Scientists identify interacting proteins key to melanoma development, treatment

Researchers have discovered how a mole develops into melanoma by showing the interaction of two key proteins involved in 60-70 percent of tumors. The Penn State scientists also demonstrate that therapeutic targeting of these proteins is necessary for drugs to effectively treat this deadly form of...

High cholesterol in midlife raises risk of late-life dementia, Kaiser Permanente study finds

...of Kuopio, Finland. "Dementia and cardiovascular disease are common major health problems, share several risk factors and often occur simultaneously, interacting with one another. A holistic approach that addresses multiple major health problems simultaneously is needed to effectively manage these disorders."...

High Cholesterol in Midlife Raises Risk of Late-Life Dementia, Kaiser Permanente Study Finds

...of Kuopio, Finland. "Dementia and cardiovascular disease are common major health problems, share several risk factors and often occur simultaneously, interacting with one another. A holistic approach that addresses multiple major health problems simultaneously is needed to effectively manage these disorders." ...

OrthoDynamix LLC Launches ArthroSteer(TM): Reaching New Limits in Arthroscopy

...llow surgeons to: Uniquely facilitate arthroscopy with a multi-control device Steer and reach around joint capsule structures while interacting with tissue that affords not just diagnosis but repair "This is the first steerable device designed specifically for arthroscopy that ca...

Babies Can Comprehend 'Canine' Language

...ey can connect audio and visual cues, he said. As for the future, researchers are exploring how humans relate to dogs, which have a long history of interacting with people, and wolves, which don't. Over time, Flom said, dogs and humans have learned how to communicate with each other. And, of course, ea...

Raptor Pharmaceuticals Corp. to Present at 2009 Cystinosis Research Network Family Conference

...stated, "We greatly appreciate all the support that we receive from the CRN and the broader cystinosis community. At the conference we look forward to interacting directly with the medical, research and patient communities regarding progress and enrollment criteria for our Phase 2b trial. We realize the effort n...

interacting in Medical Technology

More Gene Mutations Linked to Autism Risk

...nervous system development. Hakonarson and Bucan said the latest findings reinforce the view that multiple gene variants, both common and rare, may be interacting to cause the heterogeneous group of disorders included under autism spectrum disorders. AGRE, a program of Autism Speaks, provided genetic biomat...

University of California Los Angeles Selects Velos eResearch

...s of focus for implementation. Senior leadership needed quick understanding of what was happening at the research staff level from those enrolling and interacting with patients. Those users are responsible for ensuring that all regulatory activities are carried out appropriately. They also are providing needed d...

The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs

...ing a novel approach that combines a statistical tool that identifies genes interacting on the same biological pathways with highly automated gene-hunting techniqu...cs, Hakonarson's study team created a pathway-based approach that seeks out interacting or related genes along the same biological pathway. "We applied our pathway...

Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora

...Fox Chase Cancer Center, Philadelphia, to name some of the most important. "This low molecular weight compound is inhibiting growth of tumour cells by interacting with mitosis during cell proliferation for which Aurora kinases are essential." During the EORTC-NCI-AACR Symposium a recently identified biomarker ...

Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations

...f opioid pain medications in the gastrointestinal tract without affecting their ability to relieve pain. Opioids provide pain relief by specifically interacting with mu-opioid receptors within the central nervous system (CNS) -- the brain and spinal cord. However, opioids also interact with mu-opioid receptors...

ChemoCentryx Initiates Clinical Trial of CCR1 Inhibitor CCX354

... have been shown to be present in synovial fluid from the joints of RA patients. By blocking the CCR1 ligands including the super-activated forms from interacting with the CCR1 receptor, CCX354 is designed to reduce the migration of inflammatory cells leading to rheumatoid arthritis and subsequently joint destru...

interacting in Medical Products

BloodSTOP Hemostatic Gauze

Features:... Stabilizes most minor lacerations and wounds due to its tensile strength Can use multiple layers for larger bleeds Protects the wound by interacting with platelets and forming fibrin linkages to stop the bleeding Hypoallergenic and biologically inert Easy to open individual sterile packag...
Company:LifesciencePlus

BloodSTOP iX Hemostatic Gauze

Features:...s Stabilizes most minor lacerations and wounds due to its tensile strength Can use multiple layers for larger bleeds Protects the wound by interacting with platelets and forming fibrin linkages to stop the bleeding Hypoallergenic and biologically inert Easy to open individual sterile packagin...
Company:LifesciencePlus

interacting in Medical Dictionary

Tooth decay

...h decay occurs when foods containing carbohydrates (sugars and starches) ... Tooth decay , also known as caries, is caused by bacteria interacting with food ... All of us carry bacteria in our mouth which make us susceptible to tooth decay . ... For tooth decay to develop, a too...

