Surveyed Physicians Will Treat Over 50 Percent of Hepatitis C Genotype 1-Infected Patients With the Protease Inhibitor Telaprevir

WALTHAM, Mass., Aug. 4 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, based on profiles provided to them of emerging protease inhibitors, surveyed physicians indicate that they will prescr...

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

A member of a new class of antiretroviral drugs is safe and effective for patients beginning treatment against HIV, according to researchers who have completed a two-year multisite phase III clinical trial comparing it with standard antiretroviral drugs. The results are online and scheduled for...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

PRINCETON, N.J., July 7 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) announced today the nomination of PSI-352938 ("PSI-938") as a lead development candidate from two series of purine analogs for the treatment of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary n...

Cytopia Lodges IND for JAK2 Inhibitor CYT387

MELBOURNE, Australia, June 22 /PRNewswire/ -- Cytopia Ltd (ASX: CYT) announced today that it has filed an Investigational New Drug Application (IND) with the US Food and Drug Administration (FDA) for its novel, potent orally active JAK2 inhibitor CYT387. Following FDA review, the company int...

Potent metastasis inhibitor identified

Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online Early Edition of the Proceedings of the National Academy of Sciences duri...

Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer

ORLANDO (June 1, 2009)Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic breast cancer who have progressed on previous trastuzumab b...

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Inhibitor in Medical Technology

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

CAPE TOWN, South Africa , July 20 /PRNewswire/ -- New data became available today at the 5(th) International AIDS Society Conference from ARTEN ( A tazanavir/ R itonavir on a background of T enofovir and E mtricitabine [Truvada(R)] versus N evirapine). ARTEN is an open-label, multi-c...

Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting

SHENZHEN, China and SAN DIEGO, May 28 /PRNewswire/ -- Shenzhen Chipscreen Biosciences, Ltd., and HUYA Bioscience International, LLC, today announced that final data from a Phase 1 trial conducted by Chipscreen of the investigational compound chidamide (CS055/HBI-8000) will be presented at the 2009...

Scientific Data Relating to Cinryze(TM) Presented at 6th Annual C1 Inhibitor Deficiency Workshop

BUDAPEST, Hungary and EXTON, Pa., May 26 /PRNewswire-FirstCall/ -- ViroPharma Incorporated (Nasdaq: VPHM ) today announced the presentation of five abstracts relating to Cinryze(TM) (C1 esterase inhibitor [human]) therapy at the 6th Annual C1 Inhibitor Deficiency Workshop. Cinryze was appr...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

PHILADELPHIA, May 22 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, Nasdaq: SHPGY ), the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE(R) (lisdexamfetamine dimesylate) CII with the proton pump inhibitor (PP...

TargeGen Announces Successful Completion of Patient Enrollment in Clinical Trial of JAK2 Inhibitor TG101348 in Myelofibrosis Patients and Scheduled Presentation of Preliminary Trial Data at EHA Conference in Berlin

SAN DIEGO, May 14 /PRNewswire/ -- TargeGen, Inc. today announced that the Company successfully completed enrollment of a multi-center clinical trial of TG101348, an oral, potent, and highly selective inhibitor of JAK2 in patients with myelofibrosis on May 7, 2009. (Logo: http://www.newscom....

FDA Accepts Arno Therapeutics' IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway

PARSIPPANY, N.J., May 11 /PRNewswire-FirstCall/ -- Arno Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on oncology therapeutics, today announced that the U.S. Food and Drug Administration ("FDA") accepted the Company's Investigational New Drug ("IND") application for the us...

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Inhibitor in Medical Products

PTT Inhibitor Assay

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

PT Inhibitor Assay

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Plasminogen Activator Inhibitor 1, Activity

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Nonspecific Circulating Anticoagulant Inhibitor PTT

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Nonspecific Circulating Anticoagulant Inhibitor PT

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

C-1-Esterase Inhibitor Panel

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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Inhibitor in Medical Dictionary

Ritalin

.... Ritalin (methylphenidate) is used to treat attention deficit disorder (ADD) and narcolepsy. ... Do not use Ritalin if you have used an MAO inhibitor such as ... Accurate, FDA approved Ritalin information for healthcare professionals and patients ... Ritalin in the SR tablets is more slowly ...

Renin

...ls in the kidneys. ... A renin assay blood test is done to find the cause of high blood pressure (hypertension) ... renin , info on renin inhibitor ... The renin - angiotensin - aldosterone system plays an important role in ... pathways for the renin - angiotensin system have ... Brief a...

Protein C

... Results: The dynamics of the anticoagulant, anti-inflammatory and pro-fibrinolytic action of rhAPC in patients with ... deficient in protein C inhibitor with ... Severe protein C deficiency (i.e. protein C activity <1 IU dL1) is a rare ... Low levels of plasma protein C were fir...

