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ligand in Medical News

Caltech chemists say antibody surrogates are just a 'click' away

...to be both selective for and specific to the target protein," Heath says. "What Heath has shown now is that in several iterations, a high-affinity ligand for a protein can be created from blocks that do not bind to the protein all that well; the trick is to repeat the in situ screen several times, and t...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

...that binds to the EphA2 receptor (EphA2R). This receptor is highly expressed in several solid tumors including pancreatic cancer. YSA, a small peptide ligand that binds the EphA2R with high affinity, was inserted into the HI loop of the adenovirus serotype 5 fiber knob. To further increase the specificity o...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...P.S. technology. Each L.E.A.P.S. construct is composed of a T cell binding ligand (TCBL) which has previously demonstrated the ability to induce and elicit p...containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently linking ...

Researchers Spot Genes Linked to Testicular Cancer

...s at the Abramson Cancer Center, said in a news release. Nathanson and colleagues found that men with two copies of the common version of the c-KIT ligand (KITLG) gene are 4.5 times more likely to develop testicular cancer than men with two copies of the less common versions of the gene. The researche...

Stem Cell Study Offers Hope for Targeting Tumors

...essful at targeting several types of tumors while sparing healthy cells, new research has found. Stem cells carrying TNF-related apoptosis-inducing ligand (TRAIL) destroyed lung, squamous, breast and cervical cancer cells in laboratory cultures, according to British researchers. When tried on mice, the ...

Amgen Highlights Data to Be Presented at ASCO

...ain the protein, RANK Ligand, a key mediator of osteoclast activity. Data from this study provide proof-of-concept for specifically targeting the RANK ligand pathway. Denosumab treatment of giant cell tumor of bone: results of an open label phase 2 study Lead author: Th...
ligand in Medical Technology

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

...ased with these results, which continue to demonstrate that inhibiting RANK ligand with denosumab provides a clinically meaningful benefit for advanced cancer...tally the same. At the center of this destructive process is a protein RANK ligand that is stimulated by the presence of cancer in the bone. The econo...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

... Roger M. Perlmutter, M.D., Ph.D., executive vice president of Research and Development at Amgen. "These results underscore the importance of the RANK ligand pathway in bone disease, and offer the promise of improved care for patients with advanced breast cancer. We look forward to reviewing the results fr...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

... aggressive cancers known to be resistant to the current standards of care." Study results : EP-100 consists of an LHRH receptor-targeting ligand conjugated to a novel membrane-disrupting peptide called CLIP 71. The drug candidate was tested in vitro and in vivo for activity in LHRH receptor...

Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack

...he CXC chemokine receptor 4 (found on these stem cells in the bone marrow but reduced after ex vivo expansion) with the stromal-derived factor-1 alpha ligand that is expressed in ischemic heart tissue following a heart attack. This suggests that treatment of mesenchymal stem cells ex vivo with an Ad5IGF-1 ...

Adlyfe Strikes Translational Medicine Partnership With Wyeth Pharmaceuticals for Alzheimer's Biomarker Assay

...chnology is based on the synthesis of small peptides, or Pronucleon(TM) peptides, that are amino acid sequence matched to target amyloids of interest. ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with am...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

...ne marrow cells that give rise to blood platelets. PROMACTA was discovered as a result of a research collaboration between GlaxoSmithKline and ligand Pharmaceuticals (Nasdaq: LGND ). It was developed by GlaxoSmithKline. GSK plans to submit a Marketing Authorization Application (MAA) for eltrombopa...
ligand in Medical Products

Osteocalcin IRMA Test

Description:...e formation activity [7]. Serum osteocalcin measurements have also been useful in the research of toxic effects on bone [6,8]. Gundberg CM. J Clin ligand Assay 21:128-138, 1998. Price PA, et al. Proc Natl Acad Sci USA 73:3374-3375, 1976. Gallop PM, et al. New Engl J Med 302:1460, 1980. Price PA, et ...
Company:Diagnostic Systems Laboratories, Inc.

Osteocalcin ELISA Test

Description:...e formation activity [7]. Serum osteocalcin measurements have also been useful in the research of toxic effects on bone [6,8]. Gundberg CM. J Clin ligand Assay 21:128-138, 1998. Price PA, et al. Proc Natl Acad Sci USA 73:3374-3375, 1976. Gallop PM, et al. New Engl J Med 302:1460, 1980. Price PA, et ...
Company:Diagnostic Systems Laboratories, Inc.

Growth Hormone Binding Protein ELISA Test

Description:...ex approximately 50% of plasma GH. GHBP modulates GH action via a variety of mechanisms. It inhibits GH action by competing with the GH receptor for ligand and by generating unproductive heterodimers with the GH receptor at the cell surface, as opposed to the GH receptor homodimers required for signaling....
Company:Diagnostic Systems Laboratories, Inc.
ligand in Medical Definition

Nuclear medicine

...only known as a tracer. In the presence of disease, a tracer will often be distributed around the body and/or processed differently. For example, the ligand methylene-diphosphonate (MDP) can be preferentially taken up by bone . By chemically attaching technetium-99m to MDP, radioactivity can be transport...
ligand in Medical Dictionary

Myoglobin

...istidines. oxygen. val and his in pocket. ribbons. hbonds. prolines. polar and hydrohobics. reset. myoglobin saturation ... Dynamic pathways for ligand migration between solvent and a binding site in the oxygen-storage protein myoglobin are shown. The pathways are not seen in the static ... M...