Intracellular

... variably-sized coccoid forms in breast cancer. ... Intracellular bacteria in Hodgkin's disease and sclerosing mediastinal B-cell ... ... interacting with the intracellular domain of the ... Fe65L2 is able to interact, both in vitro and in vivo, with the intracellular domain of APP. ... int...

Autistic behavior

...so ... ... patterns similar to those seen in autism . Considerations ... Autistic behavior includes: Abnormal socialization (lack of need for interacting with others) ... Applied Behavior Analysis (ABA) is the most comprehensive and most effective approach to improving the lives of persons with a...

interacting in Biological News

Can interacting pathogens explain disease patterns?

A new study into the way in which parasites interact with each other could help predict when infectious diseases are likely to break out. A group of scientists in the UK and the US has been studying the behaviour of infectious parasites in rabbits. The findings could lead to us being able to p...

Cystic fibrosis proteins photographed interacting

BIRMINGHAM, Ala. New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis (CF) disease. Researchers at the University of Alabama at Birmingham (UAB) studied a CF-causing protein and another protein called epithelial sodium c...

Electronic chip, interacting with the brain, modifies pathways for controlling movement

Researchers at the University of Washington (UW) are working on an implantable electronic chip that may help establish new nerve connections in the part of the brain that controls movement. Their most recent study, to be published in the Nov. 2, 2006, edition of Nature, showed such a device can ind...

Scientists directly view immune cells interacting to avert autoimmunity

Using a new form of microscopy to penetrate living lymph nodes, UCSF scientists have for the first time viewed immune cells at work, helping clarify how T cells control autoimmunity. The technique, known as two-photon laser-scanning microscopy, was able to focus deep within the lymph node of a d...

New cancer drug delivery system is effective and reversible

...her advantage of using aptamers as targeting agents is that they are easily disabled. They readily bind to complementary DNA, which prevents them from interacting with cell receptors. The new approach will be useful for many applications, Wong said. "What we're really doing here is coming up with a general t...

Promising new treatment for Alzheimer's suggested based on Hebrew University research

...resultant mutant enzyme protein. This tail is the part of BChE which is important for protection from the Alzheimer's disease plaques. It does this by interacting with the Alzheimer's disease β-amyloid protein and preventing it from precipitating and forming those brain plaques which are the neuropathologic...

interacting in Biological Technology

Opportunities and challenges in uncertainty quantification for complex interacting systems

In spite of continued growth in computational resources the idea of a computational laboratory serving as surrogate to physical reality still faces conceptual and technical challenges. Chief among these is the characterization of physical reality itself, under conditions of incomplete knowledge an...

TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins

In vivo phosphorylation with TKB1 competent cells David L. Dankort William J. Muller Institute for Molecular Biology and Biotechnology, McMaster University, Ontario, Canada GST-fusion proteins expressed in TKB1 bacteria are used to affinity purify cellular proteins, which ...

DFG establishes 14 new research training groups

...ysics and biology. The selected research topics range from the transport of interacting electrons in nonequilibrium through semiconductor quantum dots, to nanorods...to neurons in the brain. With the description of the collective dynamics of interacting units in nonequilibrium, the Research Training Group is concentrating on ba...

ThermoGenesis Announces Abstracts to Be Presented at Upcoming Stem Cell Therapy Conference

... field of cell therapy," said John Chapman, PhD, Vice President of Scientific Affairs who directs the Company's clinical programs. "We look forward to interacting with leading clinicians and solution providers in the stem cell sector at the upcoming ISCT and identifying new opportunities for the use of our cell ...

Heart Disease: An Epidemic For Firefighters

...year. According to Dr. Superko, stress and psychological pressures related to the job, as well as diet, exercise issues and inherent personality, interacting with a genetic predisposition to heart disease, probably have tremendous impact on the risk of heart attack in these first responders. "Imagine b...

Canada's Genome Centres Promote Collaboration at International Conference

...tality and took advantage of the informal networking event. "This Canadian reception was a truly positive opportunity for me from the perspective of interacting with key leaders in the genome centres from across Canada," commented John Evey, Vice President for Development at the J. Craig Venter Institute. "The...

interacting in Biological Products

Goat Anti-SIAH Interacting Protein Polyclonal Antibody, Unconjugated from Abcam

Description: Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
Company:Abcam

Rabbit Anti-Human MLF1 Interacting Protein / PBIP1, phospho (Thr78) Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to MLF1 Interacting Protein/PBIP1 (phospho T78) ( Abpromise for all tested applications). Antigen: Synthetic peptide: PLHSTAIYAD, corresponding to amino acids 73-83 of Human MLF1 Interacting Protein Entrez Gene ID: 359815 Swiss Protein ID: Q71F23...
Company:Abcam

Rabbit Anti-TOLLIP Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... Homo sapiens toll interacting protein Antigen: Recombinant Protein...
Company:Proteintech Group, Inc.

