylgene Report Favorable Results for Phase 2 MGCD0103 Single- Agent Studies in Relapsed or Refractory Lymphomas at the 49th American Society of Hematology (ASH) Meeting

- MGCD0103 Continues to Demonstrate Single-Agent Activity - 38% Response Rate, 43% Disease Control Rate and 86% Tumor Reduction Rate in Heavily-Pretreated Patients with Relapsed or Refractory Hodgkin Lymphoma in 110mg Cohort - 67% Tumor Reduction Rate in Relap...

New NCCN Guidelines for Primary Cutaneous B-Cell Lymphoma and Updates to NCCN Guidelines for Non-Hodgkin's Lymphomas

NCCN presented new NCCN Clinical Practice Guidelines in Oncology(TM) for Primary Cutaneous B-Cell Lymphoma as well as important updates to the NCCN Guidelines for Non-Hodgkin's Lymphomas at the NCCN 14th Annual Conference. The new NCCN Guidelines were written to distinguish Primary B-Cell Lymphoma...

Experimental drug shows promise in treating certain lymphomas

BIRMINGHAM, Ala. - New clinical data showed some cancer patients with recurrent lymphoma benefited from an experimental drug called AME-133v, said a researcher at the University of Alabama at Birmingham (UAB). The data was presented April 15th during the 2008 annual meeting of the American Asso...

A Novel Treatment for KSHV-infected Lymphomas

Kaposi’s sarcoma herpesvirus (KSHV) is a human tumor virus which causes Kaposi’s sarcoma and primary// effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time less than six months after diagnosis. Researchers at the University of Helsinki have discovere...

Poor awareness of lymphomas

A recent survey conducted in Australia shows that majority of Australians actually know very little about lymphomas. // A variety of cancers affecting the lymphatic system is termed as lymphomas. Its the lymphatic system in the human body that helps to sieve out bacteria and aids to fight dise...

Helicobacter pylori Antibiotic Treatment of Peptic Ulcer May not Prevent Gastric lymphomas

Stanford, CA -- Successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind. This was reported by Research led by Dr. Anne Mueller at Stanford University // School of Medicine. The paper by Mueller et al., "The role of antigen...

Certain Arthritis, Crohn's Drugs May Raise Kids' Cancer Risk: FDA

...ldren treated with these drugs. The malignancies tended to arise about 30 months after starting on the medications. About half of the cancers were lymphomas and some of the children died, according to the FDA. The issue gained more prominence in July 2008 when doctors reporting in the New England Jour...

Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom

... others at a ceremony Aug. 12, 2009. Dr. Rowley is being recognized for her discoveries of recurring chromosomal abnormalities in leukemias and lymphomas -- findings that have revolutionized how cancer is understood and treated. Since 1984, LLS has awarded Dr. Rowley's lab eight grants, including the cu...

Damon Runyon Cancer Research Foundation awards $2.7M to 7 top young clinical investigators

...cal Investigator Awardees Andrew L. Feldman, MD Dr. Feldman's research focuses on defining the role of the transcription factor IRF4 in T-cell lymphomas (TCLs), aggressive cancers that are fatal in the majority of patients. He proposes that IRF4 represents a rational therapeutic target for TCLs and ai...

USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma

...ment." There are two types of lymphoma: B cell lymphomas and T cell lymphomas. Both B cells and T cells per..., the beginning point, or inception, of most human lymphomas occurs when two chromosomes break and the resultin... specifically looked at T cell acute lymphoblastic lymphomas (ALL). ALL accounts for half of all childhood canc...

lymphomas in Medical Technology

Rigel Commences Phase 2 Trial of R788 in Peripheral T-Cell Lymphomas

Preclinical Rationale for Clinical Trial Presented at USCAP Meeting SOUTH SAN FRANCISCO, Calif., March 13 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced the enrollment of the first patient in a Phase 2, multi-center clinical trial of R788 (fostamatinib...

Micromet to Present Clinical Update for BiTE Antibody MT103/MEDI-538 at the International Conference on Malignant Lymphomas

BETHESDA, Md., May 22 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced that the company will provide an update on the phase 1 clinical...

Gloucester Pharmaceuticals Reports Positive Interim Phase II Data on Romidepsin for T-Cell Lymphomas at the 2007 American Society of Clinical Oncology Annual Meeting

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 5, 2007 - Gloucester Pharmaceuticals, Inc., a privately held cancer therapeutics development company, today announced that data for romidepsin as a treatment for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) were presented at the Ameri...

Nuvelo Announces Publication of Preclinical Study Results Demonstrating the Potential of NTB-A as a New Target for Leukemia and Lymphomas

SAN CARLOS, Calif., June 05, 2007 /PRNewswire-FirstCall/ -- Nuvelo, Inc. today announced the publication of data from a preclinical study of novel monoclonal antibodies against the cell-surface protein NTB-A. The data demonstrate that NTB-A is a potential new target for immunotherapy of B-cell mal...

