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Kinase at Biology News

Building a human kinase gene repository

Using the human genome sequence annotation, high-throughput cloning methodologies, and automation, a group at the Harvard Institute of Proteomics lead by Leonardo Brizuela (Harvard Medical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequence information of all identified human kinase genes and have built a gene repository for this gene...

Unique dual target specificity of kinase inhibitor key for success against cancer

Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. This study reinforces the concept that successful small molecule kinase inhibitors must display a br...
Kinase at Biology Products

Baker's yeast (S. cerevisiae) Hexokinase and glucose-6-phosphate dehydrogenase from Sigma-Aldrich

Description:Useful for determination of glucose and ATP. -glucose per min at pH 7.6 at 25C....
Company:Sigma-Aldrich

Standard Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences

Description:Microarrays designed for proteomic scale kinase profiling, quantitative measurement of kinase kinetic activities, and drug discovery research built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive Protein Kinase Substrate - Peptide Microarray Service. Our standard content PKS...
Company:LC Sciences

Protein Kinase Substrate (PKS) Peptide Microarray - Comprehensive Service from LC Sciences

Description:LC Sciences provides a comprehensive kinase analysis service utilizing high density protein kinase substrate (PKS) peptide microarrays synthesized on Paraflo microfluidic chips for proteomic scale kinase profiling, quantitative measurement of kinase kinetic activities, and drug discovery research. This comprehensive service includes preparation of your kinase sample, single or dual color enzymati...
Company:LC Sciences

Custom Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences

Description:Microarrays designed for proteomic scale kinase profiling, quantitative measurement of kinase kinetic activities, and drug discovery research built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive Protein Kinase Substrate - Peptide Microarray Service. Probe content is co...
Company:LC Sciences

Enterokinase EKMax from Invitrogen

Description:EKMax™ is a recombinant preparation of the catalytic subunit of bovine enterokinase (1). EKMax™ Enterokinase is expressed and isolated from the yeast Pichia pastoris to yield a highly purified enzyme preparation (2). It recognizes the sequence Asp-Asp-Asp-Asp-Lys and cleaves the peptide bond after the lysine residue. The enzyme can be used to cleave any fusion protein that carries thi...
Company:Invitrogen

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Kinase at Biology Technology

TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins

Institute for Molecular Biology and Biotechnology, McMaster University,Ontario, Canada GST-fusion proteins expressed in TKB1 bacteria are used to affinity purifycellular proteins, which interact with a specific autophosphorylation site onthe Erb...

LiquiChip Kits for bead-based cytokine and kinase assays

The LiquiChip Human and Mouse 10-Cytokine Kits and Ser/Thr Kinase Kit provide fast and accurate quantification of a range of cytokines and serine/threonine kinases. LiquiChip 10-Cytokine Kits enable simultaneous multiplex assay of 10 different cytokines using bead-based xMAP technology. The LiquiChip Ser/Thr Kinase Kit...

Purification of Phosphoinositide 3-Kinase With UNO Columns

Polyphosphoinositides and their metabolites are important intracellular signals involved in the responses to a number of hormones and growth factors.The discovery of a phosphatidylinositol kinase that phosphorylates PI at the 3 position of the inositol ring uncovered a new pathway of PI metabolism and potential intracellula...

Purification of Two Isoforms of Pyruvate Kinase from Nordic Krill Using an UNO Q1 Column, Rev A

Pyruvate kinase (PK, E.C. 2.7.1.40) is one of the key regulatory enzymes of the glycolytic pathway in crustaceans. This enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate and the phosphorylation of ADP to ATP. In addition to the role of PK in aerobic and anaerobic energy metabolism in...

TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization

Uses High Efficiency Fluorescence Polarization (HEFP) detection method Assays a broad range of tyrosine kinases Requires no separation or wash steps Available in a kit and in bulk packaging Screening for tyrosine kinase activity can be accelerated...

