Lupus

The Lupus Foundation of America Applauds New Legislation that Caps Out-of-Pocket Drug Costs

Provides Protection for People with Lupus and other Chronic Diseases WASHINGTON, Aug. 7 /PRNewswire-USNewswire/ -- The Lupus Foundation of America (LFA) President and Chief Executive Officer, Sandra C. Raymond, issued the following statement regarding S.1630 "The Affordable Acce...

Immune responses to flu vaccine are diminished in lupus patients

Patients with the autoimmune disease systemic lupus erythematosus (SLE) have an increased risk of infection, due to both disturbances in their immune responses and treatment with immunosuppressive drugs. Because morbidity and mortality related to influenza are increased in immunocompromised patien...

Reminder - Human Genome Sciences to Host Conference Call to Discuss Top-Line Phase 3 Results for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Systemic Lupus Erythematosus

ROCKVILLE, Maryland July 20 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI ) will host a conference call today at 8:15 AM Eastern to discuss the results from BLISS-52, the first of two pivotal Phase 3 clinical trials of BENLYSTA(TM) (belimumab, formerly Ly...

Lupus Foundation of America Seeks Proposals for Research Studies on Childhood Lupus and Stem Cell Transplantation

WASHINGTON, June 22 /PRNewswire-USNewswire/ -- The Lupus Foundation of America (LFA) is seeking proposals for grant funding for research studies on lupus, an unpredictable and potentially fatal autoimmune disease. Grants will support areas of study in pediatric lupus and adult stem cell transplant...

Anxiety and depression lower quality of life in majority of systemic lupus erythematosus patients

Copenhagen, Denmark, Friday 12 June 2009: 92.8% of patients with systemic lupus erythematosus (SLE) suffer anxiety and depression which significantly affects both their physical and emotional quality of life (QoL), according to the results of a new study presented today at EULAR 2009, the Annual C...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

Copenhagen, Denmark, Thursday 11 June 2009: DNA vaccination using lupus autoantigens and interleukin-10 (IL-10, a cytokine that plays an important role in regulating the immune system) has potential as a novel therapy to induce antigen specific tolerance and may help to prevent kidney damage in pa...

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Lupus in Medical Technology

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

ROCKVILLE, Maryland and LONDON, July 20 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI ) and GlaxoSmithKline PLC (GSK) today announced that BENLYSTA(TM) (belimumab, formerly LymphoStat-B(R)) met the primary endpoint in BLISS-52, the first of two pivotal P...

Lupus Foundation of America Fosters the Next Generation of Lupus Researchers by Awarding Gina M. Finzi Memorial Student Summer Fellowships to Five Students

WASHINGTON, June 3 /PRNewswire-USNewswire/ -- To foster and support the next generation of lupus researchers, the Lupus Foundation of America (LFA), Inc. has awarded summer fellowships to five young investigators who will conduct their studies under the supervision of an established lupus investig...

Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus

- Phase 2 data demonstrate sustained improvement in disease activity through three years of LymphoStat-B (belimumab) therapy - - No increase in adverse events, malignancies, infections or laboratory abnormalities over time - ROCKVILLE, Md., June 12 /PRNewswire-F...

Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus

WASHINGTON, April 29 /PRNewswire-USNewswire/ -- Preliminary results were released today from a late-stage clinical trial of Rituxan (rituximab) for the treatment of lupus. The study did not meet its primary or secondary endpoints of clinically reducing the severity of SLE (systemic lupus eryth...

Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies

Lead drug candidate may help patients with Systemic Lupus Erythematosus (SLE) SOUTH SAN FRANCISCO, Calif., April 29 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) announced today that its lead product candidate, R788, has successfully tre...

Tolerx Achieves Milestone with Completion of Phase Ib Clinical Study of TRX1 in Cutaneous Lupus Erythematosus

CAMBRIDGE, Mass., Jan. 15 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company engaged in the discovery and development of novel therapies for the treatment of immune-mediated diseases, announced today the successful completion of a Phase Ib clinical study of TRX1, a novel humanized anti-...

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Lupus in Medical Products

Systemic Lupus Erythematosus (SLE) Latex Test

Description: Latex agglutination slide test for the qualitative and semi-qualitative detection of antinuclear antibodies to aid in the diagnosis of systemic lupus erthyematosus....
Company:Inverness Medical Innovations

Bio-Rad Helix EIA Lupus Screening Kit

Description: The ANA and ENA assays can be used to screen out patients negative for antinuclear antibodies, which are associated with various systemic rheumatic diseases such as Systemic lupus erythematosus (Lupus), Sjgren's syndrome, mixed connective tissue disease, progressive systemic sclerosis, scleroderma,...
Company:Bio-Rad Laboratories

STACLOT LA 10

Description:... Detection of lupus Anticoagulants. Freeze-dried hexagonal phase phos-phatidylethanolamine; normal plasmawith heparin inhibitor; PTT-LS reagent of cephalin and particulat...
Company:Diagnostica Stago, Inc.

