Integrin

Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer

...activation of a latent adhesion receptor (known as integrin 51). Filardo says, "Activation of integrin 51 by GPR30 is a significant event...mary breast cancer. This happens because activated integrin 51 can convert soluble plasma prot...

Protein helps immune cells to divide and conquer

... protein functions in cells by helping to transmit integrin signals, as well as transporting amino acids the ...l proliferation. "CD98hc interacts with certain integrin subunits to prompt signaling events that control c...ction, is aided by the CD98hc protein's support of integrin signaling," Cantor said. ...

Nanoparticle Stops Cancer From Spreading

...team from the University of California, San Diego, designed a "nanoparticle" anti-cancer drug delivery system that zooms in on a protein marker called integrin avB3, which is found on the surface of certain tumor blood vessels. The marker is tied to the development of new blood vessels and malignant tumor gro...

'Smart bomb' nanoparticle strategy impacts metastasis

...d vice chair of pathology, and members of his team report that the nanoparticle carrying a payload of chemotherapy homes in on a protein marker called integrin ανβ3 found on the surface of certain tumor blood vessels where it is associated with development of new blood vessels and malignant tum...

Applying Parallel Pressure Improves Vascular Grafting

...s exposed human adipose-derived stem cells (ASC) differentiated toward endothelial-like cells to physiological levels of shear stress. Measurements of integrin activity and cell attachment were taken on sample culture plates precoated with collagen I, fibronectin or gelatin -- all vascular basement membrane c...

Sticky blood protein yields clues to autism

...hat a well-known protein found in blood platelets, integrin beta3, physically associates with and regulates th... the platelet. Prior research had fingered the integrin beta3 gene as a determinant of blood serotonin lev...ntrol SERT activity. One of these turned out to be integrin beta3. Once they confirmed a physical relation...

JCI online early table of contents: March 3, 2008

...ly with the beta-3 component of a protein known as integrin alpha-IIb/beta-3, and this led to increased SERT e...ed that the demonstration that SERT interacts with integrin beta-3 provides a possible mechanistic basis for t...ase and depression. TITLE: Interactions between integrin alpha-IIb/beta-3 and the serotonin transporter reg...

NIAID scientists identify new cellular receptor for HIV

...entists identify a cell adhesion molecule known as integrin alpha 4 beta 7 as another potentially important re...s where the virus really takes hold. We found that integrin alpha 4 beta 7, whose natural function is to direc... gp120 protein, part of the HIV envelope, binds to integrin alpha 4 beta 7 on CD4+ T cells, which promotes the...

Researchers find new way to block destructive rush of immune cells

...e it would be incredibly useful to precisely block integrin activation, and thus T cell migration, said Minsoo... is that past, system-wide attempts that block all integrin activation, like the multiple sclerosis drug Tysab...ed with the association between MyH9 and the LFA-1 integrin were found to prevent the trailing edge of the cra...

GlaxoSmithKline Presents Innovative Neuroscience Pipeline

...cause no or a low immune response, could result in a significant new treatment option for patients. A phase II study with firategrast, a dual alpha4 integrin antagonist (VLA4), in MS is ongoing in 13 countries. Comprising 350 patients, the study aims to provide proof-of-concept data supporting the potential...

Integrin in Biological News

UCSD researchers create roadmap to integrin activation

Calling it an important technical advance in the study of the complex receptors and pathways of the body's cellular system, researchers at the University of California, San Diego (UCSD) School of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critica...

Research yields potential target for cancer, wound healing and fibrosis

...es such as cancer and fibrosis. The paper, β1 integrin Cytoplasmic Domain Residues Selectively Modulate F... Of the many integrins that exist, the beta-1 integrin is of great interest because it is involved in nea...els for disease, cannot survive without the beta-1 integrin gene. Beta-1...

Potential therapy for congenital muscular dystrophy

...regenerative capacity in a mouse model for alpha 7 integrin congenital myopathy," appears in the January 2009 ...ts with mutations in the adhesion molecule alpha 7 integrin experience delayed developmental milestones and im...here is currently no treatment or cure for alpha 7 integrin congenital myopathy. Interactions of alpha 7...

