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Gene linked to increasingly common type of blood cancer
PHOENIX, Ariz. July 20, 2009 California and Arizona researchers have identified a gene variant that carries nearly twice the risk of developing an increasingly common type of blood cancer, according to a study published online today by the science journal Nature Genetics . Investigators at t...WALTHAM, Mass. , July 8 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, in the treatment of dyslipidemia patients who fail to reach LDL goal, surveyed physicians are increasingly switching patients to...
TROY, Mich., June 23 /PRNewswire/ -- According to a recent Consumer Reports study, 28% of Americans have skipped doses, cut pills in half, failed to fill a prescription or shared a prescription in order to cut costs. As more and more Americans are struggling to cope with the rising cost of hea...
Education and tools high priorities for helping employees make better decisions Indianapolis, Indiana (Vocus) June 16, 2009 -- United Benefit Advisors, LLC (UBA), one of the nation's leading employee benefits advisory organizations, today released additional data from t...
At www.greatplaceinc.com , you'll find a 50-state register of senior housing options -- senior apartments, assisted living, nursing homes, adult day care and many more -- together with a 12-chapter Toolkit that offers advice and counsel on a variety of legal, social and family issuesthat impact...
Media coverage of lung cancer is increasing, and increasingly negative, new report shows
NEW YORK (October 28, 2008) CancerCare today announced that despite an overall increase in news reporting on lung cancer, the overall tone of lung cancer media coverage has become significantly more negative. "How the U.S. Media Report on Cancer," an analysis of lung, breast, colorectal and prost...increasingly in Medical Technology
Younger Adults Increasingly Treated for Heart Disease-related Conditions
Increase in use of cholesterol and hypertension medications largest among people ages 20 to 44 Drop in the age of women using heart disease medications greater than men FRANKLIN LAKES, N.J., Oct. 30 /PRNewswire-FirstCall/ -- Heart disease, high blood pressure and harde...Covance Receives Highest Level of Phase I Accreditation
...e. "As an industry leader in clinical pharmacology, Covance provides superior experience and expertise in study design and conduct to support today's increasingly complex first-in-human trials." MHRA accreditation was introduced to ensure the highest level of patient safety for early clinical developmen......nfirm "unambiguously the fate of monocytes from the spleen to the heart." "We see the integration of in vitro and in vivo readouts becoming increasingly important in research today, and we are extremely pleased that our FMT quantitative in vivo imaging technology and activatable in vivo imaging agent...
...tions in the New York area. This move is consistent with Lilly's transformation into a fully integrated pharmaceutical network (FIPNet) in which it is increasingly collaborating with external organizations and companies to speed innovation to patients. Nearly 20 current FIPNet partners are located in proximity to...
June 2009 Mayo Clinic Women's HealthSource Highlights Summer Skin Problems, Low Vision and Pilates
... -- The first instruction in a Pilates class? How to say it: puh-LAH-teez. The June issue of Mayo Clinic Women's HealthSource addresses this increasingly popular low-impact fitness technique. Pilates emphasizes mind-body connection and breath control to build strength, endurance and flexibility, particu......o date are very promising and indicate that CXA-101 is well tolerated and has broad-spectrum antibacterial coverage, including potent activity against increasingly resistant gram-negative pathogens such as Pseudomonas aeruginosa ," said Dr. Ian Friedland, chief medical officer of Calixa. "We are going to prese...
increasingly in Medical Products
Description:...ts that quantitatively measure two important cardiac risk markers: homocysteine and lipoprotein (a). An elevated serum or plasma homocysteine level is increasingly viewed as a strong and independent risk factor for cardiovascular disease. And numerous studies since the early 1970s have associated elevated levels ...
Company:Inverness Medical Innovations
Description:...ts that quantitatively measure two important cardiac risk markers: homocysteine and lipoprotein (a). An elevated serum or plasma homocysteine level is increasingly viewed as a strong and independent risk factor for cardiovascular disease. And numerous studies since the early 1970s have associated elevated levels ...
Company:Inverness Medical Innovations
Company:Midmark Corporation
Description:... Efficient operation in the cath lab has increasingly become the focus of the daily clinical routine as cardiologists balance demands for higher quality of care and lower costs. With AXIOM Sensis, Siemens...
