Kinase

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dep...

A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found

The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. EphA4 reportedly forms a hetero receptor complex with FGFR...

EntreMed Teams with JSB-Partners to Expedite Partnering of its Aurora Kinase Program

Additional Resources to Accelerate ENMD-2076 Partnering Efforts ROCKVILLE, Md., Aug. 12 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced that it ...

Activation of LYN kinase is associated with imatinib-resistance in CML patients

Activation of LYN kinase is associated with resistance to imatinib (Gleevec) in patients with chronic myelogenous leukemia (CML), researchers report in the June 24 online issue of the Journal of the National Cancer Institute . Imatinib is the standard therapy for newly diagnosed CML patients. ...

Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells

A new study provides valuable insight into a previously undescribed mechanism that regulates a prominent cancer-associated protein. The research, published by Cell Press in the February 29th issue of Molecular Cell, will enhance understanding of the fundamental processes that contribute to breast ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Demonstrates Pre-clinical Activity in Glioblastoma Multiforme

Small molecule drug inhibits key DNA repair mechanism involved in resistance DUBLIN, Calif., Oct. 31 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therap...

Kinase in Medical Technology

Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor

INDIANAPOLIS, March 17 /PRNewswire/ -- Semafore Pharmaceuticals, Inc. announced today that it has achieved proof of concept in its CRIMP (Control Resulting from Inhibiting Multiple Pathways) kinase platform by designing a small molecule that was demonstrated to inhibit members of both the PI3K (Ph...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

DUBLIN, Calif., Dec. 8 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery and development of novel cancer therapies, today announced that its oral PIM kinase inhibitor, SGI-1776, is effective both in vitro and in vivo in preclinical mode...

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

INDIANAPOLIS, Aug. 26 /PRNewswire/ -- Semafore Pharmaceuticals Inc. announced data presented at the Seventh International Congress on Targeted Therapies in Cancer in Washington, D.C., showing additional antiangiogenic activity of vascular-targeted PI3 kinase (PI3K) inhibitor SF1126, by blockin...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

INDIANAPOLIS, Aug. 26 /PRNewswire/ -- Semafore Pharmaceuticals Inc. presented data at the Seventh International Congress on Targeted Therapies in Cancer in Washington, D.C., announcing the discovery of novel multi-targeted kinase inhibitors that demonstrate significant anticancer activity in p...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models

DUBLIN, Calif., June 13 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced at the 13th Congress of the European Hema...

Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute

-Successful Collaboration with Scripps Florida and Scripps Research in La Jolla- SOUTH SAN FRANCISCO, Calif., and LA JOLLA, Calif., May 14 /PRNewswire- FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, ...

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Kinase in Medical Products

Creatine Kinase Isoenzymes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Creatine Kinase (CK-MB) Control

Description: CK-MB Control...
Company:Randox Laboratories Ltd.

Creatine Kinase (CK-MB) ROSALKI

Description: The CKMB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase MB isoenzyme activity in serum and plasma...
Company:Randox Laboratories Ltd.

Creatine Kinase (CK-NAC) SZASZ

Description: The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and plasma...
Company:Randox Laboratories Ltd.

Creatine Kinase (CK-NAC)

Description: For the quantitative in vitro determination of Cholesterol in serum and plasma....
Company:Randox Laboratories Ltd.

Creatine Kinase (CK-MB)

Description: For the quantitative in vitro determination of CK-MB in serum and plasma...
Company:Randox Laboratories Ltd.

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Kinase in Biological News

Rong Li Lab reports protein interactions of MAP kinase signaling pathway

The Stowers Institutes Rong Li Lab, in collaboration with the Institutes Imaging Center, has achieved a quantitative in vivo measurement of the dynamic protein-protein interactions in the mitogen-activated protein (MAP) kinase cascade signaling pathway, which is critical to growth and differentiat...

Unique dual target specificity of kinase inhibitor key for success against cancer

Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. ...

Building a human kinase gene repository

Using the human genome sequence annotation, high-throughput cloning methodologies, and automation, a group at the Harvard Institute of Proteomics lead by Leonardo Brizuela (Harvard Medical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequ...

Scientists uncork a potential secret of red wine's health benefits

...one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely ...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

...g-infecting bacteria, Legionella . Cells with mitochondrial disease increase their production of a signaling protein called AMP-activated protein kinase (AMPK), to promote the generation of more energy producing mitochondria. Infectious bacteria, like Legionella , target the mitochondria and might us...

Protein that promotes cancer cell growth identified

...division and invasion. The researchers also identified an RXDLL amino acid motif that controls the signaling from the EGF receptor through the protein kinase Src to the master cell proliferation regulator protein, MAPK. This same signaling pathway stimulates neuroblastoma cells to migrate and invade neighbo...

Kinase in Biological Technology

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

GIA announces the release of a comprehensive global report on Small Molecule Kinase Inhibitors market. World market for small molecule kinase inhibitor drugs is projected to reach $16.2 billion by the year 2015. This is primarily driven by the rising interest over the potential of kinase inhibito...

Nerviano Medical Sciences Receives Approval From the FDA to Enter Phase I Clinical Trials for Their Polo Like Kinase (PLK) Inhibitor

NERVIANO, Italy, May 13 /PRNewswire/ -- The FDA has approved an Investigational New Drug (IND) application by Nerviano Medical Sciences to begin a phase I clinical study with its selective PLK-1 small molecule inhibitor for the treatment of cancer. PLK-1 is a mitotic kinase required for the pr...

Sigma-Aldrich Introduces Precisio(TM) Kinases for High-Throughput Screening and Kinase Profiling

ST. LOUIS, May 13 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today introduced Precisio(TM) Kinases ( www.sigma.com/precisiokinases ), a new collection of high quality active kinases that is expected to enable scientists to achieve greater insight into protein phosphorylation and c...

