Inflammatory molecules released by pollen trigger allergies
How do pollen particles provoke allergic reactions? A new study in the February 21 issue of The Journal of Experimental Medicine puts some of the blame on bioactive molecules that are released from pollen. These molecules bind to immune cells and cause them to launch a typical allergy-promoting immune response. Pollen from plants exposed to air pollutants produce more of these allergy-provoking c...Researchers report new pro-inflammatory role for anti-inflammatory enzyme
Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase. In a study published in the Journal of Biological Chemistry, scientists report that the predominantly anti-inflammatory enzyme, endothelial nitric oxide synthase, is also involved in nitric oxide production in response to infection....Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
A team of scientists has discovered three molecules –?from a search of 58,000 compounds –?that appear to inhibit a key perpetrator of Alzheimer's disease. Ken Kosik, co...Protein finding could lead to treatment for inflammatory diseases
A protein that undesirably shields a skin poxvirus from the immune system may become the key ingredient in a new topical treatment for inflammatory diseases, say medical researchers at the University of Illinois at Urbana-Champaign. In a study appearing this month in the Journal of Virology, the scientists revealed both the function of the protein (MC160) and how it works on a molecular le...Safeguarding anti-inflammatory users from ulcers
Abolishing a common stomach-dwelling bacterium makes the long-term use of anti-inflammatory drugs safer. Many people would benefit from chronic usage// of non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and diclofenac. Not only do these drugs relieve the symptoms of arthritis, they also protect against heart attack, stroke and maybe even Alzheimer's disease. But the NSAIDs h...Gel pares inflammatory activity throughout body
Treating periodontal infections with an antibiotic gel reduced the presence of two chemical markers of inflammation throughout the body,// pointing to further evidence of the connection between oral health and overall health, investigators from the University at Buffalo School of Dental Medicine have found. The investigators divided a sample of 100 adults with chronic periodontal dise...Five New Anti-Inflammatory Compounds Produced By Indian Scientists
Five new anti-inflammatory compounds (fight against inflammation) that are 10, 000 times more potent than the most commonly used drugs such as nimusulide and aspirin have been developed and patented by Indian researchers.// Researchers from the All India Institute of Medical Sciences (AIIMS), situated in New Delhi, India, have carried out the work. "These compounds are about 10,000 ti...The Usage Of Anti-Inflammatory Drugs Questioned
A new study finds that one type of anti-inflammatory drugs could be better for older people. Non-steroidal anti-inflammatory drugs are commonly given // to older people to relieve arthritis symptoms. The problem is these drugs are associated with an increased risk of gastrointestinal problems. A specialized group of NSAIDs called COX-2 inhibitors have fewer GI problems, but have been associated w...Hope For Patients With Inflammatory Bowel Disease
Researchers say they may have discovered a potential form of relief for patients with inflammatory bowel disease.// More than 1 million Americans are estimated to have ulcerative colitis or Crohn’s disease the two major forms of inflammatory bowel disease. The conditions, can be painful and debilitating, and can cause chronic inflammation of the digestive tracts. Patients with inflammat...Inflammatory Bowel Disease Differentiation Profile
Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory Drugs
BOULDER, Colo.--(BUSINESS WIRE)--Jun 20, 2007 - Array BioPharmaInc. (Nasdaq: ARRY) announced new Phase 1 clinical data on its MEKinhibitor, ARRY-162, and its p38 inhibitor, ARRY-797. These resultswere presented at the Annual European Congress of Rheumatology(EULAR) in Barcelona, Spain, and at the International Associationof Inflammation Societies' (IAIS) 8th World Congress onInflammation in...Targeted Genetics Reports Inflammatory Arthritis Clinical Data at European Rheumatology Conference
BARCELONA, SPAIN and SEATTLE, WA -- (MARKET WIRE) -- June 14,2007 -- Targeted Genetics Corporation (NASDAQ: TGEN) today isreporting data from the dose escalation arm of the ongoing PhaseI/II clinical study of tgAAC94 in patients with inflammatoryarthritis. Philip J. Mease, M.D., clinical professor at theUniversity of Washington School of Medicine, chief of rheumatologyclinical research a...Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
- Topical Therapy Reduces TNF-alpha Production Through Inhibitionof PDE-4 Enzyme PALO ALTO, Calif., June 06, 2007 /PRNewswire/ -- AnacorPharmaceuticals, a privately held pharmaceutical company, announcedtoday the results from its placebo-controlled Phase 1 trial ofAN2728, a first-in-class topical therapy under investigation forthe treatment of psoriasis. The trial showed AN2728 to bewell...MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
Data Include Results from Phase 1 Studies with Monoclonal AntibodyTargeting Interleukin-9 (IL-9); Preclinical Data Provide FurtherRationale for IL-9 Inhibition in Developing Potential AsthmaTherapies GAITHERSBURG, Md., May 24, 2007 /PRNewswire-FirstCall/ --MedImmune, Inc. today announced the presentation of datahighlighting recent progress within the company's inflammatorydisease pipelin...