Company:Siemens Medical Solutions USA, Inc.
Company:IDS Ltd
Description:... series is ideal not only for diagnostic use but also for therapeutic applications, especially endobronchial high-frequency surgery. It is becoming increasingly widely used as an affordable and effective alternative to laser technology in tumour resection and the quenching of acute haemorrhaging. Pentax suppor...
Company:PENTAX Medical Company
Company:Inverness Medical Innovations
Description:...ts that quantitatively measure two important cardiac risk markers: homocysteine and lipoprotein (a). An elevated serum or plasma homocysteine level is increasingly viewed as a strong and independent risk factor for cardiovascular disease. And numerous studies since the early 1970s have associated elevated levels ...
Company:Inverness Medical Innovations
Ritter 222 Barrier-Free™ Exam Table
Description:... To really care for people, you must understand the patients you care for today and tomorrow. And with an increasingly aging population, your patients may need assistance in accessing an exam table. With an incredible 18-inch low height, the Ritter 222 Barrier-Free Exa...Company:Midmark Corporation
Description:... Efficient operation in the cath lab has increasingly become the focus of the daily clinical routine as cardiologists balance demands for higher quality of care and lower costs. With AXIOM Sensis, Siemens...
Company:Siemens Medical Solutions USA, Inc.
Insulin-like Growth Factor-I (IGF-I) ELISA
Description:...ol extraction to provide for the direct immunoassay of IGF-I, the whole process being completed within 4 hours. The OCTEIATM IGF-I ELISA is being used increasingly in studies associated with growth, cancer and bone metabolism....Company:IDS Ltd
Description:... series is ideal not only for diagnostic use but also for therapeutic applications, especially endobronchial high-frequency surgery. It is becoming increasingly widely used as an affordable and effective alternative to laser technology in tumour resection and the quenching of acute haemorrhaging. Pentax suppor...
Company:PENTAX Medical Company
increasingly in Medical Definition
...ay for services rendered. Those patients often turn to emergency departments for their acute care needs. That has resulted in overcrowding and made it increasingly difficult to focus adequate resources on those patients who present with true emergencies.
...
... In fact, many health care professionals and patients claim that this trust and relationship are therapeutic in their own right. Unfortunately, we are increasingly seeing these boundaries crossed, which can compromise patient care and potentially lead to fatal consequences. [1] With increasing access to comp...
...in many health care settings on paper records, but increasingly nowadays by electronic means. Patient-phy...ast 30 years medical care in the Western World has increasingly emphasized patient autonomy in decision making. ...he twentieth century, healthcare providers focused increasingly on the technology that was enabling them to make d...
...siopathology. However, the cleavage between mind and brain and the causal dichotomies are argued not to be veridical . Psychiatric disorders are increasingly showing organic manifestation and demonstrate causation from something as distant as culture. Thus the reasons for the initial division are argued not...
Artificial induction of immunity
...infections that can cause serious illness is generally beneficial. Since Pasteur provided support for a germ theory of infectious disease, we have increasingly induced immunity against a widening range of diseases to prevent the associated risks from the wild infections. It is hoped that further understandi...... In fact, many health care professionals and patients claim that this trust and relationship are therapeutic in their own right. Unfortunately, we are increasingly seeing these boundaries crossed, which can compromise patient care and potentially lead to fatal consequences. [1] With increasing access to comp...
...in many health care settings on paper records, but increasingly nowadays by electronic means. Patient-phy...ast 30 years medical care in the Western World has increasingly emphasized patient autonomy in decision making. ...he twentieth century, healthcare providers focused increasingly on the technology that was enabling them to make d...
...siopathology. However, the cleavage between mind and brain and the causal dichotomies are argued not to be veridical . Psychiatric disorders are increasingly showing organic manifestation and demonstrate causation from something as distant as culture. Thus the reasons for the initial division are argued not...
increasingly in Medical Dictionary
...n of a midwife, physician or ... A water birth can provide a lot of benefits to women when they are in labor or ... Nowadays, it is become increasingly common, even trendy, to have a water birth . ... ...
