Alcohol a potential carcinogen: knocking on the door: pay heed!

Alcohol consumption is related to liver malfunction and now it has another danger lurking behind it: cancer.According to a study by French scientists it has been found that alcohol consumption is // a major cancer-causing agent that is responsible for many types of cancer. Scientists found th...

Compirion and Anderson Surgery Center Reduce OR Inefficiencies and Improve Finances

...livered upstairs, instead of many. Materials were now to be delivered to, inventoried and dispensed from Sterile Processing . That required literally knocking out walls and rebuilding to handle the new space requirement in Sterile Processing. They next worked with IT to set up a new system of electron...

Study pinpoints novel cancer gene and biomarker

...s with the retromer complex to control the activity of TOR in mammal cells (where it's known at mTOR). To test this idea, the investigators found that knocking down GOLPH3 reduced cell size just as rapamycin did. They followed those experiments with biochemical studies to explore how GOLPH3 affects cell size....

Targeting the more lethal form of the cancer rhabdomyosarcoma

...ned that the signaling protein JNK mediated these differing effects of ILK. knocking down expression of ILK in ERMS cells induced activation of JNK and promoted...and when the cells were transplanted into immunodeficient mice. Conversely, knocking down expression of ILK in ARMS cells abrogated both JNK signaling and tumor...

Cylene to Announce New Data on Its First-in-Class Oral CK2 Inhibitor Against Cancer at BIO Conference

...elopment for the treatment of carcinoid/neuroendocrine tumors (C/NET). Quarfloxin disrupts an essential protein: DNA complex in cancer cells, thereby knocking out a critical source of support for tumor cells and selectively causing cancer cell death. Quarfloxin is safe and well-tolerated and has completed tw...

Now we know what blocks the effects of a newly developed anticancer therapy

... sensitive to being killed by adenoviruses. Further analysis revealed the molecular mechanism by which CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore sugge...

JCI online early table of contents: May 1, 2009

... sensitive to being killed by adenoviruses. Further analysis revealed the molecular mechanism by which CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore sugge...

American Academy of Orthopaedic Surgeons Announces Media Orthopaedic Reporting Excellence (MORE) Award Winners

...nalism: Advocacy Walter Eisner, OrthopedicsThisWeek.com - "Avoiding the Perp Walk, or How to Keep the Justice Department from knocking on Your Door" Broadcast Journalism: National Radio Richard Gonzales, NPR Radio - "Father Enlists to Honor ...

Severely Abused Foster Children Sue New York City Child Welfare Agencies After their Failure to Help Them

...d deprived of regular education, doctor or dental visits. One child's teeth were in such pain that the child banged her face on the garage floor until knocking her teeth out. Now adults, all suffer rickets and behavioral issues, and require costly, long-term educational, medical, psychological and sociologica...

JCI online early table of contents: April 6, 2009

...llowing exposure to conditions that induce acute kidney injury in vivo, revealed that mitochondria fragmented before the cells died. Furthermore, both knocking down expression of the protein Drp1, which is known to be involved in mitochondrial fission, and blocking its function substantially reduced mitochond...

Knocking in Medical Technology

Study Shows How Defective DNA Repair Triggers Two Neurological Diseases

...bs1. In their experiments, the researchers produced increased DNA-damage stress in the two types of engineered mice, either by using radiation or knocking out a key enzyme that stitches together broken DNA ends. The researchers then compared the resulting pathologies in the two types of mice. The sc...

Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease

...occurring amyloid; therefore, contributes to its own reproduction through the inflammatory response it triggers. "I found that by genetically knocking out CXCR2, we can reduce the amount of amyloid in various laboratory models and, by using drugs that specifically block the CXCR2 receptor, we are abl...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

...Sangamo's president and CEO. "While the current publication focuses on research and biotechnology applications, we have used these same techniques for knocking out genes in multiple crop plants and to develop ZFP Therapeutics(TM). We are developing potential treatments for HIV/AIDS by knocking-out the CCR5 ge...

Nobel Prize-Winning Discovery

...d, or turned "off," in "knock-out mice." Researchers are already capable of knocking out more than 10,000 genes. In case you're not counting, this means researc... disorder-causing genes, among other functions. Eventually, this could mean knocking out cystic fibrosis and other inherited disorders. Without Evans, Smith...

Genasense(R) Data in Melanoma to be Presented in Opening Session at First Worldwide Melanoma Center Meeting of the European Association of Dermato-Oncology

..., is a novel targeted therapy that blocks the production of Bcl-2, a protein that appears to be a fundamental cause of cancer treatment resistance. By knocking down Bcl-2, Genasense may enhance the effectiveness of chemotherapy in patients with advanced melanoma. Genasense in melanoma has Orphan Drug designat...

Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma

..., is a novel targeted therapy that blocks the production of Bcl-2, a protein that appears to be a fundamental cause of cancer treatment resistance. By knocking down Bcl-2, Genasense may enhance the effectiveness of chemotherapy in patients with advanced melanoma. Genasense in melanoma has Orphan Drug designat...

Knocking in Biological News

Newly discovered gene plays vital role in cancer

...e contribute to about half of all cancer cases," she says. "In the remaining half, p53 is probably inactivated in other ways, such as damage to Wrap53 knocking out the production of the p53 protein." The study is also one of the first to show how antisense RNA regulates genes in the human body. It is alrea...

Decreasing insulin resistance prevents obesity-related cardiovascular damage

... AUGUSTA, Ga. - knocking out one gene that contributes to insulin resistance appears to prevent much...d glucose control. "We have shown cardiovascular function is improved by knocking out this gene. The question is why," says Dr. Stepp, principal investigator...

In India: A search for more effective tuberculosis drugs

...y destroying the pathogen. The problem is that Gokhale's compound will not work in humans. Not willing to set aside seven years of work, he has been knocking on the doors of pharmaceutical companies to see if he can get any takers to help design a less toxic version. Gokhale is pushing himself because he kn...

Cell 'anchors' required to prevent muscular dystrophy

...ett's team was exploring the function of anchor protein ankyrin-B (ankB) by knocking out gene expression of the gene that makes the protein. They found newborn ...ulture don't have properly functioning costameres. They knew, however, that knocking out ankyrin-B causes the mice to die soon after birth. Fortunately, Gai ...

Key to future medical breakthroughs is systems biology, say leading European scientists

...ventional approaches of biology do not have the capacity to unravel these elaborate webs of interactions, which is why drug design often fails. Simply knocking out one target molecule in a biochemical pathway is turning out to be a flawed strategy for drug design, because cells are able to find alternative ro...

Scripps scientists develop first examples of RNA that replicates itself indefinitely

...it has some life-like properties, and that was extremely interesting." knocking on the Door of Life The group is pursuing potential applications of the... evolving novel functions on its own can it be properly called life. "We're knocking on that door," he says, "But of course we haven't achieved that." The su...

Researchers solve piece of large-scale gene silencing mystery

...f a lab rat, Pikaard's team knocked down expression of genes coding for products that prior research had suggested might be involved in silencing. By knocking these suspects down one by one and assessing whether nucleolar dominance had been disrupted after each knockdown, Pikaard and his collaborators were a...

100-meter sprint world record could go as low as 9.48 seconds

... 2008 was a great summer for sports' fans. World records tumbled at the Beijing Olympics. Usain Bolt shattered both the 100m and 200m world records, knocking tenths of a second off each. People have been getting faster and faster over the last few decades, which made marathon runner Mark Denny, from Stanfor...

GUMC researchers hone in on new strategy to treat common infection

...ead to other, possibly more effective, treatment options." In this study, the researchers used a gene microarray analysis to further understand what knocking out the Ssk1 gene does to the organism, and they discovered that the gene is critical to the pathogenic nature of the fungi. What this means is th...

USC researchers identify alternate pathway that leads to palate development

...tially hypothesized that since irregularities in the TGF- gene or its cell surface receptors sparked palate malformation in experimental mouse models, knocking out the Smad4 genes would do the same. "We found that if we blocked TGF- or the receptors, a cleft palate develops," he says, "But when Smad4 was b...

Knocking in Biological Technology

Who's that knocking at the door? Preparing for an FDA inspection

Businesses that manufacture FDA-regulated products are not the only ones that can be inspected by the U.S. Food & Drug Administration at any time. FDA also inspects clinical trial sites (studies in humans) and nonclinical laboratories that conduct animal, plant or microorganism studies used in FD...

K-State Preparing to Share Expertise With Bioscientists

...tion of expertise and facilities available at K-State's state-of-the-art Biosecurity Research Institute," Thornton said. "In fact, the demand has come knocking at our door." Because of its research and training capabilities, the BRI recently was selected to host the National Biosafety and Biocontainment T...

New approach may render disease-causing staph harmless

... by scientists at the University of California, San Diego. The UCSD team, led by Dr. Victor Nizet, a professor of pediatrics and pharmacy, showed that knocking out a gene for an enzyme in the chemical pathway that produced the Staph carotenoid reduced its virulence. When he read about this finding, Univers...

Abbott Named One of the 'Best Places to Launch a Career' by BusinessWeek

... ABBOTT PARK, Ill., Oct. 3 /PRNewswire/ -- With more than 70 million Generation Y employees starting to hit the pavement, knocking for opportunities in the global workplace, smart companies are paying attention, providing these future leaders with a workplace that is responsive to...

Of mice and men: new male contraceptives successful in rodents and humans

...d as a female contraceptive under the name "DepoProvera." The men got a shot once every 3 months and rubbed on a gel every day, and it worked well at knocking out sperm in 90% of them. However, men's opinions of the method varied widely: 6 dropped out, and of the remaining 38, half of them were satisfied or...

How 40-plus tech job seekers can prevent age discrimination

...in and start solving problems. Let's face it. In a lot of Midwest technology companies (I'm thinking AT&T and a host of others), moving fast and knocking down barriers was not part of the corporate culture. You did what you were told and that was that. In 2004, thats out. You need to have results all th...

Confoti: Revisiting a dotcom business model

...et and business development. As they continue an almost grass-roots consumer marketing effort that is generating revenue growth, the company is busy knocking on the doors of major brand and technology partners. And it's sometimes difficult to get the attention of the Big Guys who will too easily dismiss ...

Angels step up

...le to understand who they should be talking to as they raise first money. In today's market, especially, a start-up will burn precious time and energy knocking on the name- brand doors along Sand Hill Road. Instead, they are wise to seek out the unconventional investor who swims against the tide. And when ...

Lord of the Rings visual effects creator talks about entrepreneurial experiences

...Cliffhanger and Ghost. The work remained freelance however, and at times Rygiel found himself digging for the next job. It was a lot of networking, knocking on the doors every couple of months I kept getting turned away, but it got me to know the people there [in the industry], Rygiel said. This networ...

The IT drug Just say no?

...t pause begin to connect that urgent moment with all the other urgent moments that came before, and begin to line those up with all the urgent moments knocking at our door. We have to, because if we dont, all were left with is an endless tumble down the rabbit hole. ----- Byron Glick is a principal at Pr...