Cell transplantation and cardiac repair
... fraction from baseline to a six-month follow-up.
"Our data point toward a causal relationship between the total number of cells that participate in infarct
repair and the final enhancement of cardiac function," concluded Dr. Dohman.
Contact: Hans Dohman, Hospital Pro-Cardiaco, Rua Dona Mariana 219, Bot...
Cardium Reports on Recent Highlights, Financial Results and 2009 Outlook
...(TM) (Ad5IGF-1) is designed to enhance myocardial healing in and around the infarct
zone when used as an adjunct to existing vascular-directed pharmacologic an...thin the heart and that the zone of heart attack related tissue damage (the infarct
zone) was significantly reduced, and cardiac contractile function significa...
'Stent 4 Life': A campaign is launched to increase the use of primary PCI in acute coronary patients
...re study with local cardiac societies in Europe and an assessment of individual requirements for a national programme. The recently announced National infarct
Angioplasty Project in the UK is one such action plan.
"We are convinced that this action will be of benefit to all," says the report. "Engaging in...
Cardiac imaging highlighted at Biennial ICNC-9
...into the clinical decision-making process. Sessions this year include interpreting ECG-gated myocardial perfusion, how to use perfusion metabolism and infarct
imaging, and choosing the right patients for cardiac CT.
Debates will focus on the current controversies, including whether or not diagnostic invas...
Home Defibrillators Fail to Boost Survival Rates
...sually is lacking after a heart attack, Bardy said. "One thing that is not standard practice is consciousness-raising," he said. "Most post-myocardial infarct
[heart attack] patients don't have a discussion of mortality, don't have a discussion of cardiac arrest, don't have a discussion of what to do if ther...
Folate scores a win in animal studies: Brief, high doses of B vitamin blunt damage from heart attack
...ents, within the first 10 minutes of a heart attack, was almost equally as effective as preventive therapy in reversing muscle damage, and in lowering infarct
size by a factor of 10.
Folic acid is already well known to be safe to consume in high doses in the short term, and it is very inexpensive, costing...
Children with sickle cell disease, silent strokes show some relief with blood transfusions
...pearheaded a larger, Phase III study that is evaluating 1,800 children in the United States, Canada and Europe. That trial, called the Silent Cerebral infarct
Multi-Center Clinical Trial, is headed by Michael R. DeBaun, M.D., professor of pediatrics at the School of Medicine. Through it, researchers will fur...
Stem cells train heart following heart attack
...d hearts contained more blood vessels, the heart muscle cells exhibited an increased activity of DNA damage repair, and the wall was thicker where the infarct
had occurred. These results suggest that EPDCs have an almost instant stimulating effect on the surrounding heart tissue following transplantation.
Landmark trial to evaluate cardioprotective properties of insulin
...patients at 90 centers in the U.S. and Latin America will be recruited to participate in the two-year INTENSIVE (Intensive Insulin Therapy and Size of infarct
as a Validated Endpoint by Cardiac MRI) trial. Patients in the trial, which is funded by sanofi-aventis, will be treated with two forms of insulin --...
Stem Cells Show Early Promise for Heart Problems
...lls into heart scar tissue, found that it did not affect heart muscle functioning.
"It was safe but didn't improve systolic function, didn't reduce infarct
size and didn't influence global left ventricular function," said study lead author Dr. Manuel Galinanes, professor of cardiac surgery at the Universi...
Infarct in Medical Technology
Cardium's Innercool Therapies Unit Announces Publication of Positive Effects of Early and Rapid Hypothermia Following Heart Attack
...perfusion significantly reduced
overall myocardial infarct
size (a measure of tissue damage in the heart)
and...egrees Celsius to 35 degrees
Celsius on myocardial infarct
size as assessed by cardiac magnetic
resonance ima...ng prior to reperfusion reduced overall
size by 43% compared to hypothermia after reperfus...
News from the American Heart Association
...ions, especially in older patients.
Despite the potential advantages, clinical trials of facilitated PCI
have not demonstrated benefit in reducing infarct
size or improving
outcomes. Thus, the update states that full-dose fibrinolytic therapy
followed by immediate PCI may be harmful. However, facilitated...