...imed at improving the therapeutic efficacy and efficiency of TCs. ... Allergic Contact Dermatitis to TTSs: Transdermal therapeutic systems are increasingly common, but they also produce the ideal environment for cutaneous sensitization. A therapeutic HIV vaccine (also known as a treatment ... ...
... imbricated with a second layer using interrupted 1-0 vicryl sutures . ... The use of nonabsorbable sutures for lifting lax, aging skin is an increasingly ... This determines the course and number of sutures that will be placed. ... ...
...es, diagnostic guides, medical books excerpts online about Proctitis , 1 drug side effect causes. Diagnostic ... Proctitis , which is becoming increasingly common, has several causes. ... Proctitis may also be caused by some bacteria not transmitted sexually, such as ... Proctitis — Co...
... small pieces of skin tissue that connect to the body with a pedicle . ... Use of pedicle screw systems for spinal stabilization has become increasingly ... Boucher in 1959 was the first to use pedicle screws. ... To establish anatomic guidelines for the placement of C2 pedicle screws. ... Th...
...d New Jersey, 1988-1992. ... Consequently, the number of occupational asthma reports increased sharply, from ... Occupational asthma is an increasingly important cause of respiratory impairment; ... Provides information on occupational asthma . The Health and Safety Executive ... Real example...
...imed at improving the therapeutic efficacy and efficiency of TCs. ... Allergic Contact Dermatitis to TTSs: Transdermal therapeutic systems are increasingly common, but they also produce the ideal environment for cutaneous sensitization. A therapeutic HIV vaccine (also known as a treatment ... ...
... imbricated with a second layer using interrupted 1-0 vicryl sutures . ... The use of nonabsorbable sutures for lifting lax, aging skin is an increasingly ... This determines the course and number of sutures that will be placed. ... ...
...es, diagnostic guides, medical books excerpts online about Proctitis , 1 drug side effect causes. Diagnostic ... Proctitis , which is becoming increasingly common, has several causes. ... Proctitis may also be caused by some bacteria not transmitted sexually, such as ... Proctitis — Co...
... small pieces of skin tissue that connect to the body with a pedicle . ... Use of pedicle screw systems for spinal stabilization has become increasingly ... Boucher in 1959 was the first to use pedicle screws. ... To establish anatomic guidelines for the placement of C2 pedicle screws. ... Th...
...d New Jersey, 1988-1992. ... Consequently, the number of occupational asthma reports increased sharply, from ... Occupational asthma is an increasingly important cause of respiratory impairment; ... Provides information on occupational asthma . The Health and Safety Executive ... Real example...
increasingly in Biological News
Early identification of dementia increasingly difficult
If grandma seems to forget things, will she end up demented? These days, memory loss is one of the very few symptoms that may signal which 70-year-olds risk developing dementia. This is shown in a doctoral thesis at the Sahlgrenska Academy at the University of Gothenburg, Sweden. Several of the...Mountain summits in the Alps becoming increasingly similar
St Moritz/Leipzig. Alpine summit vegetation will become increasingly homogenized as a result of climate change, say researchers from the University of Bayreuth and the Helmholtz Centre for Environmental Research writing in the international Journal of Vegetation Science. The biologists assessed da...Coral reefs are increasingly vulnerable to angry oceans
Size and shape may predict the survival of corals around the world when the weather churns the oceans in the years to come, according to a new model that relies on engineering principles. The increasing violence of storms associated with global climate change, as well as future tsunamis, will hav...Emerging staph strains found to be increasingly deadly and deceptive
A study of how the immune system reacts to strains of antibiotic-resistant Staphylococcus aureus bacteria--emerging strains that sicken otherwise healthy people, or so-called "community-acquired" infections--has shown for the first time that these strains are more deadly and better at evading human...Marine microbes creating green waves in industry
...mical industries." Commenting on the findings, BBSRC Chief Executive Professor Doug Kell, said: "Green and White biotechnologies are going to be an increasingly important part of the manufacturing landscape. Looking to biological systems that have been finely tuned by evolution to solve problems, rather than s...Navigating in the ocean of molecules
...ly-based lineages form the branches of the tree," explains Stefan Wetzel: "With the help of Scaffold Hunter we move along the branches from complex to increasingly simple structures which may be similar in their effect." Thus, the researchers identify structurally simple scaffolds with promising characteristics a...increasingly in Biological Technology
McClellan questions "current pathway of short term patches" in health care policy reform
ORLANDO, Fla., May 16 /PRNewswire-FirstCall/ -- Recent legislative
emphasis on price negotiation and physician reimbursement as a means to
reduce health care costs are nothing mo...