Macrophage

...ties in response to zinc ... Cells overexpressing p19 acquire macrophage characteristics. ... Macrophage -derived chemokine (MDC/CC chemokine ligand 22 (CCL22)) mediates its ... Macrophage -derived chemokine is localized to thymic medullary epithelial cells ... Macrophage recognition of cell...

Leukocytes

...ocytes ... ... Pg was shown previously for many cells, including leukocytes , and was implicated ... Human leukocyte elastase is an endogenous ligand for the integrin CRR3 (CD11b ... ... were thought to serve only as communication molecules between leukocytes , ... However, the integrated view ...

Cobalamin

... Cobalamin may refer to several substances depending on the upper axial ligand of the cobalt ion. These are: ... biology and biochemistry of cobalamin - and folate-deficient bone marrow ... Cobalamin -responsive p...
ligand in Biological News

SuperLigands - a database of ligand structures derived from the Protein Data Bank

Scientists have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury. The research is being released by the journal Science, which is published by AAAS, ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...et spot" on ALK where PTN binds, which Wellstein says was a major discovery. "You can have hundreds of different areas on a receptor protein where its ligand could theoretically bind. We found just the right one." They collaborated with ESBAtech in Switzerland who created a small single-chain antibody fr...

Neural stem cell differentiation factor discovered

...alyzed the antagonistic effects of EGFL7 in adult neural stem cells. The self-renewal potential of these cells depends on an intact interaction of the ligand Jagged1 and its receptor Notch1. Addition of EGFL7 blocked the essential interaction and reduced the division of neural stem cells. At the same time,...

Fate in fly sensory organ precursor cells could explain human immune disorder

... Actin-related protein 3 (Arp3), a component of the seven protein Arp2/3 complex, resulted in the loss of Notch signaling. This occurs because the ligand Delta a protein that activates the Notch pathway cannot travel properly within the sensory organ cells in the absence of Arp3 protein. In addition, ...

Penn researchers discover genetic risk factor for testicular cancer

...d co-author Peter A. Kanetsky, PhD, MPH, an assistant professor of Epidemiology, found that men who have two copies of the common version of the c-KIT ligand (KITLG) gene have a 4.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. Additional...

NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA

...other biomolecules directly from blood plasma or bioreactors, without the need for prior filtration.   Selection of proprietary mixed mode ligand chemistry enables efficient control of the capture and release of target molecules by simple changes of pH, which can be readily implemented in large-...
ligand in Biological Technology

Teva Pharmaceutical's Altered Peptide Ligand Copaxone Boasts the Greatest Patient Share Among First- and Second-Line Therapies for the Treatment of Multiple Sclerosis

Lack of Flulike Side-Effects Drives Physician Prescribing of Copaxone over an Interferon-Beta Therapy, According to a New Report from Decision Resources WALTHAM, Mass., March 11 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory f...

Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody

...1M18 is a monoclonal antibody optimized to block a key signaling pathway in cancer stem cells. Specifically, OMP-21M18 selectively targets Delta-like ligand 4 (DLL4), an activator of Notch signaling, which is a pathway known to be important in stem cells and cancer. Blocking DLL4 results in broad-spectrum...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...ed by the Tissue Repair Company to hard tissue applications such as bone, including: (1) proprietary Gene Activated Matrix(TM) or GAM(TM) delivery and ligand targeting; (2) use of GAM to locally produce proteins capable of stimulating bone and other tissue growth; and (3) a substantial body of pre-clinical ...

Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO)

...ditional indications. This arrangement remains in place. About Denosumab Denosumab is a fully human monoclonal antibody that targets RANK ligand and is being investigated for its potential to prevent and treat a broad range of bone disease conditions including osteoporosis, bone metastases and ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...P.S. technology. Each L.E.A.P.S. construct is composed of a T cell binding ligand (TCBL) which has previously demonstrated the ability to induce and elicit p...containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently linking ...

