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internalization in Medical News

Helicobacter pylori can multiply in autophagic vesicles

...pylori exhibits several virulence factors to evade opsonization, retard phagocytosis, and disrupt membrane trafficking and phagosome maturation after internalization of the microorganism. In the February 2009 issue of Experimental Biology and Medicine researchers at the National Cheng Kung University, Tainan...

Nanomedicine system engineered to enhance therapeutic effects of injectable drugs

... of particles with cells was studied using fluorescence and confocal microscopy as well as a series of assays intended to determine cell viability and internalization rate of the nanoparticles. ...
internalization in Medical Technology

CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Advanced Breast Cancer

...binds to GPNMB, a specific protein that is predominantly expressed on the surface of cancer cells, including melanoma, breast cancer and glioma. Upon internalization by the targeted cell, CR011-vcMMAE is designed to release MMAE from CR011 to produce a cell-killing effect. CR011-vcMMAE is currently in two Phase II ...

CuraGen Updates CR011-vcMMAE Data at ASCO

...inds to GPNMB, a specific protein that is predominantly expressed on the surface of cancer cells, including melanoma, breast cancer and gliomas. Upon internalization into the targeted cell, CR011-vcMMAE is designed to release MMAE from CR011 to produce a cell-killing effect. CR011-vcMMAE is currently in two Phase I...

CuraGen to Present CR011-vcMMAE Data at ASCO

...inds to GPNMB, a specific protein that is predominantly expressed on the surface of cancer cells, including melanoma, breast cancer and gliomas. Upon internalization into the targeted cell, CR011-vcMMAE is designed to release MMAE from CR011 to produce a cell-killing effect. CR011-vcMMAE is currently in two Phase ...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...anti-glypican-3 antibodies was generated from which a lead candidate, MDX-1414, was selected for its high affinity, specificity, effector function and internalization properties. MDX-1414 demonstrated anti-tumor efficacy leading to significant and durable suppression of established subcutaneous tumors in a liver c...

CuraGen Announces Preliminary Data from Ongoing Phase II Study Showing Clinical Activity of CR011-vcMMAE in Patients with Metastatic Melanoma

...binds to GPNMB, a specific protein that is predominantly expressed on the surface of cancer cells, including melanoma, breast cancer and gliomas. Upon internalization into the targeted cell, CR011-vcMMAE is designed to release MMAE from CR011 to produce a cell-killing effect. CR011-vcMMAE is currently in two Phase I...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Ovarian Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... binding of AEZS-108 to cancerous cells that express these receptors, results in its accumulation in the malignant tissue. This binding is followed by internalization and retention of the cytotoxic drug, doxorubicin, in the cells. Therefore, since they target specific cells, cytotoxic conjugates are postulated to be...

Panacea Pharmaceuticals Announces Issuance of a U.S. Patent Covering Anti-HAAH Antibodies

... upon binding to the cell surface of cancer cells. In addition, cytotoxicity as measured by a cell proliferation assay has been demonstrated following internalization of a PAN-622-toxin conjugate. This fact, coupled with the exclusivity of the surface expression of HAAH to cancer cells, suggests the potential clinic...

CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Melanoma

...r cells to invade and metastasize. CR011-vcMMAE contains an enzyme-cleavable linker designed to be stable in the bloodstream and to release MMAE after internalization into tumor cells that express GPNMB, resulting in cancer cell death. About Melanoma The number of people diagnosed with melanoma is rapidly increa...

CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma

...binds to GPNMB, a specific protein that is predominantly expressed on the surface of cancer cells, including melanoma, breast cancer and gliomas. Upon internalization into the targeted cell, CR011-vcMMAE is designed to release MMAE from CR011 to produce a cell-killing effect. Preclinical studies conducted with this ...

CuraGen Advances CR011-vcMMAE into Phase II

...r cells to invade and metastasize. CR011-vcMMAE contains an enzyme-cleavable linker designed to be stable in the bloodstream and to release MMAE after internalization into tumor cells that express GPNMB, resulting in cancer cell death. ASCO Presentation Details A poster entitled "A phase I/II study of CR011-vcMM...
internalization in Biological News

New tool for next-generation cancer treatments using nanodiamonds

...esponse relative to its neighbors," Ho says. "This will allow us to investigate the ultimate efficacy of novel treatment strategies via a spectrum of internalization mechanisms." Beyond the broad research focused on developing these drug-delivery schemes, manufacturing devices to execute the delivery will requir...

Molecular mechanism provides intra-cellular traffic signal

... in diabetes. Defects in growth factor secretion and presentation of their receptors on cells result in cancer. Defects in neurotransmitter release or internalization result in brain disorders." A special set of proteins is responsible for the coordination. Molecular switches that go by the letters Ypt allow mem...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...scope. They form in response to stimulation from EGF and exist for 10 to 20 minutes before disappearing. Waves intrigue researchers because wave-based internalization of activated EGFR to the interior of the cell was a previously unknown mechanism. The wave pathway appears to be a parallel pathway vital for transmit...

Common bacteria pirate natural mechanism to get inside cells

...er methods to prevent infections, Dr. Daaka says. "In the case of bacteria, hiding inside the cells is dependent on dynamin. What we could do is limit internalization and ensuing infection by controlling dynamin activity through the inhibition of nitric oxide synthases, enzymes that produce nitric oxide." The new...

Grabbing addiction by the tail

...eir ability to listen to the signals. Earlier research showed that receptor internalization in addicted rats accompanies behavioral sensitization, a model of craving. ...ut because the artificial peptide specifically targets only the deleterious internalization process of addiction-affected neurons, and not normal receptor function, th...