Dana-Farber Cancer Institute Commences Phase 1 Trial With EntreMed's Selective Kinase Inhibitor

Dana-Farber and Colorado Treating Patients with ENMD-2076 ROCKVILLE, Md., May 8 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced that Dana-Farbe...

CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform

Munich and Freiburg, Germany, May 7, 2008 / b3c newswire / – CRELUX and ProQinase announced today that they have entered into a joint agreement to supply customers with crystal-grade protein kinases and readily available kinase complex structures. Under the agreement, CRELUX and ProQinase ...

EntreMed's Kinase Inhibitor, ENMD-2076, Presented During AACR Special Session

New Drugs on the Horizon Session Highlights New Small Molecule Drug Candidates ROCKVILLE, Md., April 14 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inf...

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Kinase in Biological Products

Anti-p38 MAP Kinase gamma Antibody, Unconjugated from Cell Signaling Technology

Description: p38 MAP Kinase gamma Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Company:Cell Signaling Technology

Chicken Anti-Human Adenylate kinase isoenzyme 6 Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: Adenylate kinase isoenzyme 6...
Company:GenWay Biotech, Inc.

Non-Receptor Tyrosine Kinase Sampler Kit from BD Biosciences Pharmingen

Description: Non-Receptor Tyrosine Kinase Sampler Kit 10 mu g each...
Company:BD Biosciences Pharmingen

Mouse Anti-Protein Kinase C Beta 2 Monoclonal Antibody, Unconjugated from AbD Serotec

Description: MOUSE ANTI PROTEIN KINASE C BETA 2 Immunogen: Protein kinase C beta 2...
Company:AbD Serotec

The Protein Kinase Factsbooks (2 Volume Set) from Promega

Description: The Protein Kinase Factsbooks (2 Volume Set)...
Company:Promega

T4 Polynucleotide Kinase Exchange Reaction Buffer from Invitrogen

Description: For use with T4 Polynucleotide Kinase for labeling of 5' ends (5' phosphate ends) of nucleic acids. In the exchange reaction T4 Polynucleotide Kinase transfers the 5' phosphate group from DNA to ADP and subsequently transfers the Gamma-phosphate of ATP to the free 5' hydroxyl group to rephosphoryla...
Company:Invitrogen

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Kinase in Biological Definition

Cell growth

...e reaching the normal size ( wee mutants). The Wee1 protein is a tyrosine kinase . It normally phosphorylates the Cdc2 cell cycle regulatory protein on a ...Cell size regulation in mammals The protein mTOR is a serine/threonine kinase that regulates translation and cell division. Nutrient availability infl...

Glycolysis

...nase, forming 1,3-bisphosphoglycerate. In the next step, phosphoglycerate kinase generates a molecule of ATP while forming 3-phosphoglycerate. At this step ...molecule of pyruvate and a molecule of ATP by means of the enzyme pyruvate kinase . This serves as an additional regulatory step. After the formation of fr...

Long-term potentiation

...R (1994) "Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 regi...) "A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation". ...897 ^ Sweatt JD (2001) "The neuronal MAP kinase cascade: a biochemical signal integration system s...

Muscle

...ity /rigidity, myoclonus (twitching) and myalgia (muscle pain). Diagnostic procedures that may reveal muscular disorders include testing creatine kinase levels in the blood and electromyography (measuring electrical activity in muscles). Neuromuscular diseases are those that affect the muscles an...

Nucleotide

...mportant roles in cellular energy transport and transformations (notably ATP and NAD+/NADH ), and in enzyme regulation (see for example, protein kinase ). The nucleobase can be a purines or pyrimidines , the sugar can be deoxyribose in DNA or ribose in RNA, and the phosphate chain can be a mo...

Oncogene

...gulatory GTPases , for example, the Ras protein . Cytoplasmic Serine / Threonine kinases and their regulatory subunits , for example, the Raf kinase , and cyclin-dependent kinases (through overexpression ). Adaptor proteins in signal transduction . Transcription factors . Relat...

Kinase in Biological Dictionary

Kinase

In chemistry and biochemistry, a kinase , alternatively known as a phosphotransferase, is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. The process is referred to as phosphorylation. An enzyme that... A protein kin...

Polynucleotide Kinase

In enzymology, a polynucleotide 5'-hydroxyl- kinase (EC 2.7.1.78) is an enzyme that catalyzes the chemical reaction Use this polynucleotide kinase to: phosphorylate 5_ -ends of DNA or RNA ... T4 Polynucleotide Kinase ; 3'-phosphatase-free. Alkaline Phosphatase, shrimp; ... Bri...

Untranslated RNA

... :: physiology; Research Support, Non-U.S. ... Tumor Suppression by the Prohibitin Gene 3' Untranslated Region RNA in Human Breast Cancer 1 ... kinase PKR by RNA from the 3' untranslated regions of human ... ... interaction of RNA -binding proteins with 5′- or 3′- untranslated regions (U...

Transmembrane receptor

... transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk ... tra...nsmembrane receptor protein serine/threonine kinase signalling pathway ... as a consequence of a transmembrane receptor serine/threonine kinase binding to ... ... as a consequence of a tran...

Proto-oncogene

... cancer cell. The RET proto - oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family ...he ret proto - oncogene ( proto -ret) encodes a receptor type tyrosine kinase with ... Proto - oncogene definition - Medical Dictionary definitions...

Phosphatase

...e -treated fragments lack the 5' phosphoryl termini required by ... Which phosphatase (CIP, Antarctic or SAP) should I use? ... Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase ) ... domain, RNA polymerase II, polypeptide A) phosphatase , subunit 1 ... Forens...