Metastatic movements in 3-D

...ration, but exactly how has been unclear. Recent work has suggested that an integrin called a5b1 drives random movement, while an integrin called avb3 has been associated with unidirectional migrationthe balance of...

UC Davis researchers discover new drug target for inflammatory disease

...ll." In the current study, Takada and team evaluated the possibility of integrin binding by sPLA2-IIA using a computer program that predicts how small molec...s in pro-inflammatory signals. We have to continue to better understand the integrin signaling process if we are to find more potential drug targets for the tre...

Researchers coat titanium with polymer to improve integration of joint replacements

...that direct bone formation. Therefore, controlling integrin binding to the titanium will result in targeted si...s. However, this region alone binds many different integrin receptors and with much less affinity than the ful...tions also known to have sites that participate in integrin binding. To evaluate the in vivo performance of...

Integrins as receptors give insight into rotavirus and diarrhea

...ibe two receptors for the enterotoxin, both of them integrins. The two, integrin alpha1 beta1 and integrin alpha2 beta1, are members of a class of molecules that are involved in atta...

Clumps of red and white blood cells may contribute to sickle cell disease

...ckle cell patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin alpha four beta one. First author Julia E. Brittain, Ph.D., a research assistant professor in the medical schools department of biochemistry and b...

Genome of marine organism tells of humans' unicellular ancestors

... that lack a centralized nervous system. Likewise, choanoflagellates have five immunoglobulin domains, though they have no immune system; collagen, integrin and cadherin domains, though they have no skeleton or matrix binding cells together; and proteins called tyrosine kinases that are a key part of signa...

Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal

...e that many pharmaceutical companies had tried to develop compounds against integrin molecules (a large and important family of adhesion molecules that promote ...st the same roadblock. While potential therapeutics bound to the cancer integrin molecules with high affinity and specificity, the compounds were quickly cl...

Integrin in Biological Technology

Expert Neurology Panel Weighs Impact of New Reports of PML in Multiple Sclerosis Patients on Tysabri

...ranslate to community-based neurologists." The report also updates progress on other approaches to treatment of MS, including: -- New interferons, integrin inhibitors, B-cell inhibitors, S1Ps, fumarates, neuroprotection/neuroregeneration. -- The potential for vaccine or MAb approaches for the treatment ...

VisEn Announces Commercial Launch of IntegriSenseTM Fluorescence Molecular Imaging Agent

...enable researchers to image and assess the role of integrin alpha v beta 3 in disease progression and therapeu...mized in vivo fluorescence imaging agent targeting integrin alpha v beta 3, a key biomarker closely associated...e agent was developed to enable in vivo imaging of integrin alpha v beta 3 expression in order to measure and ...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

... upon the interplay between the integrin family of cell adhesion recep...cellular matrix environments. integrin receptors are known to affect the dynamic balance ...that function as effectors of integrin mediated signaling. Dr. Joseph Loftus of ...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

... upon the interplay between the integrin family of cell adhesion recep...cellular matrix environments. integrin receptors are known to affect the dynamic balance ...that function as effectors of integrin mediated signaling. Dr. Joseph Loftus of ...

Integrin in Biological Definition

Transmembrane protein

...iple topogenic sequences . Examples Some cell adhesion proteins Some receptor proteins Glycophorin Insulin receptor GLUTI integrin Cadherin See also : membrane topology , transmembrane helix , membrane protein ...

Integrin in Biological Dictionary

Intercalated disc

...for contraction. To facilitate energy and calcium conductance in cardiac muscle... Key Words: intercalated discs • kindlin-2 • cardiomyopathy • integrin ... Thus, the intercalated discs ensure proper function of the heart with efficient ... ... Mechanical and Electrical Junctions at the Inter...

Glycoprotein

... glycoprotein IIb/IIIa, an integrin found on platelets that is required for ... Structure of Glycoprotein and Carbohydrate Chain - Home Page for Learning ... P- glycoprotein is...