Genetic source of rare childhood cancer found; gene is implicated in other cancers
St. Louis, April 20, 2009 The search for the cause of an inherited form of a rare, aggressive childhood lung cancer has uncovered important information about how the cancer develops and potentially sheds light on the development of other cancers. The finding by researchers at Washington Unive...UCF researchers discover a new protein family implicated in inflammatory diseases
A University of Central Florida research team has discovered a new protein family that may play an important role in preventing inflammatory diseases such as arthritis, some forms of cancer and even heart disease. The findings that in the future may aid the bodys defense system are published in...Scientists determine structure of brain receptor implicated in epilepsy and PMT
Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have published new research in the journal Molecular Pharmacology identifying the structure of a receptor in the brain implicated in conditions such as epilepsy and pre-menstrual tension. The same receptor has ...Oral Sex Implicated in Some Throat and Neck Cancers
HPV virus is cause; vaccination may reduce incidence, experts say,,,, MONDAY, Aug. 27 (HealthDay News) -- Human papillomavirus (HPV), which is believed to be responsible for most cervical cancers, may also be at the root of many cancers of the mouth and throat, new research suggests..."Tribbles" Protein Implicated in Leukemia
Researchers at the University of Pennsylvania School of Medicine have identified a new protein associated with acute myelogenous leukemia (AML). Several lines of evidence point to a protein called Tribbles // , named after the furry creatures that took over the starship Enterprise in the original S...Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers
DENVER, April 19 /PRNewswire/ -- The search for the cause of an inherited form of a rare, aggressive childhood lung cancer has uncovered important information about how the cancer develops and potentially sheds light on the development of other cancers. The finding by researchers at Washing...Diabetes Gene Raises Odds of Lower Birth Weight
...g that supports the so-called fetal insulin hypothesis. Previous studies by European diabetes researchers, said Grant, had suggested that CDKAL1 was implicated in both lower birth weight and type 2 diabetes, and the current study, using a large sample size, reinforced that association. Under the fetal ...Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA
... serotonin production by inhibiting tryptophan hydroxylase (TPH), a key enzyme in the synthesis of serotonin. Excessive levels of serotonin have been implicated in symptoms associated with carcinoid syndrome. Serotonin's breakdown product, 5-HIAA, is a biomarker used in the diagnosis of the condition. In pre...Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug
...o the clinical data to be obtained in this study to support the development of ATPotent(TM) in the rest of the world. Male factor infertility is implicated in about half of the six million infertile couples in the United States. Lack of, or low sperm motility or movement, is a common cause of human male i...Bio-Phase II 2.0mm Suture Anchor
Description:...hout crystallinity), meaning that its degradation is uniform, precluding the crystalline release associated with degrading homopolymers that have been implicated in late inflammatory reactions. Furthermore, this co-polymer ratio permits the polymer to retain most of its strength for six to eight weeks, which is...Bio-Phase II 3.0mm Suture Anchor
Description:...hout crystallinity), meaning that its degradation is uniform, precluding the crystalline release associated with degrading homopolymers that have been implicated in late inflammatory reactions. Furthermore, this co-polymer ratio permits the polymer to retain most of its strength for six to eight weeks, which is...Kallestad Anti-Thyroid Peroxidase (TPO)
Description:... Anti-Tg and Anti-TPO are two major autoantibodies implicated in autoimmune related thyroiditis and aid in the differential diagnosis of Hashimoto's thyroiditis and Graves' disease....Kallestad Anti-Thyroglobulin (Tg)
Description:... Anti-Tg and Anti-TPO are two major autoantibodies implicated in autoimmune related thyroiditis and aid in the differential diagnosis of Hashimoto's thyroiditis and Graves' disease....Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
NEW YORK (July 8, 2009) A new finding reveals that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races with these cancers, even when they receive identical medical treatment and when socioeconomic factors are controlled for. The fin...Flow of potassium into cells implicated in schizophrenia