Opiate cocktail may spare cells from morphine's dark side

.... This suggests that the promotion of MOP-receptor internalization might prevent such cellular signaling imbalances, ...ly practical approach to facilitating MOP-receptor internalization in the presence of morphine. Reasoning that because other opioid drugs promote internalization of MOP receptors, and that their presence in combi...

Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy

...lso maintained heart receptors. "These studies demonstrate a previously unknown role for the protein phosphorylation activity of PI(3)K in receptor internalization and identify non-muscle tropomyosin as an important substrate of the enzyme's activity," Rockman said. "The findings may offer a new approach to the t...

Researchers develop assay that could be applied to drug screening

... to internalize cell surface receptors. All cells traffic protein cargos across their outer membrane, and one of the most important routes for cargo internalization is clathrin mediated endocytosis (CME). CME is of fundamental importance for many cellular activities including receptor down-regulation, nutrient upt...
internalization in Biological Technology

The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies

Introduction Measurement of receptor internalization using the pH-sensitive cyanine dye, CypHer™5, has previously been reported (1,2,3). An enhanced version of this dye that shows greater relative fluorescence intensity when maximally fluorescent, greate...

The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR

Introduction CypHer5 TM is a red-excited, pH-sensitive cyanine dye that is non-fluorescent at pH 7.4 and maximally fluorescent at pH 5.5. It is therefore ideally suited for monitoring internalization of cell surface receptors via acidic endosomal vesicles upon agonist...

PDI Reports 2009 Second Quarter Financial Results

...es has gained revenue as a result of new contracts and the expansion of existing contracts, these gains were more than offset by lost revenue from the internalization of a contract sales force by a long-term client and the expiration or termination of other sales force arrangements in effect during 2008. Revenue in ...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... binding of AEZS-108 to cancerous cells that express these receptors, results in its accumulation in the malignant tissue. This binding is followed by internalization and retention of the cytotoxic drug, doxorubicin, in the cells. Therefore, since they target specific cells, cytotoxic conjugates are postulated to be...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

...on body myositis and dermatomyositis - Chris Morehouse, M.Sc., Sunday, October 26 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 46 -- internalization of the antibody (CAM-3001) following monocyte cell surface binding to the GM-CSFR alpha chain - Brandon Higgs, Ph.D., Sunday, October 26 fro...

AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers

...e binding of AEZS-108 to cancerous cells that express these receptors results in its accumulation in the malignant tissue. This binding is followed by internalization and retention of the cytotoxic drug, doxorubicin, in the cells. Therefore, since they target specific cells, cytotoxic conjugates are postulated to be...

Milwaukee area biotech ZyStor seeks more funding

...logy, a peptide tag replaces a chemical component found on some of the enzyme's carbohydrates and is embedded within the therapeutic enzyme to promote internalization into the cell. This targets the enzyme to the lysosome, and prolongs the life of enzymes in the bloodstream. Animal experiments designed to prove t...

ZyStor seeks to raise $15M for clinical trials

... a peptide tag replaces a chemical component found on some of the enzyme's carbohydrates. The tag is embedded within the therapeutic enzyme to promote internalization into the cell, targeting the enzyme to the lysosome and prolonging the life of enzymes in the bloodstream. In addition to the experiment in Florida...

Promega Corporation: Wisconsin's quiet innovator

... academic collaborations. The company's scientists receive credit whether an idea is theirs, or they have recognized an outside idea and initiated its internalization within Promega - often by licensing the technology or product. The second way Promega encourages innovation is by reward, which can be a financial ...

Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000

...The assay measuring β 2-adrenergic receptor internalization into acidic endosomal vesicles uses a red-excited ...with CypHer5 and, on agonist stimulation, receptor internalization is detected as an increase in fluorescence in the ...ng an increase in CypHer5 fluorescence, indicating internalization of the β 2-adrenergic receptor. The majorit...
internalization in Biological Products

Phagocytosis Fluorometric (dichlorofluorescein) Assay Kit, OxyBURST from Molecular Probes (Invitrogen)

Description:...on University to permit measurement of the kinetics of Fc receptor mediated internalization and the subsequent oxidative burst directly in the phagovacuole.2 The Fc Ox... than does H2DCFDA at 60 seconds and >20 times more at 15 minutes following internalization of the immune complex. Furthermore, unlike H2DCFDA, the Fc OxyBURST Green a...
Company:Molecular Probes (Invitrogen)
internalization in Biological Definition

Cell growth

... body. Their large size can be achieved either by pumping in cytosolic components from adjacent cells through cytoplasmic bridges ( Drosophila ) or by internalization of nutrient storage granules (yolk granules) by endocytosis ( frogs ). Increases in the size of plant cells is complicated by the fact that almo...

Signal transduction

...r. A receptor that is engaged in a hormone-receptor-complex can be deactivated, either by covalent modification (for example, phosphorylation), or by internalization (see ubiquitin ). Intracellular signal transduction Intracellular signal transduction is largely carried out by second messenger molecu...

Transmembrane receptor

...ulate the activity of a transmembrane receptor. Most of them work through the intracellular domain. The most important ways are phosphorylation and internalization (see ubiquitin ). See also Signal transduction G protein Second messenger Neuromodulators ...
internalization in Biological Dictionary

Hepatocytes

...oliferate efficiently ... Recently, small hepatocytes and oval cells have been proposed as important ... ... had no effect on FVIIa binding and internalization in hepatocytes . ... Rat hepatocytes were harvested by a two-step collagenase perfusion as described ... Cytokines & Cells Online Pathfinder...

Endocytosis

...lar Biology 2nd edition by... ENDOCYTOSIS AND THE ACTIN CYTOSKELETON. ENDOSOMES AS MOTILE SIGNALING PLATFORMS IN MAMMALS ... Endocytosis is the internalization of plasma membrane proteins ... ...
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