Northern California Cancer Center's First-of-Its-Kind Research Reveals Low Socioeconomic Status Often Equals Poor Chance of Lymphoma Survival

...ic status is "significantly associated with substantially poorer survival" of follicular lymphoma in California. Although survival rates for lymphomas have improved in recent years, not all groups are experiencing improvements. The NCCC team, headed by Theresa Keegan, Ph.D., found that among all pat...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...ent with, and for several months following discontinuation of SIMPONI. In patients who develop HBV reactivation, SIMPONI should be discontinued. lymphomas have been observed in patients treated with TNF blocking agents, including SIMPONI. The incidence of non-lymphoma malignancies was similar to controls...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...t: http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf . Accessed May 11, 2009 X Zhang et al. Serum diagnosis of diffuse large B-cell lymphomas and further identification of response to therapy using SELDI-TOF-MS and tree analysis patterning. BMC Cancer 2007, 7:235 American Cancer Soc...

Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-CXCR4 Antibody, MDX-1338

...). MDX-1338 is a fully human antibody that targets CXCR4, a chemokine receptor found on the surface of many cancer cells, including certain leukemias, lymphomas and other cancers. Preclinical laboratory experiments have shown that MDX-1338 can block the growth of, and even directly kill, selected human tumor c...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

...to attack the body's own tissue, leading to autoimmune disorders. Also many lymphomas are caused by uncontrolled growth of B-cells where activation of the B-cell...tment of NHL has improved significantly, nearly 25% of patients with B-cell lymphomas do not respond to standard therapy, which generally consists of high-dose r...

Hana Biosciences Announces New Positive Interim Efficacy Results in Pivotal rALLy Clinical Trial of Marqibo in Acute Lymphoblastic Leukemia

... approved by the U.S. Food and Drug Administration as a single agent and in combination regimens for the treatment of hematologic malignancies such as lymphomas and leukemias. Vincristine, a microtubule inhibitor, kills cancer cells when they enter a very specific point in the cell cycle, and its efficacy is ...

lymphomas in Medical Definition

Hematopathology

...s his/her expertise to diagnose diseases such as lymphomas and leukemias. The hematopathologist uses traditio...sease , myelodysplastic syndromes , leukemias , lymphomas , plasma cell neoplasms , and histiocytic and ma... has improved greatly over the past few decades. lymphomas are diseases that are mainly based in lymph node...

Thymocyte

...mature T cells, and not thymocytes. Cancer Thymocytes that gain oncogenic mutations allowing uncontrolled proliferation can become thymic lymphomas . Alternative lineages As well as classical T cells, a number of alternative cell lineages develop in the thymus, including gamma-delta T ...

lymphomas in Medical Dictionary

Lymphangiogram

... Information on the lymphangiogram - a test sometimes used in the diagnosis, staging, and progression of Hodgkin's Disease and the Non-Hosgkin's lymphomas (NHL) Lymphangiogram . Lymphanagiogram - Medical Encyclopedia. External Links. Internal Links ... LYMPHANGIOGRAM ... A lymphangiogram is used...

Lymphoma

...r that originates in lymphocytes of the immune system. They often originate in lymph nodes, presenting as an enlargement of the node (a tumor). lymphomas are closely related to lymphoid leukemias,... Hodgkin's lymphoma , also known as Hodgkin's disease, is a type of lymphoma . It was name...

Cell

..., faceplates, chargers, cases and more at discounted prices. ... cell lymphomas ... These malignant cells then may accumulate to form tumors in ... Angio...ing for scientists and educational outreach ... Anaplastic Large Cell lymphomas (ALCL) ... In both types the characteristic cell has large, often lobated...

Burkitt lymphoma

...Save Email Print. Images (1) African child with... Information about non-Hodgkin lymphoma treatment, clinical trials, research, ... non-Hodgkin lymphomas include Burkitt lymphoma , chronic lymphocytic leukemia ... Burkitt's lymphoma tends to occur most often in children and in adults wit...

lymphomas in Biological News

La Jolla Institute discovers novel tumor suppressor

...d a strange phenotype myeloproliferation and a variety of tumors including lymphomas and some carcinomas." Dr. Kawakami said this surprising occurrence sugge...ive disease," he said. "We also have done human cell testing in some other lymphomas and leukemias -- including myeloid leukemia -- indicating that these diseas...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators

...Missouri, is exploring how the immune system recognizes persistent viral infections. Because these viruses persist for the life of the host and cause lymphomas and tumors in immunocompromised hosts, understanding the intricate balance between viral persistence and immune control is fundamentally important to ...

Researchers identify new anti-tumor gene

...levant in the clinical treatment of a number of solid tumors and hematological malignancies, such as melanoma, renal cell carcinoma, malignant glioma, lymphomas and leukemias, either as a monotherapy or as an adjuvant to chemotherapy of radiotherapy. "We have uncovered a new way by which interferon can indu...