A study on schizophrenia has implicated machinery that maintains the flow of potassium in cells and revealed a potential molecular target for new treatments. Expression of a previously unknown form of a key such potassium channel was found to be 2.5 fold higher than normal in the brain memory hub ...MicroRNA implicated as molecular factor in alcohol tolerance
WORCESTER, Mass.In recent years, a class of small molecules known as microRNA have been found to play an important role in regulating gene products in most animal and plant species. A new study now indicates that microRNA may influence the development of alcohol tolerance, a hallmark of alcohol ab...A novel way found to prevent protein plaques implicated in Alzheimer's
NEW YORK, November 18, 2007For unknown reasons a protein called amyloid beta aggregates into toxic plaques in the brain, killing neurons. These plaques are one of the hallmarks of Alzheimers disease. Now two new animal studies show for the first time that the deadly transformation of amyloid beta ...RNA splicing factor implicated in ovarian tumor cell growth
An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago. Researchers in the UIC College of Pharmacy found that interfering with the production ...New protein implicated in autism
Autism is a common neurodevelopmental disorder characterized by severely impaired social, communicative, and behavioral functions. It is thought that genetic make-up predisposes an individual to autism, and several genes have been associated with the development of autism. Although a region of huma...Histogen Hair Regrowth Clinical Trial Presented at ISHRS Annual Meeting
...mbryonic proteins, growth factors and contains the first naturally stabilized, bioactive solution of Wnt proteins and their cofactors, which have been implicated in the induction of new hair follicle formation and growth. The five-month double-blind, placebo-controlled clinical trial was focused on evaluati...Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease
...DAS-Cog scores were evaluated over the study course. In addition to degrading insulin, the Ide protein also degrades amyloid beta peptide and has been implicated in playing a role in Alzheimer's disease. In the population of patients who were both APOE4(-) and lacked the C/C polymorphism in IDE 7, more...Novel drug discovery tool could identify promising new therapies for Parkinson's disease
...hers showed that they can rescue yeast cells from toxic levels of a protein implicated in Parkinson's disease by stimulating the cells to make very small proteins...ich was a surprise, since alpha-synuclein and other proteins that have been implicated in human Parkinson's disease are believed to play a role in vesicle traffic...Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome
... serotonin production by inhibiting tryptophan hydroxylase (TPH), a key enzyme in the synthesis of serotonin. Excessive levels of serotonin have been implicated in symptoms associated with carcinoid syndrome. Serotonin's breakdown product, 5-HIAA, is a biomarker used in the diagnosis of the condition. In pre...Cynvec to Present at The 2009 New York Venture Summit
...okines directly to tumor sites. Additionally, a screening program is underway to identify small molecules that bind to the laminin receptor, which is implicated in Alzheimer's disease, multiple sclerosis and Parkinson's. Further information on Cynvec can be found at www.cynvec.com . ...Goat Anti-Cholesterol Oxidase Polyclonal Antibody, Unconjugated from GeneTex
Description:...reacts with bacteria. Not yet tested in other species. Background Information Cholesterol oxidases exist as both type I and type II oxidases and are implicated in bacterial pathogenesis. In addition, they are important as clinical reagents, potential larvicides, and tools in cell biology....Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex
Description:...omprises the yeast Sir2-like proteins. Class I HDACs are ubiquitously expressed, and most class II HDACs are tissue-specific. Class II HDACs have been implicated in the regulation of muscle differentiation. Interaction of HDAC4, 5, and 7 with members of the MEF2 family of transcription factors represses their t...PARP Cleavage Detection Kit from Calbiochem
Description:... AVOID FREEZE/THAW CYCLES. An assay kit designed to detect poly(ADP-ribose) polymerase (PARP) cleavage by Western blotting. PARP is an enzyme implicated in DNA damage and repair mechanisms. During apoptosis, PARP is cleaved by caspase-3. Cleavage of PARP from the native 116 kDa to 85 kDa is a hallmark ...Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
Description:...hways in mammals. JNK pathway activation occurs in response to environmental stress, is associated with the nuclear accumulation of JNK itself, and is implicated in the immune response, cellular proliferation, oncogenic transformation, morphogenesis, and apoptosis.JIP1 (JNK-interacting protein-1, also known as ...