Retrospective Analysis Finds That Initiation of Insulin Glargine in Patients With Type 2 Diabetes was Associated With a Lower Incidence Rate of Myocardial Infarction as Compared With NPH Insulin
long-term effects of insulin glargine on cardiovascular outcomes. As part of this broad effort, the INTENSIVE (Intensive Insulin Therapy
and Size of infarct
as a Validated Endpoint by Cardiac MRI) trial will use
magnetic resonance imaging to compare the effects of tight glycemic control
using insulin glarg...
BioLineRx Presents Data on BL-1040 at Cardiovascular
Revascularization Therapies Conference Demonstrating Potential to
Reduce Deterioration of Infarcted Heart Tissue and Maintain
...study in 21
pigs that underwent an acute MI, and then received an
intra-coronary administration of BL-1040. The results showed that
BL-1040 attenuated infarct
expansion and prevented left ventricle
dilatation. The intracoronary administration of BL-1040 was
feasible and safe, without causing arrhythmias, tox...
Efficacy of OrbusNeich's Genous Bio-Engineered R Stent Compares
Favorably to Drug-Eluting Stents
...llment in the trial, which is a
single-center, prospective, non-randomized study of 60 patients with ST
segment elevation AMI with one infarct
lesion in a single vessel. The
primary endpoint is stent thrombosis at 30 days post-procedure. Patient
follow-up is underway, and resu...
Research Documents Scalable Production, Survival Following
Engraftment and Positive Impact on Cardiac Function in Infarcted
Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for
...in preventing the
onset of heart failure in rodent infarct
models. In the
differentiation procedure, cardiomy...l enhancement factors
directly into the myocardial infarct
zone of rats, the GRNCM1 cells
survived for at lea...ameters,
increased fractional shortening, improved infarct
and increased ejection fraction co...
Infarct in Medical Dictionary
White infarctions (anemic infarcts ) affect solid organs ... Red infarctions (hemorrhagic infarcts ), generally affect the ... infarct
- Hemorrhagic infarct
... User-edited article about myocardial infarction commonly known as heart attack, as well as its classical symptoms of ......
... . Find out the symptoms, causes of myocardial infarction or heart attack. ... Myocardial Infarction -Advanced Heart Care ... Definition of infarct
from the Merriam-Webster Online Dictionary with audio ... Learn more about " infarction " and related topics at Britannica.com ... ... site of i...
...roke. Intracranial hemorrhage. Postpartum hemorrhage ... general: Anemic infarct
- Hemorrhagic infarct
... The viral hemorrhagic fevers (VHFs) are a diverse group of ani...
... Eventually, the contusion evolves into a yellowish plaque characterized by loss ... A cerebral contusion can be distinguished from a cerebral infarct
because, in ... Online Medical Dictionary and glossary with medical definitions ... A bruise, or contusion , is caused when blood vessels are ...
Infarct in Biological News
Protein therapy may reduce infarct size in heart attack patients
Researchers are searching for new methods and therapies to reduce infarct
size and improve blood flow to the heart muscle in patients who experience myocardial infarction (MI), or heart attack.
In a study presented today at the American College of Cardiology’s Innovation in Intervention: i2 Sum...
Winners announced in the Elsevier Grand Challenge
...abs, Researcher Disruptive Technologies and co-organizer of the Challenge. "It seems clear that there is no single solution to solving the information infarct
in biology. Apart from helping develop some wonderfully innovative thinking about improved ways to publish and access science, the Challenge has alre...
A stronger heart with flavonoids
...hronic consumption and effective absorption of anthocyanins rendered the rats more resistant to myocardial infarction; in other words, the size of the infarct
was significantly reduced in rats fed the anthocyanin-rich diet.
The quantity of absorbed anthocyanins is important too. Maria Benedetta Donati, sc...
Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
...hESC-derived cardiomyocytes, their survival in the infarct
zone of rats when transplanted four days after inf...e of engraftment in the hostile environment of the infarct
zone. Moreover, a portion of the cardiomyocytes wa...5-fold increase in systolic wall thickening in the infarct
zone relative to controls (0.01).