Purple tomatoes: The richness of antioxidants against tumors

...er obtained from purple tomatoes. P53 is a key gene in the tumorigenesis process. Mice lacking p53 develop different types of tumours, es-pecially lymphomas and die at a very young age. Mice used in the experiment have been divided into three groups, fed three different diets: the first one has receive...

University of Pennsylvania researchers zero in on the tiniest members in the war on cancer

...croRNAs played a direct role in cancer," Thomas-Tikhonenko said. The Penn team individually reintroduced several of the repressed miRNAs into mouse lymphomas that also had high levels of Myc and measured the effect on lymphoma progression in animals. They found that at least five of the miRNAs could stop c...

Mutating the entire genome

...each of the two old ones. The process, “translocation,” also can create new genes from two other genes. Many cancers – certain sarcomas, leukemias and lymphomas – start with translocation. Existing methods result in the desired translocation of two chromosomes in one of every 1 million to 10 million cell...

Risk of lymphoma increases with hepatitis C virus infection

...CV) are at an increased risk of developing certain lymphomas (cancers of the lymphatic system), according to a ...preceded development of the lymphoma. The risk of lymphomas in HCV-infected patients was charted across more t...ver cancer. "Although the risk of developing lymphomas is small, our research suggests that screening of ...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...rcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi’s sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki have discovered that activation ...

Short chromosomes put cancer cells in forced rest

...ed cell growth, or cancer. The first generation pups born to these mice contained no telomerase and very long telomeres. These mice all developed lymphomas by the time they were 7 months old. The researchers then continued breeding the mice to see what would happen in later generations. By the fifth gener...

Turning a cellular sentinel into a cancer killer

...st cancer. Jacks's team used a different technique to reactivate p53 in lymphomas and sarcomas. In their experiments, the researchers produced mice whose cel...d p53 in these mice, we saw two distinct tumor phenotypes," said Jacks. "In lymphomas the responses were rapid, extensive and were accompanied by the induction o...

lymphomas in Biological Technology

Eric D. Whitman, MD to Present on the Delcath PHP System(TM) at the 7th World Congress on Melanoma

...cus on the state of the art in prevention, recognition, and treatment of cutaneous neoplasms covering melanoma and non melanoma skin cancer as well as lymphomas and rare skin tumors. About Delcath Systems, Inc. Delcath Systems, Inc. is a medical technology company specializing in cancer treatment. Th...

Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...riately evaluated and monitored prior to the initiation of, during treatment with, and for several months following discontinuation of SIMPONI. lymphomas have been observed in patients treated with TNF blocking agents, including SIMPONI. The incidence of non-lymphoma malignancies was similar to controls...

Cytopia Scientific Presentation on JAK2 Inhibitor Program at American Chemical Society Conference

...l chemistry platform. Cytopia is developing a suite of JAK2 inhibitors for multiple indications including specific cancers, particularly lymphomas and solid tumors where JAK2 has been shown to be up-regulated, and for cardiovascular diseases such as pulmonary hypertension. Fo...

Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL

...ancial guidance for 2008. Background information About Periferal T-Cell lymphomas (PTCL) PTCL represent approximately 10% of all non-Hodgkin's lymphomas (NHL) in Western populations and are associated with a poor prognosis. Most...

Genzyme Files Applications for Approval of Mozobil in the United States and Europe

...it more likely for a patient with certain types of cancers to receive a successful transplant. Specifically, patients with non-Hodgkin's and Hodgkin's lymphomas and multiple myeloma often receive high-dose chemotherapy, a process that destroys bone marrow. A stem cell transplant is required to replenish blood-...

CHOP-Zevalin(R) Investigational Regimen Produces 95% Complete Remission and 75% Estimated Two Year Progression-Free Survival in Elderly Patients with Diffuse Large B-cell Lymphoma

...tive of whether or not rituximab therapy is utilized. This publication demonstrates this in elderly patients with DLBCL while similar data in indolent lymphomas were reported at ASH 2007 from the Phase III FIT study. We are currently testing this clinically important potential of Zevalin consolidation in our o...

Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis

...to what would be expected for an age-, gender- and race-matched general population. With the current knowledge, a possible risk for the development of lymphomas or other malignancies in patients treated with a TNF antagonist cannot be excluded. All patients, and in particular patients with a medical history of...

Third Wave co-founder shoots for small target in latest project

...ed different kinds of microRNA. Normally, miR-155 is present in about 200 copies per cell, but it was found to rise to more than 10,000 in some of the lymphomas analyzed in this study, a UW-Madison release said....

Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer

... lung lung Spleen, bone marrow, germ cells Benzene 8 Lung, leukemia, lymphomas Lung, spleen liver * De Boer et al., unpublished See text for additional details. TDBP The ...

lymphomas in Biological Definition

Cancer

...ccurring to least: neuroblastoma , leukemia , central nervous system, retinoblastoma , Wilms' tumor , germ cell, soft tissue sarcomas , hepatic, lymphomas (such as Hodgkin's disease ), epithelial. Diagnosing cancer Biopsy A biopsy leads to the definitive diagnosis of most malignancies. It ...