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lactamase in Medical News

Most Important Factors Driving Usage of Antibiotics in the ICU Setting are Availability in Intravenous Formulation, Activity Against Key Gram Negative Pathogens, Drug Interactions and Bactericidal Activity

...intensive care unit (ICU) setting are an agent's availability in intravenous (IV) formulation, activity against Pseudomonas and extended-spectrum beta lactamase producing pathogens and drug-drug-interactions. Achievement of rapid therapeutic concentration is often necessary in this hospital setting and many cr...
lactamase in Medical Technology

Novexel's NXL104/ceftazidime Combination Commences Second Phase II Clinical Trial in Hospital Patients With Complicated Intra-Abdominal Infections (cIAIs)

... global problem of microbial resistance, announces today that its most advanced injectable antibacterial, which combines Novexel's broad spectrum beta lactamase inhibitor, NXL104, with the well established cephalosporin antibiotic, ceftazidime, has entered a second Phase II clinical trial. This Phase II...
lactamase in Medical Products

Extended Spectrum Beta Lactamase Susceptibility

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Antimicrobial Susceptibility-Extended Spectrum Beta Lactamase

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
lactamase in Biological News

Gaining ground in the race against antibiotic resistance

...activating the drugs. An inhibitor for one type of lactamase has already been marketed as part of a 'package dr...' with amoxicillin to fight resistance. But the lactamase enzyme that Vila's group studied is in a different...at evolution in fast-forward. The group used a lactamase gene from the Bacillus cereus soil bacteria and te...
lactamase in Biological Technology

A Microtiter-based Assay for the Determination of ID50s of b-lactamase Inhibitors Employing Reporter Substrates Detected at UV or Visible Wavelengths (MaxLine Application Note #20)

...group of β -lactamases which have a metal ion at their active site (metallo-β -lactamases). These enzymes are not sensitive to serine β lactamase inhibitors and have a much broader substrate profile than the serine enzymes. Metallo-β -lactamases (MBLs) are capable of hydrolyzing the majorit...
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