Potential heart benefit found in stem cells
...the density of the corresponding capillaries in four areas: the damaged or infarct
area, the healthy myocardium (cardiac muscle), and in two parts of the border zone.
As predicted, the infarct
areas of the heart walls in the ADSC group were thicker than in the animals...
Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack
...on of bone marrow stem cells. The researchers found that this did not alter infarct
size (area of damage) or left ventricular function after a heart attack. "M...riod based on sensitive assessment methods of left ventricular function and infarct
size. In conclusion, use of G-CSF therapy to mobilize bone marrow–derived s...
Bone marrow stem cells may heal hearts even years after heart attacks
...movement velocity rose 57 percent, and there was a significant reduction of infarct
size by 30 percent. Concerning all those parameters, no significant changes...e by 15 percent, which represents myocardial metabolism and viability, into infarct
tissue was observed," Dr. Strauer said.
"The stem cell therapy demonstra...
Survival of heart patients on beta-blockers varies greatly with genetic variation
..."Data from patients with acute myocardial infarction have shown that beta-blockers are generally effective. They are known to decrease the size of the infarct
and seem to prolong survival, on average."
Recent research, however, reveals that variations in the beta-adrenergic receptor genes affect the benef...
Infarct in Biological Technology
Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session
...eartbeat, (+4% versus +1%); end systolic volume (-5.7mL versus -0.1mL); and infarct
size, tissue death due to loss of adequate blood supply, (-10% versus -3%) ...howed a significant improvement in ejection fraction, end systolic volumes, infarct
size, reduction in subsequent MI's, and trends towards reduced deaths, admi...
Cardium's Corgentin Preclinical Program Shows High Levels of Targeting to Acutely Ischemic Heart Muscle Following Intracoronary Infusion
...have shown that ongoing damage to cells
within the infarct
zone continues to occur even after blood flow has ...ed
to enhance myocardial healing in and around the infarct
zone when used as
an adjunct to existing pharmacol... an earlier pilot study using a similar myocardial infarct
which intracoronary administration of Ad5...
New 300mg Loading Dose Tablet for Plavix(R) Receives Positive Opinion From the European Committee for Medicinal Products (CHMP)
...th an early invasive strategy. The primary endpoint
of CURRENT is the reduction of a composite endpoint of cardiovascular
death, stroke and myocardial infarct
(MI) and the results are expected by
the end of 2008.
Plavix(R) is an antiplatelet agent which prevents platelets from
CV Therapeutics Announces Presentations at the American College of Cardiology 57th Annual Scientific Session
...e Induced Ventricular
Diastolic Dysfunction; Poster; Sunday, March 30, 2008, 11:00 a.m. CST
Ranolazine's Mechanism of Action for Reducing Myocardial infarct
is Independent of Changes in Coronary Collateral Blood Flow; Poster,
Sunday, March 30, 2008, 11:00 a.m. CST
Ranolazine Prevents Ischemia-Induce...
PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
...as recognized only ten years ago. Adenosine has been shown to be a
powerful mediator of ischemic preconditioning, the most potent approach to
size in ischemia/reperfusion injury in animal studies. "Acadesine represents the first of an entirely new class of
cardioprotective agents that harne...
Infarct in Biological Definition
Computed axial tomography
...on for a "head CT" or "CT brain". Scanning is done without intravenous contrast agents (contrast may resemble a bleed). CT generally does not exclude infarct
in the acute stage, but is useful to exclude a bleed (so anticoagulant medication can be commenced safely).
For detection of tumors , CT scann...
Magnetic resonance imaging
...ding appears within 5-10 minutes of the onset of stroke symptoms (as compared with computed tomography , which often does not detect changes of acute infarct
for up to 4-6 hours) and remains for up to two weeks. As such, DWI sequences are extraordinarily sensitive for acute stroke.
Diffusion MRI is also ...
Labyrinthitis , and BPPV. In addition, the function of the vestibular system can be affected by tumors on the cochleo-vestibular nerve, an infarct
in the brain stem or in cortical regions related to the processing of vestibular signals, and cerebellar atrophy. Less severe, but often also with lar...