Rabbit Anti-Human ASIP / PAR3 Monoclonal Antibody,, Clone ZMD.283 from Invitrogen

Description:... Clone/PAD: ZMD.283. Immunogen: Fusion protein derived from human ASIP/PAR-3. Specificity: Specific for ASIP/PAR-3 (atypical PKC isotype-specific interacting protein/ partitioning defective 3). This antigen is not related to the protease-activated-receptors also called PAR. Reactivity: Human Dog Xenopus (p...
Company:Invitrogen

ProFound Label Transfer Sulfo SBED Protein:Protein Interaction Reagent from Pierce Biotechnology, Inc.

Description:...ity UV light, which activates the phenylazide moiety of Sulfo-SBED. This photoreactive group covalently links to the bound prey protein, capturing the interacting complex. Upon reduction of this complex, the biotin label that first resided with the bait protein transfers to the prey protein. The biotin label als...
Company:Pierce Biotechnology, Inc.

Mts-Atf-LC-Biotin Label Transfer Reagent, 5 mg. from Pierce Biotechnology, Inc.

Description:...-containing lysate, the Atf moiety is activated with UV light capturing the interacting complex. Reduction of the disulfide bond formed by reaction of -SH with the... the prey protein. The biotin can be used to both enrich for and detect the interacting complex or prey protein using immobilized Monomeric Avidin or Streptavidin-...
Company:Pierce Biotechnology, Inc.

interacting in Biological Definition

Chromatography

...ces in partitioning behavior between a mobile phase and a stationary phase to separate the components in a mixture. Components of a mixture may be interacting with the stationary phase based on charge, relative solubility or adsorption. There are two theories of chromatography, the plate and rate theories. ...

Morphogenesis

...c protein receptors . An important class of molecules involved in morphogenesis are transcription factor proteins that determine the fate of cells by interacting with DNA . These can be coded for by master regulatory genes and either activate or deactivate the transcription of other genes and, in turn, the...

Endosymbiotic theory

...esis was popularized by Lynn Margulis . In her 1981 work Symbiosis in Cell Evolution she argued that eukaryotic cells originated as communities of interacting entities, including endosymbiotic spirochaetes that developed into eukaryotic flagella and cilia . This last idea has not received much acceptan...

Mathematical biology

...in a wound-healing assay [8] The mechanochemical theory of morphogenesis [9] Biological pattern formation [10] Modelling the movement of interacting cell populations [11] Mathematical modelling of scar tissue formation [12] These examples are characterised by complex , nonlinear mechan...

Morphogenesis

...c protein receptors . An important class of molecules involved in morphogenesis are transcription factor proteins that determine the fate of cells by interacting with DNA . These can be coded for by master regulatory genes and either activate or deactivate the transcription of other genes and, in turn, the...

Origin of life

...ost crucial challenge unanswered by this theory is how the relatively simple organic building blocks polymerise and form even more complex structures, interacting in consistent ways to form a protocell. In the absence of a reliable source of energy, these processes contradict the laws of thermodynamics (especi...

interacting in Biological Dictionary

Potential energy

...... Similarly, there is an electric potential energy associated with interacting charges. For each pair of interacting charges, the potential energy is given by: ... At the top it has its...

Mutualism

...habitats and survive ... Information about mutualism in the free online English dictionary and ... In the more common facultative mutualism the interacting species derive benefit ... Pollination is a classic example of mutualism . ... Greater Honeyguide - has an interesting mutualism with humans. ...

Inflorescence

...se Sarah Hannah confronts her role as caretaker of her dying mentally ill mother... INFLORESCENCE showcases a stunning bouquet of exquisite girls interacting with ... INFLORESCENCE introduces an eerie dreamworld where angelic winged beings float ... ... inflorescence . The diagram to the right depicts...

Evolutionarily conserved

... evolutionarily conserved BMP-binding protein Twisted Gastrulation promotes BMP signalling ... part of an evolutionarily conserved network of interacting ... Register today for a free trial, credit card req'd. Find Plant Physiology articles plus many other academic journal articles, magazine articles...

Ecosystems

...dies and English movies, comic strips, activity pages and school homework help for kids. The Value of Ecosystems . Ecosystems are communities of interacting ... But ecosystems are also forests covering thousands of kilometers, a major river ... We are intimately familiar with ecosystems . ... Read ab...

Community

... In biological terms, a community is a group of interacting organisms sharing an environment. In human communities, intent, belief, resources, preferences, needs, risks, and a number of other conditions may b...