... While previous advances in engine technology have been based on separate and parallel developments by the fuels and lubricants industries, it is increasingly apparent that further significant improvements in diesel and gasoline engine fuel economy will require an integrated approach between automakers, tier...
In an increasingly 'flat' world, Wisconsin must adapt to compete
Four separate but ultimately connected events help to explain Wisconsin's efforts to compete in a changing world: Speaking to business leaders in Milwaukee, Hewlett-Packard vice president Kevin Gilroy said the "hypercompetitive global economy" has made it difficult for companies to stand out...Patent Attorney John Rizvi Speaks at FIME International Medical Expo
...older to maintain monopoly pricing and avoids the product becoming a commodity," said Rizvi. Patents for medical device companies have become increasingly important as more competitors from overseas and nationally are launching knock-off products based on a patent holder's intellectual property. Joh...NovaBay(R) Pharmaceuticals Names Roy J. Wu as Senior Vice President for Business Development
...r vice president for business development. Wu brings to NovaBay more than 30 years of highly successful experience in the pharmaceutical industry with increasingly responsible management positions in global business development, licensing, international marketing, project management, clinical development, and Pac...PROTOMED SA Chooses HyperWorks to Simulate Implantable Medical Devices
...medical devices are constantly challenged to improve product performance, deliver quality and reliability and meet regulatory standards. CAE tools are increasingly used in the biomed industry to meet design and quality challenges and are gaining acceptance in validation processes. "Altair Engineering is ha...... While previous advances in engine technology have been based on separate and parallel developments by the fuels and lubricants industries, it is increasingly apparent that further significant improvements in diesel and gasoline engine fuel economy will require an integrated approach between automakers, tier...
increasingly in Biological Products
QXL 520 C2 maleimide from AnaSpec
Description:... Although the mixed TAMRA isomers are predominantly used for labeling proteins, the single isomers are increasingly preferred for labeling peptides and nucleotides because they give better resolution in HPLC purification that is often required in the conjugation pro...Company:AnaSpec
nano25 from Hudson Control Group, Inc.
Description:... Low volume pipetting is increasingly essential for reducing sample and waste volumes in DNA sequencing and other biochemical applications. The eight-channel nano25 delivers with performan...Company:Hudson Control Group, Inc.
increasingly in Biological Definition
... extinction , Unified neutral theory of biodiversity .
Is biodiversity threatened?
During the last decades, erosion of biodiversity has been increasingly observed. The majority of biologists believe that a mass extinction is under way. While estimates over extinction rates range from a handful to up...
...-men's lectures to widen the audience, and Wallace remained a supporter but increasingly differed, turning to spiritualism . Variation grew to two huge volumes, ...d the Beagle I was quite orthodox" he later struggled with faith and became increasingly agnostic , particularly after the death of his daughter Anne . A popula...
...erent varieties of chromatography described below. Simultaneously, advances continally improved the technical performance of chromatography, allowing increasingly similar molecules to be resolved. Chromatography theory Chromatography is a separation method that exploits the differences in partitioning b...
...enetic approach to systematics has proven useful and coherent and has gained general support. As DNA sequencing has become easier, phylogenies are increasingly often constructed with the aid of molecular data. Computational systematics allows the use of these large data sets to construct objective phylogen...
...ence of social role validation and inclusion, people with Down syndrome are increasingly being offered better chances for realising their potential for personal and... a regular job, get a driver's licence and take care of insurances etc. One increasingly popular model in Europe lets four to six people with Down Syndrome share an...
