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Study Implicates Protein as a Trigger of Advanced Prostate Cancer Recurrence

Scientists with the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill have for the first time implicated a growth-promoting cellular protein as one trigger of the inevitable recurrence of advanced prostate cancer in men who are undergoing drug treatment to s...

Kidney Stones - Interesting New Research implicates bacteria as its cause

In India Kidney Stones are not uncommon problem due to the hot and often humid weather. Most of these stones are made up of Calcium, Oxalate and phosphates. The cause of stone disease is debatable, however it is well known that drinking less water is a risk factor for stone disease. New res...

Beetles drive groundbreaking conservation project

...r declines in numbers," said Dr Matthew Gage of UEA's School of Biological Sciences. "Our previous work on wild rabbits in the natural environment implicates sperm as being sensitive to inbreeding. However, these large-scale experimental trials in the laboratory will shed new light on the relative importanc...

A surprise 'spark' for pre-cancerous colon polyps

...own as beta-catenin resulted in colon polyp formation. Colon polyp formation precedes the development of colon cancer. While considerable evidence implicates dysregulated Wnt/beta-catenin signaling as the initiating event underlying colon adenoma formation following loss of APC, several studies examining hu...

NABP Position Paper Calls for Action Against Proliferation of Rogue Internet Drug Outlets

...and the lack of accountability of the registrars and Internet service providers that sell and host these illegally operating Web sites. The paper also implicates the credit card companies that process financial transactions involving illegal sales of prescription medicines. The current position paper, lik...

Cathepsin B increases apoptosis in fulminant hepatic failure

...s is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not kn...s is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. Inhibition o...

Researchers identify ALS gene mutation

...10 percent of ALS cases are inherited." "The discovery of this gene mutation shows new kinds of molecular defects that damage motor neurons and it implicates defective pathways previously identified in other genetic forms of ALS," said Siddique. ...

Male fertility expert Marvin Meistrich elected AAAS Fellow

...atids and finally sperm, with the male hormone testosterone crucially involved all along. A major, surprising discovery by Meistrich and colleagues implicates testosterone in the inability of surviving stem cells to restore sperm production after radiation or chemotherapy. "This was exactly backwards fr...

New Undercover Video Shows Tucson Planned Parenthood Hiding Rape of 15-Year-Old Girl

... TUCSON, Ariz., Feb. 3 /PRNewswire-USNewswire/ -- New hidden-camera footage from Tucson, AZ, implicates a third Planned Parenthood clinic in a multi-state child abuse scandal. In the video, UCLA student Lila Rose and her friend Jackie Stollar enter a T...

Scientists unmask genetic markers associated with psoriasis

...skin. Variants of TNFAIP3 also have been associated with rheumatoid arthritis and lupus, two other autoimmune conditions. The fourth novel hotspot implicates two "next-door neighbor" genes, IL4 and IL13. These genes support development of Th2 cells, a type of immune system T cell. Any condition that leads t...
implicates in Medical Technology

Scientists Unmask Genetic Markers Associated With Psoriasis

...in. Variants of TNFAIP3 also have been associated with rheumatoid arthritis and lupus, two other autoimmune conditions. The fourth novel hotspot implicates two "next-door neighbor" genes, IL4 and IL13. These genes support development of Th2 cells, a type of immune system T cell. Any condition that leads t...

Isis Initiates Clinical Trial of CRP Drug

...is and end-stage renal disease. Elevated levels of CRP have been linked to coronary artery disease and a growing body of evidence from clinical trials implicates CRP in cardiovascular disease progression. Although CRP's active participation in these diseases remains to be determined, several lines of evidence s...

Furamidine Found to Inhibit a Key Enzyme Involved in Cancer Cell DNA Repair Mechanisms

...he hydrolysis of 3'-phosphotyrolsyl bonds. They further suggest that a Tdp1 inhibitor could act synergistically with the Top1 inhibitors. Earlier work implicates Tdp1 in the repair of Top2-mediated DNA damage. Top2 inhibitors represent another class of anticancer agents where a Tdp1 inhibitor may produce a syne...
implicates in Biological News

Genetic finding implicates innate immune system in major cause of blindness

Scientists have identified one of the genes implicated in age-related macular degeneration, the most common cause of blindness in developed countries. The research, published online today in the Lancet , adds to the growing understanding of the genetics of age-related macular degeneration (AMD...

Largest study of its kind implicates gene abnormalities in bipolar disorder

The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association bet...

Building memories with actin

...enosine prevents phosphorylation and inactivation of cofilin, an inhibitor of actin filament assembly, the team found. Cofilin's involvement, in turn, implicates signaling cascades headed by GTPases, such as the RhoA-ROCK and Rac-PAK pathways. The researchers showed that a ROCK inhibitor stalled actin polymeriz...

Illinois Soil Nitrogen Test measures microbial nitrogen

...cterial over fungal nitrogen recoveries by the ISNT. Taken together, these findings suggest that the ISNT mainly detects bacterial amino sugars and implicates this form of soil nitrogen in the test's effectiveness for predicting the response of corn to nitrogen fertilization. Because the ISNT also detects so...

TGen researchers discover possible way to block the spread of deadly brain tumors

...ty to rapidly grow within the brain often means patients have little time to survive. "Controlling the actions of tumor cells by regulating NHERF-1 implicates it as a possible therapeutic target for treating brain cancer," said Dr. Kerri Kislin, a scientist in TGen's Cancer and Cell Biology Division. "Our...

Is there a relationship between sleep-wake rhythm and diabetes?

... The gene mediates insulin secretion indirectly via the release of melatonin, which implicates a previously unknown relationship between the sleep-wake rhythm and the fasting glucose level. The finding could open up new possibilities of treatmen...

Researchers identify potential new weapon in battle against HIV infection

...st Dr. Cliff Lingwood; Lund University's Dr. Martin Olsson has identified underlying genetic reasons for Pk blood group variation. "This discovery implicates the Pk level as a new risk factor for HIV infection and demonstrates the importance of blood-group-related science," says Dr. Olsson. "The conclusio...

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

...mportant consequences for the organism. According to Martienssen, "our work implicates RNAi in epigenetic chromatin changes that occur in immortalized cells." ...vity of genes that are essential. The team's epigenetic profiling study now implicates siRNA-driven heterochromatin restructuring as a mechanism that might lead t...

In the war against diseases, nerve cells need their armor

... providing access to a huge amount of patient data, and enabling them a broader clinical perspective. Importantly, this newly discovered mechanism implicates a cascade of protein molecules that have not been known to be involved in myelination. The study was carried out in mice and using in vitro cell cultu...

Bisphenol A linked to metabolic syndrome in human tissue

... CINCINNATINew research from the University of Cincinnati (UC) implicates the primary chemical used to produce hard plasticsbisphenol A (BPA)as a risk factor for metabolic syndrome and its consequences. In a laboratory st...
implicates in Biological Technology

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... cancer Nature Cell Biology In first half of 2009 Santaris Pharma and academic partners published an article titled: A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. BMC Med Genomics In June 2009 Sa...

SNPs Powerful Tools for Association Studies

...enes or regions found in different species that are very similar. The homology indicates that these genes or regions are evolutionarily conserved, and implicates their functional importance. Intronic SNPs Single nucleotide polymorphisms that occur in noncoding regions of a gene that separate the e...
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