Paranasal sinuses

...nuses : a series of 256 patients in Mexico ... Paranasal Sinus Cancer Key Terms: Adenopathy , Adjuvant therapy , Adenocarcinoma , Angiogenesis inhibitor , Antimetabolite , Antineoplaston , paranasal sinus ( ¦parə¦nāzəl ′sīnəs ) ( anatomy ) Any of the paired sinus cavities of the human face;...

Intermittent claudication

...weakness in the lower extremities during exercise, claudication n. A halt or lameness in a person's walk; a limp. ... What phosphdiesterase III inhibitor is uded to treat intermittent claudication ? ... ... Reports > Peripheral artery disease and intermittent claudication ... When symp...

Hereditary angioedema

... Overview: Hereditary angioedema (HAE) is an autosomal dominant disorder of C1 ... Treatment of hereditary angioedema with a vapor-heated C1 inhibitor ... Overview: Hereditary angioedema (HAE) is an inherited disease caused by low ... Treatment of hereditary angioedema with danazol. ......

Inhibitor in Biological News

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

Researchers at the Tulane University School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin s...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

Researchers at the University of Vermont Cardiovascular Research Institute, Colchester, Vermont have found that increased expression in the heart of plasminogen activator inhibitor type-1 (PAI-1) is profibrotic. The results, which appear in the March 2009 issue of Experimental Biology and Medici...

Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment

NEW YORK, Jan. 21, 2009 Researchers from Joslin Diabetes Center, Boston, and ActiveSite Pharmaceuticals, Inc., San Francisco, announced today that they have demonstrated that a specific inhibitor of the protease plasma kallikrein, ASP-440, developed by ActiveSite Pharmaceuticals, may provide a ne...

Scientists identify novel inhibitor of human microRNA

Scientists at The Wistar Institute and their colleagues have identified, for the first time, a molecule that can regulate microRNAs short strands of RNA that play a vital role in gene expression and are closely associated with cancer. The discovery points the way to the development of a new gener...

New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers

The first oral, broad-spectrum angiogenesis inhibitor, specially formulated through nanotechnology, shows promising anticancer results in mice, report researchers from Children's Hospital Boston. Findings were published online on June 29 by the journal Nature Biotechnology . Because it is nont...

New inhibitor has potential as cancer drug

Laboratory experiments have previously shown that cancer cells overproduce an enzyme, heparanase, which splits the bodys own polysaccharide heparan sulfate into shorter fragments. The amount of enzyme is related to the degree of malignancy. Today a study is being published in the journal Nature ...

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Inhibitor in Biological Technology

Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305

CAMBRIDGE, Massachusetts and LAUSANNE, Switzerland, August 6 /PRNewswire/ -- Curis, Inc. (NASDAQ: CRIS ), a drug development company focused on developing proprietary targeted medicines for cancer treatment and Debiopharm Group (Debiopharm), a group of companies with a focus on the developme...

LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit

COPENHAGEN, June 4 /PRNewswire/ -- Santaris Pharma today announced that the cancer drug EZN-2968 - an inhibitor of HIF-1alpha, jointly developed by Enzon Pharmaceuticals and Santaris Pharma A/S - was well tolerated and showed early signs of clinical benefit in previously treated cancer patient...

AEterna Zentaris Presents Two Posters on its PI3K Inhibitor Compound, AEZS-126, at AACR Annual Meeting

In Vitro and In Vivo Data Show AEZS-126 as Promising Oral Compound for Future Clinical Development in Cancer QUEBEC CITY, April 21 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; NASDAQ: AEZS ), a global biopharmaceutical company focused on endocrine therapy and oncology, today ...

Cytopia Scientific Presentation on JAK2 Inhibitor Program at American Chemical Society Conference

MELBOURNE, Australia, March 23 /PRNewswire/ -- Cytopia Limited (ASX: CYT) today announced that it will present data on its JAK2 program at the American Chemical Society Spring meeting, currently underway in Salt Lake City, Utah, USA. Dr Tracy Nero, Senior Scientist at Cytopia, will be presen...

InterMune to Present Abstracts on HCV Protease Inhibitor ITMN-191 and HCV Development Program at the EASL Meeting

BRISBANE, Calif., March 18 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN ) today announced that five abstracts from clinical and in-vitro studies of ITMN-191 (R7227) and the company's research programs related to the hepatitis C virus (HCV) have been accepted for presentation at the 44...

TauTaTis Discovers Potent Inhibitor of Parkinson's Disease Gene Activity

JACKSONVILLE, Fla., March 16 /PRNewswire/ -- TauTaTis, Inc. announces that its lead compound for inhibition of tau protein pathology, the specific neurodegenerative process in Alzheimer's Disease, has been recognized as the most potent inhibitor of the activity of the Parkinson's Disease gene LRRK...

