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isoforms in Medical News

Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

We have previously shown that E2 and P4 have clear and distinct effects on inflammatory response and gastric epithelial changes during early H. pylori infection. Recently, Ohtani et al., have shown a protective role of E2 administration in H. pylori-infected InGas mice. Other studies have demonstr...

MicroRNA controls expression of oncogenes

...ludes Dr. Malumbres. "This may be particularly beneficial for patients who are resistant to small molecule kinase inhibitors like Gleevec as resistant isoforms of ABL and BCR-ABL should contain the target site for miR-203 and are likely to respond to restored miR-203 function." ...

Novel enzyme inhibitor paves way for new cancer drug

...ith cancer, others are not. The trick to building inhibitors with low side effects and toxicity is to create inhibitors that knock out the troublesome isoforms without disrupting the other types, Marmorstein says ...

Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?

...KAP4-similar protein has high homogeneity with Np63, and the characteristic expression of agrNp63 alpha that is considered a potential oncogene in the isoforms of p63 is similar to Ca-Hb3. Np63 is an isoform of the p63 family. A number of studies have highlighted the oncogenic potential of agrNp63 alpha.a...

2 microRNAs promote spread of tumor cells

...ar cancer. According to Huang, miR-520c is a new miRNA whose function has not been known until now. Our most surprising finding is that miR-373 and isoforms of miR-520 are part of the same family, Huang says. Their seed sequences, or first eight nucleotides, are all very similar. It suggests this family of...

JCI online early table of contents: Jan. 10 2008

...combination of UDCA and the glucocorticoid dexamethasone, but not with either treatment alone, was shown to increase expression of the AE2 alternative isoforms AE2b1 and AE2b2 and this was associated with enhanced AE2 activity in the liver. Further analysis revealed that the combination treatment led to upreg...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) to be Presented at the Upcoming American Society of Hematology Meeting in Atlanta, Georgia

...e has been shown to inhibit or otherwise modify signaling through a number of different signal transduction pathways including Akt, MAPK, and JNK. Akt isoforms have been found to be overexpressed in renal, breast, prostate, and pancreatic cancers. Elevated levels of pAkt have been correlated with poor prognos...

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

...e has been shown to inhibit or otherwise modify signaling through a number of different signal transduction pathways including Akt, MAPK, and JNK. Akt isoforms have been found to be overexpressed in renal, breast, prostate, and pancreatic cancers. Elevated levels of pAkt have been correlated with poor prognos...

Discovery Of New Molecule Could Solve Cancer Spread Mystery

...California, San Francisco and coworkers sought to identify which PI3 kinase isoforms are critical for growth and progression of malignant glioma cells. UCSF col...aracterized a series of novel inhibitors that span the different PI3 kinase isoforms (described in the May issue of Cell). Qi-Wen Fan in the Weiss lab screened ...

Mouse Model Beneficial to Study of Head and Neck Cancer

...eta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either the H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with 100 percent incidence. ‘Head and neck lesions developed from this mous...
isoforms in Medical Technology

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

...cottsdale, AZ. About SF1126 SF1126 is the only clinical stage vascular targeted pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including mTORC1/2, DNA-PK, PLK-1, CK2, ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

...act # 2558) About SF1126 SF1126 is the only clinical stage vascular targeted pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including mTORC1/2, DNA-PK, PLK-1, CK2, ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis...

Myeloperoxidase Research Expands

...cancer prediction. Great deal of worldwide research continues with this important enzyme that Lee Biosolutions produces. Three Myeloperoxidase isoforms have been purified and identified through ion exchange chromatography by Lee Biosolutions. Human Myeoloperoxidase Isoform A, Myeloperoxidase isoform B...

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

...pe for cancer patients. SF1126, is a proprietary small molecule conjugate containing a pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including mTOR, DNA-PK, PLK-1,CK2, ATM and PIM-1 kinases all known to be involved in the cascade of che...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

... Semafore's Chief Executive Officer. "In addition to inhibiting all Class I isoforms of PI3K, our compounds SF2506 and SF2523 block additional key kinases which... containing a pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including mTOR, DNA-PK, PLK-...

Roche Gains Access to Important Oncology Target With Potential for Treating Major Cancers Such as Breast and Lung; First Drug Candidate in Phase I Clinical Testing

...ne inflammatory disorders such as arthritis and asthma. Piramed is a leading company in the discovery of highly selective drugs that inhibit different isoforms of PI3-K, enzymes that are increasingly recognized as key players in a wide variety of disease processes. The company's leadership in this area was re...

Semafore's PI3 Kinase Inhibitor SF1126 is a Vascular Targeted Conjugate in Phase I Clinical Trials in Solid Tumors and Multiple Myeloma

...nd multiple myeloma." About SF1126 SF1126 is a small molecule conjugate containing a pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including DNA-PK and mTOR. A major factor in tumor resistance to approved chemotherapy agents is though...

Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor

...isoform specific inhibitor," said Joseph J. Buggy, Ph.D., vice president of research for Pharmacyclics. "This study also confirms that individual HDAC isoforms have unique roles in cell physiology and it appears that the series of drug candidates we are developing may be useful in addressing diseases mediated...

Semafore's SF1126 Exhibits Antitumor and Antiangiogenic Activity

...erful PI3K pathway." About SF1126 SF1126 is a small molecule conjugate containing a pan-PI3K inhibitor that selectively inhibits all PI3K class IA isoforms and other key members of the PI3K superfamily, including DNA-PK and mTOR. A major factor in tumor resistance to approved chemotherapy agents is though...

Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology

...e has been shown to inhibit or otherwise modify signaling through a number of different signal transduction pathways including Akt, MAPK, and JNK. Akt isoforms have been found to be overexpressed in renal, breast, prostate, and pancreatic cancers. Elevated levels of pAkt have been correlated with poor prognos...
isoforms in Medical Products

OptiMAL Malaria Test

Features:... dehydrogenase (pLDH), an enzyme produced by all forms of the parasite The presence of pLDH is revealed using monoclonal antibodies directed against isoforms of the enzyme ...
Company:DiaMed
isoforms in Biological News

'Shock and kill' research gives new hope for HIV-1 eradication

...". To overcome this problem, the Italian researchers tested a collection of HDAC inhibitors, some of which specifically target only certain enzyme isoforms (class I HDACs) that are involved in HIV latency. The toxicity of this approach, however, was not markedly decreased, although it compromises a more l...

GEN reports growing focus on PI3-kinase pathway in cancer research

...athway and turn on AKT, an enzyme that drives tumor survival signals. Investigators at the University of London are exploring the role of PI3-kinase isoforms in normal physiology and disease. A team led by Dr. Bart Vanhaesebroeck isolated the PI3-kinase genes in various mammals and developed models to bette...

Human genes sing different tunes in different tissues

... is often highly tissue-dependent. Certain protein isoforms that are common in heart tissue, for example, migh...eved, but they have much less understanding of why isoforms display such tissue specificity, Burge said. Sc...ts have also observed that cells express different isoforms during embryonic development and at different stag...

Novel structure proteins could play a role in apoptosis

..., may have a role in apoptosis. "Since these NSP isoforms have similar structural characteristics of known s... for researchers is to examine exactly how the NSP isoforms are interacting with the B23 protein. "We have an...rm it," he said. D'Agostino added that these NSP isoforms may also have diagnostic value. "Eventually, we ...

Mechanism explains link between apolipoprotein E and Alzheimer's disease

...r AD. The researchers found that ApoE profoundly enhanced the intracellular and extracellular degradation of A?. This enhancement varied for different isoforms of ApoE with the ApoE4 isoform exhibiting an impaired ability to promote A? degradation when compared to other ApoE isoforms. The number of lipid mole...

Unique dual target specificity of kinase inhibitor key for success against cancer

...California, San Francisco and coworkers sought to identify which PI3 kinase isoforms are critical for growth and progression of malignant glioma cells. UCSF col...aracterized a series of novel inhibitors that span the different PI3 kinase isoforms (described in the May issue of Cell). Qi-Wen Fan in the Weiss lab screened ...
isoforms in Biological Technology

Purification of Two Isoforms of Pyruvate Kinase from Nordic Krill Using an UNO Q1 Column, Rev A

Introduction Pyruvate kinase (PK, E.C. 2.7.1.40) is one of the key regulatory enzymes of the glycolytic pathway in crustaceans. This enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate and the phosphorylation of ADP to A...

Intellikine Completes $51 Million Financing

...eatment of cancer, inflammation and autoimmune diseases. Intellikine has discovered multiple classes of proprietary compounds that selectively target isoforms of the PI3K pathway. The company's most advanced compound, INK128, a potent and selective TORC1/2 inhibitor with exceptional drug-like properties is ...

Caprion Proteomics Inc. and Applied Bioystems Work Together to Accelerate Protein Biomarker Verification and Validation

...ectrometry-based technique can also prove advantageous in cases where specificity is required and specific post translational modifications or protein isoforms are critical to monitor but difficult to differentiate by antibody techniques. This joint effort is another example of both companies working wit...

Intrinsic Bioprobes, Inc. Enters into a $1.27M Contract with the National Cancer Institute to Develop Multiplex Mass Spectrometric Immunoassays for Detection of Low Abundance Cancer-Related Proteins

...broad dynamic range, and require limited sample preparation. The mass spectrometric aspect of the assays also enables single-step detection of protein isoforms and their individual quantification, which is an important protein diversity aspect regularly overlooked in contemporary proteomics approaches," adds ...

Samtheo Announces License Agreement with Moffitt Cancer Center for Exclusive Rights to Novel Akt Inhibitor

...sciences LLC, with Moffitt Cancer Center, gaining exclusive worldwide rights to a small molecule that selectively inhibits the activation of all three isoforms of Akt. Persistent activation of the Akt pathway has been found to play an important role in oncogenesis and chemo- and radiation-resistance and to be...

GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research

...and turn on AKT, an enzyme that drives tumor survival signals. Investigators at the University of London are exploring the role of PI3-kinase isoforms in normal physiology and disease. A team led by Dr. Bart Vanhaesebroeck isolated the PI3-kinase genes in various mammals and developed models to bette...

Jivan Awarded US Patent #7,340,349 for Splice Array Analysis

...and System for Identifying Splice Variants of a Gene." The issued claims cover mathematical algorithms for determining the expression levels of splice isoforms of a gene in a sample using microarrays with exon junction probes. "The '349 Patent validates JIVAN's position as a leader in the growing market for...

Semafore to Present at BIO CEO & Investor Conference

...lopment initiatives. About SF1126 SF1126 is a small molecule conjugate containing a pan-PI3K inhibitor that selectively inhibits all PI3K class IA isoforms and other key members of the PI3K superfamily, including DNA-PK and mTOR. A major factor in tumor resistance to approved chemotherapy agents is though...

Sangamo BioSciences Announces ZFP Therapeutic Data From Nerve Regeneration Program at Society for Neuroscience Meeting

...that administration of the ZFP TF into the spinal cord at the time of injury produced measurable VEGF ZFP TF protein and increased levels of all major isoforms of the VEGF protein. They observed a corresponding neuroprotective effect with a statistically significant decrease in nerve fiber degradation and pos...

Protein Depletion for Plasma and Serum Proteomic Analysis

...ational modifications [4,5], as well as isoforms [38], some of which may be important in disease ... R, Allen DL, et al.: A wide range of protein isoforms in serum and plasma uncovered by a quantita...ce GE: Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer. ...
isoforms in Biological Products

Rabbit Anti-QKI Polyclonal Antibody, Unconjugated from Bethyl Laboratories

Description:...ed by A300-183A maps to the C-terminus of isoform 5 of human quaking homolog according to entry AAH19917.1 (GeneID 9444). The epitope is not found in isoforms 1, 2, 3, 4, 6, 7 or 7B according to TrEMBL entries Q9P0Y1, Q9P0Y0, Q9P0X6,...
Company:Bethyl Laboratories

SpliceArray Service from ExonHit Therapeutics Inc.

Description:...roarray platform. The patented array design monitors the expression of alternatively spliced exons that empowers you to investigate disease-associated isoforms at a resolution previously unattainable by microarrays. G-Protein Coupled Receptor (GPCR) and Ion Channel arrays are currently available under the ser...
Company:ExonHit Therapeutics Inc.

Goat Anti-PAX3 Polyclonal Antibody, Unconjugated from GeneTex

Description:... a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. Immunogen: Synthetic peptide: TTLAGAVPRMM, corresponding to N terminal amino acids 2-12 of PAX3....
Company:GeneTex

Rabbit Anti-Peroxiredoxin 1 Polyclonal Antibody, Unconjugated from GeneTex

Description:...(Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine r...
Company:GeneTex

Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

Description:...dney tissues while JIP2a, JIP2b, and JIP3 are specifically expressed in the brain, particularly in the adult cerebral cortex and hippocampus. All JIP1 isoforms inhibit JNK signaling when overexpressed. A recent study has discovered a direct interaction between JIP1 and amyloid-b-precursor protein (APP), the...
Company:Invitrogen
isoforms in Biological Definition

Intermediate filament

...See also: nuclear envelope ) Keratin IFs keratin intermediate filaments These proteins are the most diverse among IFs. The many isoforms are divided in two groups: "soft" keratins ( cytokeratins ) in epithelial cells (image to right), and "hard" keratins ( hair keratins ) which make up...

Isozyme

... Isozymes , (or isoenzymes ) are isoforms (closely related variants) of enzymes . In many cases, they are coded for by homologous genes that have diverged over time. Although, strictly ...

Spliceosome

..., thanks to the Human Genome Project we know the figure is closer to 30,000 genes. However, almost every human gene is thought to have at least two isoforms . Spliceome The term spliceome has been recently coined to describe the complete set of all possible alternative splices in an organism, in...
isoforms in Biological Dictionary

Myosin

...und in eukaryotic tissues. ... Myosin unrooted phylogenetic tree — click on image to see larger version (Source: ... The three known myosin -I isoforms have distinct distributions ... Only myosin -IC concentrates around contractile vacuoles and ... The Cell - A Molecular Approach is a basic text...

Multi-gene family

...ression of multi - gene sets ( IGF family ' and IGF signaling ... Pfam is a large collection of protein families, represented by multiple ... isoforms of myosin heavy chains, coded for by a multi - gene family PUBMED:2806546. ... ... is accelerated by all six members of the antiapoptotic BCL...

Microspore

...after meiosis, that is, the tetrad to early microspore ... about 215 mm (young microspore stage anthers), into ... microspore stage, but these isoforms ... II. 7. Microspore derived chromosome number and structural variants of barley ... occur in somatic cells of microspore derived plants...
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