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Leukemia in Medical News

Genome of Leukemia Patient Reveals Common Mutations

Findings could help scientists understand genetic basis of cancer WEDNESDAY, Aug. 5 (HealthDay News) -- Decoding the genome of a man with acute myeloid leukemia (AML) revealed genetic mutations that may be common among other cancer patients. Scientists at the Washington University S...

Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom

WHITE PLAINS, N.Y., July 30 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) congratulates Janet Davis Rowley, M.D., of University of Chicago, a pioneer in demonstrating that cancer is a genetic disease, for being awarded the 2009 Presidential Medal of Freedom. President Barack ...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

St. Jude scientists identify new genes implicated in childhood acute myeloid leukemia (AML), but analysis underscores the need for more detailed look at the complete AML genome MEMPHIS, Tenn., July 27 /PRNewswire-USNewswire/ -- The most comprehensive analysis yet of the genome o...

Molecule Helps Leukemia Cells Hide From Immune System

Discovery might lead to new strategies to fight the disease, researchers say THURSDAY, July 23 (HealthDay News) -- Leukemia stem cells cleverly cloak themselves to avoid detection by a person's immune system, according to a pair of studies by researchers at Stanford University Medical ...

Sysmex Supports Illinois Chapter Leukemia and Lymphoma Society

MUNDELEIN, Ill., July 23 /PRNewswire/ -- Sysmex today announced its customer appreciation dinner fundraiser for the Illinois Chapter of The Leukemia & Lymphoma Society (LLS) has resulted in a combined company/customer donation of $20,000 for LLS. Monies will be directed toward...

The Leukemia & Lymphoma Society and FORMA Therapeutics Enter Collaboration to Bring New Therapies to Patients Faster

WHITE PLAINS, N.Y. and CAMBRIDGE, Mass., July 20 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) and FORMA Therapeutics today announced a partnership to accelerate LLS's pipeline of research projects entering late pre-clinical development. The collaboration will beg...

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Leukemia in Medical Technology

UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients

PITTSBURGH, Pennsylvania, and JERUSALEM, Israel, June 15 /PRNewswire/ -- The University of Pittsburgh Cancer Institute (UPCI) and the Gamida Cell - Teva Joint Venture announced today that the Institute has joined an elite group of cancer centers in Europe, the United States and Israel that a...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

German Multicenter ALL Study Group Presented Data at the 14th Congress of the European Hematology Association Showing High Response Rate in Patients with Minimal Residual Disease BERLIN, June 8 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

SEATTLE and ORLANDO, Fla., June 1 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN ) announced today the presentation of encouraging Phase 1 safety and efficacy results following administration of low doses of TRU-016 in heavily pre-treated patients with high-risk genomic fa...

Foundation Venture Capital Group Invests in UMDNJ Company Working to Improve Leukemia Treatments

NEW BRUNSWICK, N.J., March 23 /PRNewswire/ -- Each year in the United States more than 138,000 people are diagnosed with leukemia, lymphoma or myeloma. These new cases account for 10 percent of the new total cancer cases in the U.S. per year. For several types of leukemia, the survival rate has ...

Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis

Study published in New England Journal of Medicine employs Quest Diagnostics' blood-based leukemia testing MADISON, N.J., Feb. 20 /PRNewswire-FirstCall/ -- Testing of blood specimens may detect abnormal white blood cells in patients years before the chronic form of lymphocytic leukemia (CLL...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

Scan of thousands of inherited genetic changes reveal specific variations linked to treatment failure and the fate of chemotherapy drugs in the body for children with acute lymphoblastic leukemia MEMPHIS, Tenn., Jan. 27 /PRNewswire-USNewswire/ -- Scientists from St. Jude Children's Research H...
Leukemia in Medical Products

Chronic Lymphocytic Leukemia (CLL)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Chromosome Analysis, Chronic Lymphocytic Leukemia (CLL) Panel by FISH

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Leukemia in Medical Definition

Hematopathology

... blood based and can be subclassified as chronic leukemia and acute leukemia . Chronic leukemia is the proliferation of too many mature blood ce...

Pathology

...oma / osteosarcoma - Chondroma / chondrosarcoma - Glioma - Lymphoma / leukemia Treatment Surgery - Chemotherapy - Radiation therapy - Immu... ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , Polycythemia vera...

Ocular oncology

...n include the prostate , kidney , thyroid , skin , colon lymphoma and leukemia . Types Tumors in the eye and orbit can be benign like dermo...oma / osteosarcoma - Chondroma / chondrosarcoma - Glioma - Lymphoma / leukemia Treatment Surgery - Chemotherapy - Radiation therapy - Immu...
Leukemia in Medical Dictionary

Leukemia

Leukemia is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation of blood cells, usually white blood cells (leukocytes). Leukemia is a broad term covering a spectrum of diseases. In turn, it... Learn about leukemia including causes, types of ...

