Scientists elucidate the kinome of key model organism
The journal PLoS Genetics has published the findings of a team of scientists at the nonprofit Boston Biomedical Research Institute that provides a whole genome analysis of the protein kinases from a scientifically valuable model organism known as Dictyostelium. Led by Dr. Janet Smith, this stu...Researchers report the cloning of a key group of human genes, the protein kinases
...nal form, and generation of a corresponding set of kinases lacking catalytic activity that are necessary for functional studies. They further used the kinome collection in several high-throughput screens, including a screen which identified two novel kinases regulating the Hedgehog signaling pathway a key ...Setting up a kinase profiler with IMAP
... by choosing enzymes from all families of the kinome (Figure 1), as shown in Table 1. ...r details). The kinases range across the kinome to showcase the generic nature of the IM...ts addressing different branches of the kinome as shown in Figure 1: IMAP Substrate Finder 1 for ...