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Kinase at Biology Dictionary

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Kinase at Medicine News

Phase 3 trials of two multi-kinase inhibitors against cancer

Sorafenib and stutent multi-kinase inhibitors against cancer is undergoing phase 3 trials// and these two drugs gained more appreciation in this years ASCO (American Society of Clinical Oncology) conference. This drug is gaining interest due to its multiple mechanism of action – known as Multi-kinase inhibitors. These drugs are in trial against different types of cancer and are found to be very e...

Enzyme Urokinase Better Option In Empyema For Kids

Researchers say that enzyme urokinase provides a better option as a treatment for empyema in children since it is 25 percent less costlier than another treatment// video-assisted thoracoscopic surgery. The researchers say both methods are equally effective. The study results appear in the second issue for July 2006 of the American Journal of Respiratory and Critical Care Medicine, pub...
Kinase at Medicine Products

Glucose (Hexokinase)

Description:For the quantitative determination of Glucose in serum. Endpoint reaction (NAD -> NADH) measured at 340 nm. Linearity: 600 mg/dl. Liquid working reagent prepared with simple 1:9 dilution....
Company:Horizon Diagnostics, Inc.

Glucose Hexokinase Reagent Set

Description:Glucose reagent is used for the quantitative determination of glucose in human serum....
Company:Teco Diagnostics

Glucose Hexokinase Liquid

Description:For the in vitro quantitative determination of glucose in human serum or plasma....
Company:Teco Diagnostics

Creatine Kinase (CK)

Description:For the quantitative determination of creatine kinase in serum. Kinetic Reaction measured at 340 nm. Linearity: 1500 IU/L at 37C....
Company:Horizon Diagnostics, Inc.

Creatine Kinase-MB (CK-MB)

Description:For the quantitative determination of creatine kinase-MB in serum. Kinetic Reaction measured at 340 nm. Linearity: 700 IU/L at 37C....
Company:Horizon Diagnostics, Inc.

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Kinase at Medicine Technology

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

ROCKVILLE, Md., June 01, 2007 /PRNewswire-FirstCall/ --EntreMed, Inc. , a clinical-stage pharmaceutical company developingtherapeutics for the treatment of cancer and inflammatory diseases,announced the presentation of preclinical results for its Aurorakinase - angiogenesis inhibitor, ENMD-981693. The data werepresented during oral and poster presentations by EntreMedscientists at the 2n...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

Other Presentations at AACR Highlight Progress in SuperGen'sOncology-Focused Pre-Clinical Pipeline LOS ANGELES, April 19, 2007 /PRNewswire-FirstCall/ -- SuperGenInc. today announced that MP470, its multi-targeted tyrosine kinaseinhibitor, suppresses the Rad51 protein, a critical component ofdouble- stranded DNA repair in cancer cells as part of a series ofpresentations at the 2007 America...

Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Bruton's Tyrosine Kinase Inhibitors

SUNNYVALE, Calif. and LOS ANGELES, April 18, 2007/PRNewswire-FirstCall/ -- Pharmacyclics, Inc. today announced datafrom two preclinical studies, one identifying a functionalbiomarker for its novel histone deacetylase (HDAC) inhibitor andanother demonstrating preclinical anti-tumor activity with itsBruton's tyrosine kinase (BTK) inhibitor compounds. The data werepresented at the American...

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

LOS ANGELES & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 -AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused onthe discovery and development of novel, targeted cancer medicines,today announced encouraging preclinical data of AV-412, a novel,next generation oral tyrosine kinase inhibitor of EGFR/HER2 usingAVEO's unique EGFR mutant and drug-resistant lung cancer tumormod...

Pharmacyclics Announces Presentations on Its Novel and Selective HDAC and Bruton's Tyrosine Kinase Inhibitor Compounds

SUNNYVALE, Calif., April 11, 2007 /PRNewswire-FirstCall/ --Pharmacyclics, Inc. announced today multiple presentationsregarding its novel histone deacetylase (HDAC) inhibitor andBruton's tyrosine kinase inhibitor compounds. The presentationswill take place at the American Association for Cancer Research(AACR) 2007 Annual Meeting being held April 14-18, 2007, at the LosAngeles Convention C...

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