...al changes in the last several decades, especially as techniques for comparing biochemical characteristics (such as ribosomal RNA and DNA) have become increasingly more sophisticated. The phylogeny presented here is after Bruns et al. (1991, 1993) for the Eumycota (true fungi) and recognizes four divisions: the...
...-men's lectures to widen the audience, and Wallace remained a supporter but increasingly differed, turning to spiritualism . Variation grew to two huge volumes, ...d the Beagle I was quite orthodox" he later struggled with faith and became increasingly agnostic , particularly after the death of his daughter Anne . A popula...
...erent varieties of chromatography described below. Simultaneously, advances continally improved the technical performance of chromatography, allowing increasingly similar molecules to be resolved. Chromatography theory Chromatography is a separation method that exploits the differences in partitioning b...
...enetic approach to systematics has proven useful and coherent and has gained general support. As DNA sequencing has become easier, phylogenies are increasingly often constructed with the aid of molecular data. Computational systematics allows the use of these large data sets to construct objective phylogen...
...ence of social role validation and inclusion, people with Down syndrome are increasingly being offered better chances for realising their potential for personal and... a regular job, get a driver's licence and take care of insurances etc. One increasingly popular model in Europe lets four to six people with Down Syndrome share an...
...al changes in the last several decades, especially as techniques for comparing biochemical characteristics (such as ribosomal RNA and DNA) have become increasingly more sophisticated. The phylogeny presented here is after Bruns et al. (1991, 1993) for the Eumycota (true fungi) and recognizes four divisions: the...
increasingly in Biological Dictionary
... mRNA, just ... The typical process of splicing nuclear introns is shown in the video below. ... Alternative gene transcript splicing has increasingly become more common-forcing genomics ... Alternative splicing was first found in viruses and a ... The Alternative Splicing Database Project a...
...native to Goldenseal Vitamins Shop for herbs like Solaray - Valerian Root 100 Cap at mySimon. Smart Shopping at mySimon. The root cap is increasingly appreciated as a complex and dynamic plant organ. ... In Arabidopsis, the root cap develops from two sets of meristematic cells, a ... For th...
...s is an attempt to connect a given genetic sequence ... Reverse genetics of negative-strand RNA viruses: ... A new technology that's looking increasingly promising in the fight against the flu is plasmid-based reverse genetics , a procedure developed by Yoshihiro Kawaoka, Ph. ... In recent years, ...
...vide sufficient residue cover to help ... fields "clean" of residue and intensively tilled to ... Crop residue management (CRM) practices are increasingly used to conserve soil and water. ... machinery may be required to adopt crop residue ... Shop for Residue at Target.com - Free Shipping on 15...
...ta globin gene ) ... g., the sex lethal gene of fruit fly), a splicing signal may be masked ... Alternative gene transcript splicing has increasingly become more common-forcing genomics ... Now, alternative splicing of gene transcripts may be the ... ... dictionary with pronunciation, synon...
...n and will continue ... ... flying team uses ethanol fuel. ... Ethanol is also a high-performance motor fuel that cuts ... Ethanol blends are increasingly used in South Africa, while ... Ethanol is a clear, colorless alcohol fuel made from the sugars found in grains, ... There are several ways to ma...
...native to Goldenseal Vitamins Shop for herbs like Solaray - Valerian Root 100 Cap at mySimon. Smart Shopping at mySimon. The root cap is increasingly appreciated as a complex and dynamic plant organ. ... In Arabidopsis, the root cap develops from two sets of meristematic cells, a ... For th...
...s is an attempt to connect a given genetic sequence ... Reverse genetics of negative-strand RNA viruses: ... A new technology that's looking increasingly promising in the fight against the flu is plasmid-based reverse genetics , a procedure developed by Yoshihiro Kawaoka, Ph. ... In recent years, ...
...vide sufficient residue cover to help ... fields "clean" of residue and intensively tilled to ... Crop residue management (CRM) practices are increasingly used to conserve soil and water. ... machinery may be required to adopt crop residue ... Shop for Residue at Target.com - Free Shipping on 15...
