A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found
The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. EphA4 reportedly forms a hetero receptor complex with FGFR...EntreMed Teams with JSB-Partners to Expedite Partnering of its Aurora Kinase Program
Additional Resources to Accelerate ENMD-2076 Partnering Efforts ROCKVILLE, Md., Aug. 12 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced that it ...Activation of LYN kinase is associated with imatinib-resistance in CML patients
Activation of LYN kinase is associated with resistance to imatinib (Gleevec) in patients with chronic myelogenous leukemia (CML), researchers report in the June 24 online issue of the Journal of the National Cancer Institute . Imatinib is the standard therapy for newly diagnosed CML patients. ...Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells
A new study provides valuable insight into a previously undescribed mechanism that regulates a prominent cancer-associated protein. The research, published by Cell Press in the February 29th issue of Molecular Cell, will enhance understanding of the fundamental processes that contribute to breast ...Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor
INDIANAPOLIS, March 17 /PRNewswire/ -- Semafore Pharmaceuticals, Inc. announced today that it has achieved proof of concept in its CRIMP (Control Resulting from Inhibiting Multiple Pathways) kinase platform by designing a small molecule that was demonstrated to inhibit members of both the PI3K (Ph...Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors
INDIANAPOLIS, Aug. 26 /PRNewswire/ -- Semafore Pharmaceuticals Inc. presented data at the Seventh International Congress on Targeted Therapies in Cancer in Washington, D.C., announcing the discovery of novel multi-targeted kinase inhibitors that demonstrate significant anticancer activity in p...SuperGen's PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models
DUBLIN, Calif., June 13 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced at the 13th Congress of the European Hema...Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute
-Successful Collaboration with Scripps Florida and Scripps Research in La Jolla- SOUTH SAN FRANCISCO, Calif., and LA JOLLA, Calif., May 14 /PRNewswire- FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, ...Creatine Kinase (CK-MB) Control
Description: CK-MB Control...Creatine Kinase (CK-MB) ROSALKI
Description: The CKMB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase MB isoenzyme activity in serum and plasma...Creatine Kinase (CK-NAC) SZASZ
Description: The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and plasma...Rong Li Lab reports protein interactions of MAP kinase signaling pathway
The Stowers Institutes Rong Li Lab, in collaboration with the Institutes Imaging Center, has achieved a quantitative in vivo measurement of the dynamic protein-protein interactions in the mitogen-activated protein (MAP) kinase cascade signaling pathway, which is critical to growth and differentiat...Unique dual target specificity of kinase inhibitor key for success against cancer
Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. ...Building a human kinase gene repository
Using the human genome sequence annotation, high-throughput cloning methodologies, and automation, a group at the Harvard Institute of Proteomics lead by Leonardo Brizuela (Harvard Medical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequ...Scientists uncork a potential secret of red wine's health benefits
...one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely ...Stress signals link pre-existing sickness with susceptibility to bacterial infection
...g-infecting bacteria, Legionella . Cells with mitochondrial disease increase their production of a signaling protein called AMP-activated protein kinase (AMPK), to promote the generation of more energy producing mitochondria. Infectious bacteria, like Legionella , target the mitochondria and might us...Protein that promotes cancer cell growth identified
...division and invasion. The researchers also identified an RXDLL amino acid motif that controls the signaling from the EGF receptor through the protein kinase Src to the master cell proliferation regulator protein, MAPK. This same signaling pathway stimulates neuroblastoma cells to migrate and invade neighbo...Sigma-Aldrich Introduces Precisio(TM) Kinases for High-Throughput Screening and Kinase Profiling
ST. LOUIS, May 13 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today introduced Precisio(TM) Kinases ( www.sigma.com/precisiokinases ), a new collection of high quality active kinases that is expected to enable scientists to achieve greater insight into protein phosphorylation and c...Dana-Farber Cancer Institute Commences Phase 1 Trial With EntreMed's Selective Kinase Inhibitor
Dana-Farber and Colorado Treating Patients with ENMD-2076 ROCKVILLE, Md., May 8 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced that Dana-Farbe...CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform
Munich and Freiburg, Germany, May 7, 2008 / b3c newswire / – CRELUX and ProQinase announced today that they have entered into a joint agreement to supply customers with crystal-grade protein kinases and readily available kinase complex structures. Under the agreement, CRELUX and ProQinase ...EntreMed's Kinase Inhibitor, ENMD-2076, Presented During AACR Special Session
New Drugs on the Horizon Session Highlights New Small Molecule Drug Candidates ROCKVILLE, Md., April 14 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inf...Anti-p38 MAP Kinase gamma Antibody, Unconjugated from Cell Signaling Technology
Description: p38 MAP Kinase gamma Antibody Shipping Temperature: HOT Storage Temperature: -20C...Non-Receptor Tyrosine Kinase Sampler Kit from BD Biosciences Pharmingen
Description: Non-Receptor Tyrosine Kinase Sampler Kit 10 mu g each...Mouse Anti-Protein Kinase C Beta 2 Monoclonal Antibody, Unconjugated from AbD Serotec
Description: MOUSE ANTI PROTEIN KINASE C BETA 2 Immunogen: Protein kinase C beta 2...The Protein Kinase Factsbooks (2 Volume Set) from Promega
Description: The Protein Kinase Factsbooks (2 Volume Set)...T4 Polynucleotide Kinase Exchange Reaction Buffer from Invitrogen
Description: For use with T4 Polynucleotide Kinase for labeling of 5' ends (5' phosphate ends) of nucleic acids. In the exchange reaction T4 Polynucleotide Kinase transfers the 5' phosphate group from DNA to ADP and subsequently transfers the Gamma-phosphate of ATP to the free 5' hydroxyl group to rephosphoryla...