Inhibitor in Biological Products

Caspase-3/7 Inhibitor I from Calbiochem

Description: ...
Company:Calbiochem

Anti-TIMP-4 (Tissue Inhibitor of Metalloproteinases-4), Loop #3 Polyclonal Antibody, Unconjugated from CHEMICON

Description: Timp-4 has been reported in heart tissues, and is produced by some fibroblasts in cell culture conditions. Treatment of cells with phorbol ester TPA stimulates production of TIMP-4 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualiz...
Company:CHEMICON

Rnase Inhibitor from Bioline

Description: ...
Company:Bioline

Caspase-8 Inhibitor Z-IETD-FMK from BioVision

Description: Recommend to use at up to 5000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Company:BioVision

Caspase-6 Inhibitor Z-VEID-FMK from BioVision

Description: Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Company:BioVision

Caspase Inhibitor Ac-DEVD-CHO, Unconjugated from Promega

Description: Ac-DEVD-CHO is an inhibitor of caspase-3/7 (DEVDase) activity. The concentration of inhibitor required to inhibit caspase activity must be determined empirically for each system. Ten micromolar inhibitor is sufficient to inhibit caspase activity in extracts of apoptotic THP-1 cells....
Company:Promega

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Inhibitor in Biological Definition

Competitive inhibitor

In biochemistry one distinguishes two ways in which a molecule may block the action of an enzymes : competitive and noncompetitive inhibition. In competitive inhibition , the molecule acts on the same active site as the normal enzyme substrate . The substrate molecules cannot enter the ac...

Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors ( SSRIs ) are a class of antidepressants . They act within the brain to increase the amount of the neurotransmitter , serotonin (5-hydroxytryptamine or 5-HT), in the synaptic gap by inhibiting its reuptake . One notable characteristic of SSRIs is t...

Active site

... but cannot be processed by the enzyme. In noncompetitive inhibition , the inhibitor binds to the enzyme at another site, the allosteric site , and this causes...titive inhibition , is similar to noncompetitive inhibition except that the inhibitor can only bind the enzyme-substrate complex rather than the free enzyme. ...

Apoptosis

...ayed by a defective death signal in a type of lung cancer cells called NCI-H460 (human non-small cell lung cancer cells). They found that the X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in H460 cells. XIAPs bind to the processed form of caspase-9, and suppress the activity of apoptotic acti...

Cancer

...id also has been shown to reduce risk of second primary tumors among patients with primary head and neck cancer . Finasteride , a 5-alpha reductase inhibitor , has been shown to lower the risk of prostate cancer. Other examples of drugs that show promise for chemoprevention include COX-2 inhibitors (which...

Neurotransmitter

...tic vesicles. Post-synaptic effect A neurotransmitter's effect is determined by its receptor. For example, GABA can act as a rapid or slow inhibitor , depending on whether an ionotropic or metabotropic receptor is the target of the molecule. Small molecule transmitters tend to have consistently inh...

Inhibitor in Biological Dictionary

Topoisomerase

...nsion generated by winding/unwinding of DNA. ... See also topoisomerase inhibitor ... Eukaryotic type II topoisomerase cannot introduce supercoils; it...anistically distinct topoisomerases: type IA and type IB Topoisomerase inhibitor Topoisomerase inhibitors are agents designed to interfere with the actio...

Tet resistance

...gh ... were tested by PCR for the presence of the tetracycline resistance genes tet (A) ... ... tetracycline resistance determinants by an inhibitor of the Tet (B) antiport protein.Antimicrob. ... tetracycline resistance mediated by hybrid Tet proteins. ... ... tetracycline resistanc...

Synapton

...cts of health care prepared by ... using the terms physostigmine, "physostigmine salcicylate", synapton , antilirium. ... Physostigmine is an AChE inhibitor originally extracted from calabar beans. ... salicylate', ' Synapton ' and 'Antilirium' in accordance with the Cochrane ... Archives of General Psy...

Signal transduction

...sduction on ScienceDirect, the world's leading platform for high quality peer-reviewed full-text publications in science, technology ... U0126: An inhibitor of MKK/ERK Signal Transduction in Mammalian Cells. 241kb. PN069 ... Signal Transduction of Neurotrophic Receptors: Basic Concepts and Availabl...

RNase

... against RNase 1, ... Recombinant murine RNase inhibitor does not contain the pair of cysteines ... RNase Assay: ... RNase inhibitor is a recombinant human placental protein whi...pecifically ... Incubation of 200 units of RNase inhibitor with 1 µg of RNA at 37°C for 1 hour ... Part Tw...

Ribonuclease

...de pairs in the DNA for the enzyme Ribonuclease ? ... Ribonuclease inhibitor Top view of porcine ribonuclease inhibitor (PDB accesion code 2BNH) ... authors methodology in ribonuclease extrac...