ForteBio Launches Two Revolutionary High-Throughput, Label-Free Instruments: The Octet(R) RED384 and the Octet QK384

...stems are supported by Version 6 Octet software for data acquisition and analysis, which includes significant enhancements such as a 2:1 heterogeneous ligand binding model, data tracking and processing capabilities that assist in high-throughput screening. The new systems also include hardware and software ...
ligand in Biological Products

Human Flt-3/Flk-2 Ligand from eBioscience

Description: Carrier-Free Recombinant Human Flt-3/Flk-2 Ligand (Flt3/Flk2 Ligand, Flt3L, Flt3-L, Flk2L, Flk2-L) 100 ug...
Company:eBioscience

GenoStat Inducible Expression System from Upstate

Description:...control is mediated by the highly specific interaction between the GenoStat ligand and the chimeric bipartite nuclear receptor complex. Gene expression levels... lower by simply increasing or decreasing the concentration of the GenoStat ligand in the tissue culture media. The GenoStat Inducible Expression System provi...
Company:Upstate

GIBCO Cell Dissociation Buffer enzyme free PBS-based from Invitrogen

Description:...ed saline for gentle dissociation of mammalian cells from support substrates and each other for studies requiring intact cell surface proteins such as ligand binding flow cytometry and immunohistochemistry (12). These buffers are not recommended for routine passage of strongly adherent cell types....
Company:Invitrogen

GIBCO Cell Dissociation Buffer enzyme free Hanks'-based from Invitrogen

Description:...ed saline for gentle dissociation of mammalian cells from support substrates and each other for studies requiring intact cell surface proteins such as ligand binding flow cytometry and immunohistochemistry (12). These buffers are not recommended for routine passage of strongly adherent cell types....
Company:Invitrogen

ProteoPrep 20 Plasma Immunodepletion Kit from Sigma-Aldrich

Description:...njugation process using small recombinant immunoaffinity ligands and conventional antibodies that permits high density conjugation on the support. The ligand selection ensures optimal specificity. Typical depletions remove 97-98% of the total protein mass in human plasma or serum....
Company:Sigma-Aldrich

Affi-Gel 10 to 15 Combination, 2 x 25 ml each from Bio-Rad

Description:... Activated affinity media for spontaneous ligand immobilization can be coupled with a ligand such as an antibody, enzyme, antigen, or receptor to create an affinity mat...
Company:Bio-Rad
ligand in Biological Definition

Affinity chromatography

...the most common use of affinity chromatography is for the purification of recombinant proteins. Essentially proteins are tagged with a known affinity ligand in order to aid their purification. That is to say that the molecule has an artificial trait imposed upon it by genetic modification which allows i...

Allostery

...The model further holds that in the absence of any ligand (substrate or otherwise), the equilibrium favors t...s to haemoglobin , occurs when the binding of one ligand enhances the attraction between substrate molecule...osteric inhibition occurs when the binding of one ligand decreases the affinity for substrate at other acti...

Allostery

...The model further holds that in the absence of any ligand (substrate or otherwise), the equilibrium favors t...s to haemoglobin , occurs when the binding of one ligand enhances the attraction between substrate molecule...osteric inhibition occurs when the binding of one ligand decreases the affinity for substrate at other acti...

Apoptosis

... Apo-1 or CD95), is another receptor of extrinsic apoptotic signals in the cell membrane, and belongs to the TNF receptor superfamily [10] . The Fas ligand (FasL, the protein that binds to Fas and activates the Fas pathway) is a transmembrane protein, and is part of the TNF family. The interaction between...

His-tag

...e Purification The his-tag can be used in affinity chromatography together with a column that has nickel bound to it. Histidine is a good ligand for nickel so the fusion protein will bind to the column. The protein can be eluted with a solution of imidazole . Detection The his tag ca...

Ion channel

...-gated calcium channels that control neurotransmitter release in pre-synaptic endings . Ligand-gated channels open in response to a specific ligand molecule on the external face of the membrane in which the channel resides. Examples include the "nicotinic" Acetylcholine receptor , AMPA recepto...
ligand in Biological Dictionary

UvrA

... then exposed ... Crystal Structure of Bacillus stearothermophilus UvrA Provid... In addition, UvrA contains three zinc modules, the number and ligand sphere of ... By the analysis of cells lacking UvrA , we demonstrate ... of UvrA . Although we present evidence ... We also show that UvrA is...

Transmembrane receptor

...e involved in the cascade of number of key ... seven transmembrane domain, but ... transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk ... transmembrane - receptor - Ig superfamily ... David Nelson Dec. 14, 2000 Seven transmembrane segment recep...

Transferrin receptor

... serum that combines with and transports iron. ... Asymmetric binding of transferrin receptor to parvovirus capsids" ... ... endocytosis of ligand occupied transferrin receptor into specialized endosomes. ... Transferrin receptor is necessary for development of erythrocytes and the ... ...

Site-specific recombination

...l character of site - specific recombination is controlled by the ... Conditional site - specific recombination in mammalian cells using a ligand ... Transgene Management Through Site - Specific Recombination (410641)Objective 1: ... system and were shown effective in prromoting site - s...

Sequence homology

...or conventional ... EBI Tools: Homology and Similarity: blast, fasta, MPsrch, scanps ... Nucleotide sequence similarity searching against the ligand Gated Ion Channel ... sitive and fast sequence homology search algorithms outside of the relational ... present new challenges for sequence ...

N Terminus

...he N terminus of G protein-coupled receptors has been implicated in binding to ... Although these data implicate the N terminus of the C5aR in ligand binding, it ... The N terminus affects inhibitory activity and folding ... Together, these data suggest that the N terminus of tengpin is n...
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