Hairy cell leukemia

Hairy cell leukemia is a mature B cell neoplasm. It is usually classified as a sub-type of chronic lymphoid leukemia for convenience. It is uncommon, representing about 2% of all leukemias, or less than a total of 2000 new... Expert-reviewed information summary about the treatment ...

Acute myelogenous leukemia

Acute myeloid leukemia (AML), also known as acute myelogenous leukemia , is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells which accumulate in the bone marrow and... Fighting leukemia , lymphoma, Hodgkin's disease and...

Acute lymphocytic leukemia

Acute lymphoblastic leukemia (ALL), is a form of leukemia , or cancer of the white blood cells characterized by excess lymphoblasts. Fighting leukemia , lymphoma, Hodgkin's ... Information > Leukemia > Acute Lymphocytic Leukemia . print page ... Acute lymphocytic leu...

Thrombocytopenia

... ... fever can cause thrombocytopenia by direct infection of ... thrombocytopenia (NAITP) ... Thrombocytopenia caused by Feline leukemia Virus and Feline ... Features information on this disorder and its causes, incidence and risk factors. ... Thrombocytopenia is any disorder in...

Purpura

... the leg ... Idiopathic thrombocytopenic purpura (ITP) ... Petechiae, purpura , and ecchymosis do not become pale (blanch) with pressure. ... leukemia ( purpura and ecchymosis) Drugs. Anticoagulants such as warfarin or ... purpura n. A condition characterized by hemorrhages in the skin and m...
Leukemia in Biological News

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children's Research Hospital. The research appears i...

Study validates means to measure possible leukemia marker

COLUMBUS, Ohio A study led by cancer researchers at The Ohio State University has validated a method for reliably measuring variations in certain proteins that may make good biomarkers in chronic leukemia patients. The study shows that liquid chromatography-mass spectrometry (LC-MS) can measure...

A miR boost enables acute leukemia cells to mature

COLUMBUS, Ohio A new study by Ohio State University cancer researchers shows that boosting the level of a molecule called miR-29b in acute myeloid leukemia (AML) cells can reverse gene changes that trap the cells in an immature, fast growing state of development. The study discovered how the ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

Cold Spring Harbor, N.Y. Being able to accurately predict how a given cancer will respond to chemotherapy would spare patients with non-responsive tumors the burden of undergoing toxic and ultimately unhelpful treatment. Just as important, knowing which of a patient's cancer-causing genetic lesi...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

PHILADELPHIA An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract. The investigators, who report t...

St. Jude identifies genomic causes of a certain type of leukemia relapse

Scientists at St. Jude Children's Research Hospital have identified distinctive genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The finding offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. ...

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Leukemia in Biological Technology

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

BETHESDA, Md., Aug. 3 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced that it has received Orphan Drug Designation from the Europ...

The Leukemia & Lymphoma Society and The International Waldenstrom's Macroglobulinemia Foundation Partner to Develop Cell Lines to Advance Research

WHITE PLAINS, N.Y., July 6 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) and The International Waldenstrom's Macroglobulinemia Foundation (IWMF) have partnered in an initiative to develop stable and immortalized Waldenstrom's macroglobulinemia (WM) cell lines that would be made widely ...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

PRINCETON, N.J., June 8 /PRNewswire/ -- Celator Pharmaceuticals today announced that new clinical and preclinical data demonstrating the extended therapeutic bioavailability and tumor cell selectivity of CPX-351 (Cytarabine:Daunorubicin) Liposome Injection in leukemia were presented at the 14th Co...

Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma

JERUSALEM, June 3 /PRNewswire/ -- The Gamida Cell-Teva Joint Venture announced today that five prestigious cord blood transplantations centers in Spain, three in Barcelona and two in Valencia, have joined the Excel study. Participating clinical sites include, in alphabetical order: ...

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

MADISON, N.J., May 28 /PRNewswire-FirstCall/ -- Quest Diagnostics scientists will present results of three studies revealing the effect of genomic abnormalities on the diagnosis and treatment of chronic myeloid leukemia (CML) and prostate cancer during the 45th Annual Meeting of the American Socie...

Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment

BRIDGEWATER, N.J., May 11 /PRNewswire-FirstCall/ -- Sanofi-aventis U.S. announced today that it has acquired from biotechnology company Antisoma plc the U.S. commercial rights to Oforta(TM) (fludarabine phosphate film-coated tablets), an oral B-cell chronic lymphocytic leukemia (CLL) drug. Ofort...
Leukemia in Biological Products

MOLT - 4 cell line slides ( human: T lymphoblast; acute lymphoblastic leukemia ) from GeneTex

Description: Human MOLT-4 cells were cultured in RPMI 1640 with 2 mM L-glutamine and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface specifi...
Company:GeneTex

RAW 264.7 cell line slides ( mouse: Abelson murine leukemia virus - induced tumor ) from GeneTex

Description: Mouse RAW 264. 7 cells were cultured in DMEM with 4 mM L-glutamine medium and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface s...
Company:GeneTex

L1210 cell line slides ( mouse: lymphocytic leukemia ) from GeneTex

Description: Mouse L1210 cells were cultured in DMEM and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface specifically treated to enhance cel...
Company:GeneTex

Anisomycin from Sigma-Aldrich

Description:...s. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selecti...
Company:Sigma-Aldrich

Puromycin, Dihydrochloride from Calbiochem

Description:...inhibitor. Inhibits translation by causing premature release of nascent polypeptide chains. Induces DNA fragmentation in thymocytes and in human HL-60 leukemia cells. Purity: ≥98% by TLC. Soluble in H 2 O. RTECS AU7355000, CAS 58-58-2, M.W. 544.4....
Company:Calbiochem

MultiScribe Reverse Transcriptase from Applied Biosystems

Description:... MultiScribe Reverse Transcriptase is a recombinant Moloney murine leukemia virus (rMoMuLV) reverse transcriptase. MultiScribe Reverse Transcriptase is similar to MuLV reverse transcriptase but differs in its recommended usage...
Company:Applied Biosystems
Leukemia in Biological Definition

Cancer

...lls , e.g. skin , digestive tract or glands . leukemia starts in the bone marrow stem cells . Lympho...nd bone marrow ) - hematological malignancies , leukemia , lymphoma , Hodgkin's disease , non-Hodgkin's ...t frequently occurring to least: neuroblastoma , leukemia , central nervous system, retinoblastoma , Wilms...

Gene therapy

...led cell division (i.e., cancer ) can occur. Gene therapy trials to treat severe combined immunodeficiency (SCID) were halted or restricted when leukemia was reported in several of the patients. Adenoviruses Adenoviruses are viruses that carry their genetic material in the form of DNA. When thes...

Oncogene

...tein , through a chromosomal aberration during cell division . A distinct aberration in a dividing stem cell in the bone marrow leads to adult leukemia An increase in protein concentration, caused by an increase of protein expression (through misregulation) an increase of protein stabilit...

Retrovirus

...retrovirus ; type species: Mouse mammary tumour virus Genus Gammaretrovirus ; type species: Murine leukeamia virus ; others include Feline leukemia virus Genus Deltaretrovirus ; type species: Bovine leukaemia virus ; others include Human T-lymphotropic virus Genus Epsilonretrovirus ...

Stem cell

...em cells have been used to treat cancer patients with conditions such as leukemia and lymphoma . During chemotherapy , most growing cells are killed by the cytotoxic agents. These agents not only kill the leukemia or neoplastic cells, but also the stem cells needed to replace the killed c...

Tumor

...lymphangiosarcoma Tumors of blood cells: hematopoietic cells: leukemia lymphoid cells: non-Hodgkin lymphoma , Hodgkin lymphoma Tumors ...t it is malignant. See also Carcinoma Sarcoma Lymphoma leukemia Polyp ...
Leukemia in Biological Dictionary

Viral oncogene

...-ras2) oncogene homolog. KRAS1. KRAS2 ... ... leukemia viral oncogene homolog 2, neuro/glioblastoma d... A VIRAL ONCOGENE . ... v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related...ised in Rabbit and recognizes Human Abelson Murine leukemia Viral Oncogene Homolog 1 (ABL1). Suggested use...

Transcriptase

...mon name for an enzyme that functions as a RNA ... All retroviruses have a reverse transcriptase , but the enzymes that are ... Moloney Murine leukemia Virus (M-MuLV) Reverse Transcriptase is an RNA-directed DNA polymerase. This enzyme can synthesize a complementary DNA strand initiating from .....

Topoisomerase

...tranded DNA but only ... Original Article from The New England Journal of Medicine -- DNA Topoisomerase II in Therapy-Related Acute Promyelocytic leukemia of topoisomerase III has no effect on the accumula ... topoisomerase III RuvC double mutants that can be ... type-1 topoisomerase is capable ...

Thrombocytes

...iny bits of protoplasm found in vertebrate blood; essential for blood clotting ... Visit CancerCompass today for all of the latest information on leukemia ... Platelets (also called thrombocytes ) help form blood clots that control bleeding. ... Where Is It Now?: Newly discovered pathways supplement ...

Stem cell

...ojkovi to Editor. ... MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells ... ... dark side of stem cells . ... leukemia initiation in stem cells does not necessarily ... All archived Cell Stem Cell articles from a year or more ago are ... Publishes reports ...

Reverse transcriptase

... cancer . RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that retroviruses need to reproduce. Moloney Murine leukemia Virus (M-MuLV) Reverse Transcriptase is an RNA-directed DNA polymerase. This enzyme can synthesize a complementary DNA strand initiating from ...
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