STACLOT LA 20

Description:... Detection of lupus Anticoagulants. Freeze-dried hexagonal phase phos-phatidylethanolamine; normal plasma with heparin inhibitor; PTT-LS reagent of cephalin and particula...
Company:Diagnostica Stago, Inc.

ImmunoDOT™ DNA/ENA Autoimmunity Screening Panel

Description:...of autoantibodies against various specific nuclear antigens (ANA, DNA, SS-A/SS-B, RNP/Sm) in serum, and is used as an aid in the diagnosis of systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), and Sjgren's syndrome....
Company:GenBio

ImmunoDOT Autoimmunity Screening Panel 6

Description:...dies against various specific nuclear antigens (SS-A, SS-B, RNP/Sm, Sm, Jo-1, and Scl-70) in serum, and is used as an aid in the diagnosis of systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjgren's syndrome and other rheumatoid diseases....
Company:GenBio

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Lupus in Medical Definition

Pathology

...• d • e Health science - Medicine - Urinary system - Pathology - Nephrology ( N00-N39 ) Diseases of the glomerulus lupus nephritis | Post-infectious glomerulonephritis | Minimal change disease | Focal segmental glomerulosclerosis | Diabetic nephropathy | IgA ne...

Lupus in Medical Dictionary

Lupus

Systemic lupus erythematosus is a chronic autoimmune connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body’s cells and tissue, resulting in... Get information on lupus (SLE) disease treatment, sig...

Vasculitis

...iew covers symptoms, causes, treatment of this inflammation of the blood vessels. ... Hypersensitivity vasculitis . ... This section of the lupus Foundation of America's website talks about vasculitis , and lupus. ... This cause of vasculitis is more common. ... Cutaneous vasculitis . Au...

Turner syndrome

...... Genetic Features of Turner Syndrome (National Institute of Child ... Article: 46,X,del(X)(q13) Turner's syndrome women with systemic lupus erythematosus in a... In Turner syndrome , cells are missing all or part of an X chromosome. ... Growth hormone may help a child with Turne...

Systemic sclerosis

...ma. U.-F. Haustein, MD. Dermatology Online ... Systemic sclerosis (SSc) is a clinically heterogeneous generalized disorder ... ... systemic lupus erythematosus and scleroderma (also known as systemic sclerosis ) ... Because systemic sclerosis patients do not always tolerate conventiona...

Systemic lupus erythematosus

... Systemic lupus erythematosus is a chronic autoimmune connect...nd tissue, resulting in... Get information on lupus (SLE) disease treatment, signs, diagnosis, type...egnancy flares, prevention and statistics. lupus , discoid on a child's face. Systemic ...

Systemic

...rror in measurements or... Get information on lupus (SLE) disease treatment, signs, diagnosis, type... systemic infection. ... Find information on lupus ( systemic lupus erythematosus, or SLE). Covers symptoms, tests, t...

Lupus in Biological News

Gene linked to lupus might explain gender difference in disease risk

DALLAS March 30, 2009 In an international human genetic study, researchers at UT Southwestern Medical Center have identified a gene linked to the autoimmune disease lupus, and its location on the X chromosome might help explain why females are 10 times more susceptible to the disease than males....

The Alliance for Lupus Research announces 2008 grantees

The Alliance for Lupus Research (ALR) recently announced it will award nearly $7 million to researchers around the world. The ALR is very proud to announce, during National Minority Health Month, that with our 2008 class of grantees the ALR has funded more than 100 research projects, and committe...

Genes linked with lupus are revealed, giving hope for new treatments

Scientists have identified a number of genes involved in Lupus, a devastating autoimmune disease, in new research published today in the journal Nature Genetics. In an international genetic study of more than 3,000 women, researchers found evidence of an association between Lupus (systemic lupu...

DNA variations signal lupus risk

BIRMINGHAM, Ala. Scientists have pinpointed a set of common variations in human DNA that signal a higher risk for lupus in women who carry them. Some of these variations are more common in relatives of lupus patients, which may help future studies examining whether lupus is more prevalent among c...

UT Southwestern secures $5 million NIH grant for lupus research

DALLAS Dec. 19, 2007 The division of rheumatic diseases in the Department of Internal Medicine at UT Southwestern Medical Center has been awarded a five-year, $5 million grant from the National Institutes of Health to fund the Center of Research Translation, which will investigate the autoimmune...

New approach for attacking lupus identified

NEW YORK CITY, Dec. 16, 2007 Investigators at Hospital for Special Surgery have identified two new targets for drugs aimed at controlling lupus. If companies are able to develop drugs that hone in on these targets, patients may be able to control their disease with few side effects. The study ...

Lupus in Biological Technology

Human Genome Sciences to Host July 20 Conference Call to Discuss Top-Line Phase 3 Results for Benlysta(TM) (Formerly Lymphostat-B(R)) in Systemic Lupus Erythematosus

ROCKVILLE, Maryland, July 1 /PRNewswire-USNewswire/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI ) today announced that it expects to have top-line results available on Monday, July 20, from BLISS-52, the first of two pivotal Phase 3 clinical trials of BENLYSTA(TM) (belimumab, formerly LymphoSta...

Human Genome Sciences Reports Positive Long-Term Data for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Patients With Active Systemic Lupus Erythematosus

- Phase 2 continuation data demonstrated sustained improvement in disease activity and patient response rate through four years of BENLYSTA therapy - - Frequency of disease flares as measured by the SELENA SLEDAI flare index and by BILAG A or B organ domain scores decreased over four years o...

Trubion Pharmaceuticals, Inc. Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Systemic Lupus Erythematosus (SLE)

SEATTLE, March 25 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN ) announced today that its collaboration partner Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), has initiated a Phase 1 clinical trial of SBI-087, Trubion's next generation CD20 drug candidate, fo...

Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9

Animal Model Shows Disease Progression Can Be Prevented BERKELEY, Calif., Nov. 26 /PRNewswire-FirstCall/ -- In a paper appearing online in the December issue of The European Journal of Immunology (Vol. 37, Issue 12), Dynavax scientists report the results of studies made possible under ...

ZymoGenetics and Merck Serono Receive FDA Special Protocol Assessment for Atacicept Pivotal Study in Lupus Nephritis

- Patient enrollment to begin in fourth quarter - SEATTLE, Oct. 4 /PRNewswire-FirstCall/ -- ZymoGenetics, Inc. (Nasdaq: ZGEN) today announced that, together with its collaborator Merck Serono, it has reached agreement with the U.S. Food and Drug Administration (FDA) on a Special Pro...

Biotech Hot in July Driven by Positive Drug Data and Acquisitions

...el investors' enthusiasm was Human Genome Sciences whose shares jumped a whopping 395 percent in July on news of positive results for its experimental lupus injectable drug Benlysta, confounding all analysts' expectations and potentially clearing the way for the first new treatment against the inflammatory...

Lupus in Biological Products

Total Protein - Alzheimer's Disease: Brain: Pons from BioChain

Description:... Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and lupus diseased tissues are available....
Company:BioChain

Total Protein - Diabetic Disease: Small Intestine: Jejunum from BioChain

Description:... Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and lupus diseased tissues are available....
Company:BioChain

Total Protein - Diabetic Disease: Esophagus from BioChain

Description:... Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and lupus diseased tissues are available....
Company:BioChain

Membrane Protein - Alzheimer's Disease:Brain: Occipital Lobe from BioChain

Description:... Membrane Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and lupus diseased tissues are available....
Company:BioChain

Lupus in Biological Definition

Apoptosis

...amental factor in the pathogenesis of numerous diseases including cancer, neuro-degenerative and ischemic diseases, AIDS and autoimmunity. In systemic lupus erythematosus (SLE) the antigen responsible for most anti-DNA antibodies, exclusively generated in this disease, are derived from nucleosomes. As nucl...

Immune system

...ns . On the other end of the scale, an overactive immune system figures in a number of other disorders, particularly autoimmune disorders such as lupus erythematosus , type I diabetes (sometimes called "juvenile onset diabetes"), multiple sclerosis , psoriasis , and rheumatoid arthritis . In thes...

Immunology

...examples include chronic granulomatous disease ), and autoimmunity , in which the immune system attacks its own antigens (examples include systemic lupus erythematosus , rheumatoid arthritis , Hashimoto's disease and myasthenia gravis ). Other immune system disorders include different hypersensitiv...

Kidney

.... kidney tumors Wilms tumor Renal cell carcinoma Renal failure (acute and chronic) Glomerulonephritis Diabetic nephropathy lupus nephritis Dialysis and kidney transplants Generally, one can live fine with just one kidney. If both kidneys do not function properly, dialy...

Lupus in Biological Dictionary

Serosa

...aced by adventitia a layer ... The serosa reduces friction as the digestive system organs work and slide across ... Clinical overview of Systemic lupus Erythematosus (SLE), a chronic, ... the joints, skin, kidney, brain, lung, heart, serosa and gastrointestinal tract. ... ... the internal reprodu...

Pericardium

...ew articles on Diseases of the pericardium ... Ongoing Trials on Diseases of the pericardium at Clinical Trials.gov ... pericardium . systemic lupus erythematosus ... Chest x-rays may detect calcium deposits in the pericardium . ... Normally, the pericardium is less than 1/8 inch ... Chest x-...

Cooperativity

...ty ... Search completed in 0.299 seconds. ... Cooperativity of APRIL with BLyS Protein: BLyS protein is a 285-amino acid member of ... Systemic lupus Erythematosus: Cooperativity of APRIL with BLyS ... Cooperativity in contractile behavior of ... It is widely held that there is cooperativity...