...ta globin gene ) ... g., the sex lethal gene of fruit fly), a splicing signal may be masked ... Alternative gene transcript splicing has increasingly become more common-forcing genomics ... Now, alternative splicing of gene transcripts may be the ... ... dictionary with pronunciation, synon...
...n and will continue ... ... flying team uses ethanol fuel. ... Ethanol is also a high-performance motor fuel that cuts ... Ethanol blends are increasingly used in South Africa, while ... Ethanol is a clear, colorless alcohol fuel made from the sugars found in grains, ... There are several ways to ma...
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(Date:11/26/2009)...l rollercoaster, study finds , , THURSDA...ctor meets the jubilant sports fan. , A new stu...o root for the winning team -- enjoy the greatest ... victory was in doubt, producing feelings of worry...ving weekend as you,re glued to the TV set, watchi...
(Date:11/26/2009)...Dental (RTDental), a leading dental group practice...pansion of its services to include LUMINEERS by a ... , Durham, NC (PRWEB) -- ...at Dr. Doug Macmillan, an experienced LUMINEERS ... training seminar. RTDental’s ability to fu...
(Date:11/25/2009)...wire/--WhenmostpeopleheartheacronymTMJ,theythinkof...ehelptheyneed.TMJstandsfortheTemporal-MandibularJo...withyourskull(temporalbone). ,, Themostcommonsy...ng,clickingorpoppingofthejaw.Butmanyothersymptomsc...tigue,sleepdisturbances,irritability,alossinfocus,...
(Date:11/25/2009)...-SentinelleMedicalInc.,aleadingmanufacturerofMagne...ScientificInc.,aleadingproviderofsoftwareenablingt...east4DAdvancedVisualizationsoftware. ,, Thisinn...ientbasedmedicalimagingofferinginthemarket.Calgary...rintaccess-requiringnosoftwaredownload,andrunsonan...
(Date:11/25/2009)...SNewswire/--AnarticlebyJanetWoodcock,M.D.,director...d"ADifficultBalance-PainManagement,DrugSafety,andt...JournalofMedicine. ,, (Logo: http://www.newscom...ticle,WoodcockdiscussesFDAeffortstostrikeabalanceb...nagingtherisksposedbyvariousanalgesics.Asexamples,...
Breaking Medicine News(10 mins):Health News:Watching the Nail-Biting Big Game Hurts So Good 2Health News:Watching the Nail-Biting Big Game Hurts So Good 3Health News:Dr. Douglas Macmillan Now Providing LUMINEERS at Research Triangle Dental 2Health News:Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology 2Health News:Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology 3[0] Watching the Nail-Biting Big Game Hurts So Good[0] Dr. Douglas Macmillan Now Providing LUMINEERS at Research Triangle Dental [1] TMJ and Chiropractic Care: An Overall Wellness Approach[1] Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology[1] FDA's Woodcock Discusses Pain Management and Drug Safety in Nov. 26, 2009 Issue of The New England Journal of Medicine
(Date:11/24/2009)...f debate. A high-profile study a few years ago sug...rbon from trees and leaves, evidence for a very cl...stems. , But new research from the University of...lgae provide a much richer diet for fish and other...s week in the Proceedings of the National Academy...
(Date:11/23/2009)...d strain of the deadly superbug MRSAan infection-c...csposes a far greater health threat than previousl...rding to a study in the December issue of Emergin...ily picked up in fitness centers, schools, and oth...den of MRSA within hospitals, the report found. ,...
(Date:11/23/2009)...nts gathered this week for the seventh annual Nati... This year,s topic, "Synthetic Biology," brought t...hers to explore the engineering, scientific, and s...thetic biology. , Bonnie L. Bassler, professor o...is year,s conference chair, challenged the attende...
Breaking Biology News(10 mins):Fish food fight: Fish don't eat trees after all, says new study 2Fish food fight: Fish don't eat trees after all, says new study 3New study finds MRSA on the rise in hospital outpatients 2Synthetic biology offers new opportunities for interdisciplinary collaboration 2Why Huntingtons Shows Up in Midlife 48864 1Why Huntingtons Shows Up in Midlife 48864 2New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 1New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 2New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 3Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 1Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 2Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 3